메뉴 건너뛰기




Volumn 19, Issue 2, 2013, Pages 168-178

Immune mechanisms in malaria: New insights in vaccine development

Author keywords

[No Author keywords available]

Indexed keywords

CIRCUMSPOROZOITE PROTEIN; MALARIA VACCINE;

EID: 84873564071     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3083     Document Type: Review
Times cited : (157)

References (131)
  • 2
    • 84856679687 scopus 로고    scopus 로고
    • Global Malaria Mortality Between 1980 and 2010: A systematic analysis
    • Murray, C.J. et al. Global malaria mortality between 1980 and 2010: A systematic analysis. Lancet 379, 413-431 (2012
    • (2012) Lancet , vol.379 , Issue.413-431
    • Murray, C.J.1
  • 3
    • 79953031598 scopus 로고    scopus 로고
    • Malaria in pregnancy: Small babies, big problem
    • Umbers, A.J., Aitken, E.H. & Rogerson, S.J. Malaria in pregnancy: Small babies, big problem. Trends Parasitol. 27, 168-175 (2011
    • (2011) Trends Parasitol , vol.27 , pp. 168-175
    • Umbers, A.J.1    Aitken, E.H.2    Rogerson, S.J.3
  • 5
    • 80054973132 scopus 로고    scopus 로고
    • Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
    • O'Brien, C., Henrich, P.P., Passi, N. & Fidock, D.A. Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Curr. Opin. Infect. Dis. 24, 570-577 (2011
    • (2011) Curr. Opin. Infect. Dis , vol.24 , pp. 570-577
    • O'Brien, C.1    Henrich, P.P.2    Passi, N.3    Fidock, D.A.4
  • 6
    • 79959773283 scopus 로고    scopus 로고
    • Target identification and validation of novel antimalarials
    • McNamara, C. & Winzeler, E.A. Target identification and validation of novel antimalarials. Future Microbiol. 6, 693-704 (2011
    • (2011) Future Microbiol , vol.6 , pp. 693-704
    • McNamara, C.1    Winzeler, E.A.2
  • 7
    • 77957985070 scopus 로고    scopus 로고
    • Pyrethroid resistance in African anopheline mosquitoes: What are the implications for malaria control
    • Ranson, H. et al. Pyrethroid resistance in African anopheline mosquitoes: What are the implications for malaria control? Trends Parasitol. 27, 91-98 (2011
    • (2011) Trends Parasitol , vol.27 , pp. 91-98
    • Ranson, H.1
  • 8
    • 79955069542 scopus 로고    scopus 로고
    • Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
    • Bousema, T. & Drakeley, C. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin. Microbiol. Rev. 24, 377-410 (2011
    • (2011) Clin. Microbiol. Rev , vol.24 , pp. 377-410
    • Bousema, T.1    Drakeley, C.2
  • 9
    • 84873534759 scopus 로고    scopus 로고
    • Malaria vaccine technology roadmap
    • Malaria Vaccine Technology Roadmap
    • Malaria Vaccine Technology Roadmap. Malaria vaccine technology roadmap. PATH Malaria Vaccine Initiative. (2006
    • (2006) PATH Malaria Vaccine Initiative
  • 10
    • 84873534850 scopus 로고    scopus 로고
    • Malaria strategy overview
    • Bill and Melinda Gates Foundation
    • Bill and Melinda Gates Foundation. Malaria strategy overview. Bill and Melinda Gates Foundation. (2011
    • (2011) Bill and Melinda Gates Foundation
  • 11
    • 81455154875 scopus 로고    scopus 로고
    • First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children
    • Agnandji, S.T. et al. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N. Engl. J. Med. 365, 1863-1875 (2011
    • (2011) N. Engl. J. Med , vol.36 , pp. 1863-1875
    • Agnandji, S.T.1
  • 12
    • 84871037616 scopus 로고    scopus 로고
    • A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants
    • RTS,S Clinical Trials Partnership
    • RTS,S Clinical Trials Partnership. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N. Engl. J. Med. 367, 2284-2295 (2012
    • (2012) N. Engl. J. Med , vol.367 , pp. 2284-2295
  • 13
    • 84873551273 scopus 로고    scopus 로고
    • Public health challenges and prospects for malaria control and elimination
    • Alonso, P.L. & Tanner, M. Public health challenges and prospects for malaria control and elimination. Nat. Med. 19, 150-155 (2013
    • (2013) Nat. Med , vol.19 , pp. 150-155
    • Alonso, P.L.1    Tanner, M.2
  • 15
    • 79955086319 scopus 로고    scopus 로고
    • Recent clinical experience with vaccines using MPLand QS-21-containing adjuvant systems
    • Garçon, N. & Van Mechelen, M. Recent clinical experience with vaccines using MPLand QS-21-containing adjuvant systems. Expert Rev. Vaccines 10, 471-486 (2011
    • (2011) Expert Rev. Vaccines , vol.10 , pp. 471-486
    • Garçon, N.1    Van Mechelen, M.2
  • 17
    • 67650699591 scopus 로고    scopus 로고
    • Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: Safety, efficacy, and immunologic associates of protection
