The Meter of Metabolism

Cell

Volumn 134, Issue 5, 2008, Pages 728-742

  Green, Carla B ^a   Takahashi, Joseph S ^b   Bass, Joseph ^b,c,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d EVANSTON HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR CONTROL; BRAIN REGION; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM; CIRCADIAN RHYTHM; DIABETES MELLITUS; ENERGY BALANCE; FEEDBACK SYSTEM; FOOD INTAKE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; HOMEOSTASIS; HUMAN; METABOLIC DISORDER; METABOLIC REGULATION; METABOLISM; MOLECULAR INTERACTION; NERVE CELL NETWORK; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 50249100374     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2008.08.022     Document Type: Review

References (144)

1. Abizaid A., Liu Z.W., Andrews Z.B., Shanabrough M., Borok E., Elsworth J.D., Roth R.H., Sleeman M.W., Picciotto M.R., Tschop M.H., et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116 (2006) 3229-3239
2. Ahima R.S., and Flier J.S. Leptin. Annu. Rev. Physiol. 62 (2000) 413-437
3. Ahima R.S., Prabakaran D., and Flier J.S. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J. Clin. Invest. 101 (1998) 1020-1027
4. Akanmu M.A., Ukponmwan O.E., Katayama Y., and Honda K. Neuropeptide-Y Y2-receptor agonist, PYY3-36 promotes non-rapid eye movement sleep in rat. Neurosci. Res. 54 (2006) 165-170
5. Akashi M., and Takumi T. The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat. Struct. Mol. Biol. 12 (2005) 441-448
6. Akhtar R.A., Reddy A.B., Maywood E.S., Clayton J.D., King V.M., Smith A.G., Gant T.W., Hastings M.H., and Kyriacou C.P. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr. Biol. 12 (2002) 540-550
7. Allison K.C., Crow S.J., Reeves R.R., West D.S., Foreyt J.P., Dilillo V.G., Wadden T.A., Jeffery R.W., Van Dorsten B., and Stunkard A.J. Binge eating disorder and night eating syndrome in adults with type 2 diabetes. Obesity (Silver Spring) 15 (2007) 1287-1293
8. Antoch M.P., Song E.J., Chang A.M., Vitaterna M.H., Zhao Y., Wilsbacher L.D., Sangoram A.M., King D.P., Pinto L.H., and Takahashi J.S. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89 (1997) 655-667
9. Asher G., Gatfield D., Stratmann M., Reinke H., Dibner C., Kreppel F., Mostoslavsky R., Alt F.W., and Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 (2008) 317-328
10. Baggs J.E., and Green C.B. Nocturnin, a deadenylase in Xenopus laevis retina. A mechanism for posttranscriptional control of circadian-related mRNA. Curr. Biol. 13 (2003) 189-198
11. Balsalobre A., Damiola F., and Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93 (1998) 929-937
12. Balsalobre A., Brown S.A., Marcacci L., Tronche F., Kellendonk C., Reichardt H.M., Schutz G., and Schibler U. Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289 (2000) 2344-2347
13. Balsalobre A., Marcacci L., and Schibler U. Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts. Curr. Biol. 10 (2000) 1291-1294
14. Bartness T.J., Song C.K., and Demas G.E. SCN efferents to peripheral tissues: Implications for biological rhythms. J. Biol. Rhythms 16 (2001) 196-204
15. Boudina S., Sena S., Theobald H., Sheng X., Wright J.J., Hu X.X., Aziz S., Johnson J.I., Bugger H., Zaha V.G., et al. Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56 (2007) 2457-2466
16. Cailotto C., van Heijningen C., van der Vliet J., van der Plasse G., Habold C., Kalsbeek A., Pevet P., and Buijs R.M. Daily rhythms in metabolic liver enzymes and plasma glucose require a balance in the autonomic output to the liver. Endocrinology 149 (2008) 1914-1925
