Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 37, Issue 1, 2012, Pages 17-22

  Milner, Erin ^a   Sousa, Jason ^a   Pybus, Brandon ^a   Auschwitz, Jennifer ^a   Caridha, Diana ^a   Gardner, Sean ^a   Grauer, Kristina ^a   Harris, Erin ^a   Hickman, Mark ^a   Kozar, Michael P ^a   Lee, Patricia ^a   Leed, Susan ^a   Li, Qigui ^a   Melendez, Victor ^a   Moon, Jay ^a   Ngundam, Franklyn ^a   O'Neil, Michael ^a   Parriott, Sandi ^a   Potter, Brittney ^a   Sciotti, Rick ^a   Tangteung, Anchalee ^b   Dow, Geoffrey S ^a   more..

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b U S ARMY   (United States)

Author keywords

Blood stage malaria; Ketotifen; Liver stage malaria; Malaria drug development

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; DRUG METABOLITE; KETOTIFEN; MEFLOQUINE; NORKETOTIFEN; PRIMAQUINE; PRODRUG; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; SCHIZONT; SINGLE DRUG DOSE; SURVIVAL RATE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTIMALARIALS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KETOTIFEN; LIVER; MALARIA; MALARIA, FALCIPARUM; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRODRUGS;

EID: 84862820224     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-012-0080-2     Document Type: Article

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