    • Kester, K.E. et al. Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: Safety, efficacy, and immunologic associates of protection. J. Infect. Dis. 200, 337-346 (2009
    • (2009) J. Infect. Dis , vol.200 , pp. 337-346
    • Kester, K.E.1
  • 20
    • 80053602298 scopus 로고    scopus 로고
    • Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria
    • Olotu, A. et al. Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria. PLoS ONE 6, e25786 (2011
    • (2011) PLoS ONE , vol.6
    • Olotu, A.1
  • 21
    • 79955687298 scopus 로고    scopus 로고
    • T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children
    • Ansong, D. et al. T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. PLoS ONE 6, e18891 (2011
    • (2011) PLoS ONE , vol.6
    • Ansong, D.1
  • 22
    • 79960149284 scopus 로고    scopus 로고
    • Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells
    • Lumsden, J.M. et al. Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells. PLoS ONE 6, e20775 (2011
    • (2011) PLoS ONE , vol.6
    • Lumsden, J.M.1
  • 23
    • 79954536974 scopus 로고    scopus 로고
    • Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/ AS02(D
    • Agnandji, S.T. et al. Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/ AS02(D). PLoS ONE 6, e18559 (2011
    • (2011) PLoS ONE , vol.6
    • Agnandji, S.T.1
  • 24
    • 84861131748 scopus 로고    scopus 로고
    • Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine
    • Horowitz, A. et al. Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine. J. Immunol. 188, 5054-5062 (2012
    • (2012) J. Immunol , vol.188 , pp. 5054-5062
    • Horowitz, A.1
  • 26
    • 70249147675 scopus 로고    scopus 로고
    • A matter of timing: Unsynchronized antigen expression and antigen presentation diminish secondary T cell responses
    • Elnekave, M., Bivas-Benita, M., Gillard, G.O., Sircar, P. & Hovav, A.H. A matter of timing: Unsynchronized antigen expression and antigen presentation diminish secondary T cell responses. J. Immunol. 183, 1013-1021 (2009
    • (2009) J. Immunol , vol.183 , pp. 1013-1021
    • Elnekave, M.1    Bivas-Benita, M.2    Gillard, G.O.3    Sircar, P.4    Hovav, A.H.5
  • 27
    • 57649123026 scopus 로고    scopus 로고
    • Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants
    • Abdulla, S. et al. Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants. N. Engl. J. Med. 359, 2533-2544 (2008
    • (2008) N. Engl. J. Med , vol.359 , pp. 2533-2544
    • Abdulla, S.1
  • 28
    • 77956195618 scopus 로고    scopus 로고
    • Early signals during CD8 T cell priming regulate the generation of central memory cells
    • Obar, J.J. & Lefrancois, L. Early signals during CD8 T cell priming regulate the generation of central memory cells. J. Immunol. 185, 263-272 (2010
    • (2010) J. Immunol , vol.185 , pp. 263-272
    • Obar, J.J.1    Lefrancois, L.2
  • 29
    • 79251588705 scopus 로고    scopus 로고
    • Increased memory conversion of naive CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure
    • Fousteri, G. et al. Increased memory conversion of naive CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure. PLoS ONE 6, e14502 (2011
    • (2011) PLoS ONE , vol.6
    • Fousteri, G.1
  • 30
    • 79951786622 scopus 로고    scopus 로고
    • Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection
    • Croom, H.A. et al. Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection. Eur. J. Immunol. 41, 682-693 (2011
    • (2011) Eur. J. Immunol , vol.41 , pp. 682-693
    • Croom, H.A.1
  • 33
    • 57649115306 scopus 로고    scopus 로고
    • Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    • Bejon, P. et al. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N. Engl. J. Med. 359, 2521-2532 (2008
    • (2008) N. Engl. J. Med , vol.359 , pp. 2521-2532
    • Bejon, P.1
  • 34
    • 67650697101 scopus 로고    scopus 로고
    • Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children
    • Sacarlal, J. et al. Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children. J. Infect. Dis. 200, 329-336 (2009
    • (2009) J. Infect. Dis , vol.200 , pp. 329-336
    • Sacarlal, J.1
  • 35
    • 79960710582 scopus 로고    scopus 로고
    • Four year immunogenicity of the RTS,S/AS02(A) malaria vaccine in Mozambican children during a phase IIb trial
    • Aide, P. et al. Four year immunogenicity of the RTS,S/AS02(A) malaria vaccine in Mozambican children during a phase IIb trial. Vaccine 29, 6059-6067 (2011
    • (2011) Vaccine , vol.29 , pp. 6059-6067
    • Aide, P.1
  • 36
    • 37649005088 scopus 로고    scopus 로고
    • How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions?
