SCOPUS 정보 검색 플랫폼

Angewandte Chemie - International Edition

Volumn 49, Issue 33, 2010, Pages 5693-5697

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins

(19) O'Neill, Paul M a Amewu, Richard K a Nixon, Gemma L c ElGarah, Fatima Bousejra a Mungthin, Mathirut b Chadwick, James a Shone, Alison E c Vivas, Livia e Lander, Hollie e Barton, Victoria a Muangnoicharoen, Sant c Bray, Patrick G c Davies, Jill c Park, B Kevin a Wittlin, Sergio d Brun, Reto d Preschel, Michael f Zhang, Kesheng f Ward, Stephen A c

a UNIVERSITY OF LIVERPOOL (United Kingdom)

b PHRAMONGKUTKLAO HOSPITAL (Thailand)

c LIVERPOOL SCHOOL OF TROPICAL MEDICINE (United Kingdom)

d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE (Switzerland)

e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (United Kingdom)

f CARBOGEN AMCIS AG (Switzerland)

Author keywords

Antimalarial agents; Drug development; Endoperoxides; Medicinal chemistry; Tetraoxanes

Indexed keywords

ANTIMALARIAL AGENT; ANTIMALARIAL DRUG; ARTEMISININ; COMBINATION THERAPY; DRUG DEVELOPMENT; ENDOPEROXIDES; IN-VITRO; MEDICINAL CHEMISTRY; PRECLINICAL DEVELOPMENT; RESISTANT STRAINS; TETRAOXANE;

ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; RKA 182; SPIRO COMPOUND; TETRAOXANE DERIVATIVE;

ALKYLATION; ARTICLE; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; MOLECULAR LIBRARY; MULTIDRUG RESISTANCE; PLASMODIUM FALCIPARUM; SYNTHESIS;

ALKYLATION; ANTIMALARIALS; ARTEMISININS; DRUG RESISTANCE, MULTIPLE; PLASMODIUM FALCIPARUM; SMALL MOLECULE LIBRARIES; SPIRO COMPOUNDS; TETRAOXANES;

EID: 77955336999 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201001026 Document Type: Article

Times cited : (117)

References (24)

1
- 2542640961
- P. M. O'Neill, G. H. Posner, J. Med. Chem. 2004, 47, 2945.
- (2004) J. Med. Chem. , vol.47 , pp. 2945
- O'Neill, P.M.¹ Posner, G.H.²

2
- 84871613429
- Geneva, World Health Organization, (WHO/CDS/RBM/2001.33).
- Report of a WHO Informal Consultation, Geneva, World Health Organization, 2001 (WHO/CDS/RBM/2001.33).
- (2001) Report of A WHO Informal Consultation

3
- 23944451082
- T. K. Mutabingwa, Acta Trop. 2005, 95, 305.
- (2005) Acta Trop. , vol.95 , pp. 305
- Mutabingwa, T.K.¹

4
- 17844382146
- B. M. Greenwood, K. Bojang, C. J. M. Whitty, G. A. T. Targett, Lancet 2005, 365, 1487.
- (2005) Lancet , vol.365 , pp. 1487
- Greenwood, M.¹ Bojang, K.² Whitty, C.J.M.³ Targett, G.A.T.⁴

5
- 0035208051
- R. K. Haynes, Curr. Opin. Infect. Dis. 2001, 14, 719.
- (2001) Curr. Opin. Infect. Dis. , vol.14 , pp. 719
- Haynes, R.K.¹

6
- 70350545718
- A. M. Dondorp, F. Nosten, N. J. White, N. Engl. J. Med. 2009, 361, 1808.
- (2009) N. Engl. J. Med. , vol.361 , pp. 1808
- Dondorp, A.M.¹ Nosten, F.² White, N.J.³

7
- 2142659388
- a) N. J. White, J. Clin. Invest. 2004, 113, 1084;
- (2004) J. Clin. Invest. , vol.113 , pp. 1084
- White, N.J.¹

