New pyrrole inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity

Journal of Medicinal Chemistry

Volumn 50, Issue 5, 2007, Pages 922-931

  La Regina, Giuseppe ^a   Silvestri, Romano ^a   Artico, Marino ^a   Lavecchia, Antonio ^b   Novellino, Ettore ^b   Befani, Olivia ^a   Turini, Paola ^a   Agostinelli, Enzo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE DERIVATIVE; ISOLEUCINE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; PYRROLE DERIVATIVE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; COW; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EVALUATION; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MONOAMINE METABOLISM; NONHUMAN; SIMULATION; STRUCTURE ANALYSIS; SURFACE CHARGE;

ANIMALS; BENZYLAMINES; BINDING SITES; BRAIN; CATTLE; ISOENZYMES; MITOCHONDRIA; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PYRROLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847770688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060882y     Document Type: Article

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