Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 9562-9575

  Suzuki, Takayoshi ^a,b   Ota, Yosuke ^c   Ri, Masaki ^d   Bando, Masashige ^e   Gotoh, Aogu ^a,c   Itoh, Yukihiro ^a   Tsumoto, Hiroki ^c   Tatum, Prima R ^c   Mizukami, Tamio ^f   Nakagawa, Hidehiko ^c   Iida, Shinsuke ^d   Ueda, Ryuzo ^d   Shirahige, Katsuhiko ^e   Miyata, Naoki ^c  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COHESIN; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; N HYDROXY 3 (1 PHENYLSULFANYLMETHYL 1H [1,2,3]TRIAZOL 4 YL)BENZAMIDE; PCI 34058; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

ACETYLATION; ARTICLE; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; MOLECULAR MODEL; NEUROBLASTOMA CELL; T CELL LYMPHOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CLICK CHEMISTRY; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; LYMPHOMA, T-CELL; MODELS, MOLECULAR; NEUROBLASTOMA; REPRESSOR PROTEINS; SMALL MOLECULE LIBRARIES; TUMOR CELLS, CULTURED;

EID: 84870021564     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300837y     Document Type: Article

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