메뉴 건너뛰기




Volumn 72, Issue 7, 2012, Pages 937-961

Dihydroartemisinin/piperaquine: A review of its use in the treatment of uncomplicated plasmodium falciparum malaria

Author keywords

Adis Drug Profiles; Artemetherlumefantrine; Artesunatemefloquine; Dihydroartemisininpiperaquine; Falciparum malaria; Pharmacology

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTESUNATE PLUS MEFLOQUINE; DIHYDROARTEMISININ; DIHYDROARTEMISININ PLUS PIPERAQUINE; HALOTHANE; ISOFLURANE; NEFAZODONE; OMEPRAZOLE; PARACETAMOL; PIPERAQUINE; PLACEBO; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THEOPHYLLINE; VERAPAMIL;

EID: 84860722723     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11203910-000000000-00000     Document Type: Review
Times cited : (86)

References (79)
  • 1
    • 42549092410 scopus 로고    scopus 로고
    • World Health Organization [online] [Accessed 2012 Jan 12]
    • World Health Organization. Guidelines for the treatment of malaria: second edition [online]. Available from URL: http://whqlibdoc.who.int/ publications/2010/9789241547925-eng.pdf [Accessed 2012 Jan 12]
    • Guidelines for the Treatment of Malaria: Second Edition
  • 2
    • 38149059991 scopus 로고    scopus 로고
    • Clinical pharmacology of artemisinin-based combination therapies
    • German PI, Aweeka FT. Clinical pharmacology of artemisinin-based combination therapies. Clin Pharmacokinet 2008; 47 (2): 91-102
    • (2008) Clin Pharmacokinet , vol.47 , Issue.2 , pp. 91-102
    • German, P.I.1    Aweeka, F.T.2
  • 3
    • 84856408211 scopus 로고    scopus 로고
    • World Health Organization [online] [Accessed 2012 Feb 14]
    • World Health Organization. World malaria report 2011 [online]. Available from URL: http://www.who.int/malar ia/world-malaria-report-2011/WMR2011- noprofiles-lowres. pdf [Accessed 2012 Feb 14]
    • (2011) World Malaria Report
  • 4
    • 77949568358 scopus 로고    scopus 로고
    • Artemisinin resistance: Current status and scenarios for containment
    • Apr
    • Dondorp AM, Yeung S, White L, et al. Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol 2010 Apr; 8 (4): 272-80
    • (2010) Nat Rev Microbiol , vol.8 , Issue.4 , pp. 272-280
    • Dondorp, A.M.1    Yeung, S.2    White, L.3
  • 5
    • 84871494336 scopus 로고    scopus 로고
    • European Medicines Agency [online] [Accessed 2012 Jan 10]
    • European Medicines Agency. Eurartesim (dihydroartemisinin/piperaquine phosphate): EU public assessment report [online]. Available from URL: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR-Public-assessment- report/human/001199/WC500118116.pdf [Accessed 2012 Jan 10]
    • Eurartesim (Dihydroartemisinin/piperaquine Phosphate): EU Public Assessment Report
  • 6
    • 79551634139 scopus 로고    scopus 로고
    • A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos
    • Mayxay M, Keomany S, Khanthavong M, et al. A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin- piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos. Am J Trop Med Hyg 2010; 83 (6): 1221-9
    • (2010) Am J Trop Med Hyg , vol.83 , Issue.6 , pp. 1221-1229
    • Mayxay, M.1    Keomany, S.2    Khanthavong, M.3
  • 8
    • 55449124885 scopus 로고    scopus 로고
    • Yeast model uncovers dual roles of mitochondria in action of artemisinin
    • Sep
    • Li W, Mo W, Shen D, et al. Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genet 2005 Sep; 1 (3): e36
    • (2005) PLoS Genet , vol.1 , Issue.3
    • Li, W.1    Mo, W.2    Shen, D.3
  • 9
    • 0042860063 scopus 로고    scopus 로고
    • Artemisinins target the SERCA of Plasmodium falciparum
    • Aug 21
    • Eckstein-Ludwig U, Webb RJ, van Goethem IDA, et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 2003 Aug 21; 424 (6951): 957-61
    • (2003) Nature , vol.424 , Issue.6951 , pp. 957-961
    • Eckstein-Ludwig, U.1    Webb, R.J.2    Van Goethem, I.D.A.3
  • 10
    • 12444319401 scopus 로고    scopus 로고
    • Piperaquine: A resurgent antimalarial drug
    • Davis TME, Hung T-Y, Sim I-K, et al. Piperaquine: a resurgent antimalarial drug. Drugs 2005; 65 (1): 75-87
