메뉴 건너뛰기




Volumn 67, Issue 5, 2007, Pages 1979-1987

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; FIBRONECTIN; PACLITAXEL; PROTEIN KINASE B BETA; TRANSCRIPTION FACTOR; UVOMORULIN; VIMENTIN;

EID: 33947192053     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1479     Document Type: Article
Times cited : (479)

References (59)
  • 1
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003;3:453-8.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 2
    • 1042292609 scopus 로고    scopus 로고
    • Akt2: A role in breast cancer metastasis
    • Chau NM, Ashcroft M. Akt2: a role in breast cancer metastasis. Breast Cancer Res 2004;6:55-7.
    • (2004) Breast Cancer Res , vol.6 , pp. 55-57
    • Chau, N.M.1    Ashcroft, M.2
  • 3
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx K, Vakaet L, Jr., Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991;66:107-19.
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1    Vakaet Jr., L.2    Mareel, M.3    Fiers, W.4    van Roy, F.5
  • 4
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E, Sancho E, Franci C, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2:84-9.
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3
  • 5
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3
  • 7
    • 0023063325 scopus 로고
    • Collagenase effects on cancer cell invasiveness and motility
    • Maslow DE. Collagenase effects on cancer cell invasiveness and motility. Invasion Metastasis 1987;7:297-310.
    • (1987) Invasion Metastasis , vol.7 , pp. 297-310
    • Maslow, D.E.1
  • 8
    • 0034604067 scopus 로고    scopus 로고
    • Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
    • Yuan ZQ, Sun M, Feldman RI, et al. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 2000;19:2324-30.
    • (2000) Oncogene , vol.19 , pp. 2324-2330
    • Yuan, Z.Q.1    Sun, M.2    Feldman, R.I.3
  • 9
    • 0034637524 scopus 로고    scopus 로고
    • Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
    • Graff JR, Konicek BW, McNulty AM, et al. Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. J Biol Chem 2000;275:24500-5.
    • (2000) J Biol Chem , vol.275 , pp. 24500-24505
    • Graff, J.R.1    Konicek, B.W.2    McNulty, A.M.3
  • 10
    • 0037118575 scopus 로고    scopus 로고
    • AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
    • Bacus SS, Altomare DA, Lyass L, et al. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 2002;21:3532-40.
    • (2002) Oncogene , vol.21 , pp. 3532-3540
    • Bacus, S.S.1    Altomare, D.A.2    Lyass, L.3
  • 11
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 12
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a central role in tumorigenesis
    • Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci U S A 2001;98:10983-5.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10983-10985
    • Testa, J.R.1    Bellacosa, A.2
  • 13
    • 0035949588 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    • Mayo LD, Donner DB. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci U S A 2001;98:11598-603.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 11598-11603
    • Mayo, L.D.1    Donner, D.B.2
  • 14
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    • Arboleda MJ, Lyons JF, Kabbinavar FF, et al. Overexpression of AKT2/protein kinase Bβ leads to up-regulation of β1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 2003;63:196-206.
    • (2003) Cancer Res , vol.63 , pp. 196-206
    • Arboleda, M.J.1    Lyons, J.F.2    Kabbinavar, F.F.3
  • 15
    • 0037728809 scopus 로고    scopus 로고
    • The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    • Grille SJ, Bellacosa A, Upson J, et al. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 2003;63:2172-8.
    • (2003) Cancer Res , vol.63 , pp. 2172-2178
    • Grille, S.J.1    Bellacosa, A.2    Upson, J.3
  • 16
    • 1142277821 scopus 로고    scopus 로고
    • Akt2 expression correlates with prognosis of human hepatocellular carcinoma
    • Xu X, Sakon M, Nagano H, et al. Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol Rep 2004;11:25-32.
    • (2004) Oncol Rep , vol.11 , pp. 25-32
    • Xu, X.1    Sakon, M.2    Nagano, H.3
  • 17
    • 0036195196 scopus 로고    scopus 로고
    • AKT protooncogene overexpression is an early event during sporadic colon carcinogenesis
    • Roy HK, Olusola BF, Clemens DL, et al. AKT protooncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002;23:201-5.
    • (2002) Carcinogenesis , vol.23 , pp. 201-205
    • Roy, H.K.1    Olusola, B.F.2    Clemens, D.L.3
  • 18
    • 0035881322 scopus 로고    scopus 로고
    • Overexpression and overactivation of Akt in thyroid carcinoma
    • Ringel MD, Hayre N, Saito J, et al. Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Res 2001;61:6105-11.
