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Volumn 19, Issue 16, 2013, Pages 1953-1969

Regulation of lifespan by the mitochondrial electron transport chain: Reactive oxygen species-dependent and reactive oxygen species-independent mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; HYDROXYL GROUP; HYDROXYL RADICAL; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; SUPEROXIDE DISMUTASE; UBIQUINOL CYTOCHROME C REDUCTASE;

EID: 84888629624     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2012.4900     Document Type: Review
Times cited : (60)

References (200)
  • 2
    • 0242585476 scopus 로고    scopus 로고
    • Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
    • Aguilaniu H, Gustafsson L, Rigoulet M, and Nystrom T. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299: 1751-1753, 2003
    • (2003) Science , vol.299 , pp. 1751-1753
    • Aguilaniu, H.1    Gustafsson, L.2    Rigoulet, M.3    Nystrom, T.4
  • 5
    • 0025776071 scopus 로고
    • Perhydroxyl radical (HOO) initiated lipid peroxidation the role of fatty acid hydroperoxides
    • Aikens J and Dix TA. Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides. J Biol Chem 266: 15091-15098, 1991
    • (1991) J Biol Chem , vol.266 , pp. 15091-15098
    • Aikens, J.1    Dix, T.A.2
  • 7
    • 84863403169 scopus 로고    scopus 로고
    • The caloric restriction paradigm: Implications for healthy human aging
    • Anderson RM and Weindruch R. The caloric restriction paradigm: Implications for healthy human aging. Am J Hum Biol 24: 101-106, 2012
    • (2012) Am J Hum Biol , vol.24 , pp. 101-106
    • Anderson, R.M.1    Weindruch, R.2
  • 8
    • 25144510360 scopus 로고    scopus 로고
    • Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
    • Andziak B, O'Connor TP, and Buffenstein R. Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat. Mech Ageing Dev 126: 1206-1212, 2005
    • (2005) Mech Ageing Dev , vol.126 , pp. 1206-1212
    • Andziak, B.1    O'Connor, T.P.2    Buffenstein, R.3
  • 10
    • 0034674055 scopus 로고    scopus 로고
    • Estimation of H2O2 gradients across biomembranes
    • Antunes F and Cadenas E. Estimation of H2O2 gradients across biomembranes. FEBS Lett 475: 121-126, 2000
    • (2000) FEBS Lett , vol.475 , pp. 121-126
    • Antunes, F.1    Cadenas, E.2
  • 11
    • 77954447250 scopus 로고    scopus 로고
    • Does oxidative stress contribute to the pathology of Friedreich's ataxiä a radical question
    • Armstrong JS, Khdour O, and Hecht SM. Does oxidative stress contribute to the pathology of Friedreich's ataxiä A radical question. FASEB J 24: 2152-2163, 2010
    • (2010) FASEB J , vol.24 , pp. 2152-2163
    • Armstrong, J.S.1    Khdour, O.2    Hecht, S.M.3
  • 12
    • 79251598022 scopus 로고    scopus 로고
    • The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation
    • Ash CE and Merry BJ. The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation. Mech Ageing Dev 132: 43-54, 2011
    • (2011) Mech Ageing Dev , vol.132 , pp. 43-54
    • Ash, C.E.1    Merry, B.J.2
  • 14
    • 0028528590 scopus 로고
    • Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds
    • Barja G, Cadenas S, Rojas C, Perez-Campo R, and Lopez-Torres M. Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds. Free Radic Res 21: 317-327, 1994
    • (1994) Free Radic Res , vol.21 , pp. 317-327
    • Barja, G.1    Cadenas, S.2    Rojas, C.3    Perez-Campo, R.4    Lopez-Torres, M.5
  • 15
    • 0033972463 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
    • Barja G and Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J 14: 312-318, 2000
    • (2000) FASEB J , vol.14 , pp. 312-318
    • Barja, G.1    Herrero, A.2
  • 17
    • 79958041601 scopus 로고    scopus 로고
    • The SirT3 divining rod points to oxidative stress
    • Bell EL and Guarente L. The SirT3 divining rod points to oxidative stress. Mol Cell 42: 561-568, 2011
    • (2011) Mol Cell , vol.42 , pp. 561-568
    • Bell, E.L.1    Guarente, L.2
  • 18
    • 77958517405 scopus 로고    scopus 로고
    • Methylglyoxal alters the function and stability of critical components of the protein quality control
    • Bento CF, Marques F, Fernandes R, and Pereira P. Methylglyoxal alters the function and stability of critical components of the protein quality control. PLoS One 5: E13007, 2010
    • (2010) PLoS One , vol.5
    • Bento, C.F.1    Marques, F.2    Fernandes, R.3    Pereira, P.4
  • 20
    • 37849052672 scopus 로고    scopus 로고
    • Systemic and mitochondrial adaptive responses to moderate exercise in rodents
    • Boveris A and Navarro A. Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic Biol Med 44: 224-229, 2008
    • (2008) Free Radic Biol Med , vol.44 , pp. 224-229
    • Boveris, A.1    Navarro, A.2
  • 21
    • 79955591489 scopus 로고    scopus 로고
    • Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats
    • Braidy N, Guillemin GJ, Mansour H, Chan-Ling T, Poljak A, and Grant R. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One 6: E19194, 2011
    • (2011) PLoS One , vol.6
    • Braidy, N.1    Guillemin, G.J.2    Mansour, H.3    Chan-Ling, T.4    Poljak, A.5    Grant, R.6
  • 22
    • 0019289058 scopus 로고
    • Superoxide radical and superoxide dismutases: Threat and defense
    • Brawn K and Fridovich I. Superoxide radical and superoxide dismutases: Threat and defense. Acta Physiol Scand Suppl 492: 9-18, 1980
    • (1980) Acta Physiol Scand Suppl , vol.492 , pp. 9-18
    • Brawn, K.1    Fridovich, I.2
  • 23
    • 37349000601 scopus 로고    scopus 로고
    • Correlation of mitochondrial superoxide dismutase and DNA polymerase beta in mammalian dermal fibroblasts with species maximal lifespan
    • Brown MF and Stuart JA. Correlation of mitochondrial superoxide dismutase and DNA polymerase beta in mammalian dermal fibroblasts with species maximal lifespan. Mech Ageing Dev 128: 696-705, 2007
    • (2007) Mech Ageing Dev , vol.128 , pp. 696-705
    • Brown, M.F.1    Stuart, J.A.2
  • 24
    • 0028918334 scopus 로고
    • Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
    • Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med 18: 775-794, 1995
    • (1995) Free Radic Biol Med , vol.18 , pp. 775-794
    • Burdon, R.H.1
  • 26
    • 84860390185 scopus 로고    scopus 로고
    • Increased life span from overexpression of superoxide dismutase in caenorhabditis elegans is not caused by decreased oxidative damage
    • Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, and Gems D. Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med 51: 1575-1582, 2011
    • (2011) Free Radic Biol Med , vol.51 , pp. 1575-1582
