메뉴 건너뛰기




Volumn 11, Issue 1, 2010, Pages 21-27

Mechanisms maintaining peripheral tolerance

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 74049160009     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1817     Document Type: Review
Times cited : (345)

References (87)
  • 1
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlS
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
    • (2007) Nature , vol.447 , pp. 661-678
  • 2
    • 53649098737 scopus 로고    scopus 로고
    • Pathway analysis of seven common diseases assessed by genome-wide association
    • Torkamani, A., Topol, E.J. & Schork, N.J. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 92, 265-272 (2008).
    • (2008) Genomics , vol.92 , pp. 265-272
    • Torkamani, A.1    Topol, E.J.2    Schork, N.J.3
  • 3
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat
    • Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2, 1032-1039 (2001).
    • (2001) Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 4
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the aire protein
    • Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395-1401 (2002).
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1
  • 5
    • 74049110516 scopus 로고    scopus 로고
    • Checkpoints in lymphocyte development and autoImmune disease
    • Von Boehmer, H. & Melchers, F. Checkpoints in lymphocyte development and autoImmune disease. Nat. Immunol. 11, 14-20 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 14-20
    • Von Boehmer, H.1    Melchers, F.2
  • 6
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing, K. & Sakaguchi, S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 11, 7-13 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 7
    • 0028824098 scopus 로고
    • Low avidity Recognition of self-antigen by T cells permits escape from central tolerance
    • Liu, G.Y. et al. Low avidity Recognition of self-antigen by T cells permits escape from central tolerance. Immunity 3, 407-415 (1995).
    • (1995) Immunity , vol.3 , pp. 407-415
    • Liu, G.Y.1
  • 8
    • 0027468174 scopus 로고
    • Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
    • Goverman, J. et al. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72, 551-560 (1993).
    • (1993) Cell , vol.72 , pp. 551-560
    • Goverman, J.1
  • 9
    • 0032795286 scopus 로고    scopus 로고
    • Tolerance and autoimmunity in TCr transgenic mice specific for myelin basic protein
    • Goverman, J. Tolerance and autoimmunity in TCr transgenic mice specific for myelin basic protein. Immunol. Rev. 169, 147-159 (1999).
    • (1999) Immunol. Rev. , vol.169 , pp. 147-159
    • Goverman, J.1
  • 10
    • 33747092627 scopus 로고    scopus 로고
    • T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    • Zehn, D. & Bevan, M.J. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 25, 261-270 (2006).
    • (2006) Immunity , vol.25 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2
  • 11
    • 39449094869 scopus 로고    scopus 로고
    • T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold T cell activation
    • Henrickson, S.E. et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat. Immunol. 9, 282-291 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 282-291
    • Henrickson, S.E.1
  • 12
    • 38949135155 scopus 로고    scopus 로고
    • The microanatomy of T-cell responses
    • Lammermann, T. & Sixt, M. The microanatomy of T-cell responses. Immunol. Rev. 221, 26-43 (2008).
    • (2008) Immunol. Rev. , vol.221 , pp. 26-43
    • Lammermann, T.1    Sixt, M.2
  • 13
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 14
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phaseS
    • Mempel, T.R., Henrickson, S.E. & von Andrian, U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 (2004).
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    Von Andrian, U.H.3
  • 15
    • 35348978611 scopus 로고    scopus 로고
    • Real-time manipulation of T cell-dendritic cell Interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation
    • Celli, S., Lemaitre, F. & Bousso, P. real-time manipulation of T cell-dendritic cell Interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 27, 625-634 (2007).
    • (2007) Immunity , vol.27 , pp. 625-634
    • Celli, S.1    Lemaitre, F.2    Bousso, P.3
  • 16
    • 0025755292 scopus 로고
    • Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
    • Ohashi, P.S. et al. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65, 305-317 (1991).
    • (1991) Cell , vol.65 , pp. 305-317
    • Ohashi, P.S.1
  • 17
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD4 T cells in the whole body
    • Reinhardt, R.L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M.K. visualizing the generation of memory CD4 T cells in the whole body. Nature 410; 101-105 (2001).
