Triazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8543-8560

  Zheng, Yi Chao ^a   Duan, Ying Chao ^a   Ma, Jin Lian ^a   Xu, Rui Min ^a   Zi, Xiaolin ^b   Lv, Wen Lei ^a   Wang, Meng Meng ^a   Ye, Xian Wei ^a   Zhu, Shun ^c   Mobley, David ^c   Zhu, Yan Yan ^a   Wang, Jun Wei ^a   Li, Jin Feng ^a   Wang, Zhi Ru ^a   Zhao, Wen ^a   Liu, Hong Min ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; [1 (2 FLUOROBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYL 4 ACETYLPIPERAZINE 1 CARBODITHIOATE; [1 (2 FLUOROBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; [1 (4 METHOXYBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; [1 (4 METHYLBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYL PIPERAZINE 1 CARBODITHIOATE; ANTINEOPLASTIC AGENT; BENZYL 4 [[[1 (2 FLUOROBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; BENZYL 4 [[[1 (3,4,5 TRIMETHOXYBENZYL) 1 H 1,2,3 TRIAZOL 4YL]METHYLTHIO]CARBONTHIOYL]PIPERAZINE 1 CARBOXYLATE; BENZYL 4 [[[1 (4 METHYLBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; DITHIOCARBAMIC ACID DERIVATIVE; ETHYL 4 [[[1 (4 METHYLBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; HISTONE DEMETHYLASE; ISOPROPYL 4 [[[1 (4 METHYLBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; LYSINE SPECIFIC DEMETHYLASE 1; TERT BUTYL 4 [[[1 (2 BROMOBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (2 CHLOROBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (2 FLUOROBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (4 FLUOROBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (4 METHOXYBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [[[1 (4 METHYLBENZYL) 1 H 1,2,3 TRIAZOL 4 YL]METHYLTHIO]CARBONOTHIOYL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER GROWTH; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CLICK CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; STOMACH CANCER; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HISTONE DEMETHYLASES; HUMANS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; STOMACH NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES; TRIAZOLES;

EID: 84887880740     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401002r     Document Type: Article

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