-
2
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005; 24: 7455-64.
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
3
-
-
65349155706
-
Induction of Akt activity by chemotherapy confers acquired resistance
-
Huang WC, Hung MC. Induction of Akt activity by chemotherapy confers acquired resistance. J Formos Med Assoc 2009; 108: 180-94.
-
(2009)
J Formos Med Assoc
, vol.108
, pp. 180-194
-
-
Huang, W.C.1
Hung, M.C.2
-
4
-
-
1542328927
-
Structure, regulation and function of PKB/AKT - A major therapeutic target
-
Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim Biophys Acta 2004; 1697: 3-16.
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
5
-
-
0031127305
-
Characterization of a 3-phosphoinositide dependent protein kinase which phosphorylates and activates protein kinase Bα
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. Characterization of a 3-phosphoinositide dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 1997; 7: 261-9.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
6
-
-
0037072272
-
Characterization of PDK2 activity against protein kinase B γ
-
Hodgkinson CP, Sale EM, Sale GJ. Characterization of PDK2 activity against protein kinase B γ. Biochemistry 2002; 41: 10351-9.
-
(2002)
Biochemistry
, vol.41
, pp. 10351-10359
-
-
Hodgkinson, C.P.1
Sale, E.M.2
Sale, G.J.3
-
7
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
8
-
-
0033599029
-
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
-
Lynch DK, Ellis CA, Edwards PA, Hiles ID. Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene 1999; 18: 8024-32.
-
(1999)
Oncogene
, vol.18
, pp. 8024-8032
-
-
Lynch, D.K.1
Ellis, C.A.2
Edwards, P.A.3
Hiles, I.D.4
-
9
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343
-
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem 2001; 276: 27462-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
Attwell, S.2
Gray, V.3
Mawji, N.4
Deng, J.T.5
Leung, D.6
Yan, J.7
Sanghera, J.8
Walsh, M.P.9
Dedhar, S.10
-
10
-
-
2442562698
-
Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Cα in endothelial cells
-
Partovian C, Simons M. Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Cα in endothelial cells. Cell Signal 2004; 16: 951-7.
-
(2004)
Cell Signal
, vol.16
, pp. 951-957
-
-
Partovian, C.1
Simons, M.2
-
11
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 2001; 15: 2203-8.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
12
-
-
0035914388
-
Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001; 276: 38349-52.
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
13
-
-
0042357084
-
Protein kinase B α/Akt1 regulates placental development and fetal growth
-
Yang ZZ, Tschopp O, Hemmings-Mieszczak M, Feng J, Brodbeck D, Perentes E, Hemmings BA. Protein kinase B α/Akt1 regulates placental development and fetal growth. J Biol Chem 2003; 278: 32124-31.
-
(2003)
J Biol Chem
, vol.278
, pp. 32124-32131
-
-
Yang, Z.Z.1
Tschopp, O.2
Hemmings-Mieszczak, M.3
Feng, J.4
Brodbeck, D.5
Perentes, E.6
Hemmings, B.A.7
-
14
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β)
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β). Science 2001; 292: 1728-31.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
15
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB β
-
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB β. J Clin Invest 2003; 112: 197-208.
-
(2003)
J Clin Invest
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
16
-
-
20044382806
-
Role for Akt3/protein kinase Bγ in attainment of normal brain size
-
Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ. Role for Akt3/protein kinase Bγ in attainment of normal brain size. Mol Cell Biol 2005; 25: 1869-78.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.7
Szabolcs, M.8
De Jong, R.9
Oltersdorf, T.10
Ludwig, T.11
Efstratiadis, A.12
Birnbaum, M.J.13
-
17
-
-
23144449547
-
Essential role of protein kinase B γ (PKB γ/Akt3) in postnatal brain development but not in glucose homeostasis
-
Tschopp O, Yang ZZ, Brodbeck D, Dummler BA, Hemmings-Mieszczak M, Watanabe T, Michaelis T, Frahm J, Hemmings BA. Essential role of protein kinase B γ (PKB γ/Akt3) in postnatal brain development but not in glucose homeostasis. Development 2005; 132: 2943-54.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
18
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 2003; 17: 1352-65.
-
(2003)
Genes Dev
, vol.17
, pp. 1352-1365
-
-
Peng, X.D.1
Xu, P.Z.2
Chen, M.L.3
Hahn-Windgassen, A.4
Skeen, J.5
Jacobs, J.6
Sundararajan, D.7
Chen, W.S.8
Crawford, S.E.9
Coleman, K.G.10
Hay, N.11
-
19
-
-
27944493875
-
Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice
-
Yang ZZ, Tschopp O, Di-Poi N, Bruder E, Baudry A, Dummler B, Wahli W, Hemmings BA. Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol 2005; 25: 10407-18.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10407-10418
-
-
Yang, Z.Z.1
Tschopp, O.2
Di-Poi, N.3
Bruder, E.4
Baudry, A.5
Dummler, B.6
Wahli, W.7
Hemmings, B.A.8
-
20
-
-
33750380920
-
Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
-
Dummler B, Tschopp O, Hynx D, Yang ZZ, Dirnhofer S, Hemmings BA. Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol 2006; 26: 8042-51.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8042-8051
-
-
Dummler, B.1
Tschopp, O.2
Hynx, D.3
Yang, Z.Z.4
Dirnhofer, S.5
Hemmings, B.A.6
-
21
-
-
0034881622
-
AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon
-
Zinda MJ, Johnson MA, Paul JD, Horn C, Konicek BW, Lu ZH, Sandusky G, Thomas JE, Neubauer BL, Lai MT, Graff JR. AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. Clin Cancer Res 2001; 7: 2475-9.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2475-2479
-
-
Zinda, M.J.1
Johnson, M.A.2
Paul, J.D.3
Horn, C.4
Konicek, B.W.5
Lu, Z.H.6
Sandusky, G.7
Thomas, J.E.8
Neubauer, B.L.9
Lai, M.T.10
Graff, J.R.11
-
22
-
-
0032493105
-
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin
-
Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR. Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. Oncogene 1998; 16: 2407-11.
