-
1
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
2
-
-
33749256407
-
Engineering cells for cell culture bioprocessing-physiological fundamentals
-
Seth G., Hossler P., Yee J.C., Hu W.S. Engineering cells for cell culture bioprocessing-physiological fundamentals. Adv Biochem Eng Biotechnol 2006, 101:119-164.
-
(2006)
Adv Biochem Eng Biotechnol
, vol.101
, pp. 119-164
-
-
Seth, G.1
Hossler, P.2
Yee, J.C.3
Hu, W.S.4
-
3
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis R.J., Mancuso A., Daikhin E., Nissim I., Yudkoff M., Wehrli S., Thompson C.B. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 2007, 104:19345-19350.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
4
-
-
37449024702
-
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008, 7:11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
5
-
-
84868481008
-
Multivariate analysis of cell culture bioprocess data-lactate consumption as process indicator
-
Le H., Kabbur S., Pollastrini L., Sun Z., Mills K., Johnson K., Karypis G., Hu W.S. Multivariate analysis of cell culture bioprocess data-lactate consumption as process indicator. J Biotechnol 2012, 162:210-223.
-
(2012)
J Biotechnol
, vol.162
, pp. 210-223
-
-
Le, H.1
Kabbur, S.2
Pollastrini, L.3
Sun, Z.4
Mills, K.5
Johnson, K.6
Karypis, G.7
Hu, W.S.8
-
6
-
-
84858000888
-
On metabolic shift to lactate consumption in fed-batch culture of mammalian cells
-
Mulukutla B.C., Gramer M., Hu W.S. On metabolic shift to lactate consumption in fed-batch culture of mammalian cells. Metab Eng 2012, 14:138-149.
-
(2012)
Metab Eng
, vol.14
, pp. 138-149
-
-
Mulukutla, B.C.1
Gramer, M.2
Hu, W.S.3
-
7
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 2004, 4:891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
8
-
-
33847785682
-
Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae
-
Vemuri G.N., Eiteman M.A., McEwen J.E., Olsson L., Nielsen J. Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 2007, 104:2402-2407.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2402-2407
-
-
Vemuri, G.N.1
Eiteman, M.A.2
McEwen, J.E.3
Olsson, L.4
Nielsen, J.5
-
9
-
-
44349186331
-
Influence of genotype and nutrition on survival and metabolism of starving yeast
-
Boer V.M., Amini S., Botstein D. Influence of genotype and nutrition on survival and metabolism of starving yeast. Proc Natl Acad Sci U S A 2008, 105:6930-6935.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6930-6935
-
-
Boer, V.M.1
Amini, S.2
Botstein, D.3
-
10
-
-
61849135453
-
Tumor suppressors and cell metabolism: a recipe for cancer growth
-
Jones R.G., Thompson C.B. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009, 23:537-548.
-
(2009)
Genes Dev
, vol.23
, pp. 537-548
-
-
Jones, R.G.1
Thompson, C.B.2
-
11
-
-
51049091904
-
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line
-
Yoo H., Antoniewicz M.R., Stephanopoulos G., Kelleher J.K. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J Biol Chem 2008, 283:20621-20627.
-
(2008)
J Biol Chem
, vol.283
, pp. 20621-20627
-
-
Yoo, H.1
Antoniewicz, M.R.2
Stephanopoulos, G.3
Kelleher, J.K.4
-
12
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo C.M., Gameiro P.A., Bell E.L., Mattaini K.R., Yang J., Hiller K., Jewell C.M., Johnson Z.R., Irvine D.J., Guarente L., et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012, 481:380-384.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
-
13
-
-
77955843732
-
Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways
-
Mulukutla B.C., Khan S., Lange A., Hu W.S. Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways. Trends Biotechnol 2010, 28:476-484.