    • Cabreiro, F.1    Ackerman, D.2    Doonan, R.3    Araiz, C.4    Back, P.5    Papp, D.6    Braeckman, B.P.7    Gems, D.8
  • 28
    • 78349232824 scopus 로고    scopus 로고
    • Themigration ofmitochondrial DNA fragments to the nucleus affects the chronological aging process of saccharomyces cerevisiae
    • Cheng X and Ivessa AS. Themigration ofmitochondrial DNA fragments to the nucleus affects the chronological aging process of Saccharomyces cerevisiae. Aging Cell 9: 919-923, 2010
    • (2010) Aging Cell , vol.9 , pp. 919-923
    • Cheng, X.1    Ivessa, A.S.2
  • 29
    • 0023732274 scopus 로고
    • A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals
    • Chevion M. A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals. Free Radic Biol Med 5: 27-37, 1988
    • (1988) Free Radic Biol Med , vol.5 , pp. 27-37
    • Chevion, M.1
  • 30
    • 78650178322 scopus 로고    scopus 로고
    • Old mice hard to replicate
    • Choi CQ. Old mice hard to replicate. Scientist 21: 64, 2007
    • (2007) Scientist , vol.21 , pp. 64
    • Choi, C.Q.1
  • 31
    • 55249104165 scopus 로고    scopus 로고
    • Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes
    • Choksi KB, Nuss JE, Deford JH, and Papaconstantinou J. Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes. Free Radic Biol Med 45: 826-838, 2008
    • (2008) Free Radic Biol Med , vol.45 , pp. 826-838
    • Choksi, K.B.1    Nuss, J.E.2    Deford, J.H.3    Papaconstantinou, J.4
  • 32
    • 77955659347 scopus 로고    scopus 로고
    • The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO
    • Chung H, Kim AK, Jung SA, Kim SW, Yu K, and Lee JH. The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO. FEBS Lett 584: 3609-3614, 2010
    • (2010) FEBS Lett , vol.584 , pp. 3609-3614
    • Chung, H.1    Kim, A.K.2    Jung, S.A.3    Kim, S.W.4    Yu, K.5    Lee, J.H.6
  • 35
    • 66149087761 scopus 로고    scopus 로고
    • A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    • Cristina D, Cary M, Lunceford A, Clarke C, and Kenyon C. A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet 5: E1000450, 2009
    • (2009) PLoS Genet , vol.5
    • Cristina, D.1    Cary, M.2    Lunceford, A.3    Clarke, C.4    Kenyon, C.5
  • 39
    • 29744435923 scopus 로고    scopus 로고
    • Cells discover fire: Employing reactive oxygen species in development and consequences for aging
    • de Magalhaes JP and Church GM. Cells discover fire: Employing reactive oxygen species in development and consequences for aging. Exp Gerontol 41: 1-10, 2006
    • (2006) Exp Gerontol , vol.41 , pp. 1-10
    • De Magalhaes, J.P.1    Church, G.M.2
  • 40
    • 34548164744 scopus 로고    scopus 로고
    • Expression of ndi1p, an alternative nadh: Ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C elegans model of mitochondrial disease
    • DeCorby A, Gaskova D, Sayles LC, and Lemire BD. Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease. Biochim Biophys Acta 1767: 1157-1163, 2007
    • (2007) Biochim Biophys Acta , vol.1767 , pp. 1157-1163
    • Decorby, A.1    Gaskova, D.2    Sayles, L.C.3    Lemire, B.D.4
  • 42
    • 77953257025 scopus 로고    scopus 로고
    • Aging and disease: Connections to sirtuins
    • Donmez G and Guarente L. Aging and disease: Connections to sirtuins. Aging Cell 9: 285-290, 2010
    • (2010) Aging Cell , vol.9 , pp. 285-290
    • Donmez, G.1    Guarente, L.2
  • 45
    • 41649119244 scopus 로고    scopus 로고
    • The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast
    • Easlon E, Tsang F, Skinner C, Wang C, and Lin SJ. The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22: 931-944, 2008
    • (2008) Genes Dev , vol.22 , pp. 931-944
    • Easlon, E.1    Tsang, F.2    Skinner, C.3    Wang, C.4    Lin, S.J.5
  • 46
    • 41149100550 scopus 로고    scopus 로고
    • Production of reactive oxygen species by complex i (NADH: Ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria
    • Esterhazy D, King MS, Yakovlev G, and Hirst J. Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria. Biochemistry 47: 3964-3971, 2008
    • (2008) Biochemistry , vol.47 , pp. 3964-3971
    • Esterhazy, D.1    King, M.S.2    Yakovlev, G.3    Hirst, J.4
  • 48
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in caenorhabditis elegans
    • Feng J, Bussiere F, and Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 1: 633-644, 2001
    • (2001) Dev Cell , vol.1 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 50
    • 34250758020 scopus 로고    scopus 로고
    • H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
    • Furukawa A, Tada-Oikawa S, Kawanishi S, and Oikawa S. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion. Cell Physiol Biochem 20: 45-54, 2007
    • (2007) Cell Physiol Biochem , vol.20 , pp. 45-54
    • Furukawa, A.1    Tada-Oikawa, S.2    Kawanishi, S.3    Oikawa, S.4
  • 51
    • 84858964912 scopus 로고    scopus 로고
    • Age-dependent increases in the oxidative damage of DNA RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LCMS/ MS: Urinary 8-oxoguanosine as a novel biomarker of aging
    • Gan W, Nie B, Shi F, Xu XM, Qian JC, Takagi Y, Hayakawa H, Sekiguchi M, and Cai JP. Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LCMS/ MS: Urinary 8-oxoguanosine as a novel biomarker of aging. Free Radic Biol Med 52: 1700-1707, 2012
    • (2012) Free Radic Biol Med , vol.52 , pp. 1700-1707
    • Gan, W.1    Nie, B.2    Shi, F.3    Xu, X.M.4    Qian, J.C.5    Takagi, Y.6    Hayakawa, H.7    Sekiguchi, M.8    Cai, J.P.9
  • 52
    • 37849021505 scopus 로고    scopus 로고
    • Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training
    • Gomez-Cabrera MC, Domenech E, and Vina J. Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training. Free Radic Biol Med 44: 126-131, 2008
    • (2008) Free Radic Biol Med , vol.44 , pp. 126-131
    • Gomez-Cabrera, M.C.1    Domenech, E.2    Vina, J.3
  • 54
    • 69949125563 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and ageing
    • Greaves LC and Turnbull DM. Mitochondrial DNA mutations and ageing. Biochim Biophys Acta 1790: 1015-1020, 2009
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 1015-1020
    • Greaves, L.C.1    Turnbull, D.M.2
  • 55
    • 23844488868 scopus 로고    scopus 로고
    • Minireview: The role of oxidative stress in relation to caloric restriction and longevity
    • Gredilla R and Barja G. Minireview: The role of oxidative stress in relation to caloric restriction and longevity. Endocrinology 146: 3713-3717, 2005
    • (2005) Endocrinology , vol.146 , pp. 3713-3717
    • Gredilla, R.1    Barja, G.2
  • 56
