Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: Oxidation of thioredoxin and caspase-3 activation

Toxicological Sciences

Volumn 95, Issue 1, 2007, Pages 163-171

  Ramachandiran, Sampath ^a,b   Hansen, Jason M ^a   Jones, Dean P ^a   Richardson J R , Jason R ^a,b,c   Miller, Gary W ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

MAPK; MPTP; Paraquat; Parkinson's disease; Rotenone; Thioredoxin

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CASPASE 3; CELL PROTEIN; DOPAMINE; MITOCHONDRIAL PROTEIN; PARAQUAT; ROTENONE; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN;

ARTICLE; CONTROLLED STUDY; CYTOSOL; DISEASE EXACERBATION; DOPAMINERGIC SYSTEM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR MECHANICS; NEUROTOXICITY; PARKINSON DISEASE; PROTEIN METABOLISM; PROTEIN MODIFICATION;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HERBICIDES; HUMANS; INSECTICIDES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOCHONDRIAL PROTEINS; NEURONS; OXIDATION-REDUCTION; PARAQUAT; PARKINSONIAN DISORDERS; ROTENONE; THIOREDOXIN; TRANSFECTION;

ANIMALIA;

EID: 33845645902     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl125     Document Type: Article

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