    • Sutherland, C.J., Drakeley, C.J. & Schellenberg, D. How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions? Malar. J. 6, 161 (2007
    • (2007) Malar. J. , vol.6 , pp. 161
    • Sutherland, C.J.1    Drakeley, C.J.2    Schellenberg, D.3
  • 37
    • 68949126830 scopus 로고    scopus 로고
    • Genetic diversity and malaria vaccine design testing and efficacy: Preventing and overcoming 'vaccine resistant malaria
    • Takala, S.L. & Plowe, C.V. Genetic diversity and malaria vaccine design, testing and efficacy: Preventing and overcoming 'vaccine resistant malaria'. Parasite Immunol. 31, 560-573 (2009
    • (2009) Parasite Immunol , vol.31 , pp. 560-573
    • Takala, S.L.1    Plowe, C.V.2
  • 38
    • 77953959679 scopus 로고    scopus 로고
    • Detecting signatures of balancing selection to identify targets of anti-parasite immunity
    • Weedall, G.D. & Conway, D.J. Detecting signatures of balancing selection to identify targets of anti-parasite immunity. Trends Parasitol. 26, 363-369 (2010
    • (2010) Trends Parasitol , vol.26 , pp. 363-369
    • Weedall, G.D.1    Conway, D.J.2
  • 40
    • 77952370937 scopus 로고    scopus 로고
    • The selection landscape of malaria parasites
    • Mackinnon, M.J. & Marsh, K. The selection landscape of malaria parasites. Science 328, 866-871 (2010
    • (2010) Science , vol.328 , pp. 866-871
    • Mackinnon, M.J.1    Marsh, K.2
  • 41
    • 43449088222 scopus 로고    scopus 로고
    • Chapter 1 strain theory of malaria. The first 50 years
    • DOI 10.1016/S0065-308X(08)00201-7, PII S0065308X08002017
    • McKenzie, F.E., Smith, D.L., O'Meara, W.P. & Riley, E.M. Strain theory of malaria: The first 50 years. Adv. Parasitol. 66, 1-46 (2008 (Pubitemid 351672128)
    • (2008) Advances in Parasitology , vol.66 , pp. 1-46
    • McKenzie, F.E.1    Smith, D.L.2    O'Meara, W.P.3    Riley, E.M.4
  • 42
    • 67349177230 scopus 로고    scopus 로고
    • Genetics of antigenic variation in Plasmodium falciparum
    • Dzikowski, R. & Deitsch, K.W. Genetics of antigenic variation in Plasmodium falciparum. Curr. Genet. 55, 103-110 (2009
    • (2009) Curr. Genet , vol.55 , pp. 103-110
    • Dzikowski, R.1    Deitsch, K.W.2
  • 43
    • 63049136021 scopus 로고    scopus 로고
    • PfEMP1 an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum
    • Pasternak, N.D. & Dzikowski, R. PfEMP1: An antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum. Int. J. Biochem. Cell Biol. 41, 1463-1466 (2009
    • (2009) Int. J. Biochem. Cell Biol , vol.41 , pp. 1463-1466
    • Pasternak, N.D.1    Dzikowski, R.2
  • 44
    • 79951787290 scopus 로고    scopus 로고
    • A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa
    • Chen, D.S. et al. A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa. PLoS ONE 6, e16629 (2011
    • (2011) PLoS ONE , vol.6
    • Chen, D.S.1
  • 45
    • 0032977856 scopus 로고    scopus 로고
    • Immunity to non-cerebral severe malaria is acquired after one or two infections
    • DOI 10.1038/6560
    • Gupta, S., Snow, R.W., Donnelly, C.A., Marsh, K. & Newbold, C. Immunity to noncerebral severe malaria is acquired after one or two infections. Nat. Med. 5, 340-343 (1999 (Pubitemid 29124373)
    • (1999) Nature Medicine , vol.5 , Issue.3 , pp. 340-343
    • Gupta, S.1    Snow, R.W.2    Donnelly, C.A.3    Marsh, K.4    Newbold, C.5
  • 46
    • 70449714156 scopus 로고    scopus 로고
    • Submicroscopic infection in Plasmodium falciparum-endemic populations: A systematic review and meta-analysis
    • Okell, L.C., Ghani, A.C., Lyons, E. & Drakeley, C.J. Submicroscopic infection in Plasmodium falciparum-endemic populations: A systematic review and meta-analysis. J. Infect. Dis. 200, 1509-1517 (2009
    • (2009) J. Infect. Dis , vol.200 , pp. 1509-1517
    • Okell, L.C.1    Ghani, A.C.2    Lyons, E.3    Drakeley, C.J.4
  • 48
    • 75449098696 scopus 로고    scopus 로고
    • Regulatory T cells in malaria-friend or foe
    • Finney, O.C., Riley, E.M. & Walther, M. Regulatory T cells in malaria - friend or foe? Trends Immunol. 31, 63-70 (2010
    • (2010) Trends Immunol , vol.31 , pp. 63-70
    • Finney, O.C.1    Riley, E.M.2    Walther, M.3
  • 49
    • 77954037319 scopus 로고    scopus 로고
    • Natural regulatory T cells in malaria: Host or parasite allies
    • Hansen, D.S. & Schofield, L. Natural regulatory T cells in malaria: Host or parasite allies? PLoS Pathog. 6, e1000771 (2010
    • (2010) PLoS Pathog , vol.6
    • Hansen, D.S.1    Schofield, L.2
  • 50
    • 0030867933 scopus 로고    scopus 로고
    • Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood
    • Sidjanski, S. & Vanderberg, J.P. Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood. Am. J. Trop. Med. Hyg. 57, 426-429 (1997 (Pubitemid 27439113)
    • (1997) American Journal of Tropical Medicine and Hygiene , vol.57 , Issue.4 , pp. 426-429