8
- 0346705252
- b) J. Wiesner, R. Ortmann, H. Jomaa, M. Schlitzer, Angew. Chem. 2003, 115, 5432;
- (2003) Angew. Chem. , vol.115 , pp. 5432
- Wiesner, J.¹ Ortmann, R.² Jomaa, H.³ Schlitzer, M.⁴

9
- 0344875966
- Angew. Chem. Int. Ed. 2003, 42, 5274.
- (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 5274

10
- 34249012765
- C. W. Jefford, Drug Discovery Today Z 2007, 12, 487.
- (2007) Drug Discovery Today Z , vol.12 , pp. 487
- Jefford, C.W.¹

11
- 4344630762
- J. L. Vennerstrom, S. Arbe-Barnes, R. Brun, S. A. Charman, F. C. Chiu, J. Chollet, Y. Dong, A. Dorn, D. Hunziker, H. Matile, K. McIntosh, M. Padmanilayam, J. Santo Tomas, C. Scheurer, B. Scorneaux, Y. Tang, H. Urwyler, S. Wittlin, W. N. Charman, Nature 2004, 430, 900.
- (2004) Nature , vol.430 , pp. 900
- Vennerstrom, J.L.¹ Arbe-Barnes, S.² Brun, R.³ Charman, S.A.⁴ Chiu, F.C.⁵ Chollet, J.⁶ Dong, Y.⁷ Dorn, A.⁸ Hunziker, D.⁹ Matile K, H.¹⁰ Padmanilayam, M.M.¹¹ Santo Tomas, J.¹² Scheurer, C.¹³ Scorneaux, B.¹⁴ Tang, Y.¹⁵ Urwyler, H.¹⁶ Wittlin, S.¹⁷ Charman, W.N.¹⁸

12
- 67349124872
- a) P. Olliaro, T. N. C. Wells, Clin. Pharmacol. Ther. 2009, 85, 584K;
- (2009) Clin. Pharmacol. Ther. , vol.85
- Olliaro, P.¹ Wells, T.N.C.²

13
- 77955328691
- a second-generation 1,2,4-trioxolane OZ439 is under development with the MMV; see
- b) a second-generation 1,2,4-trioxolane OZ439 is under development with the MMV; see http://www.mmv.org/article.ph-p3?id-article=528.

14
- 41849117634
- For details of amide and amine 1,2,4,5-tetraoxacyclohexanes and steroidal tetraoxanes with antimalarial and exceptional anticancer activity see: a) I. Opsenica, D. Opsenica, K. S. Smith, W. K. Milhous, B. A. Šolaja, J. Med. Chem. 2008, 51, 2261;
- (2008) J. Med. Chem. , vol.51 , pp. 2261
- Opsenica, I.¹ Opsenica, D.² Smith, K.S.³ Milhous, W.K.⁴ Šolaja, B.A.⁵

15
- 41849123835
- b) G. L. Ellis, R. Amewu, S. Sabbani, P. A. Stocks, A. E. Shone, D. Stanford, P. Gibbons, J. Davies, L. Vivas, S. Charnaud, E. Bongard, C. Hall, K. Rimmer, S. L. María Jesús, D. Gargallo, S. A. Ward, P. M. O'Neill, J. Med Chem. 2008, 51, 2170.
- (2008) J. Med Chem. , vol.51 , pp. 2170
- Ellis, G.L.¹ Amewu, R.² Sabbani, S.³ Stocks, P.A.⁴ Shone, A.E.⁵ Stanford, D.⁶ Gibbons, P.⁷ Davies, J.⁸ Vivas, L.⁹ Charnaud, S.¹⁰ Bongard, E.¹¹ Hall, C.¹² Rimmer, K.¹³ María Jesús, S.L.¹⁴ Gargallo, D.¹⁵ Ward, S.A.¹⁶ O'Neill, P.M.¹⁷

