Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis

Journal of Biological Chemistry

Volumn 283, Issue 22, 2008, Pages 15359-15369

  Nie, Chunlai ^a,d   Tian, Changhai ^a   Zhao, Lixia ^a   Petit, Patrice Xavier ^b   Mehrpour, Maryam ^a,c,e   Chen, Quan ^a,e  

^a NANKAI UNIVERSITY   (China)

^b INSTITUT COCHIN   (France)

^c INSERM   (France)

^d SICHUAN UNIVERSITY   (China)

^e INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; CELL CULTURE; MITOCHONDRIA; OLIGOMERIZATION; OXYGEN;

ADENOCARCINOMA CELL LINES; APOPTOSIS; CONFORMATIONAL CHANGES; CYSTEINE RESIDUES; CYTOCHROME C; DIRECT SIGNALS; DO-MAINS; HUMAN COLONS; INDUCED APOPTOSIS; MITOCHONDRIAL TRANSLOCATIONS; MOLECULAR MECHANISMS; PROAPOPTOTIC ACTIVITIES; REACTIVE OXYGEN SPECIES; WILD TYPES;

CELL DEATH;

ALANINE; CASPASE 3; CYSTEINE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; HYDROGEN PEROXIDE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SERINE; BAX PROTEIN, HUMAN; OXIDIZING AGENT;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRION; MUTATIONAL ANALYSIS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; WILD TYPE; AMINO ACID SUBSTITUTION; DRUG EFFECT; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CYSTEINE; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; OXIDANTS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

EID: 47249135572     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800847200     Document Type: Article

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