-
(1998)
Oncogene
, vol.16
, pp. 2407-2411
-
-
Altomare, D.A.1
Lyons, G.E.2
Mitsuuchi, Y.3
Cheng, J.Q.4
Testa, J.R.5
-
23
-
-
0033515625
-
A human protein kinase Bγ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
-
Brodbeck D, Cron P, Hemmings BA. A human protein kinase Bγ with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 1999; 274: 9133-6.
-
(1999)
J Biol Chem
, vol.274
, pp. 9133-9136
-
-
Brodbeck, D.1
Cron, P.2
Hemmings, B.A.3
-
24
-
-
0034742120
-
AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, Ma XL, Shelley SA, Jove R, Tsichlis PN, Nicosia SV, Cheng JQ. AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 2001; 159: 431-7.
-
(2001)
Am J Pathol
, vol.159
, pp. 431-437
-
-
Sun, M.1
Wang, G.2
Paciga, J.E.3
Feldman, R.I.4
Yuan, Z.Q.5
Ma, X.L.6
Shelley, S.A.7
Jove, R.8
Tsichlis, P.N.9
Nicosia, S.V.10
Cheng, J.Q.11
-
25
-
-
0035881568
-
Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K
-
Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV, Cheng JQ. Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K. Cancer Res 2001; 61: 5985-91.
-
(2001)
Cancer Res
, vol.61
, pp. 5985-5991
-
-
Sun, M.1
Paciga, J.E.2
Feldman, R.I.3
Yuan, Z.4
Coppola, D.5
Lu, Y.Y.6
Shelley, S.A.7
Nicosia, S.V.8
Cheng, J.Q.9
-
26
-
-
0034604067
-
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
-
Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 2000; 19: 2324-30.
-
(2000)
Oncogene
, vol.19
, pp. 2324-2330
-
-
Yuan, Z.Q.1
Sun, M.2
Feldman, R.I.3
Wang, G.4
Ma, X.5
Jiang, C.6
Coppola, D.7
Nicosia, S.V.8
Cheng, J.Q.9
-
27
-
-
1242286948
-
Frequent activation of AKT2 kinase in human pancreatic carcinomas
-
Altomare DA, Tanno S, De Rienzo A, Klein-Szanto AJ, Skele KL, Hoffman JP, Testa JR. Frequent activation of AKT2 kinase in human pancreatic carcinomas. J Cell Biochem 2002; 87: 470-6.
-
(2002)
J Cell Biochem
, vol.87
, pp. 470-476
-
-
Altomare, D.A.1
Tanno, S.2
De Rienzo, A.3
Klein-Szanto, A.J.4
Skele, K.L.5
Hoffman, J.P.6
Testa, J.R.7
-
28
-
-
1142277821
-
Akt2 expression correlates with prognosis of human hepatocellular carcinoma
-
Xu X, Sakon M, Nagano H, Hiraoka N, Yamamoto H, Hayashi N, Dono K, Nakamori S, Umeshita K, Ito Y, Matsuura N, Monden M. Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol Rep 2004; 11: 25-32.
-
(2004)
Oncol Rep
, vol.11
, pp. 25-32
-
-
Xu, X.1
Sakon, M.2
Nagano, H.3
Hiraoka, N.4
Yamamoto, H.5
Hayashi, N.6
Dono, K.7
Nakamori, S.8
Umeshita, K.9
Ito, Y.10
Matsuura, N.11
Monden, M.12
-
29
-
-
4944249733
-
Deregulated Akt3 activity promotes development of malignant melanoma
-
Stahl JM, Sharma A, Cheung M, Zimmerman M, Cheng JQ, Bosenberg MW, Kester M, Sandirasegarane L, Robertson GP. Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res 2004; 64: 7002-10.
-
(2004)
Cancer Res
, vol.64
, pp. 7002-7010
-
-
Stahl, J.M.1
Sharma, A.2
Cheung, M.3
Zimmerman, M.4
Cheng, J.Q.5
Bosenberg, M.W.6
Kester, M.7
Sandirasegarane, L.8
Robertson, G.P.9
-
30
-
-
0033618371
-
Up-regulation of Akt3 in estrogen receptordeficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani K, Thompson DA, Barthel A, Sakaue H, Liu W, Weigel RJ, Roth RA. Up-regulation of Akt3 in estrogen receptordeficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999; 274: 21528-32.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
Thompson, D.A.2
Barthel, A.3
Sakaue, H.4
Liu, W.5
Weigel, R.J.6
Roth, R.A.7
-
31
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 2005; 4: 988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
32
-
-
77952309277
-
Akt2 and Akt3 play a pivotal role in malignant gliomas
-
Mure H, Matsuzaki K, Kitazato KT, Mizobuchi Y, Kuwayama K, Kageji T, Nagahiro S. Akt2 and Akt3 play a pivotal role in malignant gliomas. Neuro Oncol 2010; 12: 221-32.