17. Canaple L., Rambaud J., Dkhissi-Benyahya O., Rayet B., Tan N.S., Michalik L., Delaunay F., Wahli W., and Laudet V. Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol. Endocrinol. 20 (2006) 1715-1727
18. Castillo M.R., Hochstetler K.J., Tavernier Jr. R.J., Greene D.M., and Bult-Ito A. Entrainment of the master circadian clock by scheduled feeding. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (2004) R551-R555
19. Challet E. Minireview: Entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals. Endocrinology 148 (2007) 5648-5655
20. Challet E., Pevet P., Vivien-Roels B., and Malan A. Phase-advanced daily rhythms of melatonin, body temperature, and locomotor activity in food-restricted rats fed during daytime. J. Biol. Rhythms 12 (1997) 65-79
21. Challet E., Losee-Olson S., and Turek F.W. Reduced glucose availability attenuates circadian responses to light in mice. Am. J. Physiol. 276 (1999) R1063-R1070
22. Chang G.Q., Karatayev O., Davydova Z., and Leibowitz S.F. Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus. Endocrinology 145 (2004) 3904-3912
23. Chen Z., Odstrcil E.A., Tu B.P., and McKnight S.L. Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science 316 (2007) 1916-1919
24. Claret M., Smith M.A., Batterham R.L., Selman C., Choudhury A.I., Fryer L.G., Clements M., Al-Qassab H., Heffron H., Xu A.W., et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J. Clin. Invest. 117 (2007) 2325-2336
25. Curtis A.M., Cheng Y., Kapoor S., Reilly D., Price T.S., and Fitzgerald G.A. Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc. Natl. Acad. Sci. USA 104 (2007) 3450-3455
26. Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., and Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev. 14 (2000) 2950-2961
27. Date Y., Ueta Y., Yamashita H., Yamaguchi H., Matsukura S., Kangawa K., Sakurai T., Yanagisawa M., and Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. USA 96 (1999) 748-753
28. Davidson A.J. Search for the feeding-entrainable circadian oscillator: A complex proposition. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (2006) R1524-R1526
29. Davidson A.J., Sellix M.T., Daniel J., Yamazaki S., Menaker M., and Block G.D. Chronic jet-lag increases mortality in aged mice. Curr. Biol. 16 (2006) R914-R916
30. Dioum E.M., Rutter J., Tuckerman J.R., Gonzalez G., Gilles-Gonzalez M.A., and McKnight S.L. NPAS2: A gas-responsive transcription factor. Science 298 (2002) 2385-2387
31. Dodd A.N., Salathia N., Hall A., Kevei E., Toth R., Nagy F., Hibberd J.M., Millar A.J., and Webb A.A. Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science 309 (2005) 630-633
32. Doi M., Hirayama J., and Sassone-Corsi P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 125 (2006) 497-508
33. Drucker D.J. The biology of incretin hormones. Cell Metab. 3 (2006) 153-165
34. Duez H., and Staels B. The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism. Diab. Vasc. Dis. Res. 5 (2008) 82-88
35. Durgan D.J., Trexler N.A., Egbejimi O., McElfresh T.A., Suk H.Y., Petterson L.E., Shaw C.A., Hardin P.E., Bray M.S., Chandler M.P., et al. The circadian clock within the cardiomyocyte is essential for responsiveness of the heart to fatty acids. J. Biol. Chem. 281 (2006) 24254-24269
36. Ellingsen T., Bener A., and Gehani A.A. Study of shift work and risk of coronary events. J. R. Soc. Health 127 (2007) 265-267
37. Elmquist J.K., Ahima R.S., Elias C.F., Flier J.S., and Saper C.B. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl. Acad. Sci. USA 95 (1998) 741-746
38. Farooqi I.S., Bullmore E., Keogh J., Gillard J., O'Rahilly S., and Fletcher P.C. Leptin regulates striatal regions and human eating behavior. Science 317 (2007) 1355
