A divergent SAR study allows optimization of a potent 5-HT2c inhibitor to a promising antimalarial scaffold

ACS Medicinal Chemistry Letters

Volumn 3, Issue 5, 2012, Pages 373-377

  Calderón, Félix ^a   Vidal Mas, Jaume ^a   Burrows, Jeremy ^b   De La Rosa, Juan Carlos ^a   Jiménez Díaz, María Belén ^a   Mulet, Teresa ^a   Prats, Sara ^a   Solana, Jorge ^a   Witty, Michael ^b   Gamo, Francisco Javier ^a   Fernández, Esther ^a  

^a GLAXOSMITHKLINE   (Spain)

^b Medicines for Malaria Venture MMV   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ATOVAQUONE; CHLOROQUINE; INDOLINE DERIVATIVE; PYRIMETHAMINE; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CYTOTOXICITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STABILITY; HUMAN; HUMAN CELL; IC 50; MICROSOME; MOUSE; NONHUMAN; PHENOTYPE; PHYSICAL CHEMISTRY; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 84861086281     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300008j     Document Type: Article

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