-
(2010)
Neuro Oncol
, vol.12
, pp. 221-232
-
-
Mure, H.1
Matsuzaki, K.2
Kitazato, K.T.3
Mizobuchi, Y.4
Kuwayama, K.5
Kageji, T.6
Nagahiro, S.7
-
33
-
-
33750571668
-
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas
-
Soung YH, Lee JW, Nam SW, Lee JY, Yoo NJ, Lee SH. Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas. Oncology 2006; 70: 285-9.
-
(2006)
Oncology
, vol.70
, pp. 285-289
-
-
Soung, Y.H.1
Lee, J.W.2
Nam, S.W.3
Lee, J.Y.4
Yoo, N.J.5
Lee, S.H.6
-
34
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007; 448: 439-44.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.H.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
35
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, De Gisi S, Malara N, Savino R, Rocco G, Chiappetta G, Franco R, Tirino V, Pirozzi G, Viglietto G. Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 2008; 7: 665-9.
-
(2008)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
Fabiani, F.4
De Rosa, N.5
De Gisi, S.6
Malara, N.7
Savino, R.8
Rocco, G.9
Chiappetta, G.10
Franco, R.11
Tirino, V.12
Pirozzi, G.13
Viglietto, G.14
-
36
-
-
70749133631
-
AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma
-
Cohen Y, Shalmon B, Korach J, Barshack I, Fridman E, Rechavi G. AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma. Gynecol Oncol 2010; 116: 88-91.
-
(2010)
Gynecol Oncol
, vol.116
, pp. 88-91
-
-
Cohen, Y.1
Shalmon, B.2
Korach, J.3
Barshack, I.4
Fridman, E.5
Rechavi, G.6
-
37
-
-
43249115083
-
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
-
Kim MS, Jeong EG, Yoo NJ, Lee SH. Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Br J Cancer 2008; 98: 1533-5.
-
(2008)
Br J Cancer
, vol.98
, pp. 1533-1535
-
-
Kim, M.S.1
Jeong, E.G.2
Yoo, N.J.3
Lee, S.H.4
-
38
-
-
77955094176
-
PI3K/Akt pathway mutations in retinoblastoma
-
Cohen Y, Merhavi-Shoham E, Avraham-Lubin BC, Savetsky M, Frenkel S, Pe'er J, Goldenberg-Cohen N. PI3K/Akt pathway mutations in retinoblastoma. Invest Ophthalmol Vis Sci 2009; 50: 5054-6.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, pp. 5054-5056
-
-
Cohen, Y.1
Merhavi-Shoham, E.2
Avraham-Lubin, B.C.3
Savetsky, M.4
Frenkel, S.5
Pe'er, J.6
Goldenberg-Cohen, N.7
-
39
-
-
53849132331
-
A novel AKT3 mutation in melanoma tumours and cell lines
-
Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG, Lazar AJ, Gershenwald JE, Mills GB. A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer 2008; 99: 1265-8.
-
(2008)
Br J Cancer
, vol.99
, pp. 1265-1268
-
-
Davies, M.A.1
Stemke-Hale, K.2
Tellez, C.3
Calderone, T.L.4
Deng, W.5
Prieto, V.G.6
Lazar, A.J.7
Gershenwald, J.E.8
Mills, G.B.9
-
40
-
-
23844445836
-
Colorectal cancer: Mutations in a signalling pathway
-
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature 2005; 436: 792.
-
(2005)
Nature
, vol.436
, pp. 792
-
-
Parsons, D.W.1
Wang, T.L.2
Samuels, Y.3
Bardelli, A.4
Cummins, J.M.5
Delong, L.6
Silliman, N.7
Ptak, J.8
Szabo, S.9
Willson, J.K.10
Markowitz, S.11
Kinzler, K.W.12
Vogelstein, B.13
Lengauer, C.14
Velculescu, V.E.15
-
41
-
-
70349678290
-
Somatic mutations are present in all members of the AKT family in endometrial carcinoma
-
author reply 1220-1
-
Dutt A, Salvesen HB, Greulich H, Sellers WR, Beroukhim R, Meyerson M. Somatic mutations are present in all members of the AKT family in endometrial carcinoma. Br J Cancer 2009; 101: 1218-9; author reply 1220-1.
-
(2009)
Br J Cancer
, vol.101
, pp. 1218-1219
-
-
Dutt, A.1
Salvesen, H.B.2
Greulich, H.3
Sellers, W.R.4
Beroukhim, R.5
Meyerson, M.6
-
42
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 1987; 84: 5034-7.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
43
-
-
0242499482
-
Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-39-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas
-
Knobbe CB, Reifenberger G. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-39-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol 2003; 13: 507-18.
-
(2003)
Brain Pathol
, vol.13
, pp. 507-518
-
-
Knobbe, C.B.1
Reifenberger, G.2
-
44
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 1992; 89: 9267-71.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
Godwin, A.K.2
Bellacosa, A.3
Taguchi, T.4
Franke, T.F.5
Hamilton, T.C.6
Tsichlis, P.N.7
Testa, J.R.8
-
45
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 1996; 93: 3636-41.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
46
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A, de Feo D, Godwin AK, Bell DW, Cheng JQ, Altomare DA, Wan M, Dubeau L, Scambia G, Masciullo V, Ferrandina G, Benedetti Panici P, Mancuso S, Neri G, Testa JR. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995; 64: 280-5.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
De Feo, D.2
Godwin, A.K.3
Bell, D.W.4
Cheng, J.Q.5
Altomare, D.A.6
Wan, M.7
Dubeau, L.8
Scambia, G.9
Masciullo, V.10
Ferrandina, G.11
Benedetti Panici, P.12
Mancuso, S.13
Neri, G.14
Testa, J.R.15
-
47
-
-
73449142838
-
Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH
-
Kirkegaard T, Witton CJ, Edwards J, Nielsen KV, Jensen LB, Campbell FM, Cooke TG, Bartlett JM. Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH. Histopathology 2010; 56: 203-11.
