Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives

Journal of Medicinal Chemistry

Volumn 48, Issue 23, 2005, Pages 7113-7122

  Chimenti, Franco ^a   Maccioni, Elias ^e   Secci, Daniela ^a   Bolasco, Adriana ^a   Chimenti, Paola ^a   Granese, Arianna ^a   Befani, Olivia ^b   Turini, Paola ^b   Alcaro, Stefane ^c   Ortuso, Francesco ^c   Cirilli, Roberto ^d   La Torre, Francesco ^d   Cardia, Maria C ^e   Distinto, Simona ^e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 THIOCARBAMOYL 3 (4 METHYLPHENYL) 5 (4 CHLOROPHENYL) 4,5 DIHYDROPYRAZOLE; HYDROGEN; KYNURAMINE; MONOAMINE OXIDASE INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CHIRALITY; CRYSTALLOGRAPHY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR MODEL; PARKINSON DISEASE; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; X RAY DIFFRACTION;

BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; MONTE CARLO METHOD; PROTEIN BINDING; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM; THIOCARBAMATES;

EID: 28544443174     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040903t     Document Type: Article

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