Akt mediates Rac/Cdc42-regulated cell motility in growth factor-stimulated cells and in invasive PTEN knockout cells

Current Biology

Volumn 11, Issue 24, 2001, Pages 1958-1962

  Higuchi, Maiko ^a   Masuyama, Norihisa ^a   Fukui, Yasuhisa ^a   Suzuki, Akira ^b   Gotoh, Yukiko ^a,c  

^a Faculty of Agricultural and Life Science   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0035846549     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00599-1     Document Type: Article

References (22)

1. Cellular survival: A play in three Akts
2. Activation of the small GTP-binding proteins Rho and Rac by growth factor receptors
3. Protein kinase B and Rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
4. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras
5. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
6. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
7. The chemotactic effect of mixture of antibody and antigen on polymorphonuclear leukocytes
8. Development of a simple cell invasion assay system
9. Motility and invasion are differentially modulated by Rho family GTPases
10. Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
11. IGF-I promotes Schwann cell motility and survival via activation of Akt
12. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
13. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
14. Rho GTPases control polarity, protrusion, and adhesion during cell movement
15. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
16. Control of cell polarity and chemotaxis by Akt/PKB and PI3 Kinase through the regulation of PAKa
17. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
18. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts
19. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
20. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
21. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
22. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases