Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 12, 2011, Pages 5740-5745

  Sanz, Laura M ^a   Jiménez Díaz, M Belen ^a   Crespo, Benigno ^a   De Cozar, Cristina ^a   Almela, M Jesus ^a   Angulo Barturen, Iñigo ^a   Castañeda, Pablo ^a   Ibañez, Javier ^a   Fernández, Esther Pilar ^a   Ferrer, Santiago ^a   Herreros, Esperanza ^a   Lozano, Sonia ^a   Martínez, María Santos ^a   Rueda, Lourdes ^d   Burrows, Jeremy N ^b   García Bustos, Jose F ^a,c   Gamo, Francisco Javier ^a  

^a GLAXOSMITHKLINE   (Spain)

^b Medicines for Malaria Venture   (Switzerland)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTIMALARIAL AGENT; ARTEMISININ; ATOVAQUONE; CHLOROQUINE; DOXORUBICIN; GSK 1057714; GSK 2611622; GSK 2645947; GSK 2661685; GSK 2678892; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; BIOLOGICAL TRAIT; CONTROLLED STUDY; CONVULSION; CYTOTOXICITY; DISORIENTATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE DRUG DOSE;

AMIDES; ANIMALS; ANTIMALARIALS; CELL LINE; ERYTHROCYTES; FEMALE; HUMANS; MALARIA, FALCIPARUM; MICE; MICE, INBRED NOD; MICE, SCID; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TREATMENT OUTCOME;

EID: 81555221105     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05188-11     Document Type: Article

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