    • Sidjanski, S.1    Vanderberg, J.P.2
  • 51
    • 57549095016 scopus 로고    scopus 로고
    • Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites
    • Gilson, P.R. & Crabb, B.S. Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites. Int. J. Parasitol. 39, 91-96 (2009
    • (2009) Int. J. Parasitol , vol.39 , pp. 91-96
    • Gilson, P.R.1    Crabb, B.S.2
  • 53
    • 84861714135 scopus 로고    scopus 로고
    • Innate recognition of malarial parasites by mammalian hosts
    • Liehl, P. & Mota, M.M. Innate recognition of malarial parasites by mammalian hosts. Int. J. Parasitol. 42, 557-566 (2012
    • (2012) Int. J. Parasitol , vol.42 , pp. 557-566
    • Liehl, P.1    Mota, M.M.2
  • 54
    • 0027434885 scopus 로고
    • Induction of hepatic inflammatory response by Plasmodium berghei sporozoites protects BALB/c mice against challenge with Plasmodium yoelii sporozoites
    • DOI 10.2307/3283617
    • Vanderberg, J.P., Khan, Z.M. & Stewart, M.J. Induction of hepatic inflammatory response by Plasmodium berghei sporozoites protects BALB/c mice against challenge with Plasmodium yoelii sporozoites. J. Parasitol. 79, 763-767 (1993 (Pubitemid 23333670)
    • (1993) Journal of Parasitology , vol.79 , Issue.5 , pp. 763-767
    • Vanderberg, J.P.1    Khan, Z.M.2    Stewart, M.J.3
  • 55
    • 0026710423 scopus 로고
    • Specific inflammatory cell infiltration of hepatic schizonts in BALB/c mice immunized with attenuated Plasmodium yoelii sporozoites
    • Khan, Z.M. & Vanderberg, J.P. Specific inflammatory cell infiltration of hepatic schizonts in BALB/c mice immunized with attenuated Plasmodium yoelii sporozoites. Int. Immunol. 4, 711-718 (1992
    • (1992) Int. Immunol , vol.4 , pp. 711-718
    • Khan, Z.M.1    Vanderberg, J.P.2
  • 57
    • 0030607413 scopus 로고    scopus 로고
    • Release of malaria circumsporozoite protein into the host cell cytoplasm and interaction with ribosomes
    • DOI 10.1016/0166-6851(96)02701-6
    • Hügel, F.U., Pradel, G. & Frevert, U. Release of malaria circumsporozoite protein into the host cell cytoplasm and interaction with ribosomes. Mol. Biochem. Parasitol. 81, 151-170 (1996 (Pubitemid 26316557)
    • (1996) Molecular and Biochemical Parasitology , vol.81 , Issue.2 , pp. 151-170
    • Hugel, F.-U.1    Pradel, G.2    Frevert, U.3
  • 59
    • 68149092706 scopus 로고    scopus 로고
    • Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area
    • Polhemus, M.E. et al. Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area. PLoS ONE 4, e6465 (2009
    • (2009) PLoS ONE , vol.4
    • Polhemus, M.E.1
  • 61
    • 33846043474 scopus 로고    scopus 로고
    • Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2
    • Dondorp, A.M. et al. Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med. 2, e204 (2005
    • (2005) PLoS Med , vol.2
    • Dondorp, A.M.1
  • 62
    • 84855550090 scopus 로고    scopus 로고
    • Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization
    • Cunnington, A.J., de Souza, J.B., Walther, M. & Riley, E.M. Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nat. Med. 18, 120-127 (2012
    • (2012) Nat. Med , vol.18 , pp. 120127
    • Cunnington, A.J.1    De Souza, J.B.2    Walther, M.3    Riley, E.M.4
  • 63
    • 80052466750 scopus 로고    scopus 로고
    • The company malaria keeps: How coinfection with Epstein-Barr virus leads to endemic Burkitt lymphoma
    • Moormann, A.M., Snider, C.J. & Chelimo, K. The company malaria keeps: How coinfection with Epstein-Barr virus leads to endemic Burkitt lymphoma. Curr. Opin. Infect. Dis. 24, 435-441 (2011
    • (2011) Curr. Opin. Infect. Dis , vol.24 , pp. 435-441
    • Moormann, A.M.1    Snider, C.J.2    Chelimo, K.3
  • 64
    • 84855494087 scopus 로고    scopus 로고
    • A review of malaria vaccine clinical projects based on the WHO rainbow table
    • Schwartz, L., Brown, G.V., Genton, B. & Moorthy, V.S. A review of malaria vaccine clinical projects based on the WHO rainbow table. Malar. J. 11, 11 (2012
    • (2012) Malar. J. , vol.11 , Issue.11
    • Schwartz, L.1    Brown, G.V.2    Genton, B.3    Moorthy, V.S.4
  • 65
    • 85011697987 scopus 로고    scopus 로고
    • A research agenda for malaria eradication: Vaccines
    • The malERA Consultative Group on Vaccines
    • The malERA Consultative Group on Vaccines. A research agenda for malaria eradication: Vaccines. PLoS Med. 8, e1000398 (2011
    • (2011) PLoS Med , vol.8
  • 66
    • 78650219138 scopus 로고    scopus 로고
    • Plasmodium immunomics
    • Doolan, D.L. Plasmodium immunomics. Int. J. Parasitol. 41, 3-20 (2011
    • (2011) Int. J. Parasitol , vol.41 , pp. 3-20
    • Doolan, D.L.1
  • 67
    • 72849137064 scopus 로고    scopus 로고
    • The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria
    • Plowe, C.V., Alonso, P. & Hoffman, S.L. The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria. J. Infect. Dis. 200, 1646-1649 (2009