    • (2005) Drugs , vol.65 , Issue.1 , pp. 75-87
    • Davis, T.M.E.1    Hung, T.-Y.2    Sim, I.-K.3
  • 11
    • 77149154625 scopus 로고    scopus 로고
    • In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda
    • Mar
    • Nsobya SL, Kiggundu M, Nanyunja S, et al. In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother 2010 Mar; 54 (3): 1200-6
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.3 , pp. 1200-1206
    • Nsobya, S.L.1    Kiggundu, M.2    Nanyunja, S.3
  • 12
    • 80755159531 scopus 로고    scopus 로고
    • Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast
    • Nov
    • Borrmann S, Sasi P, Mwai L, et al. Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast. PLoS One 2011 Nov; 6 (11): e26005
    • (2011) PLoS One , vol.6 , Issue.11
    • Borrmann, S.1    Sasi, P.2    Mwai, L.3
  • 13
    • 77956155765 scopus 로고    scopus 로고
    • Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt pfmdr1 pfmrp and pfnhe genes in Plasmodium falciparum
    • Sep
    • Briolant S, Henry M, Oeuvray C, et al. Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum. Antimicrob Agents Chemother 2010 Sep; 54 (9): 3537-44
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.9 , pp. 3537-3544
    • Briolant, S.1    Henry, M.2    Oeuvray, C.3
  • 14
    • 65649153380 scopus 로고    scopus 로고
    • Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro
    • Apr
    • Muangnoicharoen S, Johnson DJ, Looareesuwan S, et al. Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro. Antimicrob Agents Chemother 2009 Apr; 53 (4): 1362-6
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.4 , pp. 1362-1366
    • Muangnoicharoen, S.1    Johnson, D.J.2    Looareesuwan, S.3
  • 15
    • 71249142664 scopus 로고    scopus 로고
    • In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1
    • Dec
    • Mwai L, Kiara SM, Abdirahman A, et al. In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1. Antimicrob Agents Chemother 2009 Dec; 53 (12): 5069-73
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.12 , pp. 5069-5073
    • Mwai, L.1    Kiara, S.M.2    Abdirahman, A.3
  • 16
    • 81255185508 scopus 로고    scopus 로고
    • Antimalarial efficacy of piperaquine-based antimalarial combination therapies: Facts and uncertainties
    • Dec
    • Gargano N, Cenci F, Bassat Q. Antimalarial efficacy of piperaquine-based antimalarial combination therapies: facts and uncertainties. Trop Med Int Health 2011 Dec; 16 (12): 1466-73
    • (2011) Trop Med Int Health , vol.16 , Issue.12 , pp. 1466-1473
    • Gargano, N.1    Cenci, F.2    Bassat, Q.3
  • 17
    • 68049123592 scopus 로고    scopus 로고
    • Artemisinin resistance in Plasmodium falciparum malaria
    • Jul 30
    • Dondorp AM, Nosten F, Yi P, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med 2009 Jul 30; 361 (5): 455-67
    • (2009) N Engl J Med , vol.361 , Issue.5 , pp. 455-467
    • Dondorp, A.M.1    Nosten, F.2    Yi, P.3
  • 18
    • 57749099137 scopus 로고    scopus 로고
    • Evidence of artemisininresistant malaria in western Cambodia [letter]
    • Dec 11
    • Noedl H, Se Y, Schaecher K, et al. Evidence of artemisininresistant malaria in western Cambodia [letter]. N Engl J Med 2008 Dec 11; 359 (24): 2619-20
    • (2008) N Engl J Med , vol.359 , Issue.24 , pp. 2619-2620
    • Noedl, H.1    Se, Y.2    Schaecher, K.3
  • 19
    • 28244477359 scopus 로고    scopus 로고
    • Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
    • Dec 3
    • Jambou R, Legrand E, Niang M, et al. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 2005 Dec 3; 366 (9501): 1960-3
    • (2005) Lancet , vol.366 , Issue.9501 , pp. 1960-1963
    • Jambou, R.1    Legrand, E.2    Niang, M.3
  • 20
    • 0037378775 scopus 로고    scopus 로고
    • In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon
    • Apr
    • Basco LK, Ringwald P. In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon. Antimicrob Agents Chemother 2003 Apr; 47 (4): 1391-4
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.4 , pp. 1391-1394
    • Basco, L.K.1    Ringwald, P.2