    • (2001) Nature , vol.410 , pp. 101-105
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3    Zell, T.4    Jenkins, M.K.5
  • 18
    • 0035937587 scopus 로고    scopus 로고
    • Preferential localization of Effector memory cells in nonlymphoid tissue
    • Masopust, D., Vezys, V., Marzo, A.L. & Lefrancois, L. Preferential localization of Effector memory cells in nonlymphoid tissue. Science 291, 2413-2417 (2001).
    • (2001) Science , vol.291 , pp. 2413-2417
    • Masopust, D.1    Vezys, V.2    Marzo, A.L.3    Lefrancois, L.4
  • 19
    • 0031012138 scopus 로고    scopus 로고
    • P-and e-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissueS
    • Austrup, F. et al. P-and e-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature 385, 81-83 (1997).
    • (1997) Nature , vol.385 , pp. 81-83
    • Austrup, F.1
  • 20
    • 0345268754 scopus 로고    scopus 로고
    • Preferential accumulation of antigen-specific Effector CD4 T cells at an antigen injection site involves CD62e-dependent migration but not local proliferation
    • Reinhardt, R.L., Bullard, D.C., Weaver, C.T. & Jenkins, M.K. Preferential accumulation of antigen-specific Effector CD4 T cells at an antigen injection site involves CD62e-dependent migration but not local proliferation. J. Exp. Med. 197, 751-762 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 751-762
    • Reinhardt, R.L.1    Bullard, D.C.2    Weaver, C.T.3    Jenkins, M.K.4
  • 21
    • 1542308572 scopus 로고    scopus 로고
    • Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin
    • Masopust, D. et al. Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J. Immunol. 172, 4875-4882 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4875-4882
    • Masopust, D.1
  • 22
    • 65249150347 scopus 로고    scopus 로고
    • Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOvA mice
    • Bianchi, T. et al. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOvA mice. J. Immunol. 182, 4665-4674 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 4665-4674
    • Bianchi, T.1
  • 23
    • 65249151483 scopus 로고    scopus 로고
    • Langerhans cells are not required for the CD8 T cell response to epidermal self-antigenS
    • Bursch, L.S., Rich, B.E. & Hogquist, K.A. Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. J. Immunol. 182, 4657-4664 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 4657-4664
    • Bursch, L.S.1    Rich, B.E.2    Hogquist, K.A.3
  • 24
    • 33748750976 scopus 로고    scopus 로고
    • Immune cell migration as a means to control Immune privILege: Lessons from the CNS and tumors
    • Mrass, P. & Weninger, W. Immune cell migration as a means to control Immune privILege: lessons from the CNS and tumors. Immunol. Rev. 213, 195-212 (2006).
    • (2006) Immunol. Rev. , vol.213 , pp. 195-212
    • Mrass, P.1    Weninger, W.2
  • 25
    • 33846546257 scopus 로고    scopus 로고
    • Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self
    • Lee, J.W. et al. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat. Immunol. 8, 181-190 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 181-190
    • Lee, J.W.1
  • 26
    • 33749522738 scopus 로고    scopus 로고
    • A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells
    • Ackerman, A.L., Giodini, A. & Cresswell, P. A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. Immunity 25, 607-617 (2006).
    • (2006) Immunity , vol.25 , pp. 607-617
    • Ackerman, A.L.1    Giodini, A.2    Cresswell, P.3
  • 27
    • 0035903326 scopus 로고    scopus 로고
    • Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo
    • Hawiger, D. et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194, 769-780 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 769-780
    • Hawiger, D.1
  • 28
    • 0037152164 scopus 로고    scopus 로고
    • Immune tolerance after delivery of dying cells to dendritic cells in situ
    • Liu, K. et al. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196, 1091-1097 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1091-1097
    • Liu, K.1
  • 29
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class ii MHC only on thymic cortex
    • Laufer, T.M., DeKoning, J., Markowitz, J.S., Lo, D. & Glimcher, L.H. Unopposed positive selection and autoreactivity in mice expressing class ii MHC only on thymic cortex. Nature 383, 81-85 (1996).
