Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice

Mechanisms of Ageing and Development

Volumn 127, Issue 1, 2006, Pages 79-84

  Yarian, Connie S ^a   Toroser, Dikran ^a   Sohal, Rajindar S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aconitase; Aging; Citric acid cycle

Indexed keywords

ACONITATE HYDRATASE; CITRATE SYNTHASE; CITRIC ACID; FATTY ACID; FUMARATE HYDRATASE; G PROTEIN COUPLED RECEPTOR; ISOCITRATE DEHYDROGENASE (NADP); LIGAND; MALATE DEHYDROGENASE; OXOGLUTARATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; SUCCINYL COENZYME A SYNTHETASE;

AGE DISTRIBUTION; AGING; ANIMAL TISSUE; ARTICLE; BIOENERGY; CITRIC ACID CYCLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; KIDNEY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TARGETING; STATISTICAL SIGNIFICANCE;

ACONITATE HYDRATASE; AGING; ANIMALS; CITRIC ACID CYCLE; KIDNEY; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NUCLEOTIDES; OXIDATION-REDUCTION; PYRIDINES;

ANIMALIA;

EID: 28244454785     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2005.09.028     Document Type: Article

References (36)

1. B.A. Ackrell, E.B. Kearney, and T.P. Singer Mammalian succinate dehydrogenase Methods Enzymol. 53 1978 466 483
2. X. Brazzolotto, J. Gaillard, K. Pantopoulos, M.W. Hentze, and J.M. Moulis Human cytoplasmic aconitase (iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding J. Biol. Chem. 274 1999 21625 21630
3. A.L. Bulteau, M. Ikeda-Saito, and L.I. Szweda Redox-dependent modulation of aconitase activity in intact mitochondria Biochemistry 42 2003 14846 14855
4. A.L. Bulteau, H.A. O'Neill, M.C. Kennedy, M. Ikeda-Saito, G. Isaya, and L.I. Szweda Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity Science 305 2004 242 245
5. S. Cha, and R.E. Parks Jr. Succinic thiokinase. I. Purification of the enzyme from pig heart J. Biol. Chem. 239 1964 1961 1967
6. N. Das, R.L. Levine, W.C. Orr, and R.S. Sohal Selectivity of protein oxidative damage during aging in Drosophila melanogaster Biochem. J. 360 2001 209 216
7. T. Grune, T. Reinheckel, and K.J. Davies Degradation of oxidized proteins in mammalian cells FASEB J. 11 1997 526 534
8. T.M. Hagen, D.L. Yowe, J.C. Bartholomew, C.M. Wehr, K.L. Do, J.Y. Park, and B.N. Ames Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase Proc. Natl. Acad. Sci. U.S.A. 94 1997 3064 3069
9. D. Harman The aging process Proc. Natl. Acad. Sci. U.S.A. 78 1981 7124 7128
10. W. He, F.J. Miao, D.C. Lin, R.T. Schwandner, Z. Wang, J. Gao, J.L. Chen, H. Tian, and L. Ling Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors Nature 429 2004 188 193
11. S.C. Hebert Physiology: orphan detectors of metabolism Nature 429 2004 143 145
12. C.P. Henson, and W.W. Cleland Purification and kinetic studies of beef liver cytoplasmic aconitase J. Biol. Chem. 242 1967 3833 3838
13. K. Hoang, J.C. Tan, G. Derby, K.L. Blouch, M. Masek, I. Ma, K.V. Lemley, and B.D. Myers Determinants of glomerular hypofiltration in aging humans Kidney Int. 64 2003 1417 1424
14. J. Kanski, A. Behring, J. Pelling, and C. Schoneich Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging Am. J. Physiol. Heart Circ. Physiol. 288 2005 H371 H381
15. N.O. Kaplan The Enzymes, part 3 vol. 3 1960 Academic Press New York pp. 105-169
16. I.S. Kil, J.H. Lee, A.H. Shin, and J.W. Park Glycation-induced inactivation of NADP(+)-dependent isocitrate dehydrogenase: implications for diabetes and aging Free Radic. Biol. Med. 37 2004 1765 1778
17. L.K. Klaidman, A.C. Leung, and J.D. Adams Jr. High-performance liquid chromatography analysis of oxidized and reduced pyridine dinucleotides in specific brain regions Anal. Biochem. 228 1995 312 317
18. L.H. Lash, and J.M. Sall Mitochondrial isolation from liver and kidney: strategy, techniques, and criteria for purity L.H. Lash D.P. Jones Methods in Toxicology: Mitochondrial Dysfunction vol. 2 1993 Academic Press San Diego 8 12
19. A.C. Nulton-Persson, and L.I. Szweda Modulation of mitochondrial function by hydrogen peroxide J. Biol. Chem. 276 2001 23357 23361
20. N.J. Oppenheimer, L.J. Arnold, and N.O. Kaplan A structure of pyridine nucleotides in solution Proc. Natl. Acad. Sci. U.S.A. 68 1971 3200 3205
21. W.C. Orr, and R.S. Sohal Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster Science 263 1994 1128 1130
22. J.W. Park, and B.N. Ames 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detection Proc. Natl. Acad. Sci. U.S.A. 85 1988 7467 7470
23. I. Rebrin, S. Kamzalov, and R.S. Sohal Effects of age and caloric restriction on glutathione redox state in mice Free Radic. Biol. Med. 35 2003 626 635
24. J.B. Robinson Jr., L.G. Brent, B. Sumegi, and P.A. Srere An enzymatic approach to the study of the Krebs tricarboxylic acid cycle V.M. Darley-Usmar D. Rickwood M.T. Wilson Mitochondria: A Practical Approach 1987 IRL Press Washington, DC 153 169
25. F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radic. Biol. Med. 30 2001 1191 1212
26. J.A. Sheldahl, and A.L. Tappel Fluorescent products from aging Drosophila melanogaster: an indicator of free radical lipid peroxidation damage Exp. Gerontol. 9 1974 33 41
27. R.S. Sohal, and R. Weindruch Oxidative stress, caloric restriction, and aging Science 273 1996 59 63
28. E.R. Stadtman Protein oxidation and aging Science 257 1992 1220 1224
29. L. Tian, Q. Cai, and H. Wei Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging Free Radic. Biol. Med. 24 1998 1477 1484
30. J. Vasquez-Vivar, B. Kalyanaraman, and M.C. Kennedy Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation J. Biol. Chem. 275 2000 14064 14069
31. F. Verniquet, J. Gaillard, M. Neuburger, and R. Douce Rapid inactivation of plant aconitase by hydrogen peroxide Biochem. J. 276 1991 643 648
32. L.J. Yan, R.L. Levine, and R.S. Sohal Oxidative damage during aging targets mitochondrial aconitase Proc. Natl. Acad. Sci. U.S.A. 94 1997 11168 11172
33. L.J. Yan, and R.S. Sohal Mitochondrial adenine nucleotide translocase is modified oxidatively during aging Proc. Natl. Acad. Sci. U.S.A. 95 1998 12896 12901
34. L.J. Yan, and R.S. Sohal Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damage to specific mitochondrial proteins Free Radic. Biol. Med. 29 2000 1143 1150
35. C.S. Yarian, I. Rebrin, and R.S. Sohal Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondria Biochem. Biophys. Res. Commun. 330 2005 151 156
36. C.S. Yarian, and R.S. Sohal In the aging housefly aconitase is the only citric acid cycle enzyme to decline significantly J. Bioenerg. Biomembr. 37 2005 91 96