(Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators

Journal of Medicinal Chemistry

Volumn 53, Issue 14, 2010, Pages 5197-5212

  Sharma, Shiv K ^a   Wu, Yu ^b   Steinbergs, Nora ^b   Crowley, Michael L ^a   Hanson, Allison S ^a   Casero, Robert A ^b   Woster, Patrick M ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; ENZYME INHIBITOR; LYSINE SPECIFIC DEMETHYLASE 1; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; CONTROLLED STUDY; EPIGENETICS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; EPIGENESIS, GENETIC; GATA4 TRANSCRIPTION FACTOR; HISTONE DEMETHYLASES; HUMANS; MEMBRANE PROTEINS; METHYLATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; UREA;

EID: 77954691054     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100217a     Document Type: Article

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