  • 21
    • 77951228929 scopus 로고    scopus 로고
    • Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine- pyrimethamine but not dihydroartemisininpiperaquine in Burkina Faso
    • May
    • Somé AF, Séré YY, Dokomajilar C, et al. Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisininpiperaquine in Burkina Faso. Antimicrob Agents Chemother 2010May; 54 (5): 1949-54
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.5 , pp. 1949-1954
    • Somé, A.F.1    Séré, Y.Y.2    Dokomajilar, C.3
  • 22
    • 34250162858 scopus 로고    scopus 로고
    • Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and-resistant Plasmodium falciparum strains
    • Jun
    • Fivelman QL, Adagu IS, Warhurst DC. Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and-resistant Plasmodium falciparum strains. Antimicrob Agents Chemother 2007 Jun; 51 (6): 2265-7
    • (2007) Antimicrob Agents Chemother , vol.51 , Issue.6 , pp. 2265-2267
    • Fivelman, Q.L.1    Adagu, I.S.2    Warhurst, D.C.3
  • 23
    • 33746891248 scopus 로고    scopus 로고
    • In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs
    • Aug
    • Davis TME, Hamzah J, Ilett KF, et al. In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs. Antimicrob Agents Chemother 2006 Aug; 50 (8): 2883-5
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.8 , pp. 2883-2885
    • Davis, T.M.E.1    Hamzah, J.2    Ilett, K.F.3
  • 24
    • 77955606614 scopus 로고    scopus 로고
    • An open-label randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia
    • Jul
    • Valecha N, Phyo AP, Mayxay M, et al. An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia. PLoS One 2010 Jul; 5 (7): e11880
    • (2010) PLoS One , vol.5 , Issue.7
    • Valecha, N.1    Phyo, A.P.2    Mayxay, M.3
  • 25
    • 70849087812 scopus 로고    scopus 로고
    • Dihydroartemisininpiperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: A randomised, non-inferiority trial
    • Nov 17
    • Bassat Q, Mulenga M, Tinto H, et al. Dihydroartemisininpiperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial. PLoS One 2009 Nov 17; 4 (11): e7871
    • (2009) PLoS One , vol.4 , Issue.11
    • Bassat, Q.1    Mulenga, M.2    Tinto, H.3
  • 26
    • 35748964160 scopus 로고    scopus 로고
    • Electrocardiographic safety evaluation of dihydroartemisinin-piperaquine in the treatment of uncomplicated falciparum malaria
    • Sep
    • Mytton OT, Ashley EA, Peto L, et al. Electrocardiographic safety evaluation of dihydroartemisinin-piperaquine in the treatment of uncomplicated falciparum malaria. Am J Trop Med Hyg 2007 Sep; 77 (3): 447-50
    • (2007) Am J Trop Med Hyg , vol.77 , Issue.3 , pp. 447-450
    • Mytton, O.T.1    Ashley, E.A.2    Peto, L.3
  • 27
    • 0346057805 scopus 로고    scopus 로고
    • Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria
    • Jan
    • Karunajeewa H, Lim C, Hung T-Y, et al. Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria. Br J Clin Pharmacol 2004 Jan; 57 (1): 93-9
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.1 , pp. 93-9
    • Karunajeewa, H.1    Lim, C.2    Hung, T.-Y.3
  • 28
    • 8444223051 scopus 로고    scopus 로고
    • Randomized, controlled dose-optimization studies of dihydroartemisininpiperaquine for the treatment of uncomplicated multidrugresistant falciparum malaria in Thailand
    • Nov 15
    • Ashley EA, Krudsood S, Phaiphun L, et al. Randomized, controlled dose-optimization studies of dihydroartemisininpiperaquine for the treatment of uncomplicated multidrugresistant falciparum malaria in Thailand. J Infect Dis 2004 Nov 15; 190 (10): 1773-82
    • (2004) J Infect Dis , vol.190 , Issue.10 , pp. 1773-1782
    • Ashley, E.A.1    Krudsood, S.2    Phaiphun, L.3
  • 29
    • 23244447395 scopus 로고    scopus 로고
    • A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria
    • Aug 15
    • Ashley EA, McGready R, Hutagalung R, et al. A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria. Clin Infect Dis 2005 Aug 15; 41 (4): 425-32
    • (2005) Clin Infect Dis , vol.41 , Issue.4 , pp. 425-432