    • (2001) Cancer Res , vol.61 , pp. 6105-6111
    • Ringel, M.D.1    Hayre, N.2    Saito, J.3
  • 19
    • 24944528243 scopus 로고    scopus 로고
    • AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma
    • Kim CS, Vasko W, Kato Y, et al. AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma. Endocrinology 2005;146:4456-63.
    • (2005) Endocrinology , vol.146 , pp. 4456-4463
    • Kim, C.S.1    Vasko, W.2    Kato, Y.3
  • 20
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng JQ, Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A 1996;93:3636-41.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3
  • 21
    • 0031936947 scopus 로고    scopus 로고
    • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
    • Ruggeri BA, Huang L, Wood M, Cheng JQ, Testa JR. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol Carcinog 1998;21:81-6.
    • (1998) Mol Carcinog , vol.21 , pp. 81-86
    • Ruggeri, B.A.1    Huang, L.2    Wood, M.3    Cheng, J.Q.4    Testa, J.R.5
  • 22
    • 0030598884 scopus 로고    scopus 로고
    • Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer
    • Miwa W, Yasuda J, Murakami Y, et al. Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer. Biochem Biophys Res Commun 1996;225:968-74.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 968-974
    • Miwa, W.1    Yasuda, J.2    Murakami, Y.3
  • 23
    • 0032527913 scopus 로고    scopus 로고
    • AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells
    • Liu AX, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JQ. AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res 1998;58:2973-7.
    • (1998) Cancer Res , vol.58 , pp. 2973-2977
    • Liu, A.X.1    Testa, J.R.2    Hamilton, T.C.3    Jove, R.4    Nicosia, S.V.5    Cheng, J.Q.6
  • 24
    • 0026667730 scopus 로고
    • AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
    • Cheng JQ, Godwin AK, Bellacosa A, et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A 1992;89:9267-71.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 9267-9271
    • Cheng, J.Q.1    Godwin, A.K.2    Bellacosa, A.3
  • 25
    • 0035881568 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K
    • Sun M, Paciga JE, Feldman RI, et al. Phosphatidylinositol-3-OH kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor α (ERα) via interaction between ERα and PI3K. Cancer Res 2001;61:5985-91.
    • (2001) Cancer Res , vol.61 , pp. 5985-5991
    • Sun, M.1    Paciga, J.E.2    Feldman, R.I.3
  • 26
    • 0029127042 scopus 로고
    • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
    • Bellacosa A, de Feo D, Godwin AK, et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995;64:280-5.
    • (1995) Int J Cancer , vol.64 , pp. 280-285
    • Bellacosa, A.1    de Feo, D.2    Godwin, A.K.3
  • 27
    • 0037012509 scopus 로고    scopus 로고
    • A Twist in fate: Evolutionary comparison of Twist structure and function
    • Castanon I, Baylies MK. A Twist in fate: evolutionary comparison of Twist structure and function. Gene 2002;287:11-22.
    • (2002) Gene , vol.287 , pp. 11-22
    • Castanon, I.1    Baylies, M.K.2
  • 28
    • 1642523489 scopus 로고    scopus 로고
    • Helix-loop-helix proteins in mammary gland development and breast cancer
    • Desprez PY, Sumida T, Coppe JP. Helix-loop-helix proteins in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2003;8:225-39.
    • (2003) J Mammary Gland Biol Neoplasia , vol.8 , pp. 225-239
    • Desprez, P.Y.1    Sumida, T.2    Coppe, J.P.3
  • 29
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 2000;20:429-40.
    • (2000) Mol Cell Biol , vol.20 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 30
    • 0029890899 scopus 로고    scopus 로고
    • Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist
    • Spicer DB, Rhee J, Cheung WL, Lassar AB. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science 1996;272:1476-80.
    • (1996) Science , vol.272 , pp. 1476-1480
    • Spicer, D.B.1    Rhee, J.2    Cheung, W.L.3    Lassar, A.B.4
  • 31
    • 0030881743 scopus 로고    scopus 로고
    • The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist
    • Hamamori Y, Wu HY, Sartorelli V, Kedes L. The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol 1997;17:6563-73.
    • (1997) Mol Cell Biol , vol.17 , pp. 6563-6573
    • Hamamori, Y.1    Wu, H.Y.2    Sartorelli, V.3    Kedes, L.4
  • 32
    • 0033525094 scopus 로고    scopus 로고
    • Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A
    • Hamamori Y, Sartorelli V, Ogryzko V, et al. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 1999;96:405-13.
