Increasing human Th17 differentiation through activation of orphan nuclear receptor retinoid acid-related orphan receptor γ (RORγ) by a class of aryl amide compounds

Molecular Pharmacology

Volumn 82, Issue 4, 2012, Pages 583-590

  Zhang, Wei ^a   Zhang, Jing ^a   Fang, Leiping ^a   Zhou, Ling ^a   Wang, Shuai ^a   Xiang, Zhijun ^a   Li, Yuan ^a   Wisely, Bruce ^b   Zhang, Guifeng ^a   An, Gang ^a   Wang, Yonghui ^a   Leung, Stewart ^a   Zhong, Zhong ^a  

^a GLAXOSMITHKLINE   (China)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

22 HYDROXYCHOLESTEROL; 25 HYDROXYCHOLESTEROL; [N (2 (4AETHYLPHENYL) 2H BENZO[D][1,2,3]TRIAZOL 5 YL) PROPIONAMIDE]; [N (5 BENZOYL 4 PHENYLTHIAZOL 2 YL) 2 (4 (ETHYLSULFONYL)PHENYL)ACETAMIDE]; AROMATIC AMIDE; CD3 ANTIGEN; COMPOUND 1A; COMPOUND 1B; INHIBITOR Y; INTERLEUKIN 17; PROTEIN INHIBITOR; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SR 1078; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CELL DIFFERENTIATION; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LIGAND BINDING; PLASMID; PRIORITY JOURNAL; TH17 CELL; THERMOSTABILITY;

AMIDES; BENZAMIDES; CELL DIFFERENTIATION; CIRCULAR DICHROISM; GENES, REPORTER; HUMANS; INTERLEUKIN-17; JURKAT CELLS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PRIMARY CELL CULTURE; PROTEIN STABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TH17 CELLS; THIAZOLES; TRIAZOLES;

EID: 84866884599     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.078667     Document Type: Article

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