    • (1996) Nature , vol.383 , pp. 81-85
    • Laufer, T.M.1    Dekoning, J.2    Markowitz, J.S.3    Lo, D.4    Glimcher, L.H.5
  • 30
    • 0033136289 scopus 로고    scopus 로고
    • Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo
    • Laufer, T.M., Fan, L. & Glimcher, L.H. Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo. J. Immunol. 162, 5078-5084 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5078-5084
    • Laufer, T.M.1    Fan, L.2    Glimcher, L.H.3
  • 31
    • 0037152162 scopus 로고    scopus 로고
    • Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node
    • Scheinecker, C., McHugh, R., Shevach, E.M. & Germain, R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196, 1079-1090 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1079-1090
    • Scheinecker, C.1    McHugh, R.2    Shevach, E.M.3    Germain, R.N.4
  • 32
    • 41549093091 scopus 로고    scopus 로고
    • Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo
    • Luckashenak, N. et al. Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 28, 521-532 (2008).
    • (2008) Immunity , vol.28 , pp. 521-532
    • Luckashenak, N.1
  • 33
    • 11244281447 scopus 로고    scopus 로고
    • Selective rac1 Inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo
    • Kerksiek, K.M., Niedergang, F., Chavrier, P., Busch, D.H. & Brocker, T. Selective rac1 Inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood 105, 742-749 (2005).
    • (2005) Blood , vol.105 , pp. 742-749
    • Kerksiek, K.M.1    Niedergang, F.2    Chavrier, P.3    Busch, D.H.4    Brocker, T.5
  • 34
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255 (1999).
    • (1999) Nat Med. , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 35
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate Immune response
    • Rothlin, C.V., Ghosh, S., Zuniga, E.I., Oldstone, M.B. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate Immune response. Cell 131, 1124-1136 (2007).
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.4    Lemke, G.5
  • 36
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the Immune system by receptor tyrosine kinases of the Tyro 3 famILy
    • Lu, Q. & Lemke, G. Homeostatic regulation of the Immune system by receptor tyrosine kinases of the Tyro 3 famILy. Science 293, 306-311 (2001).
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 37
    • 38749108510 scopus 로고    scopus 로고
    • MerTK is required for apoptotic cell-induced T cell tolerance
    • Wallet, M.A. et al. MerTK is required for apoptotic cell-induced T cell tolerance. J. Exp. Med. 205, 219-232 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 219-232
    • Wallet, M.A.1
  • 38
    • 8444245925 scopus 로고    scopus 로고
    • Toll-dependent control mechanisms of CD4 T cell activation
    • Pasare, C. & Medzhitov, R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21, 733-741 (2004).
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medzhitov, R.2
  • 39
    • 35348968837 scopus 로고    scopus 로고
    • Disruption of e-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
    • Jiang, A. et al. Disruption of e-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity 27, 610-624 (2007)
    • (2007) Immunity , vol.27 , pp. 610-624
    • Jiang, A.1
  • 40
    • 34547152610 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells and the quest for transplant tolerance
    • Morelli, A.E. & Thomson, A.W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat. Rev. Immunol. 7, 610-621 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 610-621
    • Morelli, A.E.1    Thomson, A.W.2
  • 41
    • 0024402836 scopus 로고
    • Tolerance in trans-genic mice expressing class ii major histocompatibILity complex on pancreatic acinar cells
    • Lo, D., Burkly, L.C., Flavell, R.A., Palmiter, R.D. & Brinster, R.L. Tolerance in trans-genic mice expressing class ii major histocompatibILity complex on pancreatic acinar cells. J. Exp. Med. 170, 87-104 (1989).
    • (1989) J. Exp. Med. , vol.170 , pp. 87-104
    • Lo, D.1    Burkly, L.C.2    Flavell, R.A.3    Palmiter, R.D.4    Brinster, R.L.5
  • 42
    • 0028466130 scopus 로고
    • Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
    • Kearney, E.R., Pape, K.A., Loh, D.Y. & Jenkins, M.K. visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339 (1994).
