Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells

FEBS Letters

Volumn 584, Issue 5, 2010, Pages 984-988

  Fortier, Anne Marie ^a   Van Themsche, Céline ^a   Asselin, Éric ^a   Cadrin, Monique ^a  

^a UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

Author keywords

Akt isoform; Intermediate filament; Keratin; Vimentin

Indexed keywords

CYTOKERATIN 18; CYTOKERATIN 8; INTERMEDIATE FILAMENT PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; CANCER CELL CULTURE; CARCINOMA; CONTROLLED STUDY; ENZYME REGULATION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STABILITY; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; INSULIN; INTERMEDIATE FILAMENT PROTEINS; KERATIN-18; KERATIN-8; KERATINS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN;

EID: 76749134221     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.01.045     Document Type: Article

References (42)

1. Kim S., and Coulombe P. Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm. Genes Dev. 21 (2007) 1581-1597
2. Moll R., Divo M., and Langbein L. The human keratins: biology and pathology. Histochem. Cell Biol. 129 (2008) 705-733
3. Ramaekers F.C., Haag D., Kant A., Moesker O., Jap P.H.K., and Vooijs G.P. Coexpression of keratin- and vimentin-type intermediate filaments in human metastatic carcinoma cells. Proc. Natl. Acad. Sci. USA 80 (1983) 2618-2622
4. Thomas P.A., Kirschmann D.A., Cerhan J.R., Foldberg R., Seftor E.A., Sellers T.A., and Hendrix M.J.C. Association between keratin and vimentin expression, malignant phenotype, and survival in postmenopausal breast cancer patients. Clin. Cancer Res. 5 (1999) 2698-2703
5. Hu L., et al. Association of vimentin overexpression and hepatocellular carcinoma metastasis. Oncongene 23 (2004) 298-302
6. Bühler H., and Schaller G. Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo. Mol. Cancer Res. 3 (2005) 365-371
7. Schaller G., Fuchs I., Pritze W., Ebert A., Herbst H., Pantel K., Weitzel H., and Lengyel E. Keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer. Clin. Cancer Res. 2 (1996) 1879-1885
8. Chu Y.-W., Runyan R.B., Oshima R.G., and Hendrix M.J.C. Expression of complete keratin filaments in mouse L cells augments cell migration and invasion. Proc. Natl. Acad. Sci. USA 90 (1993) 4261-4265
9. Hendrix M.J.C., Seftor E.A., Seftor R.E.B., and Trevor K.T. Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behavior. Amer. J. Pathol. 150 (1997) 483-495
10. McInroy L., and Määttä A. Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem. Biophys. Res. Commun. 360 (2007) 109-114
11. Brugge J., Hung M.-C., and Mills G.B. A new mutational aktivation in the PI3K pathway. Cancer Cell 12 (2007) 104-107
12. Irie H.Y., Pearline R.V., Grueneberg D., Hsia M., Ravichandran P., Kothari N., Natesan S., and Brugge J.S. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J. Cell Biol. 171 (2005) 1023-1034
13. Gagnon V., Van Themsche C., Turner S., Leblanc V., and Asselin E. Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis 13 (2008) 259-271
14. Yoeli-Lerner M., Yiu G.K., Rabinovitz I., Erhardt P., Jauliac S., and Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20 (2005) 539-550
15. Maroulakou I.G., Oemler W., Naber S.P., and Tsichlis P.N. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res. 67 (2007) 167-177
16. Kim D., and Chung J. Akt: versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35 (2002) 106-115
17. Ku N.-O., Michie S., Resurreccion E.Z., Broome R.L., and Omary M.B. Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression. Proc. Natl. Acad. Sci. USA 99 (2002) 4373-4378
18. Kim S., Wong P., and Coulombe P. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441 (2006) 362-365
19. Hatano E., and Brenner D.A. Akt protects mouse hepatocytes from TNF-a and Fas-mediated apoptosis through NK-kB activation. Am. J. Physiol. Gastrointest. Liver Physiol. 281 (2002) G1357-G1368