    • 0035403165 scopus 로고    scopus 로고
    • Caloric restriction decreases mitochondrial free radical generation at complex i and lowers oxidative damage to mitochondrial DNA in the rat heart
    • Gredilla R, Sanz A, Lopez-Torres M, and Barja G. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB J 15: 1589-1591, 2001
    • (2001) FASEB J , vol.15 , pp. 1589-1591
    • Gredilla, R.1    Sanz, A.2    Lopez-Torres, M.3    Barja, G.4
  • 57
    • 84858797015 scopus 로고    scopus 로고
    • Sirtuins and calorie restriction
    • Guarente L. Sirtuins and calorie restriction. Nat Rev Mol Cell Biol 13: 207, 2012
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 207
    • Guarente, L.1
  • 58
    • 76749132709 scopus 로고    scopus 로고
    • The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
    • Guillou H, Zadravec D, Martin PG, and Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog Lipid Res 49: 186-199, 2010
    • (2010) Prog Lipid Res , vol.49 , pp. 186-199
    • Guillou, H.1    Zadravec, D.2    Martin, P.G.3    Jacobsson, A.4
  • 60
    • 0020362998 scopus 로고
    • The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts
    • Gutteridge JM. The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts. FEBS Lett 150: 454-458, 1982
    • (1982) FEBS Lett , vol.150 , pp. 454-458
    • Gutteridge, J.M.1
  • 63
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 11: 298-300, 1956
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 64
    • 0015319592 scopus 로고
    • The biologic clock the mitochondriä
    • Harman D. The biologic clock: The mitochondriä J Am Geriatr Soc 20: 145-147, 1972
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 65
    • 0142213542 scopus 로고    scopus 로고
    • The free radical theory of aging
    • Harman D. The free radical theory of aging. Antioxid Redox Signal 5: 557-561, 2003
    • (2003) Antioxid Redox Signal , vol.5 , pp. 557-561
    • Harman, D.1
  • 66
    • 34248517504 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: Evidence for a causal role in muscle fiber loss
    • Herbst A, Pak JW, McKenzie D, Bua E, Bassiouni M, and Aiken JM. Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: Evidence for a causal role in muscle fiber loss. J Gerontol Ser A Biol Sci Med Sci 62: 235-245, 2007
    • (2007) J Gerontol ser A Biol Sci Med Sci , vol.62 , pp. 235-245
    • Herbst, A.1    Pak, J.W.2    McKenzie, D.3    Bua, E.4    Bassiouni, M.5    Aiken, J.M.6
  • 67
    • 70349763406 scopus 로고    scopus 로고
    • NAD+ availability and proteotoxicity
    • Hipkiss AR. NAD+ availability and proteotoxicity. Neuromol Med 11: 97-100, 2009
    • (2009) Neuromol Med , vol.11 , pp. 97-00
    • Hipkiss, A.R.1
  • 68
    • 77954050646 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, proteotoxicity, and aging: Causes or effects, and the possible impact of NAD+ -controlled protein glycation
    • Hipkiss AR. Mitochondrial dysfunction, proteotoxicity, and aging: Causes or effects, and the possible impact of NAD+ -controlled protein glycation. Adv Clin Chem 50: 123-150, 2010
    • (2010) Adv Clin Chem , vol.50 , pp. 123-150
    • Hipkiss, A.R.1
  • 69
    • 0031058447 scopus 로고    scopus 로고
    • Mortality rate and longevity of food-restricted exercising male rats: A reevaluation
    • Holloszy JO. Mortality rate and longevity of food-restricted exercising male rats: A reevaluation. J Appl Physiol 82: 399-403, 1997
    • (1997) J Appl Physiol , vol.82 , pp. 399-403
    • Holloszy, J.O.1
  • 70
    • 0032536389 scopus 로고    scopus 로고
    • Longevity of exercising male rats: Effect of an antioxidant supplemented diet
    • Holloszy JO. Longevity of exercising male rats: Effect of an antioxidant supplemented diet. Mech Ageing Dev 100: 211-219, 1998
    • (1998) Mech Ageing Dev , vol.100 , pp. 211-219
    • Holloszy, J.O.1
  • 71
    • 48749115206 scopus 로고    scopus 로고
    • Elongation and desaturation of fatty acids are critical in growth, lipid metabolism and ontogeny of caenorhabditis elegans
    • Horikawa M, Nomura T, Hashimoto T, and Sakamoto K. Elongation and desaturation of fatty acids are critical in growth, lipid metabolism and ontogeny of Caenorhabditis elegans. J Biochem 144: 149-158, 2008
    • (2008) J Biochem , vol.144 , pp. 149-158
    • Horikawa, M.1    Nomura, T.2    Hashimoto, T.3    Sakamoto, K.4
  • 72
    • 77953631698 scopus 로고    scopus 로고
    • The secret life of NAD+ : AAn old metabolite controlling new metabolic signaling pathways
    • Houtkooper RH, Canto C, Wanders RJ, and Auwerx J. The secret life of NAD+ : An old metabolite controlling new metabolic signaling pathways. Endocr Rev 31: 194-223, 2010
    • (2010) Endocr Rev , vol.31 , pp. 194-223
    • Houtkooper, R.H.1    Canto, C.2    Wanders, R.J.3    Auwerx, J.4
  • 73
    • 34248541922 scopus 로고    scopus 로고
    • Life and death: Metabolic rate, membrane composition, and life span of animals
    • Hulbert AJ, Pamplona R, Buffenstein R, and Buttemer WA. Life and death: Metabolic rate, membrane composition, and life span of animals. Physiol Rev 87: 1175-1213, 2007
    • (2007) Physiol Rev , vol.87 , pp. 1175-1213
    • Hulbert, A.J.1    Pamplona, R.2    Buffenstein, R.3    Buttemer, W.A.4
  • 75
    • 0042886929 scopus 로고    scopus 로고
    • The mitochondrial theory of aging: Dead or alive?
    • Jacobs HT. The mitochondrial theory of aging: Dead or alive? Aging Cell 2: 11-17, 2003
    • (2003) Aging Cell , vol.2 , pp. 11-17
    • Jacobs, H.T.1
  • 78
    • 62349116477 scopus 로고    scopus 로고
    • The mitochondrial theory of aging: Insight from transgenic and knockout mouse models
    • Jang YC and Remmen VH. The mitochondrial theory of aging: Insight from transgenic and knockout mouse models. Exp Gerontol 44: 256-260, 2009
    • (2009) Exp Gerontol , vol.44 , pp. 256-260
    • Jang, Y.C.1    Remmen, V.H.2
  • 79
    • 55149107716 scopus 로고    scopus 로고
    • Radical-free biology of oxidative stress
    • Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol 295: C849-C868, 2008
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Jones, D.P.1
  • 82
    • 33744458966 scopus 로고    scopus 로고
    • Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?
    • Khrapko K, Kraytsberg Y, de Grey AD, Vijg J, and Schon EA. Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? Aging Cell 5: 279-282, 2006
    • (2006) Aging Cell , vol.5 , pp. 279-282
    • Khrapko, K.1    Kraytsberg, Y.2    De Grey, A.D.3    Vijg, J.4    Schon, E.A.5
  • 83
    • 59349086549 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and aging: Devils in the details?