    • (1994) Immunity , vol.1 , pp. 327-339
    • Kearney, E.R.1    Pape, K.A.2    Loh, D.Y.3    Jenkins, M.K.4
  • 43
    • 0032543225 scopus 로고    scopus 로고
    • CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells
    • Adler, A.J. et al. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells. J. Exp. Med. 187, 1555-1564 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1555-1564
    • Adler, A.J.1
  • 44
    • 0031467003 scopus 로고    scopus 로고
    • CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity
    • Kurts, C. et al. CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J. Exp. Med. 186, 2057-2062 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 2057-2062
    • Kurts, C.1
  • 46
    • 21244479319 scopus 로고    scopus 로고
    • The link between lymphocyte deficiency and autoimmunity: Roles of endogenous T and B lymphocytes in tolerance
    • Knoechel, B., Lohr, J., Kahn, E. & Abbas, A.K. The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance. J. Immunol. 175, 21-26 (2005)
    • (2005) J. Immunol. , vol.175 , pp. 21-26
    • Knoechel, B.1    Lohr, J.2    Kahn, E.3    Abbas, A.K.4
  • 47
    • 33646484938 scopus 로고    scopus 로고
    • CD25+Foxp3+ Regulatory T cells facILitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia
    • vanasek, T.L., Nandiwada, S.L., Jenkins, M.K. & Mueller, D.L. CD25+Foxp3+ Regulatory T cells facILitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia. J. Immunol. 176, 5880-5889 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 5880-5889
    • Vanasek, T.L.1    Nandiwada, S.L.2    Jenkins, M.K.3    Mueller, D.L.4
  • 48
    • 33749135271 scopus 로고    scopus 로고
    • Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection
    • Brown, I.E., Blank, C., Kline, J., Kacha, A.K. & Gajewski, T.F. Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection. J. Immunol. 177, 4521-4529 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 4521-4529
    • Brown, I.E.1    Blank, C.2    Kline, J.3    Kacha, A.K.4    Gajewski, T.F.5
  • 49
    • 0035881574 scopus 로고    scopus 로고
    • Adaptive tolerance of CD4+ T cells in vivo: Multiple thresholds in response to a constant level of antigen presentation
    • Tanchot, C., Barber, D.L., Chiodetti, L. & Schwartz, R.H. Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation. J. Immunol. 167, 2030-2039 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 2030-2039
    • Tanchot, C.1    Barber, D.L.2    Chiodetti, L.3    Schwartz, R.H.4
  • 50
  • 51
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosiS
    • Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. & Nagata, S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317 (1992).
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 52
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • BouILlet, P. et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-1738 (1999).
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1
  • 53
    • 0037037543 scopus 로고    scopus 로고
    • Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
    • Davey, G.M. et al. Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J. Exp. Med. 196, 947-955 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 947-955
    • Davey, G.M.1
  • 54
    • 0029609086 scopus 로고
    • Bcl-2 and Fas/ APO-1 regulate distinct pathways to lymphocyte apoptosiS
    • Strasser, A., Harris, A.W., Huang, D.C., Krammer, P.H. & Cory, S. Bcl-2 and Fas/ APO-1 regulate distinct pathways to lymphocyte apoptosis. eMBo J. 14, 6136-6147 (1995).
    • (1995) EMBo J. , vol.14 , pp. 6136-6147
    • Strasser, A.1    Harris, A.W.2    Huang, D.C.3    Krammer, P.H.4    Cory, S.5
  • 55
    • 38949210228 scopus 로고    scopus 로고
    • Apoptosis regulators Bim and Fas function conCurrently to control autoimmunity and CD8+ T cell contraction
    • Weant, A.E. et al. Apoptosis regulators Bim and Fas function conCurrently to control autoimmunity and CD8+ T cell contraction. Immunity 28, 218-230 (2008).
    • (2008) Immunity , vol.28 , pp. 218-230
    • Weant, A.E.1
  • 56
    • 38949209522 scopus 로고    scopus 로고
    • Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity
    • Hutcheson, J. et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity 28, 206-217 (2008).
    • (2008) Immunity , vol.28 , pp. 206-217
    • Hutcheson, J.1
  • 57
    • 38949119408 scopus 로고    scopus 로고
    • Apoptosis regulators Fas and Bim cooperate in shutdown of chronic Immune responses and prevention of autoimmunity
    • Hughes, P.D. et al. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic Immune responses and prevention of autoimmunity. Immunity 28, 197-205 (2008).
