-
1
-
-
82755197376
-
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
-
S.H. Adjalley, G.L. Johnston, T. Li, R.T. Eastman, E.H. Ekland, A.G. Eappen, A. Richman, B.K. Sim, M.C. Lee, S.L. Hoffman, and D.A. Fidock Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue Proc. Natl. Acad. Sci. USA 108 2011 E1214 E1223
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
-
-
Adjalley, S.H.1
Johnston, G.L.2
Li, T.3
Eastman, R.T.4
Ekland, E.H.5
Eappen, A.G.6
Richman, A.7
Sim, B.K.8
Lee, M.C.9
Hoffman, S.L.10
Fidock, D.A.11
-
2
-
-
26944499418
-
Rapid evaluation of synthetic and molecular complexity for in silico chemistry
-
DOI 10.1021/ci0501387
-
T.K. Allu, and T.I. Oprea Rapid evaluation of synthetic and molecular complexity for in silico chemistry J. Chem. Inf. Model. 45 2005 1237 1243 (Pubitemid 41476007)
-
(2005)
Journal of Chemical Information and Modeling
, vol.45
, Issue.5
, pp. 1237-1243
-
-
Allu, T.K.1
Oprea, T.I.2
-
3
-
-
37449032927
-
Structural genomics of protein phosphatases
-
DOI 10.1007/s10969-007-9036-1
-
S.C. Almo, J.B. Bonanno, J.M. Sauder, S. Emtage, T.P. Dilorenzo, V. Malashkevich, S.R. Wasserman, S. Swaminathan, S. Eswaramoorthy, and R. Agarwal Structural genomics of protein phosphatases J. Struct. Funct. Genomics 8 2007 121 140 (Pubitemid 50007113)
-
(2007)
Journal of Structural and Functional Genomics
, vol.8
, Issue.2-3
, pp. 121-140
-
-
Almo, S.C.1
Bonanno, J.B.2
Sauder, J.M.3
Emtage, S.4
Dilorenzo, T.P.5
Malashkevich, V.6
Wasserman, S.R.7
Swaminathan, S.8
Eswaramoorthy, S.9
Agarwal, R.10
Kumaran, D.11
Madegowda, M.12
Ragumani, S.13
Patskovsky, Y.14
Alvarado, J.15
Ramagopal, U.A.16
Faber-Barata, J.17
Chance, M.R.18
Sali, A.19
Fiser, A.20
Zhang, Z.-Y.21
Lawrence, D.S.22
Burley, S.K.23
more..
-
5
-
-
84856221698
-
A new molecular approach for cidal vs static antimalarial determination by quantifying mRNA levels
-
10.1016/j.molbiopara.2011.11.003 Published online November 17, 2011
-
N. Bahamontes-Rosa, A. Rodriguez-Alejandre, R. Gonzalez-Del-Rio, J.F. Garcia-Bustos, and A. Mendoza-Losana A new molecular approach for cidal vs static antimalarial determination by quantifying mRNA levels Mol. Biochem. Parasitol. 2011 10.1016/j.molbiopara.2011.11.003 Published online November 17, 2011
-
(2011)
Mol. Biochem. Parasitol.
-
-
Bahamontes-Rosa, N.1
Rodriguez-Alejandre, A.2
Gonzalez-Del-Rio, R.3
Garcia-Bustos, J.F.4
Mendoza-Losana, A.5
-
6
-
-
20444470318
-
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
-
DOI 10.1074/jbc.M501100200
-
J. Baldwin, C.H. Michnoff, N.A. Malmquist, J. White, M.G. Roth, P.K. Rathod, and M.A. Phillips High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase J. Biol. Chem. 280 2005 21847 21853 (Pubitemid 40827835)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 21847-21853
-
-
Baldwin, J.1
Michnoff, C.H.2
Malmquist, N.A.3
White, J.4
Roth, M.G.5
Rathod, P.K.6
Phillips, M.A.7
-
7
-
-
80052698379
-
Open source drug discovery - A new paradigm of collaborative research in tuberculosis drug development
-
Open Source Drug Discovery Consortium
-
A. Bhardwaj, V. Scaria, G.P. Raghava, A.M. Lynn, N. Chandra, S. Banerjee, M.V. Raghunandanan, V. Pandey, B. Taneja, J. Yadav Open Source Drug Discovery Consortium Open source drug discovery - a new paradigm of collaborative research in tuberculosis drug development Tuberculosis (Edinb.) 91 2011 479 486
-
(2011)
Tuberculosis (Edinb.)
, vol.91
, pp. 479-486
-
-
Bhardwaj, A.1
Scaria, V.2
Raghava, G.P.3
Lynn, A.M.4
Chandra, N.5
Banerjee, S.6
Raghunandanan, M.V.7
Pandey, V.8
Taneja, B.9
Yadav, J.10
-
8
-
-
79955017122
-
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development
-
K. Buchholz, T.A. Burke, K.C. Williamson, R.C. Wiegand, D.F. Wirth, and M. Marti A high-throughput screen targeting malaria transmission stages opens new avenues for drug development J. Infect. Dis. 203 2011 1445 1453
-
(2011)
J. Infect. Dis.
, vol.203
, pp. 1445-1453
-
-
Buchholz, K.1
Burke, T.A.2
Williamson, K.C.3
Wiegand, R.C.4
Wirth, D.F.5
Marti, M.6
-
9
-
-
78549246255
-
Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite
-
K. Buchholz, E.D. Putrianti, S. Rahlfs, R.H. Schirmer, K. Becker, and K. Matuschewski Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite J. Biol. Chem. 285 2010 37388 37395
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 37388-37395
-
-
Buchholz, K.1
Putrianti, E.D.2
Rahlfs, S.3
Schirmer, R.H.4
Becker, K.5
Matuschewski, K.6
-
10
-
-
79959959354
-
The state of the art in anti-malarial drug discovery and development
-
J.N. Burrows, K. Chibale, and T.N. Wells The state of the art in anti-malarial drug discovery and development Curr. Top. Med. Chem. 11 2011 1226 1254
-
(2011)
Curr. Top. Med. Chem.
