Identification and validation of tetracyclic benzothiazepines as plasmodium falciparum cytochrome bc 1 inhibitors

Chemistry and Biology

Volumn 18, Issue 12, 2011, Pages 1602-1610

  Dong, Carolyn K ^a   Urgaonkar, Sameer ^b   Cortese, Joseph F ^b   Gamo, Francisco Javier ^c   Garcia Bustos, Jose F ^c   Lafuente, Maria J ^c   Patel, Vishal ^a,d   Ross, Leila ^d   Coleman, Bradley I ^a   Derbyshire, Emily R ^d   Clish, Clary B ^b   Serrano, Adelfa E ^e   Cromwell, Mandy ^f   Barker Jr , Robert H ^f   Dvorin, Jeffrey D ^a,g   Duraisingh, Manoj T ^a   Wirth, Dyann F ^a,b   Clardy, Jon ^b,d   Mazitschek, Ralph ^b,h  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c GLAXOSMITHKLINE   (Spain)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^f GENZYME CORPORATION   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; THIAZEPINE DERIVATIVE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SENSITIVITY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PROTEIN TERTIARY STRUCTURE; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIMALARIALS; ATOVAQUONE; BINDING SITES; ELECTRON TRANSPORT COMPLEX III; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES;

PLASMODIUM FALCIPARUM;

EID: 84555196897     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.09.016     Document Type: Article

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