20. Inada H., Izawa I., Nishizawa M., Fujita E., Kiyono T., Takahashi T., Momoi T., and Inagaki M. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. J. Cell Biol. 155 (2001) 415-425
21. Gilbert S., Loranger A., and Marceau N. Keratins modulate c-Flip/Extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells. Mol. Cell Biol. 24 (2004) 7072-7081
22. Yang X., et al. Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts. Am. J. Pathol. 167 (2005) 705-719
23. Lee J.C., Schickling O., Stegh A.H., Oshima R.G., Dinsdale D., Cohen G.M., and Peter M.E. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 158 (2002) 1051-1066
24. Kim D., Kim S., Koh H., Yoon S.-O., Chung A.-S., Cho K.S., and Chung J. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J. 15 (2001) 1953-1962
25. Loranger A., Gilbert S., Brouarda J.-S., Magin T.M., and Marceau N. Keratin 8 modulation of desmoplakin deposition at desmosomes in hepatocytes. Exp. Cell Res. 312 (2006) 4108-4119
26. Long H.A., Boczonadi V., McInroy L., Goldberg M., and Määttä A. Periplakin-dependent re-organisation of keratin cytoskeleton and loss of collective migration in keratin-8-downregulated epithelial sheets. J. Cell Sci. 119 (2006) 5147-5159
27. Ivaska J., Vuoriluoto K., Huovinen T., Izawa I., Inagaki M., and Parker P.J. PKCe-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J. 24 (2005) 3834-3845
28. Van Themsche C., Leblanc V., Parent S., and Asselin E. XIAP regulates PTEN ubiquitination, content and compartmentalization. J. Biol. Chem. 284 (2009) 20462-20466
29. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCT method. Methods 25 (2001) 402-408
30. Vandermoere F., El Yazidi-Belkoura I., Demont Y., Slomianny C., Antol J., Lemoine J., and Hondermarck H. Proteomics exploration reveals that actin is a signaling target of the kinase Akt. Mol. Cell Proteomics 6 (2007) 114-124
31. Sánchez-Capelo A. Dual role for TGF-β1 in apoptosis. Cytokine Growth Factor Rev. 16 (2005) 15-34
32. Cross D.A.E., Alessi D.R., Cohen P., Andjelkovich M., and Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378 (1995) 785-789
33. Crowe D.L. Retinoic acid mediates post-transcriptional regulation of keratin 19 mRNA levels. J. Cell Sci. 106 (1993) 183-188
34. McBride S., Walsh D., Meleady P., Daly N., and Clynes M. Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines. Differentiation 64 (1999) 185-193
35. Cadrin M., Hovington H., Marceau N., and McFarlane-Anderson N. Early perturbations in keratin and actin gene expression and fibrillar organisation in griseofulvin-fed mouse liver. J. Hepatol. 33 (2000) 199-207
36. Gingras A.-C., Kennedy S.G., O'Leary M.A., Sonenberg N., and Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12 (1998) 502-513
37. Rajasekhar V.K., Viale A., Socci N.D., Wiedmann M., Hu X., and Holland E.C. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell 12 (2003) 889-901
38. Kaur S., et al. Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc. Natl. Acad. Sci. 105 (2008) 4808-4813
39. Nakamichi I., Toivola D.M., Strnad P., Michie S.A., Oshima R.G., Baribault H., and Omary M.B. Keratin 8 overexpression promotes mouse Mallory body formation. J. Cell Biol. 171 (2005) 931-937
40. Nakamichi I., Hatakeyama S., and Nakayama K.I. Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. Mol. Biol. Cell 13 (2002) 3441-3451
41. Andreoli J., and Trevor K.T. Structural and biological consequences of increased vimentin expression in simple epithelial cell types. Cell Motil. Cytoskeleton 32 (1995) 10-25
42. Nishizawa M., Izawa I., Inoko A., Hayashi Y., Nagata K., Yokoyama T., Usukura J., and Inagaki M. Identification of trichoplein, a novel keratin filament-binding protein. J. Cell Sci. 118 (2005) 1081-1090