Optimization of endochin-like quinolones for antimalarial activity

Experimental Parasitology

Volumn 127, Issue 2, 2011, Pages 545-551

  Winter, Rolf ^a,b   Kelly, Jane X ^a,b   Smilkstein, Martin J ^a   Hinrichs, David ^a,c   Koop, Dennis R ^c   Riscoe, Michael K ^a,b,c  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b PORTLAND STATE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chemotherapy; Cytochrome bc1 complex; Drug resistance; Electron transport chain; Inhibitors; Malaria; Plasmodium falciparum; Prodrug

Indexed keywords

2 HYDROXY 7 METHOXY 4 QUINOLONE; 2 METHYL 3 (N HEPTYL) 5,7 DIFLUOROQUINOLONE; 6 CHLORO 2 METHYL 3 (N HEPTYL) QUINOLONE; ELQ 100; ELQ 102; ELQ 103; ELQ 106; ELQ 107; ELQ 109; ELQ 110; ELQ 114; ELQ 115; ELQ 117; ELQ 118; ELQ 119; ELQ 120; ELQ 121; ELQ 122; ELQ 124; ELQ 125; ELQ 127; ELQ 129; ELQ 130; ELQ 131; ELQ 132; ELQ 133; ELQ 134; ENDOCHIN LIKE QUINOLONE 100; ENDOCHIN LIKE QUINOLONE 102; ENDOCHIN LIKE QUINOLONE 103; ENDOCHIN LIKE QUINOLONE 107; ENDOCHIN LIKE QUINOLONE 109; ENDOCHIN LIKE QUINOLONE 110; ENDOCHIN LIKE QUINOLONE 115; ENDOCHIN LIKE QUINOLONE 117; ENDOCHIN LIKE QUINOLONE 118; ENDOCHIN LIKE QUINOLONE 119; ENDOCHIN LIKE QUINOLONE 120; ENDOCHIN LIKE QUINOLONE 122; ENDOCHIN LIKE QUINOLONE 124; ENDOCHIN LIKE QUINOLONE 125; ENDOCHIN LIKE QUINOLONE 127; ENDOCHIN LIKE QUINOLONE 129; ENDOCHIN LIKE QUINOLONE 131; ENDOCHIN LIKE QUINOLONE 132; ENDOCHIN LIKE QUINOLONE 133; ENDOCHIN LIKE QUINOLONE 134; ENDOCHIN LIKE QUINOLONE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII INFECTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; DRUG STABILITY; FEMALE; HUMANS; MALARIA; MICE; MICROSOMES, LIVER; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; QUINOLONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA; MURINAE; PLASMODIUM FALCIPARUM; RATTUS;

EID: 78751575820     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.10.016     Document Type: Article

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