    • Ashley, E.A.1    McGready, R.2    Hutagalung, R.3
  • 30
    • 84861121469 scopus 로고    scopus 로고
    • In vitro cardiovascular effects of dihydroartemisin-piperaquine combination: Comparison with other antimalarials
    • Epub 2012 Mar 5
    • Borsini F, Crumb W, Pace S, et al. In vitro cardiovascular effects of dihydroartemisin-piperaquine combination: comparison with other antimalarials. Antimicrob Agents Chemother. Epub 2012 Mar 5
    • Antimicrob Agents Chemother
    • Borsini, F.1    Crumb, W.2    Pace, S.3
  • 31
    • 34447568519 scopus 로고    scopus 로고
    • Cardiotoxicity of antimalarial drugs
    • Aug
    • White NJ. Cardiotoxicity of antimalarial drugs. Lancet Infect Dis 2007 Aug; 7 (8): 549-58
    • (2007) Lancet Infect Dis , vol.7 , Issue.8 , pp. 549-558
    • White, N.J.1
  • 32
    • 67749113530 scopus 로고    scopus 로고
    • Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam
    • Aug
    • Nguyen DVH, Nguyen QP, Nguyen ND, et al. Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam. Antimicrob Agents Chemother 2009 Aug; 53 (8): 3534-7
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.8 , pp. 3534-3537
    • Nguyen, D.V.H.1    Nguyen, Q.P.2    Nguyen, N.D.3
  • 33
    • 80051825842 scopus 로고    scopus 로고
    • A small amount of fat does not affect piperaquine exposure in patients with malaria
    • Sep
    • Annerberg A, Lwin KM, Lindegardh N, et al. A small amount of fat does not affect piperaquine exposure in patients with malaria. Antimicrob Agents Chemother 2011 Sep; 55 (9): 3971-6
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.9 , pp. 3971-3976
    • Annerberg, A.1    Lwin, K.M.2    Lindegardh, N.3
  • 34
    • 19544380591 scopus 로고    scopus 로고
    • Effects of a high-fat meal on the relative oral bioavailability of piperaquine
    • Jun
    • Sim I-K, Davis TME, Ilett KF. Effects of a high-fat meal on the relative oral bioavailability of piperaquine. Antimicrob Agents Chemother 2005 Jun; 49 (6): 2407-11
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.6 , pp. 2407-2411
    • Sim, I.-K.1    Davis, T.M.E.2    Ilett, K.F.3
  • 35
    • 53749095258 scopus 로고    scopus 로고
    • Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects
    • Oct
    • Chinh NT, Quang NN, Thanh NX, et al. Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects. Am J Trop Med Hyg 2008 Oct; 79 (4): 620-3
    • (2008) Am J Trop Med Hyg , vol.79 , Issue.4 , pp. 620-623
    • Chinh, N.T.1    Quang, N.N.2    Thanh, N.X.3
  • 36
    • 47549100818 scopus 로고    scopus 로고
    • The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers
    • Aug
    • Hai TN, Hietala SF, Van Huong N, et al. The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers. Acta Trop 2008 Aug; 107 (2): 145-9
    • (2008) Acta Trop , vol.107 , Issue.2 , pp. 145-149
    • Hai, T.N.1    Hietala, S.F.2    Van Huong, N.3
  • 37
    • 0038359611 scopus 로고    scopus 로고
    • Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection
    • Jul 5
    • Hung TY, Davis TME, Ilett KF. Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection. J Chrom B Anal Tech Biomed Life Sci 2003 Jul 5; 791 (1-2): 93-101
    • (2003) J Chrom B Anal Tech Biomed Life Sci , vol.791 , Issue.1-2 , pp. 93-101
    • Hung, T.Y.1    Davis, T.M.E.2    Ilett, K.F.3
  • 38
    • 40549113955 scopus 로고    scopus 로고
    • Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand
    • Mar
    • Tarning J, Ashley EA, Lindegardh N, et al. Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin- piperaquine in patients with Plasmodium falciparum malaria in Thailand. Antimicrob Agents Chemother 2008 Mar; 52 (3): 1052-61
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.3 , pp. 1052-1061
    • Tarning, J.1    Ashley, E.A.2    Lindegardh, N.3
  • 39
    • 52449086887 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat
    • Aug
    • Tarning J, Lindegardh N, Sandberg S, et al. Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat. J Pharm Sci 2008 Aug; 97 (8): 3400-10
    • (2008) J Pharm Sci , vol.97 , Issue.8 , pp. 3400-3410