-
(2010)
Trends Biotechnol
, vol.28
, pp. 476-484
-
-
Mulukutla, B.C.1
Khan, S.2
Lange, A.3
Hu, W.S.4
-
14
-
-
12944262229
-
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
-
Macheda M.L., Rogers S., Best J.D. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005, 202:654-662.
-
(2005)
J Cell Physiol
, vol.202
, pp. 654-662
-
-
Macheda, M.L.1
Rogers, S.2
Best, J.D.3
-
15
-
-
0033079597
-
Oncogenic alterations of metabolism
-
Dang C.V., Semenza G.L. Oncogenic alterations of metabolism. Trends Biochem Sci 1999, 24:68-72.
-
(1999)
Trends Biochem Sci
, vol.24
, pp. 68-72
-
-
Dang, C.V.1
Semenza, G.L.2
-
16
-
-
0030049769
-
Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
-
Neermann J., Wagner R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol 1996, 166:152-169.
-
(1996)
J Cell Physiol
, vol.166
, pp. 152-169
-
-
Neermann, J.1
Wagner, R.2
-
17
-
-
0027692808
-
Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture
-
Fitzpatrick L., Jenkins H.A., Butler M. Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture. Appl Biochem Biotechnol 1993, 43:93-116.
-
(1993)
Appl Biochem Biotechnol
, vol.43
, pp. 93-116
-
-
Fitzpatrick, L.1
Jenkins, H.A.2
Butler, M.3
-
18
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim J.W., Gao P., Liu Y.C., Semenza G.L., Dang C.V. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007, 27:7381-7393.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
19
-
-
27844526600
-
Akt-dependent transformation: there is more to growth than just surviving
-
Plas D.R., Thompson C.B. Akt-dependent transformation: there is more to growth than just surviving. Oncogene 2005, 24:7435-7442.
-
(2005)
Oncogene
, vol.24
, pp. 7435-7442
-
-
Plas, D.R.1
Thompson, C.B.2
-
20
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh H., Lleonart M.E., Gil J., Wang J., Degan P., Peters G., Martinez D., Carnero A., Beach D. Glycolytic enzymes can modulate cellular life span. Cancer Res 2005, 65:177-185.
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
21
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
Ramanathan A., Wang C., Schreiber S.L. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A 2005, 102:5992-5997.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
Wang, C.2
Schreiber, S.L.3
-
22
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006, 3:177-185.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
23
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.Y., Pfeiffer H.K., Nissim I., Daikhin E., Yudkoff M., McMahon S.B., et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008, 105:18782-18787.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
-
24
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
-
25
-
-
33846061120
-
13C-based flux analysis
-
13C-based flux analysis. Mol Syst Biol 2006, 2:62.
-
(2006)
Mol Syst Biol
, vol.2
, pp. 62
-
-
Sauer, U.1
-
26
-
-
84855596555
-
Towards dynamic metabolic flux analysis in CHO cell cultures
-
Ahn W.S., Antoniewicz M.R. Towards dynamic metabolic flux analysis in CHO cell cultures. Biotechnol J 2012, 7:61-74.
-
(2012)
Biotechnol J
, vol.7
, pp. 61-74
-
-
Ahn, W.S.1
Antoniewicz, M.R.2
-
28
-
-
0028434212
-
Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism
-
Sharfstein S.T., Tucker S.N., Mancuso A., Blanch H.W., Clark D.S. Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism. Biotechnol Bioeng 1994, 43:1059-1074.
-
(1994)
Biotechnol Bioeng
, vol.43
, pp. 1059-1074
-
-
Sharfstein, S.T.1
Tucker, S.N.2
Mancuso, A.3
Blanch, H.W.4
Clark, D.S.5
-
29
-
-
84870668228
-
13C]glutamine provide new insights into CHO cell metabolism
-
13C]glutamine provide new insights into CHO cell metabolism. Metab Eng 2013, 15:34-47.