    • Khrapko K and Vijg J. Mitochondrial DNA mutations and aging: Devils in the details? Trends Genet 25: 91-98, 2009
    • (2009) Trends Genet , vol.25 , pp. 91-98
    • Khrapko, K.1    Vijg, J.2
  • 84
    • 83455200232 scopus 로고    scopus 로고
    • Caloric restriction and redox state: Does this diet increase or decrease oxidant production?
    • Kowaltowski AJ. Caloric restriction and redox state: Does this diet increase or decrease oxidant production? Redox Rep 16: 237-241, 2011
    • (2011) Redox Rep , vol.16 , pp. 237-241
    • Kowaltowski, A.J.1
  • 86
    • 0027517591 scopus 로고
    • Comparison of mitochondrial prooxidant generation and anti-oxidant defenses between rat and pigeon: Possible basis of variation in longevity and metabolic potential
    • Ku HH and Sohal RS. Comparison of mitochondrial prooxidant generation and anti-oxidant defenses between rat and pigeon: Possible basis of variation in longevity and metabolic potential. Mech Ageing Dev 72: 67-76, 1993
    • (1993) Mech Ageing Dev , vol.72 , pp. 67-76
    • Ku, H.H.1    Sohal, R.S.2
  • 87
    • 84858007124 scopus 로고    scopus 로고
    • The failure to extend lifespan via disruption of complex II is linked to preservation of dynamic control of energy metabolism
    • Kuang J and Ebert PR. The failure to extend lifespan via disruption of complex II is linked to preservation of dynamic control of energy metabolism. Mitochondrion 12: 280-287, 2012
    • (2012) Mitochondrion , vol.12 , pp. 280-287
    • Kuang, J.1    Ebert, P.R.2
  • 90
    • 66149135335 scopus 로고    scopus 로고
    • Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1 + / -mice
    • Lapointe J, Stepanyan Z, Bigras E, and Hekimi S. Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1 + / -mice. J Biol Chem 284: 20364-20374, 2009
    • (2009) J Biol Chem , vol.284 , pp. 20364-20374
    • Lapointe, J.1    Stepanyan, Z.2    Bigras, E.3    Hekimi, S.4
  • 91
    • 0032402945 scopus 로고    scopus 로고
    • Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria
    • Lass A, Sohal BH, Weindruch R, Forster MJ, and Sohal RS. Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med 25: 1089-1097, 1998
    • (1998) Free Radic Biol Med , vol.25 , pp. 1089-1097
    • Lass, A.1    Sohal, B.H.2    Weindruch, R.3    Forster, M.J.4    Sohal, R.S.5
  • 92
    • 79955598457 scopus 로고    scopus 로고
    • Mitochondrial H2O2 generated from electron transport chain complex i stimulates muscle differentiation
    • Lee S, Tak E, Lee J, Rashid MA, Murphy MP, Ha J, and Kim SS. Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation. Cell Res 21: 817-834, 2011
    • (2011) Cell Res , vol.21 , pp. 817-834
    • Lee, S.1    Tak, E.2    Lee, J.3    Rashid, M.A.4    Murphy, M.P.5    Ha, J.6    Kim, S.S.7
  • 93
    • 0347128279 scopus 로고    scopus 로고
    • Calorie restriction extends yeast life span by lowering the level of NADH
    • Lin SJ, Ford E, Haigis M, Liszt G, and Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18: 12-16, 2004
    • (2004) Genes Dev , vol.18 , pp. 12-16
    • Lin, S.J.1    Ford, E.2    Haigis, M.3    Liszt, G.4    Guarente, L.5
  • 95
    • 0027234767 scopus 로고
    • Maximum life span in vertebrates: Relationship with liver antioxidant enzymes, glutathione system, ascorbate, urate, sensitivity to peroxidation, true malondialdehyde, in vivo H2O2, and basal and maximum aerobic capacity
    • Lopez-Torres M, Perez-Campo R, Rojas C, Cadenas S, and Barja G. Maximum life span in vertebrates: Relationship with liver antioxidant enzymes, glutathione system, ascorbate, urate, sensitivity to peroxidation, true malondialdehyde, in vivo H2O2, and basal and maximum aerobic capacity. Mech Ageing Dev 70: 177-199, 1993
    • (1993) Mech Ageing Dev , vol.70 , pp. 177-199
    • Lopez-Torres, M.1    Perez-Campo, R.2    Rojas, C.3    Cadenas, S.4    Barja, G.5
  • 97
    • 77953082947 scopus 로고    scopus 로고
    • Molecular gene therapy: Overexpression of the alternative NADH dehydrogenase NDI1 restores overall physiology in a fungal model of respiratory complex i deficiency
    • Maas MF, Sellem CH, Krause F, Dencher NA, and Sainsard-Chanet A. Molecular gene therapy: Overexpression of the alternative NADH dehydrogenase NDI1 restores overall physiology in a fungal model of respiratory complex I deficiency. J Mol Biol 399: 31-40, 2010
    • (2010) J Mol Biol , vol.399 , pp. 31-40
    • Maas, M.F.1    Sellem, C.H.2    Krause, F.3    Dencher, N.A.4    Sainsard-Chanet, A.5
  • 98
    • 33344479169 scopus 로고    scopus 로고
    • The effects of exogenous antioxidants on lifespan and oxidative stress resistance in drosophila melanogaster
    • Magwere T, West M, Riyahi K, Murphy MP, Smith RA, and Partridge L. The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev 127: 356-370, 2006
    • (2006) Mech Ageing Dev , vol.127 , pp. 356-370
    • Magwere, T.1    West, M.2    Riyahi, K.3    Murphy, M.P.4    Smith, R.A.5    Partridge, L.6
  • 99
    • 50649099122 scopus 로고    scopus 로고
    • Aging and survival: The genetics of life span extension by dietary restriction
    • Mair W and Dillin A. Aging and survival: The genetics of life span extension by dietary restriction. Annu Rev Biochem 77: 727-754, 2008
    • (2008) Annu Rev Biochem , vol.77 , pp. 727-754
    • Mair, W.1    Dillin, A.2
  • 100
    • 80053439148 scopus 로고    scopus 로고
    • No immune responses by the expression of the yeast Ndi1 protein in rats
    • Marella M, Seo BB, Flotte TR, Matsuno-Yagi A, and Yagi T. No immune responses by the expression of the yeast Ndi1 protein in rats. PLoS One 6: E25910, 2011
    • (2011) PLoS One , vol.6
    • Marella, M.1    Seo, B.B.2    Flotte, T.R.3    Matsuno-Yagi, A.4    Yagi, T.5
  • 102
    • 0033032444 scopus 로고    scopus 로고
    • Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation
    • Matsura T, Kai M, Fujii Y, Ito H, and Yamada K. Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation. Free Radic Res 30: 73-83, 1999
    • (1999) Free Radic Res , vol.30 , pp. 73-83
    • Matsura, T.1    Kai, M.2    Fujii, Y.3    Ito, H.4    Yamada, K.5
  • 105
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, and Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286: 774-779, 1999
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 106
    • 85027944706 scopus 로고    scopus 로고