    • (2009) J. Infect. Dis , vol.200 , pp. 1646-1649
    • Plowe, C.V.1    Alonso, P.2    Hoffman, S.L.3
  • 68
    • 79956336419 scopus 로고    scopus 로고
    • Arrested Plasmodium liver stages as experimental anti-malaria vaccines
    • Matuschewski, K., Hafalla, J.C., Borrmann, S. & Friesen, J. Arrested Plasmodium liver stages as experimental anti-malaria vaccines. Hum. Vaccin. (suppl. 7), 16-21 (2011
    • (2011) Hum. Vaccin. , Issue.SUPPL. 7 , pp. 16-21
    • Matuschewski, K.1    Hafalla, J.C.2    Borrmann, S.3    Friesen, J.4
  • 69
    • 34548019006 scopus 로고    scopus 로고
    • T cell memory in malaria
    • DOI 10.1016/j.coi.2007.05.008, PII S0952791507001033
    • Cockburn, I.A. & Zavala, F. T cell memory in malaria. Curr. Opin. Immunol. 19, 424- 429 (2007 (Pubitemid 47284854)
    • (2007) Current Opinion in Immunology , vol.19 , Issue.4 , pp. 424-429
    • Cockburn, I.A.1    Zavala, F.2
  • 70
    • 34548276242 scopus 로고    scopus 로고
    • + T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes
    • DOI 10.1038/nm1628, PII NM1628
    • Chakravarty, S. et al. CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat. Med. 13, 1035-1041 (2007 (Pubitemid 47517509)
    • (2007) Nature Medicine , vol.13 , Issue.9 , pp. 1035-1041
    • Chakravarty, S.1    Cockburn, I.A.2    Kuk, S.3    Overstreet, M.G.4    Sacci, J.B.5    Zavala, F.6
  • 71
    • 79953268563 scopus 로고    scopus 로고
    • Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo
    • Cockburn, I.A. et al. Dendritic cells and hepatocytes use distinct pathways to process protective antigen from Plasmodium in vivo. PLoS Pathog. 7, e1001318 (2011
    • (2011) PLoS Pathog , vol.7
    • Cockburn, I.A.1
  • 72
    • 79956336419 scopus 로고    scopus 로고
    • Arrested Plasmodium liver stages as experimental anti-malaria vaccines
    • Matuschewski, K., Hafalla, J.C., Borrmann, S. & Friesen, J. Arrested Plasmodium liver stages as experimental anti-malaria vaccines. Hum. Vaccin. (suppl. 7), 16-21 (2011
    • (2011) Hum. Vaccin. , vol.16-21 , Issue.SUPPL. 7
    • Matuschewski, K.1    Hafalla, J.C.2    Borrmann, S.3    Friesen, J.4
  • 73
    • 84857066230 scopus 로고    scopus 로고
    • Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites
    • Weiss, W.R. & Jiang, C.G. Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites. PLoS ONE 7, e31247 (2012
    • (2012) PLoS ONE , vol.7
    • Weiss, W.R.1    Jiang, C.G.2
  • 74
    • 84862790662 scopus 로고    scopus 로고
    • Malaria parasite pre-erythrocytic infection: Preparation meets opportunity
    • Lindner, S.E., Miller, J.L. & Kappe, S.H. Malaria parasite pre-erythrocytic infection: Preparation meets opportunity. Cell. Microbiol. 14, 316-324 (2012
    • (2012) Cell. Microbiol , vol.14 , pp. 316-324
    • Lindner, S.E.1    Miller, J.L.2    Kappe, S.H.3
  • 75
    • 74949088116 scopus 로고    scopus 로고
    • Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria
    • Hoffman, S.L. et al. Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria. Hum. Vaccin. 6, 97-106 (2010
    • (2010) Hum. Vaccin , vol.6 , pp. 97-106
    • Hoffman, S.L.1
  • 76
    • 74949087025 scopus 로고    scopus 로고
    • Genetically engineered, attenuated whole-cell vaccine approaches for malaria
    • Vaughan, A.M., Wang, R. & Kappe, S.H. Genetically engineered, attenuated whole-cell vaccine approaches for malaria. Hum. Vaccin. 6, 107-113 (2010
    • (2010) Hum. Vaccin , vol.6 , pp. 107-113
    • Vaughan, A.M.1    Wang, R.2    Kappe, S.H.3
  • 77
    • 80055087402 scopus 로고    scopus 로고
    • Live attenuated malaria vaccine designed to protect through hepatic CD8 T cell immunity
    • Epstein, J.E. et al. Live attenuated malaria vaccine designed to protect through hepatic CD8 T cell immunity. Science 334, 475-480 (2011
    • (2011) Science , vol.334 , pp. 475-480
    • Epstein, J.E.1
  • 78
    • 84863730212 scopus 로고    scopus 로고
    • Attenuated vaccines can recombine to form virulent field viruses
    • Lee, S.W. et al. Attenuated vaccines can recombine to form virulent field viruses. Science 337, 188 (2012
    • (2012) Science , vol.337 , Issue.188
    • Lee, S.W.1
  • 80
    • 80052857926 scopus 로고    scopus 로고
    • A field trial to assess a blood-stage malaria vaccine
    • Thera, M.A. et al. A field trial to assess a blood-stage malaria vaccine. N. Engl. J. Med. 365, 1004-1013 (2011
    • (2011) N. Engl. J. Med , vol.365 , pp. 1004-1013
    • Thera, M.A.1
  • 81
    • 12344261912 scopus 로고    scopus 로고
    • The importance of the spleen in malaria
    • DOI 10.1016/j.pt.2004.11.008, PII S1471492204002946
    • Engwerda, C.R., Beattie, L. & Amante, F.H. The importance of the spleen in malaria. Trends Parasitol. 21, 75-80 (2005 (Pubitemid 40138879)
    • (2005) Trends in Parasitology , vol.21 , Issue.2 , pp. 75-80