    • Tarning, J.1    Lindegardh, N.2    Sandberg, S.3
  • 40
    • 42549129908 scopus 로고    scopus 로고
    • A randomised controlled trial to assess the efficacy of dihydroartemisininpiperaquine for the treatment of uncomplicated falciparum malaria in Peru
    • Oct
    • Grande T, Bernasconi A, Erhart A, et al. A randomised controlled trial to assess the efficacy of dihydroartemisininpiperaquine for the treatment of uncomplicated falciparum malaria in Peru. PLoS One 2007 Oct; 2 (10): e1101
    • (2007) PLoS One , vol.2 , Issue.10
    • Grande, T.1    Bernasconi, A.2    Erhart, A.3
  • 41
    • 9144262694 scopus 로고    scopus 로고
    • Dihydroartemisininpiperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: Randomised clinical trial
    • Jan 3
    • Hien TT, Dolecek C, Mai PP, et al. Dihydroartemisininpiperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial. Lancet 2004 Jan 3; 363 (9402): 18-22
    • (2004) Lancet , vol.363 , Issue.9402 , pp. 18-22
    • Hien, T.T.1    Dolecek, C.2    Mai, P.P.3
  • 42
    • 33846941261 scopus 로고    scopus 로고
    • A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia
    • Feb
    • Janssens B, van Herp M, Goubert L, et al. A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia. Trop Med Int Health 2007 Feb; 12 (2): 251-9
    • (2007) Trop Med Int Health , vol.12 , Issue.2 , pp. 251-259
    • Janssens, B.1    Van Herp, M.2    Goubert, L.3
  • 43
    • 33746456474 scopus 로고    scopus 로고
    • An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos)
    • Aug
    • Mayxay M, Thongpraseuth V, Khanthavong M, et al. An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos). Trop Med Int Health 2006 Aug; 11 (8): 1157-65
    • (2006) Trop Med Int Health , vol.11 , Issue.8 , pp. 1157-1165
    • Mayxay, M.1    Thongpraseuth, V.2    Khanthavong, M.3
  • 44
    • 30344465041 scopus 로고    scopus 로고
    • An open randomized clinical trial of Artekin vs artesunatemefloquine in the treatment of acute uncomplicated falciparum malaria
    • Sep
    • Tangpukdee N, Krudsood S, Thanachartwet W, et al. An open randomized clinical trial of Artekin vs artesunatemefloquine in the treatment of acute uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 2005 Sep; 36 (5): 1085-91
    • (2005) Southeast Asian J Trop Med Public Health , vol.36 , Issue.5 , pp. 1085-1091
    • Tangpukdee, N.1    Krudsood, S.2    Thanachartwet, W.3
  • 45
    • 79952051804 scopus 로고    scopus 로고
    • Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children
    • Feb 28
    • Nambozi M, van Gerrtruyden J-P, Hachizovu S, et al. Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children. Malar J 2011 Feb 28; 10: 50
    • (2011) Malar J , vol.10 , pp. 50
    • Nambozi, M.1    Van Gerrtruyden, J.-P.2    Hachizovu, S.3
  • 46
    • 82555195187 scopus 로고    scopus 로고
    • A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: A randomized trial
    • The 4ABC Study Group Nov
    • The 4ABC Study Group. A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial. PLoS Med 2011 Nov; 8 (11): e1001119
    • (2011) PLoS Med , vol.8 , Issue.11
  • 47
    • 57549092697 scopus 로고    scopus 로고
    • A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya
    • Nov
    • Mens PF, Sawa P, van Amsterdam SM, et al. A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya. Malar J 2008 Nov 18; 7: 237
    • (2008) Malar J , vol.18 , Issue.7 , pp. 237
    • Mens, P.F.1    Sawa, P.2    Van Amsterdam, S.M.3
  • 48
    • 77954702591 scopus 로고    scopus 로고
    • Dihydroartemisininpiperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan
    • Adam I, Salah MT, Eltahir HG, et al. Dihydroartemisininpiperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan. Ann Trop Med Parasitol 2010; 104 (4): 319-26
    • (2010) Ann Trop Med Parasitol , vol.104 , Issue.4 , pp. 319-326
    • Adam, I.1    Salah, M.T.2    Eltahir, H.G.3
  • 49
    • 34249862105 scopus 로고    scopus 로고
    • Artemetherlumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: A randomized trial
    • May
