Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2547-2555

  Wang, Xiaofang ^a   Dong, Yuxiang ^a   Wittlin, Sergio ^b,c   Charman, Susan A ^d   Chiu, Francis C K ^d   Chollet, Jacques ^b,c   Katneni, Kasiram ^d   Mannila, Janne ^d   Morizzi, Julia ^d   Ryan, Eileen ^d   Scheurer, Christian ^b,c   Steuten, Jessica ^d   Santo Tomas, Josefina ^b,c   Snyder, Christopher ^b,c   Vennerstrom, Jonathan L ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIOXOLANE; 1,2,4,5 TETRAOXANE ISOSTERE; ANTIMALARIAL AGENT; ARTEROLANE; OZ 439; PEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ABSORPTION; ADAMANTANE; ANIMALS; ANTIMALARIALS; DIOXOLANES; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC COMPOUNDS, 1-RING; MALE; MICE; PEROXIDES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAOXANES;

EID: 84875737819     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400004u     Document Type: Article

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