    • Engwerda, C.R.1    Beattie, L.2    Amante, F.H.3
  • 82
    • 84455194899 scopus 로고    scopus 로고
    • The blood-stage malaria antigen PfRH5 is susceptible to vaccineinducible cross-strain neutralizing antibody
    • Douglas, A.D. et al. The blood-stage malaria antigen PfRH5 is susceptible to vaccineinducible cross-strain neutralizing antibody. Nat. Commun. 2, 601 (2011
    • (2011) Nat. Commun , vol.2 , Issue.601
    • Douglas, A.D.1
  • 83
    • 84355161568 scopus 로고    scopus 로고
    • Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
    • Crosnier, C. et al. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature 480, 534-537 (2011
    • (2011) Nature , vol.480 , pp. 534-537
    • Crosnier, C.1
  • 84
    • 84455202275 scopus 로고    scopus 로고
    • Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
    • Tham, W.H., Healer, J. & Cowman, A.F. Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum. Trends Parasitol. 28, 23-30 (2012
    • (2012) Trends Parasitol , vol.28 , pp. 23-30
    • Tham, W.H.1    Healer, J.2    Cowman, A.F.3
  • 85
    • 8144224632 scopus 로고
    • γ-Globulin and acquired immunity to human malaria
    • Cohen, S., Mc, G.I. & Carrington, S. γ-globulin and acquired immunity to human malaria. Nature 192, 733-737 (1961
    • (1961) Nature , vol.192 , pp. 733-737
    • Cohen, S.1    Mc, G.I.2    Carrington, S.3
  • 86
    • 0025953526 scopus 로고
    • Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria
    • Sabchareon, A. et al. Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am. J. Trop. Med. Hyg. 45, 297-308 (1991
    • (1991) Am. J. Trop. Med. Hyg , vol.45 , pp. 297-308
    • Sabchareon, A.1
  • 87
    • 75749098881 scopus 로고    scopus 로고
    • The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    • Fowkes, F.J., Richards, J.S., Simpson, J.A. & Beeson, J.G. The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis. PLoS Med. 7, e1000218 (2010
    • (2010) PLoS Med , vol.7
    • Fowkes, F.J.1    Richards, J.S.2    Simpson, J.A.3    Beeson, J.G.4
  • 89
    • 0024993203 scopus 로고
    • Production by activated human T cells of interleukin 4 but not interferon-γ is associated with elevated levels of serum antibodies to activating malaria antigens
    • Troye-Blomberg, M. et al. Production by activated human T cells of interleukin 4 but not interferon-γ is associated with elevated levels of serum antibodies to activating malaria antigens. Proc. Natl. Acad. Sci. USA 87, 5484-5488 (1990
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5484-5488
    • Troye-Blomberg, M.1
  • 90
    • 84855291335 scopus 로고    scopus 로고
    • Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans
    • Teirlinck, A.C. et al. Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog. 7, e1002389 (2011
    • (2011) PLoS Pathog , vol.7
    • Teirlinck, A.C.1
  • 91
    • 40749135431 scopus 로고    scopus 로고
    • Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers
    • Huaman, M.C. et al. Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers. J. Immunol. 180, 1451-1461 (2008
    • (2008) J. Immunol , vol.180 , pp. 1451-1461
    • Huaman, M.C.1
  • 93
    • 45549097494 scopus 로고    scopus 로고
    • Immunity to malaria: More questions than answers
    • DOI 10.1038/ni.f.205, PII NI.F.205
    • Langhorne, J., Ndungu, F.M., Sponaas, A.M. & Marsh, K. Immunity to malaria: More questions than answers. Nat. Immunol. 9, 725-732 (2008 (Pubitemid 351859155)
    • (2008) Nature Immunology , vol.9 , Issue.7 , pp. 725-732
    • Langhorne, J.1    Ndungu, F.M.2    Sponaas, A.-M.3    Marsh, K.4
  • 95
    • 68049143479 scopus 로고    scopus 로고
    • Protection against a malaria challenge by sporozoite inoculation
    • Roestenberg, M. et al. Protection against a malaria challenge by sporozoite inoculation. N. Engl. J. Med. 361, 468-477 (2009
    • (2009) N. Engl. J. Med , vol.361 , pp. 468-477
    • Roestenberg, M.1
  • 96
    • 79956358442 scopus 로고    scopus 로고
    • Long-term protection against malaria after experimental sporozoite inoculation: An open-label follow-up study
    • Roestenberg, M. et al. Long-term protection against malaria after experimental sporozoite inoculation: An open-label follow-up study. Lancet 377, 1770-1776 (2011
    • (2011) Lancet , vol.377 , pp. 1770-1776
    • Roestenberg, M.1
  • 97
    • 79958717556 scopus 로고    scopus 로고
    • Superior antimalarial immunity after vaccination with late liver stagearresting genetically attenuated parasites
    • Butler, N.S. et al. Superior antimalarial immunity after vaccination with late liver stagearresting genetically attenuated parasites. Cell Host Microbe 9, 451-462 (2011
    • (2011) Cell Host Microbe , vol.9 , pp. 451-462
    • Butler, N.S.1
  • 98
    • 77955605526 scopus 로고    scopus 로고
    • Natural immunization against malaria: Causal prophylaxis with antibiotics
