A second class of nuclear receptors for oxysterols: Regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol)

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1801, Issue 8, 2010, Pages 917-923

  Wang, Yongjun ^a   Kumar, Naresh ^a   Crumbley, Christine ^a   Griffin, Patrick R ^a   Burris, Thomas P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cholesterol; Circadian; Lipid; LXR; Orphan receptor; REV ERB

Indexed keywords

24 HYDROXYCHOLESTEROL; HORMONE RECEPTOR; OXYSTEROL; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR ALPHA; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; RADIOASSAY; REGULATORY MECHANISM;

CELLS, CULTURED; GENES, REPORTER; HEP G2 CELLS; HUMANS; HYDROXYCHOLESTEROLS; MODELS, BIOLOGICAL; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, SMALL INTERFERING; STEROLS; TRANSCRIPTIONAL ACTIVATION;

EID: 77953243855     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2010.02.012     Document Type: Article

References (34)

1. Dietschy J.M., and Turley S.D. Cholesterol metabolism in the brain. Curr. Opin. Lipidol. 12 (2001) 105-112
2. Chen W.L., Chen G.X., Head D.L., Mangelsdorf D.J., and Russell D.W. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab. 5 (2007) 73-79
3. Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.-L., Sundseth S.S., Winegar D.A., Blanchard D.E., Spencer T.A., and Willson T.M. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272 (1997) 3137-3140
4. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., and Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383 (1996) 728-731
5. Janowski B.A., Grogan M.J., Jones S.A., Wisely G.B., Kliewer S.A., Corey E.J., and Mangelsdorf D.J. Structural requirements of ligands for the oxysterol liver X receptors LXR alpha and LXR beta. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 266-271
6. Whitney K.D., Watson M.A., Collins J.L., Benson W.G., Stone T.M., Numerick M.J., Tippin T.K., Wilson J.G., Winegar D.A., and Kliewer S.A. Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol. Endocrinol. 16 (2002) 1378-1385
7. Laffitte B.A., Repa J.J., Joseph S.B., Wilpiltz D.C., Kast H.R., Mangelsdorf D.J., and Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 507-512
8. Liang Y., Lin S.Z., Beyer T.P., Zhang Y.Y., Wu X., Bales K.R., DeMattos R.B., May P.C., Li S.Y.D., Jiang X.C., Eacho P.I., Cao G.Q., and Paul S.M. A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. J. Neurochem. 88 (2004) 623-634
9. Puglielli L., Tanzi R.E., and Kovacs D.M. Alzheimer's disease: the cholesterol connection. Nat. Neurosci. 6 (2003) 345-351
10. Vaya J., and Schipper H.M. Oxysterols, cholesterol homeostasis, and Alzheimer disease. J. Neurochem. 102 (2007) 1727-1737
11. Zelcer N., Khanlou N., Clare R., Jiang Q., Reed-Geaghan E.G., Landreth G.E., Vinters H.V., and Tontonoz P. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 10601-10606
12. Riddell D.R., Zhou H., Comery T.A., Kouranova E., Lo C.F., Warwick H.K., Ring R.H., Kirksey Y., Aschmies S., Xu J., Kubek K., Hirst W.D., Gonzales C., Chen Y., Murphy E., Leonard S., Vasylyev D., Oganesian A., Martone R.L., Pangalos M.N., Reinhart P.H., and Jacobsen J.S. The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol. Cell. Neurosci. 34 (2007) 621-628
13. Koldamova R.P., Lefterov I.M., Staufenbiel M., Wolfe D., Huang S., Glorioso J.C., Walter M., Roth M.G., and Lazo J.S. The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J. Biol. Chem. 280 (2005) 4079-4088
14. Jetten A.M. Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl. Recept. Signal. 7 (2009) e003
15. Winoto A., and Littman D.R. Nuclear hormone receptors in T lymphocytes. Cell 109 (2002) S57-S66
16. Kang H.S., Angers M., Beak J.Y., Wu X., Gimble J.M., Wada T., Xie W., Collins J.B., Grissom S.F., and Jetten A.M. Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol. Genomics 31 (2007) 281-294
