High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

Biotechnology and Bioengineering

Volumn 108, Issue 6, 2011, Pages 1328-1337

  Gagnon, Matthew ^a   Hiller, Gregory ^a   Luan, Yen Tung ^a   Kittredge, Amy ^b   Defelice, Jordy ^a   Drapeau, Denis ^a  

^a PFIZER INC   (United States)

^b Millipore   (United States)

Author keywords

CHO cell culture; Fed batch; Glucose limitation; Lactate; Mammalian cell culture; Monoclonal antibody production

Indexed keywords

CHO CELL CULTURE; FED BATCHES; LACTATE; MAMMALIAN CELL CULTURE; MONOCLONAL ANTIBODY PRODUCTION;

ALLERGIES; ANIMAL CELL CULTURE; BATCH DATA PROCESSING; CELL CULTURE; CELLS; GLUCOSE; GROWTH KINETICS; LACTIC ACID; MAMMALS; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

BATCH CELL CULTURE;

GLUCOSE; LACTIC ACID; MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CELL DENSITY; CELL GROWTH; CHO CELL; CULTURE MEDIUM; FED BATCH CULTURE; GROWTH CURVE; NONHUMAN; NUTRIENT; PH; SUSPENSION CELL CULTURE; TECHNOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; GLUCOSE; HYDROGEN-ION CONCENTRATION; LACTIC ACID;

CRICETULUS GRISEUS; MAMMALIA;

EID: 79954613316     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23072     Document Type: Article

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