The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1)

Journal of Biomolecular Screening

Volumn 19, Issue 3, 2014, Pages 399-406

  Helleboid, Stéphane ^a   Haug, Christian ^b   Lamottke, Kai ^b   Zhou, Yijun ^c   Wei, Jianbing ^c   Daix, Sébastien ^a   Cambula, Linda ^a   Rigou, Géraldine ^a   Hum, Dean W ^a   Walczak, Robert ^a  

^a Genfit SA   (France)

^b Bicoll GmbH   (Germany)

^c Shanghai Fuchun Kexin Biotech Co Ltd   (China)

Author keywords

high throughput screening; natural products; neoruscogenin; NR1F1; plant extracts; ROR

Indexed keywords

NEORUSCOGENIN; PLANT EXTRACT; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RIFAMPICIN; RUSCOGENIN; SAPOGENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRACAENA; DRACAENA CAMBODIANA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME METABOLISM; LUCIFERASE ASSAY; MAXIMUM PLASMA CONCENTRATION; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

HIGH-THROUGHPUT SCREENING; NATURAL PRODUCTS; NEORUSCOGENIN; NR1F1; PLANT EXTRACTS; RORΑ;

BIOLOGICAL PRODUCTS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; PLANT EXTRACTS; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; SPIROSTANS;

EID: 84893863870     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113497095     Document Type: Article

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