, vol.11
, pp. 1226-1254
-
-
Burrows, J.N.1
Chibale, K.2
Wells, T.N.3
-
11
-
-
80054735856
-
An invitation to open innovation in malaria drug discovery: 47 quality starting points from the TCAMS
-
F. Calderón, D. Barros, J.M. Bueno, J.M. Coterón, E. Fernández, F.J. Gamo, J.L. Lavandera, M.L. León, S.F.J. Macdonald, and A. Mallo An invitation to open innovation in malaria drug discovery: 47 quality starting points from the TCAMS ACS Med. Chem. Lett. 2 2011 741 746
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 741-746
-
-
Calderón, F.1
Barros, D.2
Bueno, J.M.3
Coterón, J.M.4
Fernández, E.5
Gamo, F.J.6
Lavandera, J.L.7
León, M.L.8
MacDonald, S.F.J.9
Mallo, A.10
-
12
-
-
3843112304
-
Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity
-
DOI 10.1074/jbc.M402433200
-
A. Cameron, J. Read, R. Tranter, V.J. Winter, R.B. Sessions, R.L. Brady, L. Vivas, A. Easton, H. Kendrick, and S.L. Croft Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity J. Biol. Chem. 279 2004 31429 31439 (Pubitemid 39037810)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.30
, pp. 31429-31439
-
-
Cameron, A.1
Read, J.2
Tranter, R.3
Winter, V.J.4
Sessions, R.B.5
Brady, R.L.6
Vivas, L.7
Easton, A.8
Kendrick, H.9
Croft, S.L.10
Barros, D.11
Lavandera, J.L.12
Martin, J.J.13
Risco, F.14
Garcia-Ochoa, S.15
Gamo, F.J.16
Sanz, L.17
Leon, L.18
Ruiz, J.R.19
Gabarro, R.20
Mallon, A.21
Gomez De Las Heras, F.22
more..
-
13
-
-
0029078941
-
Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro
-
C.J. Canfield, M. Pudney, and W.E. Gutteridge Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro Exp. Parasitol. 80 1995 373 381
-
(1995)
Exp. Parasitol.
, vol.80
, pp. 373-381
-
-
Canfield, C.J.1
Pudney, M.2
Gutteridge, W.E.3
-
14
-
-
34047218558
-
Generation of oxamic acid libraries: Antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase
-
S.R. Choi, A.B. Beeler, A. Pradhan, E.B. Watkins, J.M. Rimoldi, B. Tekwani, and M.A. Avery Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase J. Comb. Chem. 9 2007 292 300
-
(2007)
J. Comb. Chem.
, vol.9
, pp. 292-300
-
-
Choi, S.R.1
Beeler, A.B.2
Pradhan, A.3
Watkins, E.B.4
Rimoldi, J.M.5
Tekwani, B.6
Avery, M.A.7
-
15
-
-
34548069772
-
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors
-
DOI 10.1021/jm070336k
-
S.R. Choi, A. Pradhan, N.L. Hammond, A.G. Chittiboyina, B.L. Tekwani, and M.A. Avery Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors J. Med. Chem. 50 2007 3841 3850 (Pubitemid 47292047)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.16
, pp. 3841-3850
-
-
Choi, S.-R.1
Pradhan, A.2
Hammond, N.L.3
Chittiboyina, A.G.4
Tekwani, B.L.5
Avery, M.A.6
-
16
-
-
79961223551
-
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
-
J.M. Coteron, M. Marco, J. Esquivias, X. Deng, K.L. White, J. White, M. Koltun, F. El Mazouni, S. Kokkonda, and K. Katneni Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential J. Med. Chem. 54 2011 5540 5561
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5540-5561
-
-
Coteron, J.M.1
Marco, M.2
Esquivias, J.3
Deng, X.4
White, K.L.5
White, J.6
Koltun, M.7
El Mazouni, F.8
Kokkonda, S.9
Katneni, K.10
-
17
-
-
78049447418
-
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds
-
G.J. Crowther, A.J. Napuli, J.H. Gilligan, K. Gagaring, R. Borboa, C. Francek, Z. Chen, E.F. Dagostino, J.B. Stockmyer, and Y. Wang Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds Mol. Biochem. Parasitol. 175 2011 21 29
-
(2011)
Mol. Biochem. Parasitol.