    • An isolated case of lissencephaly caused by the insertion of a mitochondrial genome-derived DNA sequence into the 5¢ untranslated region of the PAFAH1B1 (LIS1) gene
    • Millar DS, Tysoe C, Lazarou LP, Pilz DT, Mohammed S, Anderson K, Chuzhanova N, Cooper DN, and Butler R. An isolated case of lissencephaly caused by the insertion of a mitochondrial genome-derived DNA sequence into the 5¢ untranslated region of the PAFAH1B1 (LIS1) gene. Hum Genomics 4: 384-393, 2010
    • (2010) Hum Genomics , vol.4 , pp. 384-393
    • Millar, D.S.1    Tysoe, C.2    Lazarou, L.P.3    Pilz, D.T.4    Mohammed, S.5    Anderson, K.6    Chuzhanova, N.7    Cooper, D.N.8    Butler, R.9
  • 107
    • 35448999303 scopus 로고    scopus 로고
    • Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (heterocephalus glaber): A comparative study using shotgun lipidomics
    • Mitchell TW, Buffenstein R, and Hulbert AJ. Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): A comparative study using shotgun lipidomics. Exp Gerontol 42: 1053-1062, 2007
    • (2007) Exp Gerontol , vol.42 , pp. 1053-1062
    • Mitchell, T.W.1    Buffenstein, R.2    Hulbert, A.J.3
  • 108
    • 3242737464 scopus 로고    scopus 로고
    • Lack of correlation between mitochondrial reactive oxygen species production and life span in drosophila
    • Miwa S, Riyahi K, Partridge L, and Brand MD. Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann N Y Acad Sci 1019: 388-391, 2004
    • (2004) Ann N y Acad Sci , vol.1019 , pp. 388-391
    • Miwa, S.1    Riyahi, K.2    Partridge, L.3    Brand, M.D.4
  • 109
    • 80052337273 scopus 로고    scopus 로고
    • The long life of birds: The rat-pigeon comparison revisited
    • Montgomery MK, Hulbert AJ, and Buttemer WA. The long life of birds: The rat-pigeon comparison revisited. PLoS One 6: E24138, 2011
    • (2011) PLoS One , vol.6
    • Montgomery, M.K.1    Hulbert, A.J.2    Buttemer, W.A.3
  • 110
    • 84857056197 scopus 로고    scopus 로고
    • Does the oxidative stress theory of aging explain longevity differences in birds? I mitochondrial ros production
    • Montgomery MK, Hulbert AJ, and Buttemer WA. Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production. Exp Gerontol 47: 203-210, 2012
    • (2012) Exp Gerontol , vol.47 , pp. 203-210
    • Montgomery, M.K.1    Hulbert, A.J.2    Buttemer, W.A.3
  • 111
    • 0017253145 scopus 로고
    • Characterization of fatty acid desaturase activity in rat lung microsomes
    • Montgomery MR. Characterization of fatty acid desaturase activity in rat lung microsomes. J Lipid Res 17: 12-15, 1976
    • (1976) J Lipid Res , vol.17 , pp. 12-15
    • Montgomery, M.R.1
  • 112
    • 38349126762 scopus 로고    scopus 로고
    • Mitochondrially encoded cysteine predicts animal lifespan
    • Moosmann B and Behl C. Mitochondrially encoded cysteine predicts animal lifespan. Aging Cell 7: 32-46, 2008
    • (2008) Aging Cell , vol.7 , pp. 32-46
    • Moosmann, B.1    Behl, C.2
  • 113
    • 10344221083 scopus 로고    scopus 로고
    • Complex III releases superoxide to both sides of the inner mitochondrial membrane
    • Muller FL, Liu Y, and Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 279: 49064-49073, 2004
    • (2004) J Biol Chem , vol.279 , pp. 49064-49073
    • Muller, F.L.1    Liu, Y.2    Van Remmen, H.3
  • 115
    • 0027476395 scopus 로고
    • The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages
    • Munscher C, Rieger T, Muller-Hocker J, and Kadenbach B. The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 317: 27-30, 1993
    • (1993) FEBS Lett , vol.317 , pp. 27-30
    • Munscher, C.1    Rieger, T.2    Muller-Hocker, J.3    Kadenbach, B.4
  • 116
    • 0030601888 scopus 로고    scopus 로고
    • Effects of calorie restriction and aging on the expression of antioxidant enzymes and ubiquitin in the liver of emory mice
    • Mura CV, Gong X, Taylor A, Villalobos-Molina R, and Scrofano MM. Effects of calorie restriction and aging on the expression of antioxidant enzymes and ubiquitin in the liver of Emory mice. Mech Ageing Dev 91: 115-129, 1996
    • (1996) Mech Ageing Dev , vol.91 , pp. 115-129
    • Mura, C.V.1    Gong, X.2    Taylor, A.3    Villalobos-Molina, R.4    Scrofano, M.M.5
  • 117
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 417: 1-13, 2009
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 121
    • 47249135572 scopus 로고    scopus 로고
    • Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis
    • Nie C, Tian C, Zhao L, Petit PX, Mehrpour M, and Chen Q. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. J Biol Chem 283: 15359-15369, 2008
    • (2008) J Biol Chem , vol.283 , pp. 15359-15369
    • Nie, C.1    Tian, C.2    Zhao, L.3    Petit, P.X.4    Mehrpour, M.5    Chen, Q.6
  • 122
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: In sickness and in health
    • Nunnari J and Suomalainen A. Mitochondria: In sickness and in health. Cell 148: 1145-1159, 2012
    • (2012) Cell , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 124
    • 84867582808 scopus 로고    scopus 로고
    • Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan
    • Page MM and Stuart JA. Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan. Age (Dordr) 34: 1195-1209, 2012
    • (2012) Age (Dordr , vol.34 , pp. 1195-1209
    • Page, M.M.1    Stuart, J.A.2
  • 125
    • 79958051212 scopus 로고    scopus 로고
    • Advanced lipoxidation end-products
    • Pamplona R. Advanced lipoxidation end-products. Chem Biol Interact 192: 14-20, 2011
    • (2011) Chem Biol Interact , vol.192 , pp. 14-20
    • Pamplona, R.1
  • 126
    • 34548655310 scopus 로고    scopus 로고
    • Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity
    • Pamplona R and Barja G. Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity. Ageing Res Rev 6: 189-210, 2007
    • (2007) Ageing Res Rev , vol.6 , pp. 189-210
    • Pamplona, R.1    Barja, G.2
  • 127
    • 83255191671 scopus 로고    scopus 로고
    • An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms
    • Pamplona R and Barja G. An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms. Biogerontology 12: 409-435, 2011
    • (2011) Biogerontology , vol.12 , pp. 409-435
    • Pamplona, R.1    Barja, G.2
  • 128
    • 0036236733 scopus 로고    scopus 로고
    • Membrane fatty acid unsaturation protection against oxidative stress, and maximum life span: A homeoviscous-longevity adaptation?
