Validation of isoleucine utilization targets in Plasmodium falciparum

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1627-1632

  Istvan, Eva S ^a   Dharia, Neekesh V ^b   Bopp, Selina E ^b   Gluzman, Ilya ^a   Winzeler, Elizabeth A ^b   Goldberg, Daniel E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; ISOLEUCINE; PSEUDOMONIC ACID; THIAISOLEUCINE; UNCLASSIFIED DRUG;

ALLELE; APICOPLAST; ARTICLE; CHROMOSOME; COPY NUMBER VARIATION; DNA SEQUENCE; DRUG TARGETING; GENE AMPLIFICATION; GENOME ANALYSIS; IC 50; MICROARRAY ANALYSIS; MOLECULAR CLONING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN TARGETING; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ERYTHROCYTES; GENOME, PROTOZOAN; GREEN FLUORESCENT PROTEINS; HEMOGLOBINS; HUMANS; ISOLEUCINE; ISOLEUCINE-TRNA LIGASE; MICROSCOPY, FLUORESCENCE; MUPIROCIN; MUTATION; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS;

PLASMODIUM FALCIPARUM;

EID: 79952162829     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011560108     Document Type: Article

References (24)

1. World Health Organizaton (2008) World Malaria Report 2008 (World Health Organization, Geneva), pp 1-78.
2. Dondorp AM, et al. (2010) Artemisinin resistance: Current status and scenarios for containment. Nat Rev Microbiol 8:272-280.
3. Payne SH, Loomis WF (2006) Retention and loss of amino acid biosynthetic pathways based on analysis of whole-genome sequences. Eukaryot Cell 5:272-276. (Pubitemid 43262014)
4. Liu J, Istvan ES, Gluzman IY, Gross J, Goldberg DE (2006) Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems. Proc Natl Acad Sci USA 103:8840-8845. (Pubitemid 43878106)
5. Ibba M, Soll D (2000) Aminoacyl-tRNA synthesis. Annu Rev Biochem 69:617-650.
6. Pino P, et al. (2010) Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA Met formylation in Apicomplexa. Mol Microbiol 76:706-718.
7. Fichera ME, Bhopale MK, Roos DS (1995) In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondii. Antimicrob Agents Chemother 39:1530-1537.
8. Fennell C, et al. (2009) PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation. Malar J 8:99.
9. Rathod PK, McErlean T, Lee PC (1997) Variations in frequencies of drug resistance in Plasmodium falciparum. Proc Natl Acad Sci USA 94:9389-9393. (Pubitemid 27357839)
10. Dharia NV, et al. (2009) Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol 10:R21.
11. Nureki O, et al. (1998) Enzyme structure with two catalytic sites for double-sieve selection of substrate. Science 280:578-582. (Pubitemid 28227759)
12. Antonio M, McFerran N, Pallen MJ (2002) Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 46:438-442. (Pubitemid 34087193)
13. Paulander W, Maisnier-Patin S, Andersson DI (2007) Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium. Mol Microbiol 64:1038-1048. (Pubitemid 46743967)
14. Klemba M, Beatty W, Gluzman I, Goldberg DE (2004) Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum. J Cell Biol 164:47-56. (Pubitemid 38082456)
15. Zuegge J, Ralph S, Schmuker M, McFadden GI, Schneider G (2001) Deciphering apicoplast targeting signals - feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins. Gene 280:19-26. (Pubitemid 34014880)
16. Aurrecoechea C, et al. (2009) PlasmoDB: A functional genomic database for malaria parasites. Nucleic Acids Res 37(Database issue):D539-D543.
17. Russo I, Oksman A, Goldberg DE (2009) Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Mol Microbiol 72:229-245.
18. Lim L, McFadden GI (2010) The evolution, metabolism and functions of the apicoplast. Philos Trans R Soc Lond B Biol Sci 365:749-763.
19. Nakama T, Nureki O, Yokoyama S (2001) Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. J Biol Chem 276:47387-47393.
20. Thomas CM, Hothersall J, Willis CL, Simpson TJ (2010) Resistance to and synthesis of the antibiotic mupirocin. Nat Rev Microbiol 8:281-289.
21. Busiello V, Di Girolamo M, De Marco C (1979) Thiaisoleucine and protein synthesis. Biochim Biophys Acta 561:206-214. (Pubitemid 9096563)
22. Gamo FJ, et al. (2010) Thousands of chemical starting points for antimalarial lead identification. Nature 465:305-310.
23. Guiguemde WA, et al. (2010) Chemical genetics of Plasmodium falciparum. Nature 465:311-315.
24. Silvian LF, Wang J, Steitz TA (1999) Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. Science 285:1074-1077.