, vol.175
, pp. 21-29
-
-
Crowther, G.J.1
Napuli, A.J.2
Gilligan, J.H.3
Gagaring, K.4
Borboa, R.5
Francek, C.6
Chen, Z.7
Dagostino, E.F.8
Stockmyer, J.B.9
Wang, Y.10
-
18
-
-
79953322662
-
Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery
-
L. Dembele, A. Gego, A.M. Zeeman, J.F. Franetich, O. Silvie, A. Rametti, R. Le Grand, N. Dereuddre-Bosquet, R. Sauerwein, and G.J. van Gemert Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery PLoS ONE 6 2011 e18162
-
(2011)
PLoS ONE
, vol.6
, pp. 18162
-
-
Dembele, L.1
Gego, A.2
Zeeman, A.M.3
Franetich, J.F.4
Silvie, O.5
Rametti, A.6
Le Grand, R.7
Dereuddre-Bosquet, N.8
Sauerwein, R.9
Van Gemert, G.J.10
-
19
-
-
77953873716
-
Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials
-
X. Deng, A. Nagle, T. Wu, T. Sakata, K. Henson, Z. Chen, K. Kuhen, D. Plouffe, E. Winzeler, and F. Adrian Discovery of novel 1H-imidazol-2-yl- pyrimidine-4,6-diamines as potential antimalarials Bioorg. Med. Chem. Lett. 20 2010 4027 4031
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 4027-4031
-
-
Deng, X.1
Nagle, A.2
Wu, T.3
Sakata, T.4
Henson, K.5
Chen, Z.6
Kuhen, K.7
Plouffe, D.8
Winzeler, E.9
Adrian, F.10
-
21
-
-
31144470616
-
Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): Antiparasitic activity of a PKG inhibitor
-
DOI 10.1016/j.molbiopara.2005.10.020, PII S0166685105003336
-
C.A. Diaz, J. Allocco, M.A. Powles, L. Yeung, R.G. Donald, J.W. Anderson, and P.A. Liberator Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor Mol. Biochem. Parasitol. 146 2006 78 88 (Pubitemid 43132805)
-
(2006)
Molecular and Biochemical Parasitology
, vol.146
, Issue.1
, pp. 78-88
-
-
Diaz, C.A.1
Allocco, J.2
Powles, M.A.3
Yeung, L.4
Donald, R.G.K.5
Anderson, J.W.6
Liberator, P.A.7
-
22
-
-
33847101824
-
Antimalarial drug discovery: Targeting protein kinases
-
DOI 10.1517/14728222.11.3.279
-
C. Doerig, and L. Meijer Antimalarial drug discovery: targeting protein kinases Expert Opin. Ther. Targets 11 2007 279 290 (Pubitemid 46290953)
-
(2007)
Expert Opinion on Therapeutic Targets
, vol.11
, Issue.3
, pp. 279-290
-
-
Doerig, C.1
Meijer, L.2
-
23
-
-
68049123592
-
Artemisinin resistance in Plasmodium falciparum malaria
-
A.M. Dondorp, F. Nosten, P. Yi, D. Das, A.P. Phyo, J. Tarning, K.M. Lwin, F. Ariey, W. Hanpithakpong, and S.J. Lee Artemisinin resistance in Plasmodium falciparum malaria N. Engl. J. Med. 361 2009 455 467
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 455-467
-
-
Dondorp, A.M.1
Nosten, F.2
Yi, P.3
Das, D.4
Phyo, A.P.5
Tarning, J.6
Lwin, K.M.7
Ariey, F.8
Hanpithakpong, W.9
Lee, S.J.10
-
24
-
-
84976351004
-
Falcipain-2 inhibitors
-
R. Ettari, F. Bova, M. Zappalà, S. Grasso, and N. Micale Falcipain-2 inhibitors Med. Res. Rev. 30 2010 136 167
-
(2010)
Med. Res. Rev.
, vol.30
, pp. 136-167
-
-
Ettari, R.1
Bova, F.2
Zappalà, M.3
Grasso, S.4
Micale, N.5
-
25
-
-
47349086162
-
Structural genomics of pathogenic protozoa: An overview
-
E. Fan, D. Baker, S. Fields, M.H. Gelb, F.S. Buckner, W.C. Van Voorhis, E. Phizicky, M. Dumont, C. Mehlin, and E. Grayhack Structural genomics of pathogenic protozoa: an overview Methods Mol. Biol. 426 2008 497 513
-
(2008)
Methods Mol. Biol.
, vol.426
, pp. 497-513
-
-
Fan, E.1
Baker, D.2
Fields, S.3
Gelb, M.H.4
Buckner, F.S.5
Van Voorhis, W.C.6
Phizicky, E.7
Dumont, M.8
Mehlin, C.9
Grayhack, E.10
-
26
-
-
80855142205
-
Re-engineering drug discovery and development
-
G.A. FitzGerald Re-engineering drug discovery and development LDI Issue Brief 17 2011 1 4
-
(2011)
LDI Issue Brief
, vol.17
, pp. 1-4
-
-
Fitzgerald, G.A.1
-
27
-
-
77952704258
-
Thousands of chemical starting points for antimalarial lead identification
-
F.J. Gamo, L.M. Sanz, J. Vidal, C. de Cozar, E. Alvarez, J.L. Lavandera, D.E. Vanderwall, D.V. Green, V. Kumar, and S. Hasan Thousands of chemical starting points for antimalarial lead identification Nature 465 2010 305 310
-
(2010)
Nature
, vol.465
, pp. 305-310
-
-
Gamo, F.J.1
Sanz, L.M.2
Vidal, J.3
De Cozar, C.4
Alvarez, E.5
Lavandera, J.L.6
Vanderwall, D.E.7
Green, D.V.8
Kumar, V.9
Hasan, S.10
-
28
-
-
80052325758
-
Phenotypic screens, chemical genomics, and antimalarial lead discovery
-
J.F. Garcia-Bustos, and F.J. Gamo Phenotypic screens, chemical genomics, and antimalarial lead discovery PLoS Pathog. 7 2011 e1002156
-
(2011)
PLoS Pathog.