    • (2008) Immunity , vol.28 , pp. 197-205
    • Hughes, P.D.1
  • 58
    • 49149090736 scopus 로고    scopus 로고
    • Cutting edge: Contributions of apoptosis and anergy to systemic T cell tolerance
    • Barron, L., Knoechel, B., Lohr, J. & Abbas, A.K. Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance. J. Immunol. 180, 2762-2766 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 2762-2766
    • Barron, L.1    Knoechel, B.2    Lohr, J.3    Abbas, A.K.4
  • 59
    • 66549100257 scopus 로고    scopus 로고
    • The molecular signature of CD8+ T cells undergoing deletional tolerance
    • Parish, I.A. et al. The molecular signature of CD8+ T cells undergoing deletional tolerance. Blood 113, 4575-4585 (2009).
    • (2009) Blood , vol.113 , pp. 4575-4585
    • Parish, I.A.1
  • 60
    • 18244375249 scopus 로고    scopus 로고
    • Egr-2 and egr-3 are negative regulators of T cell activation
    • Safford, M. et al. egr-2 and egr-3 are negative regulators of T cell activation. Nat. Immunol. 6, 472-480 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 472-480
    • Safford, M.1
  • 61
    • 0037077135 scopus 로고    scopus 로고
    • Transcriptional mechanisms underlying lymphocyte tolerance
    • Macian, F. et al. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109, 719-731 (2002).
    • (2002) Cell , vol.109 , pp. 719-731
    • MacIan, F.1
  • 62
    • 34249284512 scopus 로고    scopus 로고
    • MTOr at the crossroads of T cell proliferation and tolerance
    • Mondino, A. & Mueller, D.L. mTOr at the crossroads of T cell proliferation and tolerance. Semin. Immunol. 19, 162-172 (2007).
    • (2007) Semin. Immunol. , vol.19 , pp. 162-172
    • Mondino, A.1    Mueller, D.L.2
  • 63
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSILva, D.R., Urdahl, K.B. & Jenkins, M.K. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147, 3261-3267 (1991).
    • (1991) J. Immunol. , vol.147 , pp. 3261-3267
    • Desilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 64
    • 0026537347 scopus 로고
    • CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell cloneS
    • Harding, F.A., McArthur, J.G., Gross, J.A., raulet, D.H. & Allison, J.P. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356, 607-609 (1992).
    • (1992) Nature , vol.356 , pp. 607-609
    • Harding, F.A.1    McArthur, J.G.2    Gross, J.A.3    Raulet, D.H.4    Allison, J.P.5
  • 65
    • 0033104824 scopus 로고    scopus 로고
    • Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
    • Powell, J.D., Lerner, C.G. & Schwartz, R.H. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J. Immunol. 162, 2775-2784 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 2775-2784
    • Powell, J.D.1    Lerner, C.G.2    Schwartz, R.H.3
  • 66
    • 0036884923 scopus 로고    scopus 로고
    • Clonal anergy is maintained independently of T cell proliferation
    • Colombetti, S., Benigni, F., Basso, V. & Mondino, A. Clonal anergy is maintained independently of T cell proliferation. J. Immunol. 169, 6178-6186 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 6178-6186
    • Colombetti, S.1    Benigni, F.2    Basso, V.3    Mondino, A.4
  • 67
    • 0028483990 scopus 로고
    • Treatment of murine lupus with CTLA4ig
    • Finck, B.K., Linsley, P.S. & Wofsy, D. Treatment of murine lupus with CTLA4ig. Science 265, 1225-1227 (1994).
    • (1994) Science , vol.265 , pp. 1225-1227
    • Finck, B.K.1    Linsley, P.S.2    Wofsy, D.3
  • 68
    • 0028785417 scopus 로고
    • Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis
    • Racke, M.K. et al. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Invest. 96, 2195-2203 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 2195-2203
    • Racke, M.K.1
  • 69
    • 0029553431 scopus 로고
    • Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine eAe
    • MILler, S.D. et al. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine eAe. Immunity 3, 739-745 (1995).
    • (1995) Immunity , vol.3 , pp. 739-745
    • Miller, S.D.1
  • 70
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoRegulatory T cells that control autoImmune diabetes
    • Salomon, B. et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoRegulatory T cells that control autoImmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 71
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas, T.L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405-413 (1994).
