The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 2, 2012, Pages 582-587

  Gibbs, Julie E ^a   Blaikley, John ^a   Beesley, Stephen ^a   Matthews, Laura ^a   Simpson, Karen D ^b   Boyce, Susan H ^b   Farrow, Stuart N ^b   Else, Kathryn J ^a   Singh, Dave ^c   Ray, David W ^a   Loudon, Andrew S I ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; INTERLEUKIN 6; NUCLEAR RECEPTOR NR1D1; PROTEIN BMAL1;

ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; ANIMALS; ARNTL TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; ENDOTOXINS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, KNOCKOUT; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; TIME FACTORS;

ANIMALIA; MUS;

EID: 84856019342     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106750109     Document Type: Article

References (33)

1. Harrington M (2010) Location, location, location: Important for jet-lagged circadian loops. J Clin Invest 120:2265-2267.
2. Perry MG, Kirwan JR, Jessop DS, Hunt LP (2009) Overnight variations in cortisol, interleukin 6, tumour necrosis factor alpha and other cytokines in people with rheumatoid arthritis. Ann Rheum Dis 68(1):63-68.
3. Halberg F, Johnson EA, Brown BW, Bittner JJ (1960) Susceptibility rhythm to E. coli endotoxin and bioassay. Proc Soc Exp Biol Med 103:142-144.
4. Castanon-Cervantes O, et al. (2010) Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol 185:5796-5805.
5. Hayashi M, Shimba S, Tezuka M (2007) Characterization of the molecular clock in mouse peritoneal macrophages. Biol Pharm Bull 30:621-626. (Pubitemid 46570972)
6. Keller M, et al. (2009) A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci USA 106:21407-21412.
7. Yin L, Lazar MA (2005) The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Mol Endocrinol 19:1452-1459. (Pubitemid 41002977)
8. Yoo SH, et al. (2004) PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA 101:5339-5346.
9. Sasaki M, Yoshitane H, Du NH, Okano T, Fukada Y (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem 284:25149-25159.
10. Fontaine C, et al. (2008) The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages. Mol Endocrinol 22:1797-1811.
11. Journiac N, et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc Natl Acad Sci USA 106: 21365-21370.
12. Preitner N, et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110: 251-260. (Pubitemid 34876552)
13. Meng QJ, et al. (2008) Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner. J Cell Sci 121:3629-3635.
14. Raghuram S, et al. (2007) Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol 14:1207-1213. (Pubitemid 350223341)
15. Mitsui S, Yamaguchi S, Matsuo T, Ishida Y, Okamura H (2001) Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev 15: 995-1006. (Pubitemid 32323549)
16. Duez H, et al. (2008) Regulation of bile acid synthesis by the nuclear receptor Reverbalpha. Gastroenterology 135:689-698.
17. Kashiwada M, Cassel SL, Colgan JD, Rothman PB (2011) NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J 30:2071-2082.
18. Gascoyne DM, et al. (2009) The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat Immunol 10:1118-1124.
19. Motomura Y, et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12:450-459.
20. Kobayashi T, et al. (2011) NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J Immunol 186:4649-4655.
21. Marpegan L, et al. (2009) Diurnal variation in endotoxin-induced mortality in mice: Correlation with proinflammatory factors. Chronobiol Int 26:1430-1442.
22. Le Martelot G, et al. (2009) REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol 7:e1000181.
23. Bechtold DA, Gibbs JE, Loudon AS (2010) Circadian dysfunction in disease. Trends Pharmacol Sci 31(5):191-198.
24. Kumar N, et al. (2010) Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Endocrinology 151:3015-3025.
25. Piantadosi CA, et al. (2011) Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem 286:16374-16385.
26. Marvin KA, et al. (2009) Nuclear receptors homo sapiens Rev-erbbeta and Drosophila melanogaster E75 are thiolate-ligated heme proteins which undergo redox-mediated ligand switching and bind CO and NO. Biochemistry 48:7056-7071.
27. Marinou I, Walters K, Winfield J, Bax DE, Wilson AG (2010) A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility. Ann Rheum Dis 69:1191-1194.
28. Smolen JS, et al.; OPTION Investigators (2008) Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 371:987-997. (Pubitemid 351392039)
29. Dasgupta B, Corkill M, Kirkham B, Gibson T, Panayi G (1992) Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol 19 (1):22-25.
30. Ghisletti S, et al. (2009) Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev 23:681-693.
31. Huang W, et al. (2011) Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. Nature 470:414-418.
32. Storch KF, et al. (2007) Intrinsic circadian clock of the mammalian retina: Importance for retinal processing of visual information. Cell 130:730-741.
33. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Förster I (1999) Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8: 265-277. (Pubitemid 29523965)