17. Kallen J.A., Schlaeppi J.M., Bitsch F., Geisse S., Geiser M., Delhon I., and Fournier B. X-ray structure of the hROR alpha LBD at 1.63 angstrom: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of ROR alpha. Structure 10 (2002) 1697-1707
18. Wang Y., Kumar N., Solt L.A., Richardson T.I., Helvering L.M., Crumbley C., Garcia-Ordonez R.A., Stayrook K.R., Zhang X., Novick S., Chalmers M.J., Griffin P.R., and Burris T.P. Modulation of RORalpha and RORgamma activity by 7-oxygenated sterol ligands. J. Biol. Chem. 285 (2010) 5013-5025
19. Raghuram S., Stayrook K.R., Huang P., Rogers P.M., Nosie A.K., McClure D.B., Burris L.L., Khorasanizadeh S., Burris T.P., and Rastinejad F. Identification of heme as the ligand for the orphan nuclear receptors REV-ERB[alpha] and REV-ERB[beta]. Nat. Struct. Mol. Biol. 14 (2007) 1207-1213
20. Kumar N., Solt L.A., Conkright J.J., Wang Y., Istrate M.A., Busby S.A., Garcia-Ordonez R., Burris T.P., and Griffin P.R. The benzenesulfonamide T0901317 is a novel ROR{alpha}/{gamma} inverse agonist. Mol. Pharmacol. 77 (2010) 228-236
21. Burris T.P. Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Mol. Endocrinol. 22 (2008) 1509-1520
22. Chopra A.R., Louet J.F., Saha P., An J., DeMayo F., Xu J.M., York B., Karpen S., Finegold M., Moore D., Chan L., Newgard C.B., and O'Malley B.W. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's Disease. Science 322 (2008) 1395-1399
23. Delerive P., Chin W.W., and Suen C.S. Identification of Reverb alpha as a novel ROR alpha target gene. J. Biol. Chem. 277 (2002) 35013-35018
24. Raspe E., Mautino G., Duval C., Fontaine C., Duez H., Barbier O., Monte D., Fruchart J., Fruchart J.C., and Staels B. Transcriptional regulation of human Rev-erb alpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha. J. Biol. Chem. 277 (2002) 49275-49281
25. Sato T.K., Panda S., Miraglia L.J., Reyes T.M., Rudic R.D., McNamara P., Naik K.A., Fitzgerald G.A., Kay S.A., and Hogenesch J.B. A functional genomics strategy reveals rora as a component of the mammalian circadian clock. Neuron 43 (2004) 527-537
26. Metivier R., Penot G., Hubner M.R., Reid G., Brand H., Kos M., and Gannon F. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115 (2003) 751-763
27. Spencer T.A., Gayen A.K., Phirwa S., Nelson J.A., Taylor F.R., Kandutsch A.A., and Erickson S.K. 24(S), 25-Epoxycholesterol - evidence consistent with a role in the regulation of hepatic cholesterogenesis. J. Biol. Chem. 260 (1985) 3391-3394
28. Wong J., Quinn C.M., Guillemin G., and Brown A.J. Primary human astrocytes produce 24(< i>S), 25-epoxycholesterol with implications for brain cholesterol homeostasis. J. Neurochem. 103 (2007) 1764-1773
29. Lutjohann D., Papassotiropoulos A., Bjorkhem I., Locatelli S., Bagli M., Oehring R.D., Schlegel U., Jessen F., Rao M.L., von Bergmann K., and Heun R. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J. Lipid Res. 41 (2000) 195-198
30. Bretillon L., Lutjohann D., Stahle L., Widhe T., Bindl L., Eggertsen G., Diczfalusy U., and Bjorkhem I. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. J. Lipid Res. 41 (2000) 840-845
31. Jick H., Zornberg G.L., Jick S.S., Seshadri S., and Drachman D.A. Statins and the risk of dementia. Lancet 356 (2000) 1627-1631
32. Wolozin B., Kellman W., Ruosseau P., Celesia G.G., and Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57 (2000) 1439-1443
33. Vega G.L., Weiner M.F., Lipton A.M., von Bergmann K., Lutjohann D., Moore C., and Svetlik D. Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Arch. Neurol. 60 (2003) 510-515
34. Jiang Q., Lee C.Y.D., Mandrekar S., Wilkinson B., Cramer P., Zelcer N., Mann K., Lamb B., Willson T.M., Collins J.L., Richardson J.C., Smith J.D., Comery T.A., Riddell D., Holtzman D.M., Tontonoz P., and Landreth G.E. ApoE promotes the proteolytic degradation of A beta. Neuron 58 (2008) 681-693