MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

Science Signaling

Volumn 2, Issue 92, 2009, Pages

  Iliopoulos, Dimitrios ^a   Polytarchou, Christos ^b   Hatziapostolou, Maria ^b   Kottakis, Filippos ^b   Maroulakou, Ioanna G ^b   Struhl, Kevin ^a   Tsichlis, Philip N ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; PROTEIN KINASE B; PROTEIN KINASE B BETA; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; CADHERIN; ISOPROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER; CANCER STEM CELL; CARCINOGENESIS; CELL RENEWAL; CELL STIMULATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENETIC TRANSDUCTION; HYPOTHESIS; KIDNEY EPITHELIUM; LUNG FIBROBLAST; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; ANIMAL; CARCINOMA; CHEMISTRY; CYTOLOGY; EPITHELIUM; GENE EXPRESSION REGULATION; HUMAN; MESODERM; METABOLISM; STEM CELL; TUMOR CELL LINE;

MOUSE MAMMARY TUMOR VIRUS; MUS;

ANIMALS; CADHERINS; CARCINOMA; CELL LINE, TUMOR; EPITHELIUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MESODERM; MICE; MICRORNAS; NEOPLASM METASTASIS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 73349099030     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000356     Document Type: Article

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26. We thank N. Terrin for help with the statistical analyses and P. Hinds, C. Kuperwasser, and A. Charest of the Molecular Oncology Research Institute, Tufts Medical Center, for helpful discussions and for reviewing the manuscript. This work was supported by NIH grants NIH R01CA57436 (P.N.T) and R01CA107486 (K.S.) and a pilot project grant from the Tufts Medical Center Cancer Center (P.N.T). C.P. is a fellow of the Leukemia and Lymphoma Society.