, vol.7
, pp. 1002156
-
-
Garcia-Bustos, J.F.1
Gamo, F.J.2
-
31
-
-
0037015614
-
Genome sequence of the human malaria parasite Plasmodium falciparum
-
M.J. Gardner, N. Hall, E. Fung, O. White, M. Berriman, R.W. Hyman, J.M. Carlton, A. Pain, K.E. Nelson, and S. Bowman Genome sequence of the human malaria parasite Plasmodium falciparum Nature 419 2002 498 511
-
(2002)
Nature
, vol.419
, pp. 498-511
-
-
Gardner, M.J.1
Hall, N.2
Fung, E.3
White, O.4
Berriman, M.5
Hyman, R.W.6
Carlton, J.M.7
Pain, A.8
Nelson, K.E.9
Bowman, S.10
-
32
-
-
0029916863
-
Frequency of drug resistance in Plasmodium falciparum: A nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance
-
S. Gassis, and P.K. Rathod Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance Antimicrob. Agents Chemother. 40 1996 914 919 (Pubitemid 26115224)
-
(1996)
Antimicrobial Agents and Chemotherapy
, vol.40
, Issue.4
, pp. 914-919
-
-
Gassis, S.1
Rathod, P.K.2
-
33
-
-
84862192766
-
ChEMBL: A large-scale bioactivity database for drug discovery
-
10.1093/nar/gkr777 Published online September 23, 2011
-
A. Gaulton, L.J. Bellis, A.P. Bento, J. Chambers, M. Davies, A. Hersey, Y. Light, S. McGlinchey, D. Michalovich, and B. Al-Lazikani ChEMBL: a large-scale bioactivity database for drug discovery Nucl. Acids Res. 40 2012 D1100 D1107 10.1093/nar/gkr777 Published online September 23, 2011
-
(2012)
Nucl. Acids Res.
, vol.40
-
-
Gaulton, A.1
Bellis, L.J.2
Bento, A.P.3
Chambers, J.4
Davies, M.5
Hersey, A.6
Light, Y.7
McGlinchey, S.8
Michalovich, D.9
Al-Lazikani, B.10
-
34
-
-
77950643062
-
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials
-
C. Granchi, S. Bertini, M. Macchia, and F. Minutolo Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials Curr. Med. Chem. 17 2010 672 697
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 672-697
-
-
Granchi, C.1
Bertini, S.2
MacChia, M.3
Minutolo, F.4
-
35
-
-
77952718950
-
Chemical genetics of Plasmodium falciparum
-
W.A. Guiguemde, A.A. Shelat, D. Bouck, S. Duffy, G.J. Crowther, P.H. Davis, D.C. Smithson, M. Connelly, J. Clark, and F. Zhu Chemical genetics of Plasmodium falciparum Nature 465 2010 311 315
-
(2010)
Nature
, vol.465
, pp. 311-315
-
-
Guiguemde, W.A.1
Shelat, A.A.2
Bouck, D.3
Duffy, S.4
Crowther, G.J.5
Davis, P.H.6
Smithson, D.C.7
Connelly, M.8
Clark, J.9
Zhu, F.10
-
36
-
-
0018431981
-
Conversion of dihydroorotate to orotate in parasitic protozoa
-
W.E. Gutteridge, D. Dave, and W.H. Richards Conversion of dihydroorotate to orotate in parasitic protozoa Biochim. Biophys. Acta 582 1979 390 401
-
(1979)
Biochim. Biophys. Acta
, vol.582
, pp. 390-401
-
-
Gutteridge, W.E.1
Dave, D.2
Richards, W.H.3
-
37
-
-
17944376779
-
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
-
DOI 10.1016/S0960-894X(01)00404-8, PII S0960894X01004048
-
D.A. Heerding, G. Chan, W.E. DeWolf, A.P. Fosberry, C.A. Janson, D.D. Jaworski, E. McManus, W.H. Miller, T.D. Moore, and D.J. Payne 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) Bioorg. Med. Chem. Lett. 11 2001 2061 2065 (Pubitemid 32763001)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.16
, pp. 2061-2065
-
-
Heerding, D.A.1
Chan, G.2
DeWolf Jr., W.E.3
Fosberry, A.P.4
Janson, C.A.5
Jaworski, D.D.6
McManus, E.7
Miller, W.H.8
Moore, T.D.9
Payne, D.J.10
Qiu, X.11
Rittenhouse, S.F.12
Slater-Radosti, C.13
Smith, W.14
Takata, D.T.15
Vaidya, K.S.16
Yuan, C.C.K.17
Huffman, W.F.18
-
39
-
-
79952162829
-
Validation of isoleucine utilization targets in Plasmodium falciparum
-
E.S. Istvan, N.V. Dharia, S.E. Bopp, I. Gluzman, E.A. Winzeler, and D.E. Goldberg Validation of isoleucine utilization targets in Plasmodium falciparum Proc. Natl. Acad. Sci. USA 108 2011 1627 1632
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 1627-1632
-
-
Istvan, E.S.1
Dharia, N.V.2
Bopp, S.E.3
Gluzman, I.4
Winzeler, E.A.5
Goldberg, D.E.6
-
40
-
-
0035163181
-
The impact of whole genome sequence data on drug discovery - A malaria case study
-
M.P. Joachimiak, C. Chang, P.J. Rosenthal, and F.E. Cohen The impact of whole genome sequence data on drug discovery - a malaria case study Mol. Med. 7 2001 698 710 (Pubitemid 33070984)
-
(2001)
Molecular Medicine
, vol.7
, Issue.10
, pp. 698-710
-
-
Joachimiak, M.P.1
Chang, C.2
Rosenthal, P.J.3
Cohen, F.E.4
-
41
-
-
79961089179
-
Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function
-
H. Ke, J.M. Morrisey, S.M. Ganesan, H.J. Painter, M.W. Mather, and A.B. Vaidya Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function Eukaryot. Cell 10 2011 1053 1061
-
(2011)
Eukaryot. Cell
, vol.10
, pp. 1053-1061
-
-
Ke, H.1
Morrisey, J.M.2
Ganesan, S.M.3
Painter, H.J.4
Mather, M.W.5
Vaidya, A.B.6
-
43
-
-
38649120829
-
Drugs and their molecular targets: An updated overview
-
DOI 10.1111/j.1472-8206.2007.00548.x
-
Y. Landry, and J.P. Gies Drugs and their molecular targets: an updated overview Fundam. Clin. Pharmacol. 22 2008 1 18 (Pubitemid 351171284)
-
(2008)
Fundamental and Clinical Pharmacology
, vol.22
, Issue.1
, pp. 1-18
-
-
Landry, Y.1
Gies, J.-P.2
-
45
-
-
79959773283
-
Target identification and validation of novel antimalarials
-
C. McNamara, and E.A. Winzeler Target identification and validation of novel antimalarials Future Microbiol. 6 2011 693 704
-
(2011)
Future Microbiol.
