Hydrogen peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells

Free Radical Research

Volumn 45, Issue 4, 2011, Pages 389-399

  Seo, Gimoon ^a   Kim, Seong Keun ^a   Byun, Yu Jeong ^a   Oh, Eunhye ^a   Jeong, Seong Whan ^a   Chae, Gue Tae ^a   Lee, Seong Beom ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

autophagic cell death; glutathione; Hydrogen peroxide; mTOR; Rheb; ubiquitination

Indexed keywords

3 METHYLADENINE; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; BECLIN 1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLOHEXIMIDE; GLUTATHIONE; HYDROGEN PEROXIDE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEASOME; PROTEIN P62; RHEB PROTEIN; SMALL INTERFERING RNA; STAUROSPORINE; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UBIQUITINATION;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLUTATHIONE; HYDROGEN PEROXIDE; LYSOSOMES; MACROLIDES; MACROPHAGES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; UBIQUITINATION;

MURINAE;

EID: 79952424876     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2010.535530     Document Type: Article

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