    • Kamya MR, Yeka A, Bukirwa H, et al. Artemetherlumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials 2007 May; 2 (5): e20
    • (2007) PLoS Clin Trials , vol.2 , Issue.5
    • Kamya, M.R.1    Yeka, A.2    Bukirwa, H.3
  • 50
    • 79960562239 scopus 로고    scopus 로고
    • Multicentric assessment of the efficacy and tolerability of dihydroartemisininpiperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa
    • Jul
    • Yavo W, Faye B, Kuete T, et al. Multicentric assessment of the efficacy and tolerability of dihydroartemisininpiperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa. Malaria J 2011 Jul 20; 10: 198
    • (2011) Malaria J , vol.20 , Issue.10 , pp. 198
    • Yavo, W.1    Faye, B.2    Kuete, T.3
  • 51
    • 48649096145 scopus 로고    scopus 로고
    • Artemetherlumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: A randomized trial to guide policy in Uganda
    • Jun
    • Yeka A, Dorsey G, Kamya MR, et al. Artemetherlumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One 2008 Jun; 3 (6): e2390
    • (2008) PLoS One , vol.3 , Issue.6
    • Yeka, A.1    Dorsey, G.2    Kamya, M.R.3
  • 52
    • 38449087076 scopus 로고    scopus 로고
    • Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso
    • Dec 1
    • Zongo I, Dorsey G, Rouamba N, et al. Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis 2007 Dec 1; 45 (11): 1453-61
    • (2007) Clin Infect Dis , vol.45 , Issue.11 , pp. 1453-1461
    • Zongo, I.1    Dorsey, G.2    Rouamba, N.3
  • 53
    • 72849113797 scopus 로고    scopus 로고
    • Artemetherlumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: A longitudinal, randomized trial in young Ugandan children
    • Arinaitwe E, Sandison TG, Wanzira H, et al. Artemetherlumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis 2009; 49 (11): 1629-37
    • (2009) Clin Infect Dis , vol.49 , Issue.11 , pp. 1629-1637
    • Arinaitwe, E.1    Sandison, T.G.2    Wanzira, H.3
  • 54
    • 80054971149 scopus 로고    scopus 로고
    • Randomized trials of artemisinin-piperaquine, dihydroartemisinin- piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area
    • Aug 10
    • Song J, Socheat D, Tan B, et al. Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area. Malaria J 2011 Aug 10; 10: 231
    • (2011) Malaria J , vol.10 , pp. 231
    • Song, J.1    Socheat, D.2    Tan, B.3
  • 55
    • 33749055093 scopus 로고    scopus 로고
    • Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children
    • Dec
    • Karema C, Fanello CI, Van Overmeir C, et al. Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. Trans R Soc Trop Med Hyg 2006 Dec; 100 (12): 1105-11
    • (2006) Trans R Soc Trop Med Hyg , vol.100 , Issue.12 , pp. 1105-1111
    • Karema, C.1    Fanello, C.I.2    Van Overmeir, C.3
  • 56
    • 65649149723 scopus 로고    scopus 로고
    • Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam
    • May
    • Thanh NX, Trung TN, Phong NC, et al. Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam. Trop Med Int Health 2009 May; 14 (5): 504-511
    • (2009) Trop Med Int Health , vol.14 , Issue.5 , pp. 504-511
    • Thanh, N.X.1    Trung, T.N.2    Phong, N.C.3
  • 57
    • 67650505663 scopus 로고    scopus 로고
    • A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisininpiperaquine phosphate in treatment of falciparum malaria
    • Jun
    • Trung TN, Tan B, Van Phuc D, et al. A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisininpiperaquine phosphate in treatment of falciparum malaria. Chin J Integr Med 2009 Jun; 15 (3): 189-92
    • (2009) Chin J Integr Med , vol.15 , Issue.3 , pp. 189-192
    • Trung, T.N.1    Tan, B.2    Van Phuc, D.3
  • 58
    • 84858449712 scopus 로고    scopus 로고
    • Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment
    • Feb
    • Carrara VI, Zwang J, Ashley EA, et al. Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment. PLoS One 2009 Feb; 4 (2): e4551
    • (2009) PLoS One , vol.4 , Issue.2
    • Carrara, V.I.1    Zwang, J.2    Ashley, E.A.3
  • 59
    • 58649122842 scopus 로고    scopus 로고
