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Volumn 44, Issue 4, 2009, Pages 256-260

The mitochondrial theory of aging: Insight from transgenic and knockout mouse models

Author keywords

Aging; Mitochondria; Mitochondrial theory of aging; Oxidative stress; Transgenic and knockout mouse models

Indexed keywords

CATALASE; THIOREDOXIN; THIOREDOXIN 2;

EID: 62349116477     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2008.12.006     Document Type: Short Survey
Times cited : (145)

References (42)
  • 1
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames B.N., Shigenaga M.K., et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. 90 17 (1993) 7915-7922
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , Issue.17 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2
  • 2
    • 25444469412 scopus 로고    scopus 로고
    • Mitochondrial metabolism of reactive oxygen species
    • Andreyev A.Y., Kushnareva Y.E., et al. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Moscow) 70 2 (2005) 200-214
    • (2005) Biochemistry (Moscow) , vol.70 , Issue.2 , pp. 200-214
    • Andreyev, A.Y.1    Kushnareva, Y.E.2
  • 3
    • 2542446099 scopus 로고    scopus 로고
    • Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism?
    • Barja G. Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism?. Biol. Rev. Camb. Philos. Soc. 79 2 (2004) 235-251
    • (2004) Biol. Rev. Camb. Philos. Soc. , vol.79 , Issue.2 , pp. 235-251
    • Barja, G.1
  • 4
    • 0033972463 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
    • Barja G., and Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J. 14 2 (2000) 312-318
    • (2000) FASEB J. , vol.14 , Issue.2 , pp. 312-318
    • Barja, G.1    Herrero, A.2
  • 5
    • 0031916984 scopus 로고    scopus 로고
    • The free radical theory of aging matures
    • Beckman K.B., and Ames B.N. The free radical theory of aging matures. Physiol. Rev. 78 2 (1998) 547-581
    • (1998) Physiol. Rev. , vol.78 , Issue.2 , pp. 547-581
    • Beckman, K.B.1    Ames, B.N.2
  • 6
    • 46349093995 scopus 로고    scopus 로고
    • Brain mitochondrial dysfunction in aging
    • Boveris A., and Navarro A. Brain mitochondrial dysfunction in aging. IUBMB Life 60 5 (2008) 308-314
    • (2008) IUBMB Life , vol.60 , Issue.5 , pp. 308-314
    • Boveris, A.1    Navarro, A.2
  • 7
    • 0032805796 scopus 로고    scopus 로고
    • Mitochondrial DNA repair pathways
    • Croteau D.L., Stierum R.H., et al. Mitochondrial DNA repair pathways. Mutat. Res. 434 3 (1999) 137-148
    • (1999) Mutat. Res. , vol.434 , Issue.3 , pp. 137-148
    • Croteau, D.L.1    Stierum, R.H.2
  • 8
    • 39949083028 scopus 로고    scopus 로고
    • The role of mitochondria in aging of skeletal muscle
    • Figueiredo P.A., Mota M.P., et al. The role of mitochondria in aging of skeletal muscle. Biogerontology 9 2 (2008) 67-84
    • (2008) Biogerontology , vol.9 , Issue.2 , pp. 67-84
    • Figueiredo, P.A.1    Mota, M.P.2
  • 9
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956) 298-300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 10
    • 0015319592 scopus 로고
    • The biologic clock: the mitochondria?
    • Harman D. The biologic clock: the mitochondria?. J. Am. Geriatr. Soc. 20 4 (1972) 145-147
    • (1972) J. Am. Geriatr. Soc. , vol.20 , Issue.4 , pp. 145-147
    • Harman, D.1
  • 11
    • 33846345418 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase
    • Hu D., Cao P., et al. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol. Learn. Mem. 87 3 (2007) 372-384
    • (2007) Neurobiol. Learn. Mem. , vol.87 , Issue.3 , pp. 372-384
    • Hu, D.1    Cao, P.2
  • 13
    • 25844520458 scopus 로고    scopus 로고
    • Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
    • Jezek P.L., and Hlavata L. Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int. J. Biochem. Cell. Biol. 37 12 (2005) 2478-2503
    • (2005) Int. J. Biochem. Cell. Biol. , vol.37 , Issue.12 , pp. 2478-2503
    • Jezek, P.L.1    Hlavata, L.2
  • 14
    • 22344456832 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
    • Kujoth G.C., Hiona A., et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309 5733 (2005) 481-484
    • (2005) Science , vol.309 , Issue.5733 , pp. 481-484
    • Kujoth, G.C.1    Hiona, A.2
  • 15
    • 0029838063 scopus 로고    scopus 로고
    • Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice
    • Lebovitz R.M., Zhang H., et al. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. USA 93 18 (1996) 9782-9787