39. Feillet C.A., Ripperger J.A., Magnone M.C., Dulloo A., Albrecht U., and Challet E. Lack of food anticipation in Per2 mutant mice. Curr. Biol. 16 (2006) 2016-2022
40. Fu L., Pelicano H., Liu J., Huang P., and Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111 (2002) 41-50
41. Fu L., Patel M.S., Bradley A., Wagner E.F., and Karsenty G. The molecular clock mediates leptin-regulated bone formation. Cell 122 (2005) 803-815
42. Fulton S., Pissios P., Manchon R.P., Stiles L., Frank L., Pothos E.N., Maratos-Flier E., and Flier J.S. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51 (2006) 811-822
43. Gamble K.L., Allen G.C., Zhou T., and McMahon D.G. Gastrin-releasing peptide mediates light-like resetting of the suprachiasmatic nucleus circadian pacemaker through cAMP response element-binding protein and Per1 activation. J. Neurosci. 27 (2007) 12078-12087
44. Garbarino-Pico E., Niu S., Rollag M.D., Strayer C.A., Besharse J.C., and Green C.B. Immediate early response of the circadian polyA ribonuclease nocturnin to two extracellular stimuli. RNA 13 (2007) 745-755
45. Gimble J.M., Zvonic S., Floyd Z.E., Kassem M., and Nuttall M.E. Playing with bone and fat. J. Cell. Biochem. 98 (2006) 251-266
46. Gooley J.J., Schomer A., and Saper C.B. The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat. Neurosci. 9 (2006) 398-407
47. Gorbacheva V.Y., Kondratov R.V., Zhang R., Cherukuri S., Gudkov A.V., Takahashi J.S., and Antoch M.P. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc. Natl. Acad. Sci. USA 102 (2005) 3407-3412
48. Green C.B., Douris N., Kojima S., Strayer C.A., Fogerty J., Lourim D., Keller S.R., and Besharse J.C. Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc. Natl. Acad. Sci. USA 104 (2007) 9888-9893
49. Gu Y.Z., Hogenesch J.B., and Bradfield C.A. The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40 (2000) 519-561
50. Guan X.M., Hess J.F., Yu H., Hey P.J., and van der Ploeg L.H. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol. Cell. Endocrinol. 133 (1997) 1-7
51. Hagan M.M., Rushing P.A., Pritchard L.M., Schwartz M.W., Strack A.M., Van Der Ploeg L.H., Woods S.C., and Seeley R.J. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 (2000) R47-R52
52. Harris G.C., Wimmer M., and Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 (2005) 556-559
53. Hirota T., Okano T., Kokame K., Shirotani-Ikejima H., Miyata T., and Fukada Y. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. J. Biol. Chem. 277 (2002) 44244-44251
54. Holterhus P.M., Odendahl R., Oesingmann S., Lepler R., Wagner V., Hiort O., Holl R., Initiative G.A.D., and Group G.P.C.W. Classification of distinct baseline insulin infusion patterns in children and adolescents with type 1 diabetes on continuous subcutaneous insulin infusion therapy. Diabetes Care 30 (2007) 568-573
55. Hong H.K., Chong J.L., Song W., Song E.J., Jyawook A.A., Schook A.C., Ko C.H., and Takahashi J.S. Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior. PLoS Genet 3 (2007) e33
56. Hoogerwerf W.A., Hellmich H.L., Cornelissen G., Halberg F., Shahinian V.B., Bostwick J., Savidge T.C., and Cassone V.M. Clock gene expression in the murine gastrointestinal tract: Endogenous rhythmicity and effects of a feeding regimen. Gastroenterology 133 (2007) 1250-1260
57. Horvath T.L., and Gao X.B. Input organization and plasticity of hypocretin neurons: Possible clues to obesity's association with insomnia. Cell Metab. 1 (2005) 279-286
58. Inoue I., Shinoda Y., Ikeda M., Hayashi K., Kanazawa K., Nomura M., Matsunaga T., Xu H., Kawai S., Awata T., et al. CLOCK/BMAL1 is involved in lipid metabolism via transactivation of the peroxisome proliferator-activated receptor (PPAR) response element. J. Atheroscler. Thromb. 12 (2005) 169-174