-
(2013)
Metab Eng
, vol.15
, pp. 34-47
-
-
Ahn, W.S.1
Antnoniewicz, M.R.2
-
30
-
-
84878388792
-
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture
-
Templeton N., Dean J., Reddy P., Young J.D. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture. Biotechnol Bioeng 2013, 110:2013-2024.
-
(2013)
Biotechnol Bioeng
, vol.110
, pp. 2013-2024
-
-
Templeton, N.1
Dean, J.2
Reddy, P.3
Young, J.D.4
-
32
-
-
84872376676
-
13C flux analysis of Myc-induced metabolic reprogramming in B-cells
-
13C flux analysis of Myc-induced metabolic reprogramming in B-cells. Metab Eng 2013, 15:206-217.
-
(2013)
Metab Eng
, vol.15
, pp. 206-217
-
-
Murphy, T.A.1
Dang, C.V.2
Young, J.D.3
-
33
-
-
79955939126
-
Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis
-
Henry O., Jolicoeur M., Kamen A. Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis. Bioprocess Biosyst Eng 2011, 34:263-273.
-
(2011)
Bioprocess Biosyst Eng
, vol.34
, pp. 263-273
-
-
Henry, O.1
Jolicoeur, M.2
Kamen, A.3
-
34
-
-
0030571616
-
Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network
-
Xie L., Wang D.I. Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network. Biotechnol Bioeng 1996, 52:591-601.
-
(1996)
Biotechnol Bioeng
, vol.52
, pp. 591-601
-
-
Xie, L.1
Wang, D.I.2
-
35
-
-
0028077867
-
Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization
-
Petch D., Butler M. Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization. J Cell Physiol 1994, 161:71-76.
-
(1994)
J Cell Physiol
, vol.161
, pp. 71-76
-
-
Petch, D.1
Butler, M.2
-
36
-
-
84855453655
-
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
-
Le A., Lane A.N., Hamaker M., Bose S., Gouw A., Barbi J., Tsukamoto T., Rojas C.J., Slusher B.S., Zhang H., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab 2012, 15:110-121.
-
(2012)
Cell Metab
, vol.15
, pp. 110-121
-
-
Le, A.1
Lane, A.N.2
Hamaker, M.3
Bose, S.4
Gouw, A.5
Barbi, J.6
Tsukamoto, T.7
Rojas, C.J.8
Slusher, B.S.9
Zhang, H.10
-
37
-
-
0035829827
-
Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control
-
Altamirano C., Cairo J.J., Godia F. Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control. Biotechnol Bioeng 2001, 76:351-360.
-
(2001)
Biotechnol Bioeng
, vol.76
, pp. 351-360
-
-
Altamirano, C.1
Cairo, J.J.2
Godia, F.3
-
38
-
-
33748300981
-
Considerations on the lactate consumption by CHO cells in the presence of galactose
-
Altamirano C., Illanes A., Becerra S., Cairo J.J., Godia F. Considerations on the lactate consumption by CHO cells in the presence of galactose. J Biotechnol 2006, 125:547-556.
-
(2006)
J Biotechnol
, vol.125
, pp. 547-556
-
-
Altamirano, C.1
Illanes, A.2
Becerra, S.3
Cairo, J.J.4
Godia, F.5
-
39
-
-
78649410664
-
Metabolic flux analysis of CHO cell metabolism in the late non-growth phase
-
Sengupta N., Rose S.T., Morgan J.A. Metabolic flux analysis of CHO cell metabolism in the late non-growth phase. Biotechnol Bioeng 2011, 108:82-92.
-
(2011)
Biotechnol Bioeng
, vol.108
, pp. 82-92
-
-
Sengupta, N.1
Rose, S.T.2
Morgan, J.A.3
-
40
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., Hurley P.J., Bunz F., Hwang P.M. p53 regulates mitochondrial respiration. Science 2006, 312:1650-1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
41
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K., Tsuruta A., Selak M.A., Vidal M.N., Nakano K., Bartrons R., Gottlieb E., Vousden K.H. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006, 126:107-120.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
42
-
-
80053035284
-
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
-
Hardie D.G. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev 2011, 25:1895-1908.