    • (1999) Cell , vol.96 , pp. 405-413
    • Hamamori, Y.1    Sartorelli, V.2    Ogryzko, V.3
  • 33
    • 0033200349 scopus 로고    scopus 로고
    • Twist is a potential oncogene that inhibits apoptosis
    • Maestro R, Dei Tos AP, Hamamori Y, et al. Twist is a potential oncogene that inhibits apoptosis. Genes Dev 1999;13:2207-17.
    • (1999) Genes Dev , vol.13 , pp. 2207-2217
    • Maestro, R.1    Dei Tos, A.P.2    Hamamori, Y.3
  • 34
    • 3442894137 scopus 로고    scopus 로고
    • Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
    • Hoek K, Rimm DL, Williams KR, et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res 2004;64:5270-82.
    • (2004) Cancer Res , vol.64 , pp. 5270-5282
    • Hoek, K.1    Rimm, D.L.2    Williams, K.R.3
  • 35
    • 10944221249 scopus 로고    scopus 로고
    • Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells
    • Valsesia-Wittmann S, Magdeleine M, Dupasquier S, et al. Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells. Cancer Cell 2004;6:625-30.
    • (2004) Cancer Cell , vol.6 , pp. 625-630
    • Valsesia-Wittmann, S.1    Magdeleine, M.2    Dupasquier, S.3
  • 36
    • 0842286741 scopus 로고    scopus 로고
    • Identification of a novel function of TWIST, a bHLH protein, in the development of acquired Taxol resistance in human cancer cells
    • Wang X, Ling MT, Guan XY, et al. Identification of a novel function of TWIST, a bHLH protein, in the development of acquired Taxol resistance in human cancer cells. Oncogene 2004;23:474-82.
    • (2004) Oncogene , vol.23 , pp. 474-482
    • Wang, X.1    Ling, M.T.2    Guan, X.Y.3
  • 37
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117:927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 38
    • 20444453337 scopus 로고    scopus 로고
    • Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target
    • Kwok WK, Ling MT, Lee TW, et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res 2005;65:5153-62.
    • (2005) Cancer Res , vol.65 , pp. 5153-5162
    • Kwok, W.K.1    Ling, M.T.2    Lee, T.W.3
  • 39
    • 28344444026 scopus 로고    scopus 로고
    • Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    • Mironchik Y, Winnard PT, Jr., Vesuna F, et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 2005;65:10801-9.
    • (2005) Cancer Res , vol.65 , pp. 10801-10809
    • Mironchik, Y.1    Winnard Jr., P.T.2    Vesuna, F.3
  • 40
    • 26444495099 scopus 로고    scopus 로고
    • Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas
    • Entz-Werle N, Stoetzel C, Berard-Marec P, et al. Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. Int J Cancer 2005;117:349-55.
    • (2005) Int J Cancer , vol.117 , pp. 349-355
    • Entz-Werle, N.1    Stoetzel, C.2    Berard-Marec, P.3
  • 41
    • 4143079424 scopus 로고    scopus 로고
    • Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sezary syndrome identified by gene expression analysis
    • van Doorn R, Dijkman R, Vermeer MH, et al. Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sezary syndrome identified by gene expression analysis. Cancer Res 2004;64:5578-86.
    • (2004) Cancer Res , vol.64 , pp. 5578-5586
    • van Doorn, R.1    Dijkman, R.2    Vermeer, M.H.3
  • 42
    • 0036840363 scopus 로고    scopus 로고
    • Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
    • Rosivatz E, Becker I, Specht K, et al. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002;161:1881-91.
    • (2002) Am J Pathol , vol.161 , pp. 1881-1891
    • Rosivatz, E.1    Becker, I.2    Specht, K.3
  • 43
    • 20144387626 scopus 로고    scopus 로고
    • Expression of twist and wnt in human breast cancer
    • Watanabe O, Imamura H, Shimizu T, et al. Expression of twist and wnt in human breast cancer. Anticancer Res 2004;24:3851-6.
    • (2004) Anticancer Res , vol.24 , pp. 3851-3856
    • Watanabe, O.1    Imamura, H.2    Shimizu, T.3
  • 44
    • 0037189574 scopus 로고    scopus 로고
    • Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter
    • Kaneko S, Feldman RI, Yu L, et al. Positive feedback regulation between Akt2 and MyoD during muscle differentiation. Cloning of Akt2 promoter. J Biol Chem 2002;277:23230-5.
    • (2002) J Biol Chem , vol.277 , pp. 23230-23235
    • Kaneko, S.1    Feldman, R.I.2    Yu, L.3
  • 45
    • 0037405123 scopus 로고    scopus 로고
    • Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity
    • Sierra J, Villagra A, Paredes R, et al. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol 2003;23:3339-51.