59. Kaasik K., and Lee C.C. Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. Nature 430 (2004) 467-471
60. Kalra S.P., and Kalra P.S. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38 (2004) 201-211
61. Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., and Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 20 (1999) 68-100
62. Kalsbeek A., La Fleur S., Van Heijningen C., and Buijs R.M. Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J. Neurosci. 24 (2004) 7604-7613
63. Karlsson B., Knutsson A., and Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup. Environ. Med. 58 (2001) 747-752
64. Kemp D.M., Ubeda M., and Habener J.F. Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: Potential role in incretin-mediated cell function by sensitization of cAMP signaling. Mol. Cell. Endocrinol. 191 (2002) 157-166
65. Kewley R.J., Whitelaw M.L., and Chapman-Smith A. The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. Int. J. Biochem. Cell Biol. 36 (2004) 189-204
66. Kim S.P., Catalano K.J., Hsu I.R., Chiu J.D., Richey J.M., and Bergman R.N. Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia. Am. J. Physiol. Endocrinol. Metab. 292 (2007) E1590-E1598
67. King D.P., Zhao Y., Sangoram A.M., Wilsbacher L.D., Tanaka M., Antoch M.P., Steeves T.D., Vitaterna M.H., Kornhauser J.M., Lowrey P.L., et al. Positional cloning of the mouse circadian Clock gene. Cell 89 (1997) 641-653
68. Kita Y., Shiozawa M., Jin W., Majewski R.R., Besharse J.C., Greene A.S., and Jacob H.J. Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics 12 (2002) 55-65
69. Kohsaka A., Laposky A.D., Ramsey K.M., Estrada C., Joshu C., Kobayashi Y., Turek F.W., and Bass J. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 6 (2007) 414-421
70. Kondratov R.V., Kondratova A.A., Gorbacheva V.Y., Vykhovanets O.V., and Antoch M.P. Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 20 (2006) 1868-1873
71. Kondratov R.V., Gorbacheva V.Y., and Antoch M.P. The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. Curr. Top. Dev. Biol. 78 (2007) 173-216
72. Kornmann B., Schaad O., Bujard H., Takahashi J.S., and Schibler U. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol. 5 (2007) e34
73. Ladenheim E.E., Hampton L.L., Whitney A.C., White W.O., Battey J.F., and Moran T.H. Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice. J. Endocrinol. 174 (2002) 273-281
74. Lamont E.W., Diaz L.R., Barry-Shaw J., Stewart J., and Amir S. Daily restricted feeding rescues a rhythm of period2 expression in the arrhythmic suprachiasmatic nucleus. Neuroscience 132 (2005) 245-248
75. Landry G.J., Yamakawa G.R., and Mistlberger R.E. Robust food anticipatory circadian rhythms in rats with complete ablation of the thalamic paraventricular nucleus. Brain Res. 1141 (2007) 108-118
76. Laposky A.D., Bass J., Kohsaka A., and Turek F.W. Sleep and circadian rhythms: Key components in the regulation of energy metabolism. FEBS Lett. 582 (2007) 142-151
77. Leone T.C., Lehman J.J., Finck B.N., Schaeffer P.J., Wende A.R., Boudina S., Courtois M., Wozniak D.F., Sambandam N., Bernal-Mizrachi C., et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 3 (2005) e101
78. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1 (2005) 361-370
79. Liu C., Li S., Liu T., Borjigin J., and Lin J.D. Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447 (2007) 477-481
80. Lowrey P.L., and Takahashi J.S. Mammalian circadian biology: Elucidating genome-wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 5 (2004) 407-441
81. Martin T.L., Alquier T., Asakura K., Furukawa N., Preitner F., and Kahn B.B. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J. Biol. Chem. 281 (2006) 18933-18941
