Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4413-4417

  Shin, Youseung ^a   Noel, Romain ^a   Banerjee, Subhashis ^a   Kojetin, Douglas ^a   Song, Xinyi ^a   He, Yuanjun ^a   Lin, Li ^a   Cameron, Michael D ^a   Burris, Thomas P ^a   Kamenecka, Theodore M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Agonists; Drug discovery; Medicinal chemistry; Nuclear hormone receptor; SAR

Indexed keywords

NUCLEAR RECEPTOR NR1D1; NUCLEAR RECEPTOR NR1D1 AGONIST; SMALL MOLECULE TRANSPORT AGENT; TERTIARY AMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR LIBRARY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; BENZYLAMINES; BRAIN; MICE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

ANIMALIA;

EID: 84862230223     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.126     Document Type: Article

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