CD8+ T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function

Journal of Experimental Medicine

Volumn 195, Issue 11, 2002, Pages 1407-1418

  Öhlén, Claes ^a   Kalos, Michael ^a,d   Cheng, Laurence E ^a   Shur, Aaron C ^b   Hong, Doley J ^b   Carson, Bryan D ^a   Kokot, Niels C T ^a   Lerner, Cara G ^a   Sather, Blythe D ^a   Huseby, Eric S ^a,e   Greenberg, Philip D ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d GLAXOSMITHKLINE   (United States)

^e NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Autoimmunity; CTL; Hepatocyte; Signaling; Tumor immunology

Indexed keywords

CALCIUM ION; GAMMA INTERFERON; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CELL PROLIFERATION; CYTOKINE PRODUCTION; CYTOLYSIS; ENZYME PHOSPHORYLATION; IMMUNOLOGICAL TOLERANCE; LIVER CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD95; ANTIGENS, NEOPLASM; CALCIUM; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELL EXTRACTS; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNE TOLERANCE; INTERFERON TYPE II; INTERLEUKIN-2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037013829     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011063     Document Type: Article

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