    • Pamplona R, Barja G, and Portero-Otin M. Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: A homeoviscous-longevity adaptation? Ann N Y Acad Sci 959: 475-490, 2002
    • (2002) Ann N y Acad Sci , vol.959 , pp. 475-490
    • Pamplona, R.1    Barja, G.2    Portero-Otin, M.3
  • 129
    • 0036013946 scopus 로고    scopus 로고
    • Aging increases nepsilon-(carboxymethyl)lysine and caloric restriction decreases nepsilon-(carboxyethyl)lysine and nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins
    • Pamplona R, Portero-Otin M, Bellmun MJ, Gredilla R, and Barja G. Aging increases nepsilon-(carboxymethyl)lysine and caloric restriction decreases nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins. Free Radic Res 36: 47-54, 2002
    • (2002) Free Radic Res , vol.36 , pp. 47-54
    • Pamplona, R.1    Portero-Otin, M.2    Bellmun, M.J.3    Gredilla, R.4    Barja, G.5
  • 130
    • 0036756755 scopus 로고    scopus 로고
    • Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls
    • Pamplona R, Portero-Otin M, Requena J, Gredilla R, and Barja G. Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls. Mech Ageing Dev 123: 1437-1446, 2002
    • (2002) Mech Ageing Dev , vol.123 , pp. 1437-1446
    • Pamplona, R.1    Portero-Otin, M.2    Requena, J.3    Gredilla, R.4    Barja, G.5
  • 131
    • 0033555921 scopus 로고    scopus 로고
    • A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat
    • Pamplona R, Portero-Otin M, Requena JR, Thorpe SR, Herrero A, and Barja G. A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat. Mech Ageing Dev 106: 283-296, 1999
    • (1999) Mech Ageing Dev , vol.106 , pp. 283-296
    • Pamplona, R.1    Portero-Otin, M.2    Requena, J.R.3    Thorpe, S.R.4    Herrero, A.5    Barja, G.6
  • 132
    • 0032937547 scopus 로고    scopus 로고
    • Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse
    • Pamplona R, Portero-Otin M, Riba D, Ledo F, Gredilla R, Herrero A, and Barja G. Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. Aging (Milano) 11: 44-49, 1999
    • (1999) Aging (Milano , vol.11 , pp. 44-49
    • Pamplona, R.1    Portero-Otin, M.2    Riba, D.3    Ledo, F.4    Gredilla, R.5    Herrero, A.6    Barja, G.7
  • 134
    • 0031686714 scopus 로고    scopus 로고
    • Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals
    • Pamplona R, Portero-Otin M, Riba D, Ruiz C, Prat J, Bellmunt MJ, and Barja G. Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. J Lipid Res 39: 1989-1994, 1998
    • (1998) J Lipid Res , vol.39 , pp. 1989-1994
    • Pamplona, R.1    Portero-Otin, M.2    Riba, D.3    Ruiz, C.4    Prat, J.5    Bellmunt, M.J.6    Barja, G.7
  • 135
    • 0030019678 scopus 로고    scopus 로고
    • Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: The pigeon and human case
    • Pamplona R, Prat J, Cadenas S, Rojas C, Perez-Campo R, Lopez Torres M, and Barja G. Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: The pigeon and human case. Mech Ageing Dev 86: 53-66, 1996
    • (1996) Mech Ageing Dev , vol.86 , pp. 53-66
    • Pamplona, R.1    Prat, J.2    Cadenas, S.3    Rojas, C.4    Perez-Campo, R.5    Lopez Torres, M.6    Barja, G.7
  • 138
    • 78649521247 scopus 로고    scopus 로고
    • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
    • Qiu X, Brown K, Hirschey MD, Verdin E, and Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 12: 662-667, 2010
    • (2010) Cell Metab , vol.12 , pp. 662-667
    • Qiu, X.1    Brown, K.2    Hirschey, M.D.3    Verdin, E.4    Chen, D.5
  • 139
    • 0038814116 scopus 로고    scopus 로고
    • Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon
    • Radak Z, Takahashi R, Kumiyama A, Nakamoto H, Ohno H, Ookawara T, and Goto S. Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Exp Gerontol 37: 1423-1430, 2002
    • (2002) Exp Gerontol , vol.37 , pp. 1423-1430
    • Radak, Z.1    Takahashi, R.2    Kumiyama, A.3    Nakamoto, H.4    Ohno, H.5    Ookawara, T.6    Goto, S.7
  • 140
    • 84856395570 scopus 로고    scopus 로고
    • Dietary restriction lowers endogenous levels of oxidative stress in different brain regions of adult mice
    • Suppl: OL
    • Rathod P, Hemnani T, and Parihar MS. Dietary restriction lowers endogenous levels of oxidative stress in different brain regions of adult mice. Cell Mol Biol (Noisy-le-grand) 57 Suppl: OL1575-1580, 2011
    • (2011) Cell Mol Biol (Noisy-le-grand , vol.57 , pp. 1575-1580
    • Rathod, P.1    Hemnani, T.2    Parihar, M.S.3
  • 141
    • 0034681114 scopus 로고    scopus 로고
    • Modifications of proteins by polyunsaturated fatty acid peroxidation products
    • Refsgaard HH, Tsai L, and Stadtman ER. Modifications of proteins by polyunsaturated fatty acid peroxidation products. Proc Natl Acad Sci U S A 97: 611-616, 2000
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 611-616
    • Refsgaard, H.H.1    Tsai, L.2    Stadtman, E.R.3
  • 142
    • 0024266283 scopus 로고
    • Do mitochondrial DNA fragments promote cancer and aging?
    • Richter C. Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett 241: 1-5, 1988
    • (1988) FEBS Lett , vol.241 , pp. 1-15
    • Richter, C.1
  • 143
    • 79959350253 scopus 로고    scopus 로고
    • Extending life span by increasing oxidative stress
    • Ristow Mand Schmeisser S. Extending life span by increasing oxidative stress. Free Radic Biol Med 51: 327-336, 2011
    • (2011) Free Radic Biol Med , vol.51 , pp. 327-336
    • Ristow Mand Schmeisser, S.1
  • 145
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • Rogina B and Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 101: 15998-16003, 2004
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 148
    • 24344474190 scopus 로고    scopus 로고
    • Protein methionine content and MD alysine adducts are inversely related to maximum life span in the heart of mammals
    • Ruiz MC, Ayala V, Portero-Otin M, Requena JR, Barja G, and Pamplona R. Protein methionine content and MDAlysine adducts are inversely related to maximum life span in the heart of mammals. Mech Ageing Dev 126: 1106-1114, 2005
    • (2005) Mech Ageing Dev , vol.126 , pp. 1106-1114
    • Ruiz, M.C.1    Ayala, V.2    Portero-Otin, M.3    Requena, J.R.4    Barja, G.5    Pamplona, R.6
  • 149
    • 70450253363 scopus 로고    scopus 로고
    • Respiratory chain alternative enzymes as tools to better understand and counteract respiratory chain deficiencies in human cells and animals
    • Rustin P and Jacobs HT. Respiratory chain alternative enzymes as tools to better understand and counteract respiratory chain deficiencies in human cells and animals. Physiol Plant 137: 362-370, 2009
    • (2009) Physiol Plant , vol.137 , pp. 362-370
    • Rustin, P.1    Jacobs, H.T.2
  • 150
    • 37849010499 scopus 로고    scopus 로고
    • Production, detection, and adaptive responses to free radicals in exercise
    • Sachdev S and Davies KJ. Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med 44: 215-223, 2008
    • (2008) Free Radic Biol Med , vol.44 , pp. 215-223
    • Sachdev, S.1    Davies, K.J.2
  • 151
    • 79952537765 scopus 로고    scopus 로고
    • Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species
    • Salway KD, Page MM, Faure PA, Burness G, and Stuart JA. Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species. Age (Dordr) 33: 33-47, 2011
    • (2011) Age (Dordr , vol.33 , pp. 33-47
    • Salway, K.D.1    Page, M.M.2    Faure, P.A.3    Burness, G.4    Stuart, J.A.5
  • 152
    • 77953163811 scopus 로고    scopus 로고
    • Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila
    • Sanz A, Fernandez-Ayala DJ, Stefanatos RK, and Jacobs HT. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY) 2: 200-223, 2010
    • (2010) Aging (Albany NY , vol.2 , pp. 200-223
    • Sanz, A.1    Fernandez-Ayala, D.J.2    Stefanatos, R.K.3    Jacobs, H.T.4
  • 153
    • 33646704229 scopus 로고    scopus 로고
    • Is the mitochondrial free radical theory of aging intact?