-
(2010)
Histopathology
, vol.56
, pp. 203-211
-
-
Kirkegaard, T.1
Witton, C.J.2
Edwards, J.3
Nielsen, K.V.4
Jensen, L.B.5
Campbell, F.M.6
Cooke, T.G.7
Bartlett, J.M.8
-
48
-
-
59849097995
-
Differential regulation of Akt/protein kinase B isoforms during cell cycle progression
-
Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM, Lee SY, Yun J, Kim CD, Birnbaum MJ, Bae SS. Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. FEBS Lett 2009; 583: 685-90.
-
(2009)
FEBS Lett
, vol.583
, pp. 685-690
-
-
Yun, S.J.1
Tucker, D.F.2
Kim, E.K.3
Kim, M.S.4
Do, K.H.5
Ha, J.M.6
Lee, S.Y.7
Yun, J.8
Kim, C.D.9
Birnbaum, M.J.10
Bae, S.S.11
-
49
-
-
33750285711
-
Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
-
Meng Q, Xia C, Fang J, Rojanasakul Y, Jiang BH. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signal 2006; 18: 2262-71.
-
(2006)
Cell Signal
, vol.18
, pp. 2262-2271
-
-
Meng, Q.1
Xia, C.2
Fang, J.3
Rojanasakul, Y.4
Jiang, B.H.5
-
50
-
-
33845599982
-
Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: Increased expression of AKT in advanced ovarian cancer
-
Noske A, Kaszubiak A, Weichert W, Sers C, Niesporek S, Koch I, Schaefer B, Sehouli J, Dietel M, Lage H, Denkert C. Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer. Cancer Lett 2007; 246: 190-200.
-
(2007)
Cancer Lett
, vol.246
, pp. 190-200
-
-
Noske, A.1
Kaszubiak, A.2
Weichert, W.3
Sers, C.4
Niesporek, S.5
Koch, I.6
Schaefer, B.7
Sehouli, J.8
Dietel, M.9
Lage, H.10
Denkert, C.11
-
51
-
-
0034868089
-
Downregulation of Akt1 inhibits anchorageindependent cell growth and induces apoptosis in cancer cells
-
Liu X, Shi Y, Han EK, Chen Z, Rosenberg SH, Giranda VL, Luo Y, Ng SC. Downregulation of Akt1 inhibits anchorageindependent cell growth and induces apoptosis in cancer cells. Neoplasia 2001; 3: 278-86.
-
(2001)
Neoplasia
, vol.3
, pp. 278-286
-
-
Liu, X.1
Shi, Y.2
Han, E.K.3
Chen, Z.4
Rosenberg, S.H.5
Giranda, V.L.6
Luo, Y.7
Ng, S.C.8
-
52
-
-
77249179196
-
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
-
Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N. Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci USA 2010; 107: 2598-603.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 2598-2603
-
-
Ericson, K.1
Gan, C.2
Cheong, I.3
Rago, C.4
Samuels, Y.5
Velculescu, V.E.6
Kinzler, K.W.7
Huso, D.L.8
Vogelstein, B.9
Papadopoulos, N.10
-
54
-
-
0042525911
-
Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo
-
Faridi J, Wang L, Endemann G, Roth RA. Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo. Clin Cancer Res 2003; 9: 2933-9.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2933-2939
-
-
Faridi, J.1
Wang, L.2
Endemann, G.3
Roth, R.A.4
-
55
-
-
34548266099
-
AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines
-
Koseoglu S, Lu Z, Kumar C, Kirschmeier P, Zou J. AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer Biol Ther 2007; 6: 755-62.
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 755-762
-
-
Koseoglu, S.1
Lu, Z.2
Kumar, C.3
Kirschmeier, P.4
Zou, J.5
-
56
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
-
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007; 67: 167-77.
-
(2007)
Cancer Res
, vol.67
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
-
57
-
-
70350435062
-
Antitumor activity of a novel antisense oligonucleotide against Akt1
-
Yoon H, Kim DJ, Ahn EH, Gellert GC, Shay JW, Ahn CH, Lee YB. Antitumor activity of a novel antisense oligonucleotide against Akt1. J Cell Biochem 2009; 108: 832-8.
-
(2009)
J Cell Biochem
, vol.108
, pp. 832-838
-
-
Yoon, H.1
Kim, D.J.2
Ahn, E.H.3
Gellert, G.C.4
Shay, J.W.5
Ahn, C.H.6
Lee, Y.B.7
-
58
-
-
34447125097
-
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
-
Liu LZ, Zhou XD, Qian G, Shi X, Fang J, Jiang BH. AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Cancer Res 2007; 67: 6325-32.
-
(2007)
Cancer Res
, vol.67
, pp. 6325-6332
-
-
Liu, L.Z.1
Zhou, X.D.2
Qian, G.3
Shi, X.4
Fang, J.5
Jiang, B.H.6
-
59
-
-
42149159986
-
Akt1 inhibition by RNA interference sensitizes human non-small cell lung cancer cells to cisplatin
-
Lee MW, Kim DS, Min NY, Kim HT. Akt1 inhibition by RNA interference sensitizes human non-small cell lung cancer cells to cisplatin. Int J Cancer 2008; 122: 2380-4.
