Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 19, 2007, Pages 8023-8028

  Huang, Yi ^a   Greene, Eriko ^a   Stewart, Tracy Murray ^a   Goodwin, Andrew C ^a   Baylin, Stephen B ^a   Woster, Patrick M ^b   Casero Jr , Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Chromatin; Histone; Lysine demethylase; Methylation

Indexed keywords

1,11 BIS(N2,N3 DIMETHYL N1 GUANIDINO) 4,8 DIAZAUNDECANE; 1,15 BIS[N5 [3,3 (DIPHENYL)PROPYL] N1 BIGUANIDO] 4,12 DIAZAPENTADECANE; BIGUANIDE; COMPLEMENTARY DNA; GUANIDINE DERIVATIVE; HISTONE; LYSINE SPECIFIC DEMETHYLASE 1; ORNITHINE DECARBOXYLASE; POLYAMINE DERIVATIVE; POLYAMINE OXIDASE; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR GATA; UNCLASSIFIED DRUG; BIGUANIDE DERIVATIVE; ENZYME INHIBITOR; GATA4 PROTEIN, HUMAN; LYSINE SPECIFIC DEMETHYLASE 1, HUMAN; MEMBRANE PROTEIN; N DEMETHYLASE; POLYAMINE; SFRP1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR GATA 4;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HCT116; CHEMICAL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; COLORECTAL TUMOR; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; TUMOR CELL LINE;

EUKARYOTA;

BIGUANIDES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA METHYLATION; ENZYME INHIBITORS; GATA4 TRANSCRIPTION FACTOR; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; OXIDOREDUCTASES, N-DEMETHYLATING; POLYAMINES; PROMOTER REGIONS (GENETICS);

EID: 34249934238     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700720104     Document Type: Article

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