    • Friesen, J. et al. Natural immunization against malaria: Causal prophylaxis with antibiotics. Sci. Transl. Med. 2, 40ra49 (2010
    • (2010) Sci. Transl. Med , vol.2
    • Friesen, J.1
  • 99
    • 85046915383 scopus 로고    scopus 로고
    • The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development
    • Hviid, L. The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development. Hum. Vaccin. 6, 84-89 (2010
    • (2010) Hum. Vaccin , vol.6 , pp. 84-89
    • Hviid, L.1
  • 100
    • 79958072217 scopus 로고    scopus 로고
    • Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    • Janes, J.H. et al. Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family. PLoS Pathog. 7, e1002032 (2011
    • (2011) PLoS Pathog , vol.7
    • Janes, J.H.1
  • 101
    • 34548432522 scopus 로고    scopus 로고
    • Mosquito stage, transmission blocking vaccines for malaria
    • DOI 10.1097/QCO.0b013e3282a95e12, PII 0000143220071000000006
    • Saul, A. Mosquito stage, transmission blocking vaccines for malaria. Curr. Opin. Infect. Dis. 20, 476-481 (2007 (Pubitemid 47359643)
    • (2007) Current Opinion in Infectious Diseases , vol.20 , Issue.5 , pp. 476-481
    • Saul, A.1
  • 102
    • 12744253490 scopus 로고    scopus 로고
    • Evaluation of the standard membrane feeding assay (SMFA) for the determination of malaria transmission-reducing activity using empirical data
    • van der Kolk, M. et al. Evaluation of the standard membrane feeding assay (SMFA) for the determination of malaria transmission-reducing activity using empirical data. Parasitology 130, 13-22 (2005
    • (2005) Parasitology , vol.130 , pp. 13-22
    • Van Der Kolk, M.1
  • 103
    • 70449356589 scopus 로고    scopus 로고
    • Multiple functions of human T cells generated by experimental malaria challenge
    • Todryk, S.M. et al. Multiple functions of human T cells generated by experimental malaria challenge. Eur. J. Immunol. 39, 3042-3051 (2009
    • (2009) Eur. J. Immunol , vol.39 , pp. 3042-3051
    • Todryk, S.M.1
  • 104
    • 80051646256 scopus 로고    scopus 로고
    • CD8+ T effector memory cells protect against liver-stage malaria
    • Reyes-Sandoval, A. et al. CD8+ T effector memory cells protect against liver-stage malaria. J. Immunol. 187, 1347-1357 (2011
    • (2011) J. Immunol , vol.187 , pp. 1347-1357
    • Reyes-Sandoval, A.1
  • 105
    • 80053894662 scopus 로고    scopus 로고
    • Adenovirus-5-vectored P Falciparum Vaccine Expressing CSP And AMA 1 Part B: Safety, immunogenicity and protective efficacy of the CSP component
    • Tamminga, C. et al. Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: Safety, immunogenicity and protective efficacy of the CSP component. PLoS ONE 6, e25868 (2011
    • (2011) PLoS ONE , vol.6
    • Tamminga, C.1
  • 106
    • 80053509291 scopus 로고    scopus 로고
    • Combining liver- and blood-stage malaria viral-vectored vaccines: Investigating mechanisms of CD8+ T cell interference
    • Forbes, E.K. et al. Combining liver- and blood-stage malaria viral-vectored vaccines: Investigating mechanisms of CD8+ T cell interference. J. Immunol. 187, 3738-3750 (2011
    • (2011) J. Immunol , vol.187 , pp. 3738-3750
    • Forbes, E.K.1
  • 107
    • 73449147009 scopus 로고    scopus 로고
    • Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses
    • Reyes-Sandoval, A. et al. Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses. Infect. Immun. 78, 145-153 (2010
    • (2010) Infect. Immun , vol.78 , pp. 145-153
    • Reyes-Sandoval, A.1
  • 110
    • 33646826522 scopus 로고    scopus 로고
    • Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area
    • DOI 10.1016/j.vaccine.2006.03.029, PII S0264410X0600332X
    • Bejon, P. et al. Immunogenicity of the candidate malaria vaccines FP9 and modified vaccinia virus Ankara encoding the pre-erythrocytic antigen ME-TRAP in 1-6 year old children in a malaria endemic area. Vaccine 24, 4709-4715 (2006 (Pubitemid 43776788)
    • (2006) Vaccine , vol.24 , Issue.22 , pp. 4709-4715
    • Bejon, P.1    Mwacharo, J.2    Kai, O.K.3    Todryk, S.4    Keating, S.5    Lang, T.6    Gilbert, S.C.7    Peshu, N.8    Marsh, K.9    Hill, A.V.S.10
  • 111
    • 66349084437 scopus 로고    scopus 로고
    • IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection
    • Nie, C.Q. et al. IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection. PLoS Pathog. 5, e1000369 (2009
    • (2009) PLoS Pathog , vol.5
    • Nie, C.Q.1
  • 112
    • 44849129838 scopus 로고    scopus 로고
    • CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-γ-induced chemokines
    • Van den Steen, P.E. et al. CXCR3 determines strain susceptibility to murine cerebral malaria by mediating T lymphocyte migration toward IFN-γ-induced chemokines. Eur. J. Immunol. 38, 1082-1095 (2008
    • (2008) Eur. J. Immunol , vol.38 , pp. 1082-1095