-
(2008)
Int J Cancer
, vol.122
, pp. 2380-2384
-
-
Lee, M.W.1
Kim, D.S.2
Min, N.Y.3
Kim, H.T.4
-
60
-
-
38649135366
-
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol
-
Gagnon V, Van Themsche C, Turner S, Leblanc V, Asselin E. Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis 2008; 13: 259-71.
-
(2008)
Apoptosis
, vol.13
, pp. 259-271
-
-
Gagnon, V.1
Van Themsche, C.2
Turner, S.3
Leblanc, V.4
Asselin, E.5
-
61
-
-
4444346646
-
AKT involvement in cisplatin chemoresistance of human uterine cancer cells
-
Gagnon V, Mathieu I, Sexton E, Leblanc K, Asselin E. AKT involvement in cisplatin chemoresistance of human uterine cancer cells. Gynecol Oncol 2004; 94: 785-95.
-
(2004)
Gynecol Oncol
, vol.94
, pp. 785-795
-
-
Gagnon, V.1
Mathieu, I.2
Sexton, E.3
Leblanc, K.4
Asselin, E.5
-
62
-
-
33947192053
-
Twist transcriptionally upregulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
-
Cheng GZ, Chan J, Wang Q, Zhang W, Sun CD, Wang LH. Twist transcriptionally upregulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 2007; 67: 1979-87.
-
(2007)
Cancer Res
, vol.67
, pp. 1979-1987
-
-
Cheng, G.Z.1
Chan, J.2
Wang, Q.3
Zhang, W.4
Sun, C.D.5
Wang, L.H.6
-
63
-
-
38849091289
-
Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells
-
Xing H, Weng D, Chen G, Tao W, Zhu T, Yang X, Meng L, Wang S, Lu Y, Ma D. Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells. Cancer Lett 2008; 261: 108-19.
-
(2008)
Cancer Lett
, vol.261
, pp. 108-119
-
-
Xing, H.1
Weng, D.2
Chen, G.3
Tao, W.4
Zhu, T.5
Yang, X.6
Meng, L.7
Wang, S.8
Lu, Y.9
Ma, D.10
-
64
-
-
57449110379
-
Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells
-
Weng D, Song X, Xing H, Ma X, Xia X, Weng Y, Zhou J, Xu G, Meng L, Zhu T, Wang S, Ma D. Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells. Cancer Lett 2009; 273: 257-65.
-
(2009)
Cancer Lett
, vol.273
, pp. 257-265
-
-
Weng, D.1
Song, X.2
Xing, H.3
Ma, X.4
Xia, X.5
Weng, Y.6
Zhou, J.7
Xu, G.8
Meng, L.9
Zhu, T.10
Wang, S.11
Ma, D.12
-
65
-
-
33745283242
-
Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy
-
Schimmer AD, Dalili S. Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy. Hematology Am Soc Hematol Educ Program 2005; 215-9.
-
(2005)
Hematology Am Soc Hematol Educ Program
, pp. 215-219
-
-
Schimmer, A.D.1
Dalili, S.2
-
66
-
-
33947501431
-
Transforming growth factor-β3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent up-regulation of X-linked inhibitor of apoptosis and protein kinase c-dependent induction of matrix metalloproteinase-9
-
Van Themsche C, Mathieu I, Parent S, Asselin E. Transforming growth factor-β3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent up-regulation of X-linked inhibitor of apoptosis and protein kinase c-dependent induction of matrix metalloproteinase-9. J Biol Chem 2007; 282: 4794-802.
-
(2007)
J Biol Chem
, vol.282
, pp. 4794-4802
-
-
Van Themsche, C.1
Mathieu, I.2
Parent, S.3
Asselin, E.4
-
67
-
-
47949128357
-
X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor α-induced apoptosis
-
Van Themsche C, Lafontaine L, Asselin E. X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor α-induced apoptosis. Endocrinology 2008; 149: 3789-98.
-
(2008)
Endocrinology
, vol.149
, pp. 3789-3798
-
-
Van Themsche, C.1
Lafontaine, L.2
Asselin, E.3
-
68
-
-
67650727602
-
Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation
-
Gill C, Dowling C, O'Neill AJ, Watson RW. Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation. Mol Cancer 2009; 8: 39.
-
(2009)
Mol Cancer
, vol.8
, pp. 39
-
-
Gill, C.1
Dowling, C.2
O'Neill, A.J.3
Watson, R.W.4
-
69
-
-
4444280830
-
X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells
-
Amantana A, London CA, Iversen PL, Devi GR. X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. Mol Cancer Ther 2004; 3: 699-707.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 699-707
-
-
Amantana, A.1
London, C.A.2
Iversen, P.L.3
Devi, G.R.4
-
70
-
-
0037478904
-
Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo
-
Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD, LaCasse EC. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 2003; 9: 2826-36.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2826-2836
-
-
Hu, Y.1
Cherton-Horvat, G.2
Dragowska, V.3
Baird, S.4
Korneluk, R.G.5
Durkin, J.P.6
Mayer, L.D.7
Lacasse, E.C.8
-
71
-
-
73449109091
-
XIAP-mediated protection of H460 lung cancer cells against cisplatin
-
Cheng YJ, Jiang HS, Hsu SL, Lin LC, Wu CL, Ghanta VK, Hsueh CM. XIAP-mediated protection of H460 lung cancer cells against cisplatin. Eur J Pharmacol 2010; 627: 75-84.
-
(2010)
Eur J Pharmacol
, vol.627
, pp. 75-84
-
-
Cheng, Y.J.1
Jiang, H.S.2
Hsu, S.L.3
Lin, L.C.4
Wu, C.L.5
Ghanta, V.K.6
Hsueh, C.M.7
-
72
-
-
2942545582
-
Akt activity in endometrial cancer cells: Regulation of cell survival through cIAP-1
-
Gagnon V, St-Germain ME, Parent S, Asselin E. Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. Int J Oncol 2003; 23: 803-10.
-
(2003)
Int J Oncol
, vol.23
, pp. 803-810
-
-
Gagnon, V.1
St-Germain, M.E.2
Parent, S.3
Asselin, E.4
-
73
-
-
67650067290
-
Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells
-
Srinivasan S, Koduru S, Kumar R, Venguswamy G, Kyprianou N, Damodaran C. Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells. Int J Cancer 2009; 125: 961-7.
-
(2009)
Int J Cancer
, vol.125
, pp. 961-967
-
-
Srinivasan, S.1
Koduru, S.2
Kumar, R.3
Venguswamy, G.4
Kyprianou, N.5
Damodaran, C.6
-
74
-
-
0242610903
-
P53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells
-
Fraser M, Leung BM, Yan X, Dan HC, Cheng JQ, Tsang BK. p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells. Cancer Res 2003; 63: 7081-8.
-
(2003)
Cancer Res
, vol.63
, pp. 7081-7088
-
-
Fraser, M.1
Leung, B.M.2
Yan, X.3
Dan, H.C.4
Cheng, J.Q.5
Tsang, B.K.6
-
75
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 2004; 279: 5405-12.
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
Feldman, R.I.4
Nicosia, S.V.5
Wang, H.G.6
Tsang, B.K.7
Cheng, J.Q.8
-
76
-
-
0038342509
-
AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: Implication of AKT2 in chemoresistance
-
Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem 2003; 278: 23432-40.
-
(2003)
J Biol Chem
, vol.278
, pp. 23432-23440
-
-
Yuan, Z.Q.1
Feldman, R.I.2
Sussman, G.E.3
Coppola, D.4
Nicosia, S.V.5
Cheng, J.Q.6
-
77
-
-
0035846549
-
Akt mediates Rac/Cdc42-regulated cell motility in growth factorstimulated cells and in invasive PTEN knockout cells
-
Higuchi M, Masuyama N, Fukui Y, Suzuki A, Gotoh Y. Akt mediates Rac/Cdc42-regulated cell motility in growth factorstimulated cells and in invasive PTEN knockout cells. Curr Biol 2001; 11: 1958-62.
-
(2001)
Curr Biol
, vol.11
, pp. 1958-1962
-
-
Higuchi, M.1
Masuyama, N.2
Fukui, Y.3
Suzuki, A.4
Gotoh, Y.5
-
78
-
-
0242664130
-
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration
-
Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J. Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol 2003; 23: 8058-69.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8058-8069
-
-
Zhou, G.L.1
Zhuo, Y.2
King, C.C.3
Fryer, B.H.4
Bokoch, G.M.5
Field, J.6
-
79
-
-
23644446866
-
Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis
-
Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest 2005; 115: 2119-27.
-
(2005)
J Clin Invest
, vol.115
, pp. 2119-2127
-
-
Ackah, E.1
Yu, J.2
Zoellner, S.3
Iwakiri, Y.4
Skurk, C.5
Shibata, R.6
Ouchi, N.7
Easton, R.M.8
Galasso, G.9
Birnbaum, M.J.10
Walsh, K.11
Sessa, W.C.12
-
80
-
-
33845975305
-
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration
-
Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J. Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem 2006; 281: 36443-53.
-
(2006)
J Biol Chem
, vol.281
, pp. 36443-36453
-
-
Zhou, G.L.1
Tucker, D.F.2
Bae, S.S.3
Bhatheja, K.4
Birnbaum, M.J.5
Field, J.6
-
81
-
-
24144496081
-
Akt/PKB regulates actin organization and cell motility via Girdin/APE
-
Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K, Takahashi M. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 2005; 9: 389-402.
-
(2005)
Dev Cell
, vol.9
, pp. 389-402
-
-
Enomoto, A.1
Murakami, H.2
Asai, N.3
Morone, N.4
Watanabe, T.5
Kawai, K.6
Murakumo, Y.7
Usukura, J.8
Kaibuchi, K.9
Takahashi, M.10
-
82
-
-
0034852195
-
Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production
-
Kim D, Kim S, Koh H, Yoon SO, Chung AS, Cho KS, Chung J. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 2001; 15: 1953-62.
-
(2001)
FASEB J
, vol.15
, pp. 1953-1962
-
-
Kim, D.1
Kim, S.2
Koh, H.3
Yoon, S.O.4
Chung, A.S.5
Cho, K.S.6
Chung, J.7
-
83
-
-
0035887436
-
Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells
-
Park BK, Zeng X, Glazer RI. Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells. Cancer Res 2001; 61: 7647-53.
-
(2001)
Cancer Res
, vol.61
, pp. 7647-7653
-
-
Park, B.K.1
Zeng, X.2
Glazer, R.I.3
-
84
-
-
34249301918
-
Akt1 governs breast cancer progression in vivo
-
Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG. Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci USA 2007; 104: 7438-43.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7438-7443
-
-
Ju, X.1
Katiyar, S.2
Wang, C.3
Liu, M.4
Jiao, X.5
Li, S.6
Zhou, J.7
Turner, J.8
Lisanti, M.P.9
Russell, R.G.10
Mueller, S.C.11
Ojeifo, J.12
Chen, W.S.13
Hay, N.14
Pestell, R.G.15
-
85
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005; 20: 539-50.