    • Sanz A, Pamplona R, and Barja G. Is the mitochondrial free radical theory of aging intact? Antioxid Redox Signal 8: 582-599, 2006
    • (2006) Antioxid Redox Signal , vol.8 , pp. 582-599
    • Sanz, A.1    Pamplona, R.2    Barja, G.3
  • 155
    • 77449156533 scopus 로고    scopus 로고
    • The mitochondrial free radical theory of aging: A critical view
    • Sanz A and Stefanatos RK. The mitochondrial free radical theory of aging: A critical view. Curr Aging Sci 1: 10-21, 2008
    • (2008) Curr Aging Sci , vol.1 , pp. 10-21
    • Sanz, A.1    Stefanatos, R.K.2
  • 156
    • 77954675571 scopus 로고    scopus 로고
    • Age-related increase of reactive oxygen generation in the brains of mammals and birds: Is reactive oxygen a signaling molecule to determine the aging process and life span?
    • Sasaki T, Unno K, Tahara S, and Kaneko T. Age-related increase of reactive oxygen generation in the brains of mammals and birds: Is reactive oxygen a signaling molecule to determine the aging process and life span? Geriatr Gerontol Int 10 Suppl 1: S10-S24, 2010
    • (2010) Geriatr Gerontol Int 10 Suppl , vol.1
    • Sasaki, T.1    Unno, K.2    Tahara, S.3    Kaneko, T.4
  • 158
    • 34748850786 scopus 로고    scopus 로고
    • Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    • Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, and Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 6: 280-293, 2007
    • (2007) Cell Metab , vol.6 , pp. 280-293
    • Schulz, T.J.1    Zarse, K.2    Voigt, A.3    Urban, N.4    Birringer, M.5    Ristow, M.6
  • 160
    • 0024415301 scopus 로고
    • Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction
    • Semsei I, Rao G, and Richardson A. Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction. Biochem Biophys Res Commun 164: 620-625, 1989
    • (1989) Biochem Biophys Res Commun , vol.164 , pp. 620-625
    • Semsei, I.1    Rao, G.2    Richardson, A.3
  • 162
    • 84856597613 scopus 로고    scopus 로고
    • Effect of PARP-1 overexpression and pharmacological inhibition of NF-kB on the lifespan of Drosophila melanogaster
    • Shaposhnikov MV, Moskalev AA, and Plyusnina EN. Effect of PARP-1 overexpression and pharmacological inhibition of NF-kB on the lifespan of Drosophila melanogaster. Adv Gerontol 24: 405-419, 2011
    • (2011) Adv Gerontol , vol.24 , pp. 405-419
    • Shaposhnikov, M.V.1    Moskalev, A.A.2    Plyusnina, E.N.3
  • 165
    • 0025665173 scopus 로고
    • Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/ NADP+ and NADH/NAD+ in drosophila melanogaster
    • Sohal RS, Arnold L, and Orr WC. Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/ NADP+ and NADH/NAD+ in Drosophila melanogaster. Mech Ageing Dev 56: 223-235, 1990
    • (1990) Mech Ageing Dev , vol.56 , pp. 223-235
    • Sohal, R.S.1    Arnold, L.2    Orr, W.C.3
  • 166
    • 0028342438 scopus 로고
    • Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
    • Sohal RS, Ku HH, Agarwal S, Forster MJ, and Lal H. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mech Ageing Dev 74: 121-133, 1994
    • (1994) Mech Ageing Dev , vol.74 , pp. 121-133
    • Sohal, R.S.1    Ku, H.H.2    Agarwal, S.3    Forster, M.J.4    Lal, H.5
  • 167
    • 84856293321 scopus 로고    scopus 로고
    • The redox stress hypothesis of aging
    • Sohal RS and Orr WC. The redox stress hypothesis of aging. Free Radic Biol Med 52: 539-555, 2012
    • (2012) Free Radic Biol Med , vol.52 , pp. 539-555
    • Sohal, R.S.1    Orr, W.C.2
  • 168
    • 0029147191 scopus 로고
    • Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies
    • Sohal RS, Sohal BH, and Orr WC. Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies. Free Radic Biol Med 19: 499-504, 1995
    • (1995) Free Radic Biol Med , vol.19 , pp. 499-504
    • Sohal, R.S.1    Sohal, B.H.2    Orr, W.C.3
  • 169
    • 0025363588 scopus 로고
    • Hydrogen peroxide production by liver mitochondria in different species
    • Sohal RS, Svensson I, and Brunk UT. Hydrogen peroxide production by liver mitochondria in different species. Mech Ageing Dev 53: 209-215, 1990
    • (1990) Mech Ageing Dev , vol.53 , pp. 209-215
    • Sohal, R.S.1    Svensson, I.2    Brunk, U.T.3
  • 170
    • 0024323120 scopus 로고
    • Superoxide anion radical production in different animal species
    • Sohal RS, Svensson I, Sohal BH, and Brunk UT. Superoxide anion radical production in different animal species. Mech Ageing Dev 49: 129-135, 1989
    • (1989) Mech Ageing Dev , vol.49 , pp. 129-135
    • Sohal, R.S.1    Svensson, I.2    Sohal, B.H.3    Brunk, U.T.4
  • 171
    • 79956032310 scopus 로고    scopus 로고
    • Mitochondrial complex I: A central regulator of the aging process
    • Stefanatos R and Sanz A. Mitochondrial complex I: A central regulator of the aging process. Cell Cycle 10: 1528-1532, 2011
    • (2011) Cell Cycle , vol.10 , pp. 1528-1532
    • Stefanatos, R.1    Sanz, A.2
  • 172
    • 13844266312 scopus 로고    scopus 로고
    • No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA
    • Stuart JA, Bourque BM, de Souza-Pinto NC, and Bohr VA. No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. Free Radic Biol Med 38: 737-745, 2005
    • (2005) Free Radic Biol Med , vol.38 , pp. 737-745
    • Stuart, J.A.1    Bourque, B.M.2    De Souza-Pinto, N.C.3    Bohr, V.A.4
  • 173
    • 33749330178 scopus 로고    scopus 로고
    • A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein
    • Tabner BJ, Turnbull S, King JE, Benson FE, El-Agnaf OM, and Allsop D. A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein. Free Radic Res 40: 731-739, 2006
    • (2006) Free Radic Res , vol.40 , pp. 731-739
    • Tabner, B.J.1    Turnbull, S.2    King, J.E.3    Benson, F.E.4    El-Agnaf, O.M.5    Allsop, D.6
  • 175
    • 75349112375 scopus 로고    scopus 로고
    • Mitochondrial turnover and aging of long-lived postmitotic cells: The mitochondrial-lysosomal axis theory of aging
