The antimalarial ferroquine: Role of the metal and intramolecular hydrogen bond in activity and resistance

ACS Chemical Biology

Volumn 6, Issue 3, 2011, Pages 275-287

  Dubar, Faustine ^a   Egan, Timothy J ^b   Pradines, Bruno ^c   Kuter, David ^b   Ncokazi, Kanyile K ^b   Forge, Delphine ^d   Paul, Jean François ^a   Pierrot, Christine ^h   Kalamou, Hadidjatou ^h   Khalife, Jamal ^h   Buisine, Eric ^e   Rogier, Christophe ^c   Vezin, Hervé ^a   Forfar, Isabelle ^f   Slomianny, Christian ^a   Trivelli, Xavier ^a   Kapishnikov, Sergey ^g   Leiserowitz, Leslie ^g   Dive, Daniel ^h   Biot, Christophe ^a,h  

^a UNIV LILLE   (France)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^d UNIVERSITY OF MONS   (Belgium)

^e Ecole Nationale Superieure de Chimie de Lille   (France)

^f UNIVERSITÉ DE BORDEAUX   (France)

^g WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^h INSERM U1019   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE; CHLOROQUINE RESISTANCE TRANSPORTER; FERROQUINE; HEMATIN; HEMOZOIN; HYDROXYL GROUP; METAL; METHYLFERROQUINE; METHYLRUTHENOQUINE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; RUTHENOQUINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BINDING SITE; CELL VACUOLE; COPY NUMBER VARIATION; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; CYTOTOXICITY; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; IONIZATION; LIPOPHILICITY; MOUSE; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PH MEASUREMENT; PHYSICAL CHEMISTRY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY;

PLASMODIUM FALCIPARUM;

EID: 79955626199     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100322v     Document Type: Article

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