-
(2011)
Genes Dev
, vol.25
, pp. 1895-1908
-
-
Hardie, D.G.1
-
43
-
-
0033587379
-
Metabolic flux analysis of hybridoma continuous culture steady state multiplicity
-
Follstad B.D., Balcarcel R.R., Stephanopoulos G., Wang D.I. Metabolic flux analysis of hybridoma continuous culture steady state multiplicity. Biotechnol Bioeng 1999, 63:675-683.
-
(1999)
Biotechnol Bioeng
, vol.63
, pp. 675-683
-
-
Follstad, B.D.1
Balcarcel, R.R.2
Stephanopoulos, G.3
Wang, D.I.4
-
44
-
-
0034606665
-
Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells
-
Europa A.F., Gambhir A., Fu P.C., Hu W.S. Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells. Biotechnol Bioeng 2000, 67:25-34.
-
(2000)
Biotechnol Bioeng
, vol.67
, pp. 25-34
-
-
Europa, A.F.1
Gambhir, A.2
Fu, P.C.3
Hu, W.S.4
-
45
-
-
33749251791
-
Fedbatch culture and dynamic nutrient feeding
-
Wlaschin K.F., Hu W.S. Fedbatch culture and dynamic nutrient feeding. Adv Biochem Eng Biotechnol 2006, 101:43-74.
-
(2006)
Adv Biochem Eng Biotechnol
, vol.101
, pp. 43-74
-
-
Wlaschin, K.F.1
Hu, W.S.2
-
46
-
-
79954613316
-
High-end pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO fed-batch cultures
-
Gagnon M., Hiller G., Luan Y.T., Kittredge A., DeFelice J., Drapeau D. High-end pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO fed-batch cultures. Biotechnol Bioeng 2011, 108:1328-1337.
-
(2011)
Biotechnol Bioeng
, vol.108
, pp. 1328-1337
-
-
Gagnon, M.1
Hiller, G.2
Luan, Y.T.3
Kittredge, A.4
DeFelice, J.5
Drapeau, D.6
-
47
-
-
0029059493
-
High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding
-
Zhou W., Rehm J., Hu W.S. High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding. Biotechnol Bioeng 1995, 46:579-587.
-
(1995)
Biotechnol Bioeng
, vol.46
, pp. 579-587
-
-
Zhou, W.1
Rehm, J.2
Hu, W.S.3
-
48
-
-
0030916886
-
Alteration of mammalian cell metabolism by dynamic nutrient feeding
-
Zhou W., Rehm J., Europa A., Hu W.S. Alteration of mammalian cell metabolism by dynamic nutrient feeding. Cytotechnology 1997, 24:99-108.
-
(1997)
Cytotechnology
, vol.24
, pp. 99-108
-
-
Zhou, W.1
Rehm, J.2
Europa, A.3
Hu, W.S.4
-
49
-
-
76749123832
-
Metabolic flux analysis in mammalian cell culture
-
Quek L.E., Dietmair S., Kromer J.O., Nielsen L.K. Metabolic flux analysis in mammalian cell culture. Metab Eng 2010, 12:161-171.
-
(2010)
Metab Eng
, vol.12
, pp. 161-171
-
-
Quek, L.E.1
Dietmair, S.2
Kromer, J.O.3
Nielsen, L.K.4
-
50
-
-
0035808169
-
Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production
-
Chen K., Liu Q., Xie L., Sharp P.A., Wang D.I. Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production. Biotechnol Bioeng 2001, 72:55-61.
-
(2001)
Biotechnol Bioeng
, vol.72
, pp. 55-61
-
-
Chen, K.1
Liu, Q.2
Xie, L.3
Sharp, P.A.4
Wang, D.I.5
-
52
-
-
84862307869
-
Systems biotechnology of animal cells: the road to prediction
-
Carinhas N., Oliveira R., Alves P.M., Carrondo M.J., Teixeira A.P. Systems biotechnology of animal cells: the road to prediction. Trends Biotechnol 2012, 30:377-385.