    • Van Den Steen, P.E.1
  • 113
    • 57249089019 scopus 로고    scopus 로고
    • G (CXCL9 is a more sensitive measure than IFN-γ of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines
    • Berthoud, T.K., Dunachie, S.J., Todryk, S., Hill, A.V. & Fletcher, H.A. MIG (CXCL9) is a more sensitive measure than IFN-γ of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines. J. Immunol. Methods 340, 33-41 (2009
    • (2009) J. Immunol. Methods , vol.340 , pp. 33-41
    • Berthoud, T.K.1    Dunachie, S.J.2    Todryk, S.3    Hill, A.V.4    Fletcher, H.A.5
  • 114
    • 57849085182 scopus 로고    scopus 로고
    • Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    • Querec, T.D. et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat. Immunol. 10, 116-125 (2009
    • (2009) Nat. Immunol , vol.10 , pp. 116-125
    • Querec, T.D.1
  • 115
    • 80051989398 scopus 로고    scopus 로고
    • Systems biology of vaccination for seasonal influenza in humans
    • Nakaya, H.I. et al. Systems biology of vaccination for seasonal influenza in humans. Nat. Immunol. 12, 786-795 (2011
    • (2011) Nat. Immunol , vol.12 , pp. 786-795
    • Nakaya, H.I.1
  • 117
    • 0242658694 scopus 로고    scopus 로고
    • Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine
    • DOI 10.1242/jeb.00644
    • Luke, T.C. & Hoffman, S.L. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J. Exp. Biol. 206, 3803-3808 (2003 (Pubitemid 37365462)
    • (2003) Journal of Experimental Biology , vol.206 , Issue.21 , pp. 3803-3808
    • Luke, T.C.1    Hoffman, S.L.2
  • 119
    • 0036716487 scopus 로고    scopus 로고
    • The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies
    • Nwuba, R.I. et al. The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies. Infect. Immun. 70, 5328-5331 (2002
    • (2002) Infect. Immun , vol.70 , pp. 5328-5331
    • Nwuba, R.I.1
  • 121
    • 0033958230 scopus 로고    scopus 로고
    • 19 across distantly related Plasmodium species
    • DOI 10.1038/71595
    • O'Donnell, R.A., Saul, A., Cowman, A.F. & Crabb, B.S. Functional conservation of the malaria vaccine antigen MSP-119 across distantly related Plasmodium species. Nat. Med. 6, 91-95 (2000 (Pubitemid 30048533)
    • (2000) Nature Medicine , vol.6 , Issue.1 , pp. 91-95
    • O'Donnell, R.A.1    Saul, A.2    Cowman, A.F.3    Crabb, B.S.4
  • 123
    • 68149164395 scopus 로고    scopus 로고
    • Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area
    • Weiss, G.E. et al. Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area. J. Immunol. 183, 2176-2182 (2009
    • (2009) J. Immunol , vol.183 , pp. 2176-2182
    • Weiss, G.E.1
  • 126
    • 77952496627 scopus 로고    scopus 로고
    • Revisiting the circulation time of Plasmodium falciparum gametocytes: Molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
    • Bousema, T. et al. Revisiting the circulation time of Plasmodium falciparum gametocytes: Molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs. Malar. J. 9, 136 (2010
    • (2010) Malar. J. , vol.9 , Issue.136
    • Bousema, T.1
  • 127
    • 78649758719 scopus 로고    scopus 로고
    • The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania
    • Bousema, T. et al. The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania. PLoS ONE 5, e14114 (2010
    • (2010) PLoS ONE , vol.5
    • Bousema, T.1
  • 128
    • 33845884042 scopus 로고    scopus 로고
    • RTS,S/AS02A for malaria
    • DOI 10.1586/14760584.5.5.611
    • Bojang, K.A. RTS,S/AS02A for malaria. Expert Rev. Vaccines 5, 611-615 (2006 (Pubitemid 46021043)
    • (2006) Expert Review of Vaccines , vol.5 , Issue.5 , pp. 611-615
    • Bojang, K.A.1
  • 129
    • 0024312642 scopus 로고
    • Rationale for the development of an engineered sporozoite malaria vaccine
    • Nussenzweig, V. & Nussenzweig, R.S. Rationale for the development of an engineered sporozoite malaria vaccine. Adv. Immunol. 45, 283-334 (1989 (Pubitemid 19195509)
    • (1989) Advances in Immunology , vol.45 , pp. 283-334
    • Nussenzweig, V.1    Nussenzweig, R.S.2
  • 130
    • 0031791192 scopus 로고    scopus 로고
    • Malaria in 1998: Advances in diagnosis, drugs and vaccine development
    • Heppner, D.G. & Ballou, W.R. Malaria in 1998: Advances in diagnosis, drugs and vaccine development. Curr. Opin. Infect. Dis. 11, 519-530 (1998 (Pubitemid 28510493)
    • (1998) Current Opinion in Infectious Diseases , vol.11 , Issue.5 , pp. 519-530
    • Heppner, D.G.1    Ballou, W.R.2
  • 131
    • 68949088019 scopus 로고    scopus 로고
    • The development of the RTS,S malaria vaccine candidate: Challenges and lessons
    • Ballou, W.R. The development of the RTS,S malaria vaccine candidate: Challenges and lessons. Parasite Immunol. 31, 492-500 (2009
    • (2009) Parasite Immunol , vol.31 , pp. 492-500
    • Ballou, W.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.