Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells

Journal of Immunology

Volumn 191, Issue 2, 2013, Pages 540-544

  Youngblood, Ben ^a   Noto, Alessandra ^b   Porichis, Filippos ^c   Akondy, Rama S ^a   Ndhlovu, Zaza M ^c,d   Austin, James W ^a   Bordi, Rebeka ^b   Procopio, Francesco A ^b   Miura, Toshiyuki ^e,f   Allen, Todd M ^c   Sidney, John ^g   Sette, Alessandro ^g   Walker, Bruce D ^c,h   Ahmed, Rafi ^a   Boss, Jeremy M ^a   Seḱaly, Rafick Pierre ^b   Kaufmann, Daniel E ^c,i  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Vaccine and Gene Therapy Institute of Florida   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e VIIV HEALTHCARE   (United States)

^f NAGASAKI UNIVERSITY   (Japan)

^g LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^h HOWARD HUGHES MEDICAL INSTITUTE   (United States)

ⁱ CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; PROGRAMMED DEATH 1 RECEPTOR;

ANTIGEN PRESENTATION; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DEAMINATION; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE LOCUS; GENETIC HETEROGENEITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIRUS LOAD;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD8-POSITIVE T-LYMPHOCYTES; DNA METHYLATION; HIV INFECTIONS; HIV-1; HUMANS; PROGRAMMED CELL DEATH 1 RECEPTOR; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; VIRAL LOAD;

EID: 84880119204     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1203161     Document Type: Article

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