    • Terman A, Kurz T, Navratil M, Arriaga EA, and Brunk UT. Mitochondrial turnover and aging of long-lived postmitotic cells: The mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal 12: 503-535, 2010
    • (2010) Antioxid Redox Signal , vol.12 , pp. 503-535
    • Terman, A.1    Kurz, T.2    Navratil, M.3    Arriaga, E.A.4    Brunk, U.T.5
  • 176
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA and Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230, 2001
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 177
    • 34748907199 scopus 로고    scopus 로고
    • Carbonylation of mitochondrial proteins in drosophila melanogaster during aging
    • Toroser D, Orr WC, and Sohal RS. Carbonylation of mitochondrial proteins in Drosophila melanogaster during aging. Biochem Biophys Res Commun 363: 418-424, 2007
    • (2007) Biochem Biophys Res Commun , vol.363 , pp. 418-424
    • Toroser, D.1    Orr, W.C.2    Sohal, R.S.3
  • 179
    • 14644415932 scopus 로고    scopus 로고
    • An allometric comparison of microsomal membrane lipid composition and sodium pump molecular activity in the brain of mammals and birds
    • Turner N, Else PL, and Hulbert AJ. An allometric comparison of microsomal membrane lipid composition and sodium pump molecular activity in the brain of mammals and birds. J Exp Biol 208: 371-381, 2005
    • (2005) J Exp Biol , vol.208 , pp. 371-381
    • Turner, N.1    Else, P.L.2    Hulbert, A.J.3
  • 180
    • 33744915039 scopus 로고    scopus 로고
    • Scaling of Na+ K + -ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts
    • Turner N, Haga KL, Else PL, and Hulbert AJ. Scaling of Na+, K + -ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. Physiol Biochem Zool 79: 522-533, 2006
    • (2006) Physiol Biochem Zool , vol.79 , pp. 522-533
    • Turner, N.1    Haga, K.L.2    Else, P.L.3    Hulbert, A.J.4
  • 182
    • 84859575436 scopus 로고    scopus 로고
    • Superoxide dismutase is dispensable for normal animal lifespan
    • Van Raamsdonk JM and Hekimi S. Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci U S A 109: 5785-5790, 2012
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 5785-5790
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 184
    • 67549136242 scopus 로고    scopus 로고
    • Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect
    • Veatch JR, McMurray MA, Nelson ZW, and Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137: 1247-1258, 2009
    • (2009) Cell , vol.137 , pp. 1247-1258
    • Veatch, J.R.1    McMurray, M.A.2    Nelson, Z.W.3    Gottschling, D.E.4
  • 186
    • 45449108592 scopus 로고    scopus 로고
    • The role of DNA damage and repair in aging: New approaches to an old problem
    • Vijg J. The role of DNA damage and repair in aging: New approaches to an old problem. Mech Ageing Dev 129: 498-502, 2008
    • (2008) Mech Ageing Dev , vol.129 , pp. 498-502
    • Vijg, J.1
  • 188
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Annu Rev Genet 39: 359-407, 2005
    • (2005) Annu Rev Genet , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 189
    • 0030747292 scopus 로고    scopus 로고
    • The rate of mitochondrial mutagenesis is faster in mice than humans
    • Wang E, Wong A, and Cortopassi G. The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat Res 377: 157-166, 1997
    • (1997) Mutat Res , vol.377 , pp. 157-166
    • Wang, E.1    Wong, A.2    Cortopassi, G.3
  • 190
    • 0022517746 scopus 로고
    • The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
    • Weindruch R, Walford RL, Fligiel S, and Guthrie D. The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake. J Nutr 116: 641-654, 1986
    • (1986) J Nutr , vol.116 , pp. 641-654
    • Weindruch, R.1    Walford, R.L.2    Fligiel, S.3    Guthrie, D.4
  • 191
    • 0028817243 scopus 로고
    • Activities of antioxidant enzymes in various tissues of male fischer 344 rats are altered by food restriction
    • Xia E, Rao G, Van Remmen H, Heydari AR, and Richardson A. Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction. J Nutr 125: 195-201, 1995
    • (1995) J Nutr , vol.125 , pp. 195-201
    • Xia, E.1    Rao, G.2    Van Remmen, H.3    Heydari, A.R.4    Richardson, A.5
  • 192
    • 78650455712 scopus 로고    scopus 로고
    • A mitochondrial superoxide signal triggers increased longevity in caenorhabditis elegans
    • Yang W and Hekimi S. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol 8: E1000556, 2010
    • (2010) PLoS Biol , vol.8
    • Yang, W.1    Hekimi, S.2
  • 193
    • 28244454785 scopus 로고    scopus 로고
    • Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice
    • Yarian CS, Toroser D, and Sohal RS. Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice. Mech Ageing Dev 127: 79-84, 2006
    • (2006) Mech Ageing Dev , vol.127 , pp. 79-84
    • Yarian, C.S.1    Toroser, D.2    Sohal, R.S.3
  • 197
    • 26944475237 scopus 로고    scopus 로고
    • Calorie restriction delays lipid oxidative damage in Drosophila melanogaster
    • Zheng J, Mutcherson R, 2nd, and Helfand SL. Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. Aging Cell 4: 209-216, 2005
    • (2005) Aging Cell , vol.4 , pp. 209-216
    • Zheng, J.1    Mutcherson II, R.2    Helfand, S.L.3
  • 198
    • 33745891786 scopus 로고    scopus 로고
    • Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors
    • Zheng W, Khrapko K, Coller HA, Thilly WG, and Copeland WC. Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors. Mutat Res 599: 11-20, 2006
    • (2006) Mutat Res , vol.599 , pp. 11-20
    • Zheng, W.1    Khrapko, K.2    Coller, H.A.3    Thilly, W.G.4    Copeland, W.C.5
  • 200
    • 64149106822 scopus 로고    scopus 로고
    • Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1
    • Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Cang H, and Yi J. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1. Cell Res 19: 449-457, 2009
    • (2009) Cell Res , vol.19 , pp. 449-457
    • Zuo, Y.1    Xiang, B.2    Yang, J.3    Sun, X.4    Wang, Y.5    Cang, H.6    Yi, J.7


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