-
(2012)
Trends Biotechnol
, vol.30
, pp. 377-385
-
-
Carinhas, N.1
Oliveira, R.2
Alves, P.M.3
Carrondo, M.J.4
Teixeira, A.P.5
-
53
-
-
84875268975
-
From gene switches to mammalian designer cells: present and future prospects
-
Auslander S., Fussenegger M. From gene switches to mammalian designer cells: present and future prospects. Trends Biotechnol 2013, 31:155-168.
-
(2013)
Trends Biotechnol
, vol.31
, pp. 155-168
-
-
Auslander, S.1
Fussenegger, M.2
-
54
-
-
0032937141
-
Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering
-
Paredes C., Prats E., Cairo J.J., Azorin F., Cornudella L., Godia F. Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering. Cytotechnology 1999, 30:85-93.
-
(1999)
Cytotechnology
, vol.30
, pp. 85-93
-
-
Paredes, C.1
Prats, E.2
Cairo, J.J.3
Azorin, F.4
Cornudella, L.5
Godia, F.6
-
55
-
-
34547518231
-
Engineering cell metabolism for high-density cell culture via manipulation of sugar transport
-
Wlaschin K.F., Hu W.S. Engineering cell metabolism for high-density cell culture via manipulation of sugar transport. J Biotechnol 2007, 131:168-176.
-
(2007)
J Biotechnol
, vol.131
, pp. 168-176
-
-
Wlaschin, K.F.1
Hu, W.S.2
-
56
-
-
0035930949
-
Blocking of acidosis-mediated apoptosis by a reduction of lactate dehydrogenase activity through antisense mRNA expression
-
Jeong D., Kim T.S., Lee J.W., Kim K.T., Kim H.J., Kim I.H., Kim I.Y. Blocking of acidosis-mediated apoptosis by a reduction of lactate dehydrogenase activity through antisense mRNA expression. Biochem Biophys Res Commun 2001, 289:1141-1149.
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 1141-1149
-
-
Jeong, D.1
Kim, T.S.2
Lee, J.W.3
Kim, K.T.4
Kim, H.J.5
Kim, I.H.6
Kim, I.Y.7
-
57
-
-
33846643485
-
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
-
Kim S.H., Lee G.M. Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin. Appl Microbiol Biotechnol 2007, 74:152-159.
-
(2007)
Appl Microbiol Biotechnol
, vol.74
, pp. 152-159
-
-
Kim, S.H.1
Lee, G.M.2
-
58
-
-
79955540196
-
Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
-
Zhou M., Crawford Y., Ng D., Tung J., Pynn A.F., Meier A., Yuk I.H., Vijayasankaran N., Leach K., Joly J., et al. Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases. J Biotechnol 2011, 153:27-34.
-
(2011)
J Biotechnol
, vol.153
, pp. 27-34
-
-
Zhou, M.1
Crawford, Y.2
Ng, D.3
Tung, J.4
Pynn, A.F.5
Meier, A.6
Yuk, I.H.7
Vijayasankaran, N.8
Leach, K.9
Joly, J.10
-
59
-
-
0037186256
-
Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells
-
Irani N., Beccaria A.J., Wagner R. Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells. J Biotechnol 2002, 93:269-282.
-
(2002)
J Biotechnol
, vol.93
, pp. 269-282
-
-
Irani, N.1
Beccaria, A.J.2
Wagner, R.3
-
60
-
-
0033385223
-
Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction
-
Irani N., Wirth M., van Den Heuvel J., Wagner R. Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction. Biotechnol Bioeng 1999, 66:238-246.
