Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ

Nature Structural and Molecular Biology

Volumn 14, Issue 12, 2007, Pages 1207-1213

  Raghuram, Srilatha ^a   Stayrook, Keith R ^b   Huang, Pengxiang ^a   Rogers, Pamela M ^c   Nosie, Amanda K ^b   McClure, Don B ^b   Burris, Lorri L ^b   Khorasanizadeh, Sepideh ^d   Burris, Thomas P ^c   Rastinejad, Fraydoon ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HEME; PROTEIN BMAL1; PROTEIN NR1D1; PROTEIN NR1D2; REV PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LIGAND BINDING; MAMMAL CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STABILITY; THERMOSTABILITY;

CELL LINE; CIRCULAR DICHROISM; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEME; HUMANS; LIGANDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 36849084107     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb1344     Document Type: Article

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