82. Masaki T., Chiba S., Yasuda T., Noguchi H., Kakuma T., Watanabe T., Sakata T., and Yoshimatsu H. Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes 53 (2004) 2250-2260
83. Matsumoto M., Han S., Kitamura T., and Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J. Clin. Invest. 116 (2006) 2464-2472
84. Matsuo T., Yamaguchi S., Mitsui S., Emi A., Shimoda F., and Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science 302 (2003) 255-259
85. McCarthy J.J., Andrews J.L., McDearmon E.L., Campbell K.S., Barber B.K., Miller B.H., Walker J.R., Hogenesch J.B., Takahashi J.S., and Esser K.A. Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol. Genomics 31 (2007) 86-95
86. McClung C.A., Sidiropoulou K., Vitaterna M., Takahashi J.S., White F.J., Cooper D.C., and Nestler E.J. Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc. Natl. Acad. Sci. USA 102 (2005) 9377-9381
87. McDearmon E.L., Patel K.N., Ko C.H., Walisser J.A., Schook A.C., Chong J.L., Wilsbacher L.D., Song E.J., Hong H.K., Bradfield C.A., et al. Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science 314 (2006) 1304-1308
88. McNamara P., Seo S.B., Rudic R.D., Sehgal A., Chakravarti D., and FitzGerald G.A. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 105 (2001) 877-889
89. Mendoza J., Angeles-Castellanos M., and Escobar C. A daily palatable meal without food deprivation entrains the suprachiasmatic nucleus of rats. Eur. J. Neurosci. 22 (2005) 2855-2862
90. Mendoza J., Graff C., Dardente H., Pevet P., and Challet E. Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. J. Neurosci. 25 (2005) 1514-1522
91. Mieda M., Williams S.C., Richardson J.A., Tanaka K., and Yanagisawa M. The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc. Natl. Acad. Sci. USA 103 (2006) 12150-12155
92. Mistlberger R.E. Effects of scheduled food and water access on circadian rhythms of hamsters in constant light, dark, and light:dark. Physiol. Behav. 53 (1993) 509-516
93. Murphy K.G., and Bloom S.R. Gut hormones and the regulation of energy homeostasis. Nature 444 (2006) 854-859
94. Nakahata Y., Kaluzova M., Grimaldi B., Sahar S., Hirayama J., Chen D., Guarente L.P., and Sassone-Corsi P. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134 (2008) 329-340
95. Nyholm B., Walker M., Gravholt C.H., Shearing P.A., Sturis J., Alberti K.G., Holst J.J., and Schmitz O. Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: Evidence of several aberrations. Diabetologia 42 (1999) 1314-1323
96. Oishi K., Atsumi G., Sugiyama S., Kodomari I., Kasamatsu M., Machida K., and Ishida N. Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice. FEBS Lett. 580 (2006) 127-130
97. Oster H., Damerow S., Kiessling S., Jakubcakova V., Abraham D., Tian J., Hoffmann M.W., and Eichele G. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Cell Metab. 4 (2006) 163-173
98. Ouyang Y., Andersson C.R., Kondo T., Golden S.S., and Johnson C.H. Resonating circadian clocks enhance fitness in cyanobacteria. Proc. Natl. Acad. Sci. USA 95 (1998) 8660-8664
99. Panda S., Antoch M.P., Miller B.H., Su A.I., Schook A.B., Straume M., Schultz P.G., Kay S.A., Takahashi J.S., and Hogenesch J.B. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109 (2002) 307-320
100. Parton L.E., Ye C.P., Coppari R., Enriori P.J., Choi B., Zhang C.Y., Xu C., Vianna C.R., Balthasar N., Lee C.E., et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449 (2007) 228-232
101. Penev P.D., Kolker D.E., Zee P.C., and Turek F.W. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease. Am. J. Physiol. 275 (1998) H2334-H2337
102. Pocai A., Obici S., Schwartz G.J., and Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metab. 1 (2005) 53-61
103. Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., and Schibler U. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110 (2002) 251-260
104. Raghuram S., Stayrook K.R., Huang P., Rogers P.M., Nosie A.K., McClure D.B., Burris L.L., Khorasanizadeh S., Burris T.P., and Rastinejad F. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat. Struct. Mol. Biol. 14 (2007) 1207-1213
105. Ralph M.R., Foster R.G., Davis F.C., and Menaker M. Transplanted suprachiasmatic nucleus determines circadian period. Science 247 (1990) 975-978
106. Ramsey K.M., Marcheva B., Kohsaka A., and Bass J. The clockwork of metabolism. Annu. Rev. Nutr. 27 (2007) 219-240
107. Reddy A.B., Karp N.A., Maywood E.S., Sage E.A., Deery M., O'Neill J.S., Wong G.K., Chesham J., Odell M., Lilley K.S., et al. Circadian orchestration of the hepatic proteome. Curr. Biol. 16 (2006) 1107-1115
108. Reddy A.B., Maywood E.S., Karp N.A., King V.M., Inoue Y., Gonzalez F.J., Lilley K.S., Kyriacou C.P., and Hastings M.H. Glucocorticoid signaling synchronizes the liver circadian transcriptome. Hepatology 45 (2007) 1478-1488
109. Reilly D.F., Westgate E.J., and FitzGerald G.A. Peripheral circadian clocks in the vasculature. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 1694-1705
110. Rudic R.D., McNamara P., Curtis A.M., Boston R.C., Panda S., Hogenesch J.B., and Fitzgerald G.A. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2 (2004) e377
111. Rutter J., Reick M., Wu L.C., and McKnight S.L. Regulation of CLOCK and NPAS2 DNA binding by the redox state of NAD cofactors. Science 293 (2001) 510-514
112. Sakkou M., Wiedmer P., Anlag K., Hamm A., Seuntjens E., Ettwiller L., Tschop M.H., and Treier M. A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 5 (2007) 450-463
113. Sandoval D., Cota D., and Seeley R.J. The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation. Annu. Rev. Physiol. 70 (2007) 513-535
114. Sato T.K., Panda S., Miraglia L.J., Reyes T.M., Rudic R.D., McNamara P., Naik K.A., FitzGerald G.A., Kay S.A., and Hogenesch J.B. A functional genomics strategy reveals RORalpha as a component of the mammalian circadian clock. Neuron 43 (2004) 527-537
115. Shimba S., Ishii N., Ohta Y., Ohno T., Watabe Y., Hayashi M., Wada T., Aoyagi T., and Tezuka M. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc. Natl. Acad. Sci. USA 102 (2005) 12071-12076
116. Siepka S.M., Yoo S.H., Park J., Lee C., and Takahashi J.S. Genetics and neurobiology of circadian clocks in mammals. Cold Spring Harb. Symp. Quant. Biol. 72 (2007) 251-259
117. Sindelar D.K., Palmiter R.D., Woods S.C., and Schwartz M.W. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides 26 (2005) 2597-2602
118. Spiegel K., Tasali E., Penev P., and Van Cauter E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann. Intern. Med. 141 (2004) 846-850
119. Stephan F.K. The "other" circadian system: Food as a Zeitgeber. J. Biol. Rhythms 17 (2002) 284-292
120. Stokkan K.A., Yamazaki S., Tei H., Sakaki Y., and Menaker M. Entrainment of the circadian clock in the liver by feeding. Science 291 (2001) 490-493
121. Storch K., Lipan O., Leykin I., Viswanathan N., Davis F., Wong W., and Weitz C. Extensive and divergent circadian gene expression in liver and heart. Nature 417 (2002) 78-83
122. Sun S., Albrecht U., Zhuchenko O., Bailey J., Eichele G., and Lee C. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 90 (1997) 1003-1011
123. Taheri S., Lin L., Austin D., Young T., and Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 1 (2004) e62
124. Tang-Christensen M., Vrang N., Ortmann S., Bidlingmaier M., Horvath T.L., and Tschop M. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145 (2004) 4645-4652