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
86
-
-
77951962854
-
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration
-
Chin YR, Toker A. The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Mol Cell 2010; 38: 333-44.
-
(2010)
Mol Cell
, vol.38
, pp. 333-344
-
-
Chin, Y.R.1
Toker, A.2
-
87
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005; 171: 1023-34.
-
(2005)
J Cell Biol
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
88
-
-
42449086310
-
Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells
-
Wang J, Wan W, Sun R, Liu Y, Sun X, Ma D, Zhang N. Reduction of Akt2 expression inhibits chemotaxis signal transduction in human breast cancer cells. Cell Signal 2008; 20: 1025-34.
-
(2008)
Cell Signal
, vol.20
, pp. 1025-1034
-
-
Wang, J.1
Wan, W.2
Sun, R.3
Liu, Y.4
Sun, X.5
Ma, D.6
Zhang, N.7
-
89
-
-
67650065524
-
Reduction of Akt2 inhibits migration and invasion of glioma cells
-
Zhang B, Gu F, She C, Guo H, Li W, Niu R, Fu L, Zhang N, Ma Y. Reduction of Akt2 inhibits migration and invasion of glioma cells. Int J Cancer 2009; 125: 585-95.
-
(2009)
Int J Cancer
, vol.125
, pp. 585-595
-
-
Zhang, B.1
Gu, F.2
She, C.3
Guo, H.4
Li, W.5
Niu, R.6
Fu, L.7
Zhang, N.8
Ma, Y.9
-
90
-
-
16244409820
-
Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549
-
Sithanandam G, Fornwald LW, Fields J, Anderson LM. Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549. Oncogene 2005; 24: 1847-59.
-
(2005)
Oncogene
, vol.24
, pp. 1847-1859
-
-
Sithanandam, G.1
Fornwald, L.W.2
Fields, J.3
Anderson, L.M.4
-
91
-
-
0037229714
-
Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R, Danino M, Karlan BY, Slamon DJ. Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 2003; 63: 196-206.
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
Bray, M.R.4
Snow, B.E.5
Ayala, R.6
Danino, M.7
Karlan, B.Y.8
Slamon, D.J.9
-
92
-
-
65549110635
-
Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration
-
Fan Y, Gong Y, Ghosh PK, Graham LM, Fox PL. Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration. Dev Cell 2009; 16: 661-74.
-
(2009)
Dev Cell
, vol.16
, pp. 661-674
-
-
Fan, Y.1
Gong, Y.2
Ghosh, P.K.3
Graham, L.M.4
Fox, P.L.5
-
93
-
-
58149503692
-
Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis
-
Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH, Evers BM. Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci USA 2008; 105: 20315-20.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20315-20320
-
-
Rychahou, P.G.1
Kang, J.2
Gulhati, P.3
Doan, H.Q.4
Chen, L.A.5
Xiao, S.Y.6
Chung, D.H.7
Evers, B.M.8
-
94
-
-
33645213629
-
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
-
Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell MJ. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci USA 2006; 103: 4134-9.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4134-4139
-
-
Liu, H.1
Radisky, D.C.2
Nelson, C.M.3
Zhang, H.4
Fata, J.E.5
Roth, R.A.6
Bissell, M.J.7
-
95
-
-
33646854721
-
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
-
Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem 2006; 281: 8313-6.
-
(2006)
J Biol Chem
, vol.281
, pp. 8313-8316
-
-
Chong-Kopera, H.1
Inoki, K.2
Li, Y.3
Zhu, T.4
Garcia-Gonzalo, F.R.5
Rosa, J.L.6
Guan, K.L.7
-
96
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009; 37: 217-22.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
-
97
-
-
73349099030
-
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
-
Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN. MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal 2009; 2: ra62.
-
(2009)
Sci Signal
, vol.2
, pp. ra62
-
-
Iliopoulos, D.1
Polytarchou, C.2
Hatziapostolou, M.3
Kottakis, F.4
Maroulakou, I.G.5
Struhl, K.6
Tsichlis, P.N.7
-
98
-
-
2342527930
-
Activation of Akt-1 (PKB-α) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
-
Hutchinson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt-1 (PKB-α) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 2004; 64: 3171-8.
-
(2004)
Cancer Res
, vol.64
, pp. 3171-3178
-
-
Hutchinson, J.N.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
99
-
-
67449136114
-
Akt1 and Akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
-
Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ. Akt1 and Akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res 2009; 69: 5057-64.
-
(2009)
Cancer Res
, vol.69
, pp. 5057-5064
-
-
Dillon, R.L.1
Marcotte, R.2
Hennessy, B.T.3
Woodgett, J.R.4
Mills, G.B.5
Muller, W.J.6
-
100
-
-
77749292082
-
The Akt isoforms are present at distinct subcellular locations
-
Santi SA, Lee H. The Akt isoforms are present at distinct subcellular locations. Am J Physiol Cell Physiol 2010; 298: C580-91.
-
(2010)
Am J Physiol Cell Physiol
, vol.298
, pp. C580-C591
-
-
Santi, S.A.1
Lee, H.2
-
101
-
-
79952117054
-
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase
-
Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One 2010; 5: e9910.
