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Volumn 28, Issue 5, 2008, Pages 662-674

Peripheral CD8+ T Cell Tolerance to Self-Proteins Is Regulated Proximally at the T Cell Receptor

Author keywords

CELLIMMUNO; MOLIMMUNO

Indexed keywords

ANTIGEN; T LYMPHOCYTE RECEPTOR; TUMOR PROTEIN; VIRUS PROTEIN;

EID: 43049179817     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.03.012     Document Type: Article
Times cited : (46)

References (52)
  • 2
    • 13444270503 scopus 로고    scopus 로고
    • The role of models in understanding CD8+ T-cell memory
    • Antia R., Ganusov V.V., and Ahmed R. The role of models in understanding CD8+ T-cell memory. Nat. Rev. Immunol. 5 (2005) 101-111
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 101-111
    • Antia, R.1    Ganusov, V.V.2    Ahmed, R.3
  • 4
    • 0025791952 scopus 로고
    • T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire
    • Casanova J.L., Romero P., Widmann C., Kourilsky P., and Maryanski J.L. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: Implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174 (1991) 1371-1383
    • (1991) J. Exp. Med. , vol.174 , pp. 1371-1383
    • Casanova, J.L.1    Romero, P.2    Widmann, C.3    Kourilsky, P.4    Maryanski, J.L.5
  • 5
    • 0036839499 scopus 로고    scopus 로고
    • Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool
    • Cheng L.E., and Greenberg P.D. Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J. Immunol. 169 (2002) 4990-4997
    • (2002) J. Immunol. , vol.169 , pp. 4990-4997
    • Cheng, L.E.1    Greenberg, P.D.2
  • 6
    • 32044440789 scopus 로고    scopus 로고
    • Adaptive tolerance and clonal anergy are distinct biochemical states
    • Chiodetti L., Choi S., Barber D.L., and Schwartz R.H. Adaptive tolerance and clonal anergy are distinct biochemical states. J. Immunol. 176 (2006) 2279-2291
    • (2006) J. Immunol. , vol.176 , pp. 2279-2291
    • Chiodetti, L.1    Choi, S.2    Barber, D.L.3    Schwartz, R.H.4
  • 7
    • 0033120578 scopus 로고    scopus 로고
    • Cutting edge: A test of the dominant negative signal model for TCR antagonism
    • Daniels M.A., Schober S.L., Hogquist K.A., and Jameson S.C. Cutting edge: A test of the dominant negative signal model for TCR antagonism. J. Immunol. 162 (1999) 3761-3764
    • (1999) J. Immunol. , vol.162 , pp. 3761-3764
    • Daniels, M.A.1    Schober, S.L.2    Hogquist, K.A.3    Jameson, S.C.4
  • 9
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva D.R., Urdahl K.B., and Jenkins M.K. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147 (1991) 3261-3267
    • (1991) J. Immunol. , vol.147 , pp. 3261-3267
    • DeSilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 10
    • 0033199986 scopus 로고    scopus 로고
    • Cross-antagonism of a T cell clone expressing two distinct T cell receptors
    • Dittel B.N., Stefanova I., Germain R.N., and Janeway Jr. C.A. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11 (1999) 289-298
    • (1999) Immunity , vol.11 , pp. 289-298
    • Dittel, B.N.1    Stefanova, I.2    Germain, R.N.3    Janeway Jr., C.A.4
  • 11
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat. Rev. Immunol. 4 (2004) 941-952
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 941-952
    • Gabrilovich, D.1
  • 12
    • 1042290495 scopus 로고    scopus 로고
    • Molecular interactions at the T cell-antigen-presenting cell interface
    • Gascoigne N.R., and Zal T. Molecular interactions at the T cell-antigen-presenting cell interface. Curr. Opin. Immunol. 16 (2004) 114-119
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 114-119
    • Gascoigne, N.R.1    Zal, T.2
  • 13
    • 0037188899 scopus 로고    scopus 로고
    • Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
    • Gil D., Schamel W.W., Montoya M., Sanchez-Madrid F., and Alarcon B. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109 (2002) 901-912
    • (2002) Cell , vol.109 , pp. 901-912
    • Gil, D.1    Schamel, W.W.2    Montoya, M.3    Sanchez-Madrid, F.4    Alarcon, B.5
  • 14
    • 3442882817 scopus 로고    scopus 로고
    • Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors
    • Gladow M., Uckert W., and Blankenstein T. Dual T cell receptor T cells with two defined specificities mediate tumor suppression via both receptors. Eur. J. Immunol. 34 (2004) 1882-1891
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1882-1891
    • Gladow, M.1    Uckert, W.2    Blankenstein, T.3
  • 15
    • 0036784603 scopus 로고    scopus 로고
    • Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo
    • Grayson J.M., Harrington L.E., Lanier J.G., Wherry E.J., and Ahmed R. Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. J. Immunol. 169 (2002) 3760-3770
    • (2002) J. Immunol. , vol.169 , pp. 3760-3770
    • Grayson, J.M.1    Harrington, L.E.2    Lanier, J.G.3    Wherry, E.J.4    Ahmed, R.5
  • 16
    • 0026443849 scopus 로고
    • Adaptive cellular interactions in the immune system: The tunable activation threshold and the significance of subthreshold responses
    • Grossman Z., and Paul W.E. Adaptive cellular interactions in the immune system: The tunable activation threshold and the significance of subthreshold responses. Proc. Natl. Acad. Sci. USA 89 (1992) 10365-10369
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10365-10369
    • Grossman, Z.1    Paul, W.E.2
  • 17
    • 0141650477 scopus 로고    scopus 로고
    • Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo
    • Guillaume S., Tuosto L., Tanchot C., Di Bartolo V., Acuto O., and Rocha B. Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo. Eur. J. Immunol. 33 (2003) 2551-2556
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2551-2556
    • Guillaume, S.1    Tuosto, L.2    Tanchot, C.3    Di Bartolo, V.4    Acuto, O.5    Rocha, B.6
  • 18
    • 25444487733 scopus 로고    scopus 로고
    • Induction of peripheral tolerance in dual TCR T cells: An evidence for non-dominant signaling by one TCR
    • Hah C., Kim M., and Kim K. Induction of peripheral tolerance in dual TCR T cells: An evidence for non-dominant signaling by one TCR. J. Biochem. Mol. Biol. 38 (2005) 334-342
    • (2005) J. Biochem. Mol. Biol. , vol.38 , pp. 334-342
    • Hah, C.1    Kim, M.2    Kim, K.3
  • 20
    • 0027451442 scopus 로고
    • Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice
    • Heath W.R., and Miller J.F. Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice. J. Exp. Med. 178 (1993) 1807-1811
    • (1993) J. Exp. Med. , vol.178 , pp. 1807-1811
    • Heath, W.R.1    Miller, J.F.2
  • 21
    • 1842631467 scopus 로고    scopus 로고
    • Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer
    • Heemskerk M.H., Hoogeboom M., Hagedoorn R., Kester M.G., Willemze R., and Falkenburg J.H. Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer. J. Exp. Med. 199 (2004) 885-894
    • (2004) J. Exp. Med. , vol.199 , pp. 885-894
    • Heemskerk, M.H.1    Hoogeboom, M.2    Hagedoorn, R.3    Kester, M.G.4    Willemze, R.5    Falkenburg, J.H.6
  • 23
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby E.S., Liggitt D., Brabb T., Schnabel B., Ohlen C., and Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J. Exp. Med. 194 (2001) 669-676
    • (2001) J. Exp. Med. , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlen, C.5    Goverman, J.6
  • 24
    • 0032727709 scopus 로고    scopus 로고
    • Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
    • Janes P.W., Ley S.C., and Magee A.I. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147 (1999) 447-461
    • (1999) J. Cell Biol. , vol.147 , pp. 447-461
    • Janes, P.W.1    Ley, S.C.2    Magee, A.I.3
  • 25
    • 0033998793 scopus 로고    scopus 로고
    • The role of lipid rafts in T cell antigen receptor (TCR) signalling
    • Janes P.W., Ley S.C., Magee A.I., and Kabouridis P.S. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin. Immunol. 12 (2000) 23-34
    • (2000) Semin. Immunol. , vol.12 , pp. 23-34
    • Janes, P.W.1    Ley, S.C.2    Magee, A.I.3    Kabouridis, P.S.4
  • 26
    • 25444456369 scopus 로고    scopus 로고
    • Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells
    • Kusmartsev S., Nagaraj S., and Gabrilovich D.I. Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. J. Immunol. 175 (2005) 4583-4592
    • (2005) J. Immunol. , vol.175 , pp. 4583-4592
    • Kusmartsev, S.1    Nagaraj, S.2    Gabrilovich, D.I.3
  • 27
    • 0024281396 scopus 로고
    • Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells
    • Lo D., Burkly L.C., Widera G., Cowing C., Flavell R.A., Palmiter R.D., and Brinster R.L. Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 53 (1988) 159-168
    • (1988) Cell , vol.53 , pp. 159-168
    • Lo, D.1    Burkly, L.C.2    Widera, G.3    Cowing, C.4    Flavell, R.A.5    Palmiter, R.D.6    Brinster, R.L.7
  • 28
    • 0029817246 scopus 로고    scopus 로고
    • T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions
    • Lohman B.L., Razvi E.S., and Welsh R.M. T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions. J. Virol. 70 (1996) 8199-8203
    • (1996) J. Virol. , vol.70 , pp. 8199-8203
    • Lohman, B.L.1    Razvi, E.S.2    Welsh, R.M.3
  • 29
    • 0024976414 scopus 로고
    • Tolerance of class I histocompatibility antigens expressed extrathymically
    • Morahan G., Allison J., and Miller J.F. Tolerance of class I histocompatibility antigens expressed extrathymically. Nature 339 (1989) 622-624
    • (1989) Nature , vol.339 , pp. 622-624
    • Morahan, G.1    Allison, J.2    Miller, J.F.3
  • 31
    • 34249806314 scopus 로고    scopus 로고
    • Induction of tolerance in CD8+ T cells to a transgenic autoantigen expressed in the liver does not require cross-presentation
    • Morimoto J., Tan X., Teague R.M., Ohlen C., and Greenberg P.D. Induction of tolerance in CD8+ T cells to a transgenic autoantigen expressed in the liver does not require cross-presentation. J. Immunol. 178 (2007) 6849-6860
    • (2007) J. Immunol. , vol.178 , pp. 6849-6860
    • Morimoto, J.1    Tan, X.2    Teague, R.M.3    Ohlen, C.4    Greenberg, P.D.5
  • 33
    • 0037406722 scopus 로고    scopus 로고
    • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl
    • Niederberger N., Holmberg K., Alam S.M., Sakati W., Naramura M., Gu H., and Gascoigne N.R. Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. J. Immunol. 170 (2003) 4557-4563
    • (2003) J. Immunol. , vol.170 , pp. 4557-4563
    • Niederberger, N.1    Holmberg, K.2    Alam, S.M.3    Sakati, W.4    Naramura, M.5    Gu, H.6    Gascoigne, N.R.7
  • 34
    • 0035865214 scopus 로고    scopus 로고
    • Expression of a tolerizing tumor antigen in peripheral tissue does not preclude recovery of high-affinity CD8+ T cells or CTL immunotherapy of tumors expressing the antigen
    • Ohlen C., Kalos M., Hong D.J., Shur A.C., and Greenberg P.D. Expression of a tolerizing tumor antigen in peripheral tissue does not preclude recovery of high-affinity CD8+ T cells or CTL immunotherapy of tumors expressing the antigen. J. Immunol. 166 (2001) 2863-2870
    • (2001) J. Immunol. , vol.166 , pp. 2863-2870
    • Ohlen, C.1    Kalos, M.2    Hong, D.J.3    Shur, A.C.4    Greenberg, P.D.5
  • 37
    • 0042470540 scopus 로고    scopus 로고
    • Does the immune system see tumors as foreign or self?
    • Pardoll D. Does the immune system see tumors as foreign or self?. Annu. Rev. Immunol. 21 (2003) 807-839
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 807-839
    • Pardoll, D.1
  • 38
    • 0026701534 scopus 로고
    • Maintenance of in vivo tolerance by persistence of antigen
    • Ramsdell F., and Fowlkes B.J. Maintenance of in vivo tolerance by persistence of antigen. Science 257 (1992) 1130-1134
    • (1992) Science , vol.257 , pp. 1130-1134
    • Ramsdell, F.1    Fowlkes, B.J.2
  • 39
    • 0033566824 scopus 로고    scopus 로고
    • Cutting edge: Dueling TCRs: Peptide antagonism of CD4+ T cells with dual antigen specificities
    • Robertson J.M., and Evavold B.D. Cutting edge: Dueling TCRs: Peptide antagonism of CD4+ T cells with dual antigen specificities. J. Immunol. 163 (1999) 1750-1754
    • (1999) J. Immunol. , vol.163 , pp. 1750-1754
    • Robertson, J.M.1    Evavold, B.D.2
  • 40
    • 0027532184 scopus 로고
    • Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
    • Rocha B., Tanchot C., and Von Boehmer H. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 177 (1993) 1517-1521
    • (1993) J. Exp. Med. , vol.177 , pp. 1517-1521
    • Rocha, B.1    Tanchot, C.2    Von Boehmer, H.3
  • 41
    • 13944278036 scopus 로고    scopus 로고
    • Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor
    • Roszkowski J.J., Lyons G.E., Kast W.M., Yee C., Van Besien K., and Nishimura M.I. Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor. Cancer Res. 65 (2005) 1570-1576
    • (2005) Cancer Res. , vol.65 , pp. 1570-1576
    • Roszkowski, J.J.1    Lyons, G.E.2    Kast, W.M.3    Yee, C.4    Van Besien, K.5    Nishimura, M.I.6
  • 42
    • 27144546396 scopus 로고    scopus 로고
    • Cholera toxin B-subunit prevents activation and proliferation of human CD4+ T cells by activation of a neutral sphingomyelinase in lipid rafts
    • Rouquette-Jazdanian A.K., Foussat A., Lamy L., Pelassy C., Lagadec P., Breittmayer J.P., and Aussel C. Cholera toxin B-subunit prevents activation and proliferation of human CD4+ T cells by activation of a neutral sphingomyelinase in lipid rafts. J. Immunol. 175 (2005) 5637-5648
    • (2005) J. Immunol. , vol.175 , pp. 5637-5648
    • Rouquette-Jazdanian, A.K.1    Foussat, A.2    Lamy, L.3    Pelassy, C.4    Lagadec, P.5    Breittmayer, J.P.6    Aussel, C.7
  • 43
    • 0141993921 scopus 로고    scopus 로고
    • The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells
    • Singh N.J., and Schwartz R.H. The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells. J. Exp. Med. 198 (2003) 1107-1117
    • (2003) J. Exp. Med. , vol.198 , pp. 1107-1117
    • Singh, N.J.1    Schwartz, R.H.2
  • 45
    • 0035801475 scopus 로고    scopus 로고
    • Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis
    • Steinman L. Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis. J. Exp. Med. 194 (2001) F27-F30
    • (2001) J. Exp. Med. , vol.194
    • Steinman, L.1
  • 46
    • 0033579813 scopus 로고    scopus 로고
    • T cell receptor (TCR) antagonism without a negative signal: Evidence from T cell hybridomas expressing two independent TCRs
    • Stotz S.H., Bolliger L., Carbone F.R., and Palmer E. T cell receptor (TCR) antagonism without a negative signal: Evidence from T cell hybridomas expressing two independent TCRs. J. Exp. Med. 189 (1999) 253-264
    • (1999) J. Exp. Med. , vol.189 , pp. 253-264
    • Stotz, S.H.1    Bolliger, L.2    Carbone, F.R.3    Palmer, E.4
  • 48
    • 0035881574 scopus 로고    scopus 로고
    • Adaptive tolerance of CD4+ T cells in vivo: Multiple thresholds in response to a constant level of antigen presentation
    • Tanchot C., Barber D.L., Chiodetti L., and Schwartz R.H. Adaptive tolerance of CD4+ T cells in vivo: Multiple thresholds in response to a constant level of antigen presentation. J. Immunol. 167 (2001) 2030-2039
    • (2001) J. Immunol. , vol.167 , pp. 2030-2039
    • Tanchot, C.1    Barber, D.L.2    Chiodetti, L.3    Schwartz, R.H.4
  • 50
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti S., Muller S., Cella M., Padovan E., and Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375 (1995) 148-151
    • (1995) Nature , vol.375 , pp. 148-151
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 51
    • 0037406912 scopus 로고    scopus 로고
    • Study of the mechanism of TCR antagonism using dual-TCR-expressing T cells
    • Yang W., and Grey H.M. Study of the mechanism of TCR antagonism using dual-TCR-expressing T cells. J. Immunol. 170 (2003) 4532-4538
    • (2003) J. Immunol. , vol.170 , pp. 4532-4538
    • Yang, W.1    Grey, H.M.2
  • 52
    • 0029810903 scopus 로고    scopus 로고
    • Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function
    • Zal T., Weiss S., Mellor A., and Stockinger B. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93 (1996) 9102-9107
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9102-9107
    • Zal, T.1    Weiss, S.2    Mellor, A.3    Stockinger, B.4


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