-
(1999)
Biotechnol Bioeng
, vol.66
, pp. 238-246
-
-
Irani, N.1
Wirth, M.2
van Den Heuvel, J.3
Wagner, R.4
-
61
-
-
0037274314
-
Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme
-
Elias C.B., Carpentier E., Durocher Y., Bisson L., Wagner R., Kamen A. Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme. Biotechnol Prog 2003, 19:90-97.
-
(2003)
Biotechnol Prog
, vol.19
, pp. 90-97
-
-
Elias, C.B.1
Carpentier, E.2
Durocher, Y.3
Bisson, L.4
Wagner, R.5
Kamen, A.6
-
62
-
-
80052034701
-
Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase
-
Henry O., Durocher Y. Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase. Metab Eng 2011, 13:499-507.
-
(2011)
Metab Eng
, vol.13
, pp. 499-507
-
-
Henry, O.1
Durocher, Y.2
-
63
-
-
1842425836
-
Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells
-
Fogolin M.B., Wagner R., Etcheverrigaray M., Kratje R. Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells. J Biotechnol 2004, 109:179-191.
-
(2004)
J Biotechnol
, vol.109
, pp. 179-191
-
-
Fogolin, M.B.1
Wagner, R.2
Etcheverrigaray, M.3
Kratje, R.4
-
64
-
-
34548043957
-
Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44)
-
Kim S.H., Lee G.M. Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44). Appl Microbiol Biotechnol 2007, 76:659-665.
-
(2007)
Appl Microbiol Biotechnol
, vol.76
, pp. 659-665
-
-
Kim, S.H.1
Lee, G.M.2
-
65
-
-
14744283551
-
High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker
-
Bebbington C.R., Renner G., Thomson S., King D., Abrams D., Yarranton G.T. High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker. Biotechnology (N Y) 1992, 10:169-175.
-
(1992)
Biotechnology (N Y)
, vol.10
, pp. 169-175
-
-
Bebbington, C.R.1
Renner, G.2
Thomson, S.3
King, D.4
Abrams, D.5
Yarranton, G.T.6
-
66
-
-
11944265249
-
High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification
-
Cockett M.I., Bebbington C.R., Yarranton G.T. High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification. Biotechnology (N Y) 1990, 8:662-667.
-
(1990)
Biotechnology (N Y)
, vol.8
, pp. 662-667
-
-
Cockett, M.I.1
Bebbington, C.R.2
Yarranton, G.T.3
-
67
-
-
0034714090
-
Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr-cells decreases accumulation of ammonium ion in culture media
-
Park H., Kim I.H., Kim I.Y., Kim K.H., Kim H.J. Expression of carbamoyl phosphate synthetase I and ornithine transcarbamoylase genes in Chinese hamster ovary dhfr-cells decreases accumulation of ammonium ion in culture media. J Biotechnol 2000, 81:129-140.
-
(2000)
J Biotechnol
, vol.81
, pp. 129-140
-
-
Park, H.1
Kim, I.H.2
Kim, I.Y.3
Kim, K.H.4
Kim, H.J.5
-
68
-
-
0028171092
-
Effect of Vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant Chinese hamster ovary cells
-
Pendse G.J., Bailey J.E. Effect of Vitreoscilla hemoglobin expression on growth and specific tissue plasminogen activator productivity in recombinant Chinese hamster ovary cells. Biotechnol Bioeng 1994, 44:1367-1370.
-
(1994)
Biotechnol Bioeng
, vol.44
, pp. 1367-1370
-
-
Pendse, G.J.1
Bailey, J.E.2
-
69
-
-
65549153512
-
Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture
-
Dorai H., Kyung Y.S., Ellis D., Kinney C., Lin C., Jan D., Moore G., Betenbaugh M.J. Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture. Biotechnol Bioeng 2009, 103:592-608.
-
(2009)
Biotechnol Bioeng
, vol.103
, pp. 592-608
-
-
Dorai, H.1
Kyung, Y.S.2
Ellis, D.3
Kinney, C.4
Lin, C.5
Jan, D.6
Moore, G.7
Betenbaugh, M.J.8
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