    • (2003) Mol Cell Biol , vol.23 , pp. 3339-3351
    • Sierra, J.1    Villagra, A.2    Paredes, R.3
  • 46
    • 85047682789 scopus 로고    scopus 로고
    • Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent
    • Ofir R, Seidman R, Rabinski T, et al. Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent. Cell Death Differ 2002;9:636-42.
    • (2002) Cell Death Differ , vol.9 , pp. 636-642
    • Ofir, R.1    Seidman, R.2    Rabinski, T.3
  • 47
    • 0034027514 scopus 로고    scopus 로고
    • Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis
    • Page C, Lin HJ, Jin Y, et al. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer Res 2000;20:407-16.
    • (2000) Anticancer Res , vol.20 , pp. 407-416
    • Page, C.1    Lin, H.J.2    Jin, Y.3
  • 48
    • 12344288380 scopus 로고    scopus 로고
    • Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin
    • VanderWeele DJ, Zhou R, Rudin CM. Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin. Mol Cancer Ther 2004;3:1605-13.
    • (2004) Mol Cancer Ther , vol.3 , pp. 1605-1613
    • VanderWeele, D.J.1    Zhou, R.2    Rudin, C.M.3
  • 49
    • 0345700653 scopus 로고    scopus 로고
    • Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation
    • Howe LR, Watanabe O, Leonard J, Brown AM. Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res 2003;63:1906-13.
    • (2003) Cancer Res , vol.63 , pp. 1906-1913
    • Howe, L.R.1    Watanabe, O.2    Leonard, J.3    Brown, A.M.4
  • 50
    • 10144237223 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells
    • Ohigashi T, Mizuno R, Nakashima J, Marumo K, Murai M. Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. Prostate 2005;62:61-8.
    • (2005) Prostate , vol.62 , pp. 61-68
    • Ohigashi, T.1    Mizuno, R.2    Nakashima, J.3    Marumo, K.4    Murai, M.5
  • 51
    • 27544496133 scopus 로고    scopus 로고
    • Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness
    • Zi X, Guo Y, Simoneau AR, et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res 2005;65:9762-70.
    • (2005) Cancer Res , vol.65 , pp. 9762-9770
    • Zi, X.1    Guo, Y.2    Simoneau, A.R.3
  • 52
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005;24:7455-64.
    • (2005) Oncogene , vol.24 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 53
    • 28244496507 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway
    • Park S, Kim D, Kaneko S, et al. Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway. J Biol Chem 2005;280:38932-41.
    • (2005) J Biol Chem , vol.280 , pp. 38932-38941
    • Park, S.1    Kim, D.2    Kaneko, S.3
  • 54
    • 24644457736 scopus 로고    scopus 로고
    • Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
    • Xu Q, Briggs J, Park S, et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 2005;24:5552-60.
    • (2005) Oncogene , vol.24 , pp. 5552-5560
    • Xu, Q.1    Briggs, J.2    Park, S.3
  • 55
    • 24144497139 scopus 로고    scopus 로고
    • Regulation of AKT1 expression by β-catenin/Tcf/Lef signaling in colorectal cancer cells
    • Dihlmann S, Kloor M, Fallsehr C, von Knebel Doeberitz M. Regulation of AKT1 expression by β-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis 2005;26:1503-12.
    • (2005) Carcinogenesis , vol.26 , pp. 1503-1512
    • Dihlmann, S.1    Kloor, M.2    Fallsehr, C.3    von Knebel Doeberitz, M.4
  • 56
    • 16844376635 scopus 로고    scopus 로고
    • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
    • Firulli BA, Krawchuk D, Centonze VE, et al. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet 2005;37:373-81.
    • (2005) Nat Genet , vol.37 , pp. 373-381
    • Firulli, B.A.1    Krawchuk, D.2    Centonze, V.E.3
  • 58
    • 0034846639 scopus 로고    scopus 로고
    • Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
    • Castanon I, Von Stetina S, Kass J, Baylies MK. Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development. Development 2001;128:3145-59.
    • (2001) Development , vol.128 , pp. 3145-3159
    • Castanon, I.1    Von Stetina, S.2    Kass, J.3    Baylies, M.K.4
  • 59
    • 33645733588 scopus 로고    scopus 로고
    • N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1
    • Alexander NR, Tran NL, Rekapally H, Summers CE, Glackin C, Heimark RL. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res 2006;66:3365-9.
    • (2006) Cancer Res , vol.66 , pp. 3365-3369
    • Alexander, N.R.1    Tran, N.L.2    Rekapally, H.3    Summers, C.E.4    Glackin, C.5    Heimark, R.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.