Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells

Amino Acids

Volumn 42, Issue 2-3, 2012, Pages 887-898

  Zhu, Qingsong ^a   Huang, Yi ^b   Marton, Laurence J ^c   Woster, Patrick M ^d   Davidson, Nancy E ^b   Casero Jr , Robert A ^a,e  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acetylation; Chromatin; Epigenetics; Gene silencing; Histone methylation

Indexed keywords

2D; AMINE OXIDASE (FLAVIN CONTAINING); ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR; HISTONE H3; LYSINE SPECIFIC DEMETHYLASE 1; PG 11144; POLYAMINE DERIVATIVE; PUTRESCINE; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG; HISTONE DEMETHYLASE; POLYAMINE; PRIMER DNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; BREAST TUMOR; CHROMATIN; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FEMALE; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR CELL LINE;

BASE SEQUENCE; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATIN; DNA PRIMERS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEMETHYLASES; HUMANS; POLYAMINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84861715426     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1004-1     Document Type: Article

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