Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3739-3742

  Noel, Romain ^a   Song, Xinyi ^a   Shin, Youseung ^a   Banerjee, Subhashis ^a   Kojetin, Douglas ^a   Lin, Li ^a   Ruiz, Claudia H ^a   Cameron, Michael D ^a   Burris, Thomas P ^a   Kamenecka, Theodore M ^a  

^a Translational Research Institute   (United States)

Author keywords

Agonist; Nuclear hormone receptor; Structure activity relationship

Indexed keywords

GSK 4112; GSK4112; NUCLEAR RECEPTOR NR1D1; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IN VIVO STUDY; NONHUMAN; PROCESS OPTIMIZATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; INJECTIONS, INTRAPERITONEAL; ISOQUINOLINES; NAPHTHALENES; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 1; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861199298     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.023     Document Type: Article

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