, vol.6
, pp. 693-704
-
-
McNamara, C.1
Winzeler, E.A.2
-
46
-
-
83255176722
-
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
-
S. Meister, D.M. Plouffe, K.L. Kuhen, G.M. Bonamy, T. Wu, S.W. Barnes, S.E. Bopp, R. Borboa, A.T. Bright, and J. Che Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery Science 334 2011 1372 1377
-
(2011)
Science
, vol.334
, pp. 1372-1377
-
-
Meister, S.1
Plouffe, D.M.2
Kuhen, K.L.3
Bonamy, G.M.4
Wu, T.5
Barnes, S.W.6
Bopp, S.E.7
Borboa, R.8
Bright, A.T.9
Che, J.10
-
47
-
-
79961008996
-
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription
-
S. Mok, M. Imwong, M.J. Mackinnon, J. Sim, R. Ramadoss, P. Yi, M. Mayxay, K. Chotivanich, K.Y. Liong, and B. Russell Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription BMC Genomics 12 2011 391
-
(2011)
BMC Genomics
, vol.12
, pp. 391
-
-
Mok, S.1
Imwong, M.2
MacKinnon, M.J.3
Sim, J.4
Ramadoss, R.5
Yi, P.6
Mayxay, M.7
Chotivanich, K.8
Liong, K.Y.9
Russell, B.10
-
48
-
-
81555228431
-
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
-
T.G. Nam, C.W. McNamara, S. Bopp, N.V. Dharia, S. Meister, G.M. Bonamy, D.M. Plouffe, N. Kato, S. McCormack, and B. Bursulaya A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor ACS Chem. Biol. 6 2011 1214 1222
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 1214-1222
-
-
Nam, T.G.1
McNamara, C.W.2
Bopp, S.3
Dharia, N.V.4
Meister, S.5
Bonamy, G.M.6
Plouffe, D.M.7
Kato, N.8
McCormack, S.9
Bursulaya, B.10
-
50
-
-
34249336412
-
Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening
-
DOI 10.1016/j.bbrc.2007.04.113, PII S0006291X0700825X
-
G. Nicola, C.A. Smith, E. Lucumi, M.R. Kuo, L. Karagyozov, D.A. Fidock, J.C. Sacchettini, and R. Abagyan Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening Biochem. Biophys. Res. Commun. 358 2007 686 691 (Pubitemid 46805154)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.358
, Issue.3
, pp. 686-691
-
-
Nicola, G.1
Smith, C.A.2
Lucumi, E.3
Kuo, M.R.4
Karagyozov, L.5
Fidock, D.A.6
Sacchettini, J.C.7
Abagyan, R.8
-
51
-
-
0242492756
-
Virtual drug discovery and development for neglected diseases through public-private partnerships
-
S. Nwaka, and R.G. Ridley Virtual drug discovery and development for neglected diseases through public-private partnerships Nat. Rev. Drug Discov. 2 2003 919 928 (Pubitemid 37419900)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.11
, pp. 919-928
-
-
Nwaka, S.1
Ridley, R.G.2
-
52
-
-
79960656719
-
Combining indoor residual spraying and insecticide-treated nets for malaria control in Africa: A review of possible outcomes and an outline of suggestions for the future
-
F.O. Okumu, and S.J. Moore Combining indoor residual spraying and insecticide-treated nets for malaria control in Africa: a review of possible outcomes and an outline of suggestions for the future Malar. J. 10 2011 208
-
(2011)
Malar. J.
, vol.10
, pp. 208
-
-
Okumu, F.O.1
Moore, S.J.2
-
53
-
-
33847398001
-
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
-
DOI 10.1038/nature05572, PII NATURE05572
-
H.J. Painter, J.M. Morrisey, M.W. Mather, and A.B. Vaidya Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum Nature 446 2007 88 91 (Pubitemid 46348043)
-
(2007)
Nature
, vol.446
, Issue.7131
, pp. 88-91
-
-
Painter, H.J.1
Morrisey, J.M.2
Mather, M.W.3
Vaidya, A.B.4
-
54
-
-
79960294141
-
Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies
-
J. Penna-Coutinho, W.A. Cortopassi, A.A. Oliveira, T.C. Frana, and A.U. Krettli Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies PLoS ONE 6 2011 e21237
-
(2011)
PLoS ONE
, vol.6
, pp. 21237
-
-
Penna-Coutinho, J.1
Cortopassi, W.A.2
Oliveira, A.A.3
Frana, T.C.4
Krettli, A.U.5
-
55
-
-
0037066782
-
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase
-
DOI 10.1074/jbc.M112000200
-
R. Perozzo, M. Kuo, A.S. Sidhu, J.T. Valiyaveettil, R. Bittman, W.R. Jacobs Jr., D.A. Fidock, and J.C. Sacchettini Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase J. Biol. Chem. 277 2002 13106 13114 (Pubitemid 34952681)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.15
, pp. 13106-13114
-
-
Perozzo, R.1
Kuo, M.2
Sidhu, A.B.S.3
Valiyaveettil, J.T.4
Bittman, R.5
Jacobs Jr., W.R.6
Fidock, D.A.7
Sacchettini, J.C.8
-
56
-
-
79957580467
-
Drug-resistant malaria: Molecular mechanisms and implications for public health
-
I. Petersen, R. Eastman, and M. Lanzer Drug-resistant malaria: molecular mechanisms and implications for public health FEBS Lett. 585 2011 1551 1562
-
(2011)
FEBS Lett.