125. Tasali E., Leproult R., Ehrmann D.A., and Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc. Natl. Acad. Sci. USA 105 (2008) 1044-1049
126. Tei H., Okamura H., Shigeyoshi Y., Fukuhara C., Ozawa R., Hirose M., and Sakaki Y. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature 389 (1997) 512-516
127. Turek F.W., Joshu C., Kohsaka A., Lin E., Ivanova G., McDearmon E., Laposky A., Losee-Olson S., Easton A., Jensen D.R., et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308 (2005) 1043-1045
128. Ueda H.R., Chen W., Adachi A., Wakamatsu H., Hayashi S., Takasugi T., Nagano M., Nakahama K., Suzuki Y., Sugano S., et al. A transcription factor response element for gene expression during circadian night. Nature 418 (2002) 534-539
129. Um J.H., Yang S., Yamazaki S., Kang H., Viollet B., Foretz M., and Chung J.H. Activation of 5′-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2. J. Biol. Chem. 282 (2007) 20794-20798
130. Van Cauter E., Polonsky K.S., and Scheen A.J. Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr. Rev. 18 (1997) 716-738
131. van der Veen D.R., Minh N.L., Gos P., Arneric M., Gerkema M.P., and Schibler U. Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc. Natl. Acad. Sci. USA 103 (2006) 3393-3398
132. Williams D.L., Baskin D.G., and Schwartz M.W. Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 55 (2006) 3387-3393
133. Yamanaka A., Beuckmann C.T., Willie J.T., Hara J., Tsujino N., Mieda M., Tominaga M., Yagami K., Sugiyama F., Goto K., et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38 (2003) 701-713
134. Yamazaki S., Numano R., Abe M., Hida A., Takahashi R., Ueda M., Block G.D., Sakaki Y., Menaker M., and Tei H. Resetting central and peripheral circadian oscillators in transgenic rats. Science 288 (2000) 682-685
135. Yang X., Downes M., Yu R.T., Bookout A.L., He W., Straume M., Mangelsdorf D.J., and Evans R.M. Nuclear receptor expression links the circadian clock to metabolism. Cell 126 (2006) 801-810
136. Yannielli P., and Harrington M.E. Let there be "more" light: Enhancement of light actions on the circadian system through non-photic pathways. Prog. Neurobiol. 74 (2004) 59-76
137. Yannielli P.C., Molyneux P.C., Harrington M.E., and Golombek D.A. Ghrelin effects on the circadian system of mice. J. Neurosci. 27 (2007) 2890-2895
138. Yi C.X., van der Vliet J., Dai J., Yin G., Ru L., and Buijs R.M. Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus. Endocrinology 147 (2006) 283-294
139. Yin L., Wu N., Curtin J.C., Qatanani M., Szwergold N.R., Reid R.A., Waitt G.M., Parks D.J., Pearce K.H., Wisely G.B., et al. Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science 318 (2007) 1786-1789
140. Yoo S.H., Yamazaki S., Lowrey P.L., Shimomura K., Ko C.H., Buhr E.D., Siepka S.M., Hong H.K., Oh W.J., Yoo O.J., et al. PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc. Natl. Acad. Sci. USA 101 (2004) 5339-5346
141. Young M.E. The circadian clock within the heart: Potential influence on myocardial gene expression, metabolism, and function. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H1-H16
142. Zheng X., Yang Z., Yue Z., Alvarez J.D., and Sehgal A. FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. USA 104 (2007) 15899-15904
143. Zigman J.M., Jones J.E., Lee C.E., Saper C.B., and Elmquist J.K. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J. Comp. Neurol. 494 (2006) 528-548
144. Zvonic S., Ptitsyn A.A., Conrad S.A., Scott L.K., Floyd Z.E., Kilroy G., Wu X., Goh B.C., Mynatt R.L., and Gimble J.M. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55 (2006) 962-970