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1
  • 72
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of Resting T cells
    • Krummel, M.F. & Allison, J.P. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of Resting T cells. J. Exp. Med. 183, 2533-2540 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 73
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 985-988 (1995).
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 74
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative Regulatory role of CTLA-4
    • Tivol, E.A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative Regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1
  • 75
    • 33746748176 scopus 로고    scopus 로고
    • Inhibition of T cell activation and autoImmune diabetes using a B cell surface-linked CTLA-4 agonist
    • Fife, B.T., Griffin, M.D., Abbas, A.K., Locksley, R.M. & Bluestone, J.A. Inhibition of T cell activation and autoImmune diabetes using a B cell surface-linked CTLA-4 agonist. J. Clin. Invest. 116, 2252-2261 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2252-2261
    • Fife, B.T.1    Griffin, M.D.2    Abbas, A.K.3    Locksley, R.M.4    Bluestone, J.A.5
  • 76
    • 0029100024 scopus 로고
    • Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
    • Kearney, E.R. et al. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155, 1032-1036 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 1032-1036
    • Kearney, E.R.1
  • 77
    • 0030966217 scopus 로고    scopus 로고
    • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    • Perez, V.L. et al. induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
    • (1997) Immunity , vol.6 , pp. 411-417
    • Perez, V.L.1
  • 78
    • 0035889885 scopus 로고    scopus 로고
    • Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: Enhanced cell cycle progression promotes recall antigen responsiveness
    • Vanasek, T.L., Khoruts, A., Zell, T. & Mueller, D.L. Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness. J. Immunol. 167, 5636-5644 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 5636-5644
    • Vanasek, T.L.1    Khoruts, A.2    Zell, T.3    Mueller, D.L.4
  • 80
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3+ Regulatory T cell function
    • wing, K. et al. CTLA-4 control over Foxp3+ Regulatory T cell function. Science 322, 271-275 (2008).
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1
  • 81
    • 3042592443 scopus 로고    scopus 로고
    • Cooperative roles of CTLA-4 and Regulatory T cells in tolerance to an islet cell antigen
    • Eggena, M.P. et al. Cooperative roles of CTLA-4 and Regulatory T cells in tolerance to an islet cell antigen. J. Exp. Med. 199, 1725-1730 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 1725-1730
    • Eggena, M.P.1
  • 82
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupuslike autoImmune diseases by disruption of the PD-1 gene encoding an iTiM motif-carrying immunoreceptor
    • Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupuslike autoImmune diseases by disruption of the PD-1 gene encoding an iTiM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999).
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 83
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 famILy member leads to negative regulation of lymphocyte activation
    • Freeman, G.J. et al. engagement of the PD-1 immunoinhibitory receptor by a novel B7 famILy member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192, 1027-1034 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1027-1034
    • Freeman, G.J.1
  • 84
    • 33645846313 scopus 로고    scopus 로고
    • Tissue expression of PD-L1 mediates peripheral T cell tolerance
    • Keir, M.E. et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J. Exp. Med. 203, 883-895 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 883-895
    • Keir, M.E.1
  • 85
    • 33751552197 scopus 로고    scopus 로고
    • Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
    • Fife, B.T. et al. insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J. Exp. Med. 203, 2737-2747 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2737-2747
    • Fife, B.T.1
  • 86
    • 70350433514 scopus 로고    scopus 로고
    • Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCr-induced stop signal
    • advance online publication doi:10.1038/nI.1790 (27 September)
    • Fife, B.T. et al. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCr-induced stop signal. Nat. Immunol. advance online publication, doi:10.1038/nI.1790 (27 September 2009).
    • (2009) Nat. Immunol.
    • Fife, B.T.1
  • 87
    • 14944360112 scopus 로고    scopus 로고
    • Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
    • Probst, H.C., McCoy, K., Okazaki, T., Honjo, T. & van den Broek, M. Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. Nat. Immunol. 6, 280-286 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 280-286
    • Probst, H.C.1    McCoy, K.2    Okazaki, T.3    Honjo, T.4    Van Den Broek, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.