, vol.585
, pp. 1551-1562
-
-
Petersen, I.1
Eastman, R.2
Lanzer, M.3
-
57
-
-
26044468809
-
Opportunities and challenges in antiparasitic drug discovery
-
DOI 10.1038/nrd1824, PII N1824
-
R. Pink, A. Hudson, M.A. Mouris, and M. Bendig Opportunities and challenges in antiparasitic drug discovery Nat. Rev. Drug Discov. 4 2005 727 740 (Pubitemid 43090494)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.9
, pp. 727-740
-
-
Pink, R.1
Hudson, A.2
Mouries, M.-A.3
Bendig, M.4
-
58
-
-
48249095940
-
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
-
D. Plouffe, A. Brinker, C. McNamara, K. Henson, N. Kato, K. Kuhen, A. Nagle, F. Adrián, J.T. Matzen, and P. Anderson In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen Proc. Natl. Acad. Sci. USA 105 2008 9059 9064
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9059-9064
-
-
Plouffe, D.1
Brinker, A.2
McNamara, C.3
Henson, K.4
Kato, N.5
Kuhen, K.6
Nagle, A.7
Adrián, F.8
Matzen, J.T.9
Anderson, P.10
-
60
-
-
81855183788
-
Collaboration versus outsourcing: The need to think outside the box
-
G.M. Robertson, and L.M. Mayr Collaboration versus outsourcing: the need to think outside the box Future Med. Chem. 3 2011 1995 2020
-
(2011)
Future Med. Chem.
, vol.3
, pp. 1995-2020
-
-
Robertson, G.M.1
Mayr, L.M.2
-
61
-
-
80053336043
-
Falcipains and other cysteine proteases of malaria parasites
-
P.J. Rosenthal Falcipains and other cysteine proteases of malaria parasites Adv. Exp. Med. Biol. 712 2011 30 48
-
(2011)
Adv. Exp. Med. Biol.
, vol.712
, pp. 30-48
-
-
Rosenthal, P.J.1
-
62
-
-
77956280420
-
Spiroindolones, a potent compound class for the treatment of malaria
-
M. Rottmann, C. McNamara, B.K. Yeung, M.C. Lee, B. Zou, B. Russell, P. Seitz, D.M. Plouffe, N.V. Dharia, and J. Tan Spiroindolones, a potent compound class for the treatment of malaria Science 329 2010 1175 1180
-
(2010)
Science
, vol.329
, pp. 1175-1180
-
-
Rottmann, M.1
McNamara, C.2
Yeung, B.K.3
Lee, M.C.4
Zou, B.5
Russell, B.6
Seitz, P.7
Plouffe, D.M.8
Dharia, N.V.9
Tan, J.10
-
63
-
-
77954029768
-
Transporters as mediators of drug resistance in Plasmodium falciparum
-
C.P. Sanchez, A. Dave, W.D. Stein, and M. Lanzer Transporters as mediators of drug resistance in Plasmodium falciparum Int. J. Parasitol. 40 2010 1109 1118
-
(2010)
Int. J. Parasitol.
, vol.40
, pp. 1109-1118
-
-
Sanchez, C.P.1
Dave, A.2
Stein, W.D.3
Lanzer, M.4
-
64
-
-
81555221105
-
Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen
-
L.M. Sanz, M.B. Jiménez-Díaz, B. Crespo, C. De-Cozar, M.J. Almela, I. Angulo-Barturen, P. Castañeda, J. Ibañez, E.P. Fernández, and S. Ferrer Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen Antimicrob. Agents Chemother. 55 2011 5740 5745
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 5740-5745
-
-
Sanz, L.M.1
Jiménez-Díaz, M.B.2
Crespo, B.3
De-Cozar, C.4
Almela, M.J.5
Angulo-Barturen, I.6
Castañeda, P.7
Ibañez, J.8
Fernández, E.P.9
Ferrer, S.10
-
65
-
-
78651077288
-
Intrahost modeling of artemisinin resistance in Plasmodium falciparum
-
S. Saralamba, W. Pan-Ngum, R.J. Maude, S.J. Lee, J. Tarning, N. Lindegrdh, K. Chotivanich, F. Nosten, N.P. Day, and D. Socheat Intrahost modeling of artemisinin resistance in Plasmodium falciparum Proc. Natl. Acad. Sci. USA 108 2011 397 402
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 397-402
-
-
Saralamba, S.1
Pan-Ngum, W.2
Maude, R.J.3
Lee, S.J.4
Tarning, J.5
Lindegrdh, N.6
Chotivanich, K.7
Nosten, F.8
Day, N.P.9
Socheat, D.10
-
66
-
-
34247198331
-
Clustering and rule-based classifications of chemical structures evaluated in the biological activity space
-
DOI 10.1021/ci6004004
-
A. Schuffenhauer, N. Brown, P. Ertl, J.L. Jenkins, P. Selzer, and J. Hamon Clustering and rule-based classifications of chemical structures evaluated in the biological activity space J. Chem. Inf. Model. 47 2007 325 336 (Pubitemid 46615937)
-
(2007)
Journal of Chemical Information and Modeling
, vol.47
, Issue.2
, pp. 325-336
-
-
Schuffenhauer, A.1
Brown, N.2
Ertl, P.3
Jenkins, J.L.4
Selzer, P.5
Hamon, J.6
-
67
-
-
33846871027
-
The scaffold tree - Visualization of the scaffold universe by hierarchical scaffold classification
-
DOI 10.1021/ci600338x
-
A. Schuffenhauer, P. Ertl, S. Roggo, S. Wetzel, M.A. Koch, and H. Waldmann The scaffold tree - visualization of the scaffold universe by hierarchical scaffold classification J. Chem. Inf. Model. 47 2007 47 58 (Pubitemid 46225559)
-
(2007)
Journal of Chemical Information and Modeling
, vol.47
, Issue.1
, pp. 47-58
-
-
Schuffenhauer, A.1
Ertl, P.2
Roggo, S.3
Wetzel, S.4
Koch, M.A.5
Waldmann, H.6
-
68
-
-
79959368201
-
Protective immunity to pre-erythrocytic stage malaria
-
R.J. Schwenk, and T.L. Richie Protective immunity to pre-erythrocytic stage malaria Trends Parasitol. 27 2011 306 314
-
(2011)
Trends Parasitol.