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , Issue.18 , pp. 9782-9787
    • Lebovitz, R.M.1    Zhang, H.2
  • 16
    • 0028827252 scopus 로고
    • Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
    • Li Y., Huang T.T., et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11 4 (1995) 376-3781
    • (1995) Nat. Genet. , vol.11 , Issue.4 , pp. 376-3781
    • Li, Y.1    Huang, T.T.2
  • 17
    • 15844429977 scopus 로고    scopus 로고
    • Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo
    • Longo V.D., Gralla E.B., et al. Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J. Biol. Chem. 271 21 (1996) 12275-12280
    • (1996) J. Biol. Chem. , vol.271 , Issue.21 , pp. 12275-12280
    • Longo, V.D.1    Gralla, E.B.2
  • 18
    • 32244448364 scopus 로고    scopus 로고
    • Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging
    • Mansouri A., Muller F.L., et al. Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech. Ageing Dev. 127 3 (2006) 298-306
    • (2006) Mech. Ageing Dev. , vol.127 , Issue.3 , pp. 298-306
    • Mansouri, A.1    Muller, F.L.2
  • 19
    • 27144466357 scopus 로고    scopus 로고
    • Evaluating evidence for aging
    • Miller R.A., et al. Evaluating evidence for aging. Science 310 5747 (2005) 441-443
    • (2005) Science , vol.310 , Issue.5747 , pp. 441-443
    • Miller, R.A.1
  • 20
    • 0019160038 scopus 로고
    • Mitochondrial role in cell aging
    • Miquel J., Economos A.C., et al. Mitochondrial role in cell aging. Exp. Gerontol. 15 6 (1980) 575-591
    • (1980) Exp. Gerontol. , vol.15 , Issue.6 , pp. 575-591
    • Miquel, J.1    Economos, A.C.2
  • 21
    • 0036671827 scopus 로고    scopus 로고
    • Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
    • Mitsui A., Hamuro J., et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid. Redox. Signal. 4 4 (2002) 693-696
    • (2002) Antioxid. Redox. Signal. , vol.4 , Issue.4 , pp. 693-696
    • Mitsui, A.1    Hamuro, J.2
  • 22
    • 10344221083 scopus 로고    scopus 로고
    • Complex III Releases superoxide to both sides of the inner mitochondrial membrane
    • Muller F.L., Liu Y., et al. Complex III Releases superoxide to both sides of the inner mitochondrial membrane. J. Biol. Chem. 279 47 (2004) 49064-49073
    • (2004) J. Biol. Chem. , vol.279 , Issue.47 , pp. 49064-49073
    • Muller, F.L.1    Liu, Y.2
  • 23
  • 24
    • 39149137166 scopus 로고    scopus 로고
    • Thioredoxin 2 haploin sufficiency in mice results in impaired mitochondrial function and increased oxidative stress
    • Pérez V.I., Lew C.M., et al. Thioredoxin 2 haploin sufficiency in mice results in impaired mitochondrial function and increased oxidative stress. Free Rad. Biol. Med. 44 5 (2008) 882-892
    • (2008) Free Rad. Biol. Med. , vol.44 , Issue.5 , pp. 882-892
    • Pérez, V.I.1    Lew, C.M.2
  • 25
    • 59049086591 scopus 로고    scopus 로고
    • The overexpression of major antioxidant enzymes does not extend the lifespan of mice
    • Pérez V.I., Van Remmen H., Bokov A., Epstein C.J., Vijg J., and Richardson A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell. 8 1 (2009) 73-75
    • (2009) Aging Cell. , vol.8 , Issue.1 , pp. 73-75
    • Pérez, V.I.1    Van Remmen, H.2    Bokov, A.3    Epstein, C.J.4    Vijg, J.5    Richardson, A.6
  • 26
    • 34247863639 scopus 로고    scopus 로고
    • Murine weight loss exhibits significant genetic variation during dietary restriction
    • Rikke B.A., Battaglia M.E., et al. Murine weight loss exhibits significant genetic variation during dietary restriction. Physiol. Genomics 27 2 (2006) 122-130
    • (2006) Physiol. Genomics , vol.27 , Issue.2 , pp. 122-130
    • Rikke, B.A.1    Battaglia, M.E.2
  • 27
    • 33845876643 scopus 로고    scopus 로고
    • Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
    • Scheckhuber C.Q., Erjavec N., et al. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat. Cell Biol. 9 1 (2007) 99-105
    • (2007) Nat. Cell Biol. , vol.9 , Issue.1 , pp. 99-105
    • Scheckhuber, C.Q.1    Erjavec, N.2
  • 28
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine lifespan by overexpression of catalase targeted to mitochondria
    • Schriner S.E., Linford N.J., et al. Extension of murine lifespan by overexpression of catalase targeted to mitochondria. Science 308 5730 (2005) 1909-1911
    • (2005) Science , vol.308 , Issue.5730 , pp. 1909-1911
    • Schriner, S.E.1    Linford, N.J.2
  • 29
    • 0035989388 scopus 로고    scopus 로고
    • Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
