Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging

Free Radical Biology and Medicine

Volumn 52, Issue 9, 2012, Pages 1700-1707

  Gan, Wei ^a,b,c   Nie, Ben ^c,d   Shi, Fei ^a,c   Xu, Xin Min ^a,b,c   Qian, Jian Chang ^c,d   Takagi, Yasumitsu ^e   Hayakawa, Hiroshi ^e   Sekiguchi, Mutsuo ^e   Cai, Jian Ping ^c  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b National Center for Clinical Laboratory   (China)

^c BEIJING HOSPITAL   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

^e FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

8 Oxoguanosine; Free radicals; Mass spectrometry; Oxidative damage; Senescence accelerated mouse

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; DNA; RNA;

AGING; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BRAIN; CONTROLLED STUDY; DNA DAMAGE; HEART; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; LUNG; MALE; METABOLISM; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; SENESCENCE ACCELERATED MOUSE; TESTIS; URINALYSIS; URINE; URINE LEVEL;

AGING; ANIMALS; BIOLOGICAL MARKERS; BRAIN; CHROMATOGRAPHY, LIQUID; DNA; DNA DAMAGE; GUANOSINE; KIDNEY; LIVER; LUNG; MALE; MICE; MYOCARDIUM; OXIDATIVE STRESS; RNA; TANDEM MASS SPECTROMETRY; TESTIS;

MUS;

EID: 84858964912     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.02.016     Document Type: Article

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