, vol.27
, pp. 306-314
-
-
Schwenk, R.J.1
Richie, T.L.2
-
69
-
-
34447517392
-
Scaffold composition and biological relevance of screening libraries
-
DOI 10.1038/nchembio0807-442, PII NCHEMBIO0807442
-
A.A. Shelat, and R.K. Guy Scaffold composition and biological relevance of screening libraries Nat. Chem. Biol. 3 2007 442 446 (Pubitemid 47080378)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.8
, pp. 442-446
-
-
Shelat, A.A.1
Guy, R.K.2
-
70
-
-
0037234454
-
Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity
-
DOI 10.1038/nm808
-
O. Silvie, E. Rubinstein, J.F. Franetich, M. Prenant, E. Belnoue, L. Rénia, L. Hannoun, W. Eling, S. Levy, C. Boucheix, and D. Mazier Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity Nat. Med. 9 2003 93 96 (Pubitemid 36098266)
-
(2003)
Nature Medicine
, vol.9
, Issue.1
, pp. 93-96
-
-
Silvie, O.1
Rubinstein, E.2
Franetich, J.-F.3
Prenant, M.4
Belnoue, E.5
Renia, L.6
Hannoun, L.7
Elings, W.8
Levy, S.9
Boucheix, C.10
Mazier, D.11
-
72
-
-
77956487852
-
Anti-folate drug resistance in Africa: Meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
-
S. Sridaran, S.K. McClintock, L.M. Syphard, K.M. Herman, J.W. Barnwell, and V. Udhayakumar Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations Malar. J. 9 2010 247
-
(2010)
Malar. J.
, vol.9
, pp. 247
-
-
Sridaran, S.1
McClintock, S.K.2
Syphard, L.M.3
Herman, K.M.4
Barnwell, J.W.5
Udhayakumar, V.6
-
73
-
-
79958186689
-
Utility of protein structures in overcoming ADMET-related issues of drug-like compounds
-
F. Stoll, A.H. Göller, and A. Hillisch Utility of protein structures in overcoming ADMET-related issues of drug-like compounds Drug Discov. Today 16 2011 530 538
-
(2011)
Drug Discov. Today
, vol.16
, pp. 530-538
-
-
Stoll, F.1
Göller, A.H.2
Hillisch, A.3
-
74
-
-
1642383842
-
Essential eukaryotic core
-
G.L. Strobel, and J. Arnold Essential eukaryotic core Evolution 58 2004 441 446 (Pubitemid 38370199)
-
(2004)
Evolution
, vol.58
, Issue.2
, pp. 441-446
-
-
Strobel, G.L.1
Arnold, J.2
-
75
-
-
0035126479
-
Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum
-
DOI 10.1038/84612
-
N. Surolia, and A. Surolia Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum Nat. Med. 7 2001 167 173 (Pubitemid 32148482)
-
(2001)
Nature Medicine
, vol.7
, Issue.2
, pp. 167-173
-
-
Surolia, N.1
Surolia, A.2
-
77
-
-
59849125892
-
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
-
A.M. Vaughan, M.T. O'Neill, A.S. Tarun, N. Camargo, T.M. Phuong, A.S. Aly, A.F. Cowman, and S.H. Kappe Type II fatty acid synthesis is essential only for malaria parasite late liver stage development Cell. Microbiol. 11 2009 506 520
-
(2009)
Cell. Microbiol.
, vol.11
, pp. 506-520
-
-
Vaughan, A.M.1
O'Neill, M.T.2
Tarun, A.S.3
Camargo, N.4
Phuong, T.M.5
Aly, A.S.6
Cowman, A.F.7
Kappe, S.H.8
-
78
-
-
33845482665
-
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms
-
DOI 10.1016/j.molbiopara.2006.10.011, PII S0166685106003124
-
M. Vedadi, J. Lew, J. Artz, M. Amani, Y. Zhao, A. Dong, G.A. Wasney, M. Gao, T. Hills, and S. Brokx Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms Mol. Biochem. Parasitol. 151 2007 100 110 (Pubitemid 44911074)
-
(2007)
Molecular and Biochemical Parasitology
, vol.151
, Issue.1
, pp. 100-110
-
-
Vedadi, M.1
Lew, J.2
Artz, J.3
Amani, M.4
Zhao, Y.5
Dong, A.6
Wasney, G.A.7
Gao, M.8
Hills, T.9
Brokx, S.10
Qiu, W.11
Sharma, S.12
Diassiti, A.13
Alam, Z.14
Melone, M.15
Mulichak, A.16
Wernimont, A.17
Bray, J.18
Loppnau, P.19
Plotnikova, O.20
Newberry, K.21
Sundararajan, E.22
Houston, S.23
Walker, J.24
Tempel, W.25
Bochkarev, A.26
Kozieradzki, I.27
Edwards, A.28
Arrowsmith, C.29
Roos, D.30
Kain, K.31
Hui, R.32
more..