    • Sun J., Folk D., et al. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 161 2 (2002) 661-672
    • (2002) Genetics , vol.161 , Issue.2 , pp. 661-672
    • Sun, J.1    Folk, D.2
  • 30
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • Taguchi A., Wartschow L.M., et al. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317 5836 (2007) 369-372
    • (2007) Science , vol.317 , Issue.5836 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2
  • 31
    • 53349153165 scopus 로고    scopus 로고
    • Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria
    • Treuting P.M., Linford N.J., et al. Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria. J. Gerontol. A Biol. Sci. Med. Sci. 63 8 (2008) 813-822
    • (2008) J. Gerontol. A Biol. Sci. Med. Sci. , vol.63 , Issue.8 , pp. 813-822
    • Treuting, P.M.1    Linford, N.J.2
  • 32
    • 2642580016 scopus 로고    scopus 로고
    • Premature ageing in mice expressing defective mitochondrial DNA polymerase
    • Trifunovic A., Wredenberg A., et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429 6990 (2004) 417-423
    • (2004) Nature , vol.429 , Issue.6990 , pp. 417-423
    • Trifunovic, A.1    Wredenberg, A.2
  • 33
    • 85047695800 scopus 로고    scopus 로고
    • A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
    • Trinei M., Giorgio M., et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene 21 24 (2002) 3872-3878
    • (2002) Oncogene , vol.21 , Issue.24 , pp. 3872-3878
    • Trinei, M.1    Giorgio, M.2
  • 34
    • 29144486726 scopus 로고    scopus 로고
    • Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice
    • Tyynismaa H., Mjosund K.P., et al. Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc. Natl. Acad. Sci. 102 49 (2005) 17687-17692
    • (2005) Proc. Natl. Acad. Sci. , vol.102 , Issue.49 , pp. 17687-17692
    • Tyynismaa, H.1    Mjosund, K.P.2
  • 35
    • 0034988397 scopus 로고    scopus 로고
    • Oxidative damage to mitochondria and aging
    • Van Remmen H., and Richardson A. Oxidative damage to mitochondria and aging. Exp. Gerontol. 36 7 (2001) 957-968
    • (2001) Exp. Gerontol. , vol.36 , Issue.7 , pp. 957-968
    • Van Remmen, H.1    Richardson, A.2
  • 36
    • 0033102629 scopus 로고    scopus 로고
    • Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse
    • Van Remmen H., Salvador C., et al. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch. Biochem. Biophys. 363 1 (1999) 91-97
    • (1999) Arch. Biochem. Biophys. , vol.363 , Issue.1 , pp. 91-97
    • Van Remmen, H.1    Salvador, C.2
  • 37
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • Van Remmen H., Ikeno Y., et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics 16 1 (2003) 29-37
    • (2003) Physiol. Genomics , vol.16 , Issue.1 , pp. 29-37
    • Van Remmen, H.1    Ikeno, Y.2
  • 38
    • 34047116291 scopus 로고    scopus 로고
    • Mitochondrial point mutations do not limit the natural lifespan of mice
    • Vermulst M., Bielas J.H., et al. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat. Genet. 39 4 (2007) 540-543
    • (2007) Nat. Genet. , vol.39 , Issue.4 , pp. 540-543
    • Vermulst, M.1    Bielas, J.H.2
  • 39
    • 41349087783 scopus 로고    scopus 로고
    • DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
    • Vermulst M., Wanagat J., et al. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat. Genet. 40 4 (2008) 392-394
    • (2008) Nat. Genet. , vol.40 , Issue.4 , pp. 392-394
    • Vermulst, M.1    Wanagat, J.2
  • 40
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes F.M., and Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. 94 2 (1997) 514-519
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , Issue.2 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 41
    • 27844561111 scopus 로고    scopus 로고
    • Regulation of oxidative stress by the anti-aging hormone klotho
    • Yamamoto M., Clark J.D., et al. Regulation of oxidative stress by the anti-aging hormone klotho. J. Biol. Chem. 280 45 (2005) 38029-38034
    • (2005) J. Biol. Chem. , vol.280 , Issue.45 , pp. 38029-38034
    • Yamamoto, M.1    Clark, J.D.2
  • 42
    • 0142182386 scopus 로고    scopus 로고
    • The role of thioredoxin in the aging process: involvement of oxidative stress
    • Yoshida T., Oka S., et al. The role of thioredoxin in the aging process: involvement of oxidative stress. Antioxid. Redox Signal 5 5 (2003) 563-570
    • (2003) Antioxid. Redox Signal , vol.5 , Issue.5 , pp. 563-570
    • Yoshida, T.1    Oka, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.