Digoxin and its derivatives suppress T H17 cell differentiation by antagonizing RORγ3t activity

Nature

Volumn 472, Issue 7344, 2011, Pages 486-490

  Huh, Jun R ^a   Leung, Monica W L ^a   Huang, Pengxiang ^b   Ryan, Daniel A ^c   Krout, Michael R ^c   Malapaka, Raghu R V ^d   Chow, Jonathan ^a   Manel, Nicolas ^a,e   Ciofani, Maria ^a   Kim, Sangwon V ^a   Cuesta, Adolfo ^a   Santori, Fabio R ^a   Lafaille, Juan J ^a   Xu, H Eric ^d   Gin, David Y ^c   Rastinejad, Fraydoon ^b   Littman, Dan R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d VAN ANDEL RESEARCH INSTITUTE   (United States)

^e PSL RESEARCH UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

20,22 DIHYDRODIGOXIN 21,23 DIOL; DIGOXIN; DIGOXIN 21 SALICYLIDENE; INTERLEUKIN 17; ORPHAN NUCLEAR RECEPTOR; RETINOIC ACID RECEPTOR RELATED ORPHAN NUCLEAR RECEPTOR; UNCLASSIFIED DRUG;

CYTOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; GENOME; IMMUNITY; INHIBITOR; RODENT;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DRUG INHIBITION; DRUG PROTEIN BINDING; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH17 CELL;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL LINE; DIGOXIN; DROSOPHILA; HUMANS; INTERLEUKIN-17; MICE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; TH17 CELLS; TRANSCRIPTION, GENETIC;

HEXAPODA; MURINAE; MUS;

EID: 79955538365     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09978     Document Type: Article

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