-
(2010)
PLoS One
, vol.5
, pp. e9910
-
-
Ding, Z.1
Liang, J.2
Li, J.3
Lu, Y.4
Ariyaratna, V.5
Lu, Z.6
Davies, M.A.7
Westwick, J.K.8
Mills, G.B.9
-
102
-
-
33846514800
-
Proteomics exploration reveals that actin is a signaling target of the kinase Akt
-
Vandermoere F, El Yazidi-Belkoura I, Demont Y, Slomianny C, Antol J, Lemoine J, Hondermarck H. Proteomics exploration reveals that actin is a signaling target of the kinase Akt. Mol Cell Proteomics 2007; 6: 114-24.
-
(2007)
Mol Cell Proteomics
, vol.6
, pp. 114-124
-
-
Vandermoere, F.1
El Yazidi-Belkoura, I.2
Demont, Y.3
Slomianny, C.4
Antol, J.5
Lemoine, J.6
Hondermarck, H.7
-
103
-
-
0034791125
-
Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest
-
Paramio JM, Segrelles C, Ruiz S, Jorcano JL. Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Mol Cell Biol 2001; 21: 7449-59.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7449-7459
-
-
Paramio, J.M.1
Segrelles, C.2
Ruiz, S.3
Jorcano, J.L.4
-
104
-
-
84929591920
-
Localization of keratin intermediate filaments, Fas-receptor and phospho-Akt in griseofulvin treated hepatocellular carcinoma cells HepG2
-
San Francisco, CA, USA, December 10-14, Mol Biol Cell: abstract 2528
-
Fortier AM, Asselin E, Cadrin M. Localization of keratin intermediate filaments, Fas-receptor and phospho-Akt in griseofulvin treated hepatocellular carcinoma cells HepG2. In: 45th American Society for Cell Biology Annual Meeting, San Francisco, CA, USA, December 10-14, Mol Biol Cell 2005; 16(Suppl): abstract 2528.
-
(2005)
45th American Society for Cell Biology Annual Meeting
, vol.16
-
-
Fortier, A.M.1
Asselin, E.2
Cadrin, M.3
-
105
-
-
77953706944
-
Ligation of β4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament
-
Kippenberger S, Hofmann M, Zoller N, Thaci D, Muller J, Kaufmann R, Bernd A. Ligation of β4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament. Biochim Biophys Acta 2010; 1803: 940-50.
-
(2010)
Biochim Biophys Acta
, vol.1803
, pp. 940-950
-
-
Kippenberger, S.1
Hofmann, M.2
Zoller, N.3
Thaci, D.4
Muller, J.5
Kaufmann, R.6
Bernd, A.7
-
106
-
-
34249682108
-
Novel functions of vimentin in cell adhesion, migration, and signaling
-
Ivaska J, Pallari HM, Nevo J, Eriksson JE. Novel functions of vimentin in cell adhesion, migration, and signaling. Exp Cell Res 2007; 313: 2050-62.
-
(2007)
Exp Cell Res
, vol.313
, pp. 2050-2062
-
-
Ivaska, J.1
Pallari, H.M.2
Nevo, J.3
Eriksson, J.E.4
-
107
-
-
0031770943
-
RhoA-binding kinase α translocation is facilitated by the collapse of the vimentin intermediate filament network
-
Sin WC, Chen XQ, Leung T, Lim L. RhoA-binding kinase α translocation is facilitated by the collapse of the vimentin intermediate filament network. Mol Cell Biol 1998; 18: 6325-39.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6325-6339
-
-
Sin, W.C.1
Chen, X.Q.2
Leung, T.3
Lim, L.4
-
108
-
-
76749134221
-
Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells
-
Fortier AM, Van Themsche C, Asselin E, Cadrin M. Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells. FEBS Lett 2010; 584: 984-8.
-
(2010)
FEBS Lett
, vol.584
, pp. 984-988
-
-
Fortier, A.M.1
Van Themsche, C.2
Asselin, E.3
Cadrin, M.4
-
109
-
-
68049144964
-
Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1
-
Bousquet E, Mazieres J, Privat M, Rizzati V, Casanova A, Ledoux A, Mery E, Couderc B, Favre G, Pradines A. Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1. Cancer Res 2009; 69: 6092-9.
-
(2009)
Cancer Res
, vol.69
, pp. 6092-6099
-
-
Bousquet, E.1
Mazieres, J.2
Privat, M.3
Rizzati, V.4
Casanova, A.5
Ledoux, A.6
Mery, E.7
Couderc, B.8
Favre, G.9
Pradines, A.10
-
110
-
-
33847298591
-
Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion
-
Vasko V, Espinosa AV, Scouten W, He H, Auer H, Liyanarachchi S, Larin A, Savchenko V, Francis GL, de la Chapelle A, Saji M, Ringel MD. Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion. Proc Natl Acad Sci USA 2007; 104: 2803-8.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2803-2808
-
-
Vasko, V.1
Espinosa, A.V.2
Scouten, W.3
He, H.4
Auer, H.5
Liyanarachchi, S.6
Larin, A.7
Savchenko, V.8
Francis, G.L.9
De La-Chapelle, A.10
Saji, M.11
Ringel, M.D.12
-
111
-
-
0034693241
-
Cdc42Hs and Rac1 GTPases induce the collapse of the vimentin intermediate filament network
-
Meriane M, Mary S, Comunale F, Vignal E, Fort P, Gauthier-Rouviere C. Cdc42Hs and Rac1 GTPases induce the collapse of the vimentin intermediate filament network. J Biol Chem 2000; 275: 33046-52.
-
(2000)
J Biol Chem
, vol.275
, pp. 33046-33052
-
-
Meriane, M.1
Mary, S.2
Comunale, F.3
Vignal, E.4
Fort, P.5
Gauthier-Rouviere, C.6
|