    • Failure of artesunatemefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia
    • Jan
    • Rogers WO, Sem R, Tero T, et al. Failure of artesunatemefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar J 2009 Jan 12; 8: 10
    • (2009) Malar J , vol.12 , Issue.8 , pp. 10
    • Rogers, W.O.1    Sem, R.2    Tero, T.3
  • 60
    • 57749116211 scopus 로고    scopus 로고
    • A trial of combination antimalarial therapies in children from Papua New Guinea
    • Dec 11
    • Karunajeewa HA, Mueller I, Senn M, et al. A trial of combination antimalarial therapies in children from Papua New Guinea. N Engl J Med 2008 Dec 11; 359 (24): 2545-57
    • (2008) N Engl J Med , vol.359 , Issue.24 , pp. 2545-2557
    • Karunajeewa, H.A.1    Mueller, I.2    Senn, M.3
  • 61
    • 84857233900 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
    • Mar
    • Tarning J, Zongo I, Somé FA, et al. Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria. Clin Pharmacol Ther 2012 Mar; 91 (3): 497-505
    • (2012) Clin Pharmacol Ther , vol.91 , Issue.3 , pp. 497-505
    • Tarning, J.1    Zongo, I.2    Somé, F.A.3
  • 63
    • 77952605533 scopus 로고    scopus 로고
    • Artemisinin combination therapy for vivax malaria
    • Jun
    • Douglas NM, Anstey NM, Angus BJ, et al. Artemisinin combination therapy for vivax malaria. Lancet Infect Dis 2010 Jun; 10 (6): 405-16
    • (2010) Lancet Infect Dis , vol.10 , Issue.6 , pp. 405-416
    • Douglas, N.M.1    Anstey, N.M.2    Angus, B.J.3
  • 64
    • 34447617873 scopus 로고    scopus 로고
    • Efficacy and safety of dihydroartemisinin-piperaquine
    • Sep
    • Myint HY, Ashley EA, Day NP, et al. Efficacy and safety of dihydroartemisinin-piperaquine. Trans R Soc Trop Med Hyg 2007 Sep; 101 (9): 858-66
    • (2007) Trans R Soc Trop Med Hyg , vol.101 , Issue.9 , pp. 858-866
    • Myint, H.Y.1    Ashley, E.A.2    Day, N.P.3
  • 65
    • 68149158508 scopus 로고    scopus 로고
    • Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: A prospective multi-centre individual patient data analysis
    • Jul
    • Zwang J, Ashley EA, Karema C, et al. Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis. PLoS One 2009 Jul; 4 (7): e6358
    • (2009) PLoS One , vol.4 , Issue.7
    • Zwang, J.1    Ashley, E.A.2    Karema, C.3
  • 66
    • 0003864029 scopus 로고    scopus 로고
    • World Health Organization [online] [Accessed 2012 Jan 18]
    • World Health Organization. International travel and health 2011 [online]. Available from URL: http://www.who.int/ith/en/[Accessed 2012 Jan 18]
    • (2011) International Travel and Health
  • 67
    • 80054895561 scopus 로고    scopus 로고
    • Diagnosis and therapy for hospitalized imported malaria in adults in Italy
    • Antinori S, Cigardi B, Galimberti L, et al. Diagnosis and therapy for hospitalized imported malaria in adults in Italy. J Travel Med 2011; 18 (6): 379-85
    • (2011) J Travel Med , vol.18 , Issue.6 , pp. 379-385
    • Antinori, S.1    Cigardi, B.2    Galimberti, L.3
  • 68
    • 34547855900 scopus 로고    scopus 로고
    • Counterfeit or substandard antimicrobial drugs: A review of the scientific evidence
    • Aug
    • Kelesidis T, Kelesidis I, Rafailidis PI, et al. Counterfeit or substandard antimicrobial drugs: a review of the scientific evidence. J Antimicrob Chemother 2007 Aug; 60 (2): 214-36
    • (2007) J Antimicrob Chemother , vol.60 , Issue.2 , pp. 214-236
    • Kelesidis, T.1    Kelesidis, I.2    Rafailidis, P.I.3
  • 70
    • 78149462780 scopus 로고    scopus 로고
    • Efficacy safety and tolerability of three regimens for prevention of malaria: A randomized placebo-controlled trial in Ugandan schoolchildren
    • Oct
    • Nankabirwa J, Cundill B, Clarke S, et al. Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. PLoS One 2010 Oct; 5 (10): e13438
    • (2010) PLoS One , vol.5 , Issue.10
    • Nankabirwa, J.1    Cundill, B.2    Clarke, S.3
  • 71
    • 70349656475 scopus 로고    scopus 로고
    • Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children
    • Sep
    • Cisse B, Cairns M, Faye E, et al. Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children. PLoS One 2009 Sep; 4 (9): e7164