-
79
-
-
79957470784
-
Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance
-
M.I. Veiga, P.E. Ferreira, L. Jörnhagen, M. Malmberg, A. Kone, B.A. Schmidt, M. Petzold, A. Björkman, F. Nosten, and J.P. Gil Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance PLoS ONE 6 2011 e20212
-
(2011)
PLoS ONE
, vol.6
, pp. 20212
-
-
Veiga, M.I.1
Ferreira, P.E.2
Jörnhagen, L.3
Malmberg, M.4
Kone, A.5
Schmidt, B.A.6
Petzold, M.7
Björkman, A.8
Nosten, F.9
Gil, J.P.10
-
80
-
-
70350778454
-
New medicines to improve control and contribute to the eradication of malaria
-
T.N. Wells, P.L. Alonso, and W.E. Gutteridge New medicines to improve control and contribute to the eradication of malaria Nat. Rev. Drug Discov. 8 2009 879 891
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 879-891
-
-
Wells, T.N.1
Alonso, P.L.2
Gutteridge, W.E.3
-
82
-
-
79955956020
-
Integrating structure-based and ligand-based approaches for computational drug design
-
G.L. Wilson, and M.A. Lill Integrating structure-based and ligand-based approaches for computational drug design Future Med. Chem. 3 2011 735 750
-
(2011)
Future Med. Chem.
, vol.3
, pp. 735-750
-
-
Wilson, G.L.1
Lill, M.A.2
-
83
-
-
84856408211
-
-
World Health Organization
-
World Health Organization (2011). World Malaria Report 2011 (http://www.who.int/malaria/world-malaria-report-2011/en/).
-
(2011)
World Malaria Report 2011
-
-
-
84
-
-
71849105991
-
Cell-based optimization of novel benzamides as potential antimalarial leads
-
T. Wu, A. Nagle, T. Sakata, K. Henson, R. Borboa, Z. Chen, K. Kuhen, D. Plouffe, E. Winzeler, and F. Adrian Cell-based optimization of novel benzamides as potential antimalarial leads Bioorg. Med. Chem. Lett. 19 2009 6970 6974
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 6970-6974
-
-
Wu, T.1
Nagle, A.2
Sakata, T.3
Henson, K.4
Borboa, R.5
Chen, Z.6
Kuhen, K.7
Plouffe, D.8
Winzeler, E.9
Adrian, F.10
-
85
-
-
79960645150
-
Imidazolopiperazines: Hit to lead optimization of new antimalarial agents
-
T. Wu, A. Nagle, K. Kuhen, K. Gagaring, R. Borboa, C. Francek, Z. Chen, D. Plouffe, A. Goh, and S.B. Lakshminarayana Imidazolopiperazines: hit to lead optimization of new antimalarial agents J. Med. Chem. 54 2011 5116 5130
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5116-5130
-
-
Wu, T.1
Nagle, A.2
Kuhen, K.3
Gagaring, K.4
Borboa, R.5
Francek, C.6
Chen, Z.7
Plouffe, D.8
Goh, A.9
Lakshminarayana, S.B.10
-
86
-
-
80052308799
-
Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum
-
E. Yeh, and J.L. DeRisi Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum PLoS Biol. 9 2011 e1001138
-
(2011)
PLoS Biol.
, vol.9
, pp. 1001138
-
-
Yeh, E.1
Derisi, J.L.2
-
87
-
-
77954745330
-
Spirotetrahydro beta-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria
-
B.K. Yeung, B. Zou, M. Rottmann, S.B. Lakshminarayana, S.H. Ang, S.Y. Leong, J. Tan, J. Wong, S. Keller-Maerki, and C. Fischli Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria J. Med. Chem. 53 2010 5155 5164
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5155-5164
-
-
Yeung, B.K.1
Zou, B.2
Rottmann, M.3
Lakshminarayana, S.B.4
Ang, S.H.5
Leong, S.Y.6
Tan, J.7
Wong, J.8
Keller-Maerki, S.9
Fischli, C.10
-
88
-
-
57049187017
-
The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites
-
DOI 10.1016/j.chom.2008.11.001, PII S1931312808003685
-
M. Yu, T.R. Kumar, L.J. Nkrumah, A. Coppi, S. Retzlaff, C.D. Li, B.J. Kelly, P.A. Moura, V. Lakshmanan, and J.S. Freundlich The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites Cell Host Microbe 4 2008 567 578 (Pubitemid 352762958)
-
(2008)
Cell Host and Microbe
, vol.4
, Issue.6
, pp. 567-578
-
-
Yu, M.1
Kumar, T.R.S.2
Nkrumah, L.J.3
Coppi, A.4
Retzlaff, S.5
Li, C.D.6
Kelly, B.J.7
Moura, P.A.8
Lakshmanan, V.9
Freundlich, J.S.10
Valderramos, J.-C.11
Vilcheze, C.12
Siedner, M.13
Tsai, J.H.-C.14
Falkard, B.15
Sidhu, A.B.S.16
Purcell, L.A.17
Gratraud, P.18
Kremer, L.19
Waters, A.P.20
Schiehser, G.21
Jacobus, D.P.22
Janse, C.J.23
Ager, A.24
Jacobs Jr., W.R.25
Sacchettini, J.C.26
Heussler, V.27
Sinnis, P.28
Fidock, D.A.29
more..
|