Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP+-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity

Toxicological Sciences

Volumn 136, Issue 1, 2013, Pages 166-182

  Garcia Garcia, Aracely ^a   Anandhan, Annandurai ^a   Burns, Michaela ^a   Chen, Han ^a   Zhou, You ^a   Franco, Rodrigo ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

6 hydroxydopamine; Apoptosis; Atg5; Autophagy; Cathepsins; MPP+; Neurodegeneration; Paraquat; Parkinson's disease; Rotenone

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; AUTOPHAGY PROTEIN 5; CASPASE 3; CASPASE INHIBITOR; CATHEPSIN; CHLOROQUINE; HYDROLASE; MAMMALIAN TARGET OF RAPAMYCIN; NEUROTOXIN; OXIDOPAMINE; PARAQUAT; RAPAMYCIN; ROTENONE; TREHALOSE; WORTMANNIN;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LYSOSOME; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

6-HYDROXYDOPAMINE; APOPTOSIS; ATG5; AUTOPHAGY; CATHEPSINS; MPP+; NEURODEGENERATION; PARAQUAT; PARKINSON'S DISEASE.; ROTENONE;

1-METHYL-4-PHENYLPYRIDINIUM; APOPTOSIS; CASPASE 3; CASPASE INHIBITORS; CATHEPSINS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; OXIDOPAMINE; PARAQUAT; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; ROTENONE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSFECTION;

EID: 84887335580     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft188     Document Type: Article

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