    • (2009) PLoS One , vol.4 , Issue.9
    • Cisse, B.1    Cairns, M.2    Faye, E.3
  • 72
    • 77955283844 scopus 로고    scopus 로고
    • A randomised trial to compare the safety tolerability and efficacy of three drug combinations for intermittent preventive treatment in children
    • Jun
    • Bojang K, Akor F, Bittaye O, et al. A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children. PLoS One 2010 Jun; 5 (6): e11225
    • (2010) PLoS One , vol.5 , Issue.6
    • Bojang, K.1    Akor, F.2    Bittaye, O.3
  • 73
    • 84863115620 scopus 로고    scopus 로고
    • A randomised doubleblind placebo controlled trial of monthly versus second monthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria
    • Mar
    • Lwin KM, Phyo AP, Tarning J, et al. A randomised, doubleblind, placebo controlled trial of monthly versus second monthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria. Antimicrob Agents Chemother 2012 Mar; 56 (3): 1571-7
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.3 , pp. 1571-1577
    • Lwin, K.M.1    Phyo, A.P.2    Tarning, J.3
  • 74
    • 80054767617 scopus 로고    scopus 로고
    • Dihydroartemisininpiperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: A randomized controlled trial
    • Nov 15
    • Phyo AP, Lwin KM, Price RN, et al. Dihydroartemisininpiperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial. Clin Infect Dis 2011 Nov 15; 53 (10): 977-84
    • (2011) Clin Infect Dis , vol.53 , Issue.10 , pp. 977-984
    • Phyo, A.P.1    Lwin, K.M.2    Price, R.N.3
  • 75
    • 77951054683 scopus 로고    scopus 로고
    • Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: An open randomized, noninferiority, trial
    • Apr
    • Awab GR, Pukrittayakamee S, Imwong M, et al. Dihydroartemisinin- piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, noninferiority, trial. Malaria J 2010 Apr 21; 9: 105
    • (2010) Malaria J , vol.21 , Issue.9 , pp. 105
    • Awab, G.R.1    Pukrittayakamee, S.2    Imwong, M.3
  • 76
    • 42549139438 scopus 로고    scopus 로고
    • Adverse pregnancy outcomes in an area where multidrug-resistant Plasmodium vivax and Plasmodium falciparum infections are endemic
    • May 1
    • Poespoprodjo JR, Fobia W, Kenangalem E, et al. Adverse pregnancy outcomes in an area where multidrug-resistant Plasmodium vivax and Plasmodium falciparum infections are endemic. Clin Infect Dis 2008 May 1; 46 (9): 1374-81
    • (2008) Clin Infect Dis , vol.46 , Issue.9 , pp. 1374-1381
    • Poespoprodjo, J.R.1    Fobia, W.2    Kenangalem, E.3
  • 77
    • 45349085248 scopus 로고    scopus 로고
    • Dihydroartemisinin-piperaquine rescue treatment of multidrugresistant Plasmodium falciparum malaria in pregnancy: A preliminary report
    • Rijken MJ, McGready R, Boel ME, et al. Dihydroartemisinin-piperaquine rescue treatment of multidrugresistant Plasmodium falciparum malaria in pregnancy: a preliminary report. AmJ TropMedHyg 2008; 78 (4): 543-5
    • (2008) AmJ Trop Med Hyg , vol.78 , Issue.4 , pp. 543-545
    • Rijken, M.J.1    McGready, R.2    Boel, M.E.3
  • 78
    • 81555206674 scopus 로고    scopus 로고
    • Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria
    • Dec
    • Rijken MJ, McGready R, Phyo AP, et al. Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria. Antimicrob Agents Chemother 2011 Dec; 55 (12): 5500-6
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.12 , pp. 5500-5506
    • Rijken, M.J.1    McGready, R.2    Phyo, A.P.3
  • 79
    • 84858669751 scopus 로고    scopus 로고
    • Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and non-pregnant women with uncomplicated malaria
    • Apr
    • Tarning J, Rijken MJ, McGready R, et al. Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and non-pregnant women with uncomplicated malaria. Antimicrob Agents Chemother 2012 Apr; 56 (4): 1997-2007
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.4 , pp. 1997-2007
    • Tarning, J.1    Rijken, M.J.2    McGready, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.