16
- 33751564517
- a) R. Amewu, A. V. Stachulski, S. A. Ward, N. G. Berry, P. G. Bray, J. Davies, G. Labat, L. Vivas, P. M. O'Neill, Org. Biomol. Chem. 2006, 4, 4431;
- (2006) Org. Biomol. Chem. , vol.4 , pp. 4431
- Amewu, R.¹ Stachulski, A.V.² Ward, S.A.³ Berry, N.G.⁴ Bray, P.G.⁵ Davies, J.⁶ Labat, G.⁷ Vivas, L.⁸ O'Neill, P.M.⁹

17
- 59649099224
- b) P. Ghorai, P. H. Dussault, Org. Lett. 2009, 11, 213.
- (2009) Org. Lett. , vol.11 , pp. 213
- Ghorai, P.¹ Dussault, P.H.²

18
- 37549039510
- G. M. Sheldrick, Acta. Crystallogr. Sect. A 2008, 64, 112.
- (2008) Acta. Crystallogr. Sect. A , vol.64 , pp. 112
- Sheldrick, G.M.¹

19
- 2142640849
- M. Smilkstein, N. Sriwilaijaroen, J. X. Kelly, P. Wilairat, M. Riscoe, Antimicrob. Agents Chemother. 2004, 48, 1803.
- (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 1803
- Smilkstein, M.¹ Sriwilaijaroen, N.² Kelly, J.X.³ Wilairat, P.⁴ Riscoe, M.⁵

20
- 0036742376
- W. Peters, S. L. Fleck, B. L. Robinson, L. B. Stewart, C. W. Jefford, Ann. Trop. Med. Parasitol. 2002, 96, 559.
- (2002) Ann. Trop. Med. Parasitol. , vol.96 , pp. 559
- Peters, W.¹ Fleck, S.L.² Robinson, B.L.³ Stewart, L.B.⁴ Jefford, C.W.⁵

21
- 33749493418
- R. K. Haynes, B. Fugmann, J. Stetter, K. Rieckmann, H. D. Heilmann, H. W. Chan, M. K. Cheung, W. L. Lam, H. N. Wong, S. L. Croft, L. Vivas, L. Rattray, L. Stewart, W. Peters, B. L. Robinson, M. D. Edstein, B. Kotecka, D. E. Kyle, B. Beckermann, M. Gerisch, M. Radtke, G. Schmuck, W. Steinke, U. Wollborn, K. Schmeer, A. Romer, Angew. Chem. 2006, 118, 2136;
- (2006) Angew. Chem. , vol.118 , pp. 2136
- Haynes, R.K.¹ Fugmann, B.² Stetter, J.³ Rieckmann, K.⁴ Heilmann, H.D.⁵ Chan, H.W.⁶ Cheung, M.K.⁷ Lam, W.L.⁸ Wong, H.N.⁹ Croft, S.L.¹⁰ Vivas, L.¹¹ Rattray, L.¹² Stewart, L.¹³ Peters, W.¹⁴ Robinson, B.L.¹⁵ Edstein, M.D.¹⁶ Kotecka, B.¹⁷ Kyle, D.E.¹⁸ Beckermann, B.¹⁹ Gerisch, M.²⁰ more..

22
- 33745975677
- Angew. Chem. Int. Ed. 2006, 45, 2082.
- (2006) Angew. Chem. Int. Ed. , vol.45 , pp. 2082

23
- 0000678481
- A. Robert, J. Cazelles, B. Meunier, Angew. Chem. 2001, 113, 2008;
- (2001) Angew. Chem. , vol.113 , pp. 2008
- Robert, A.¹ Cazelles, J.² Meunier, B.³

24
- 0035906935
- Angew. Chem. Int. Ed. 2001, 40, 1954.
- (2001) Angew. Chem. Int. Ed. , vol.40 , pp. 1954

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.