Haloperidol and clozapine block formation of autophagolysosomes in rat primary neurons

Neuroscience

Volumn 209, Issue , 2012, Pages 64-73

  Park, J ^a   Chung, S ^a   An, H ^a   Kim, J ^a   Seo, J ^a   Kim, D H ^a,b   Yoon, S Y ^a,b  

^a University of Ulsan College of Medicine   (South Korea)

^b Asan Medical Center   (South Korea)

Author keywords

Autophagy; Clozapine; Haloperidol; Neurotoxicity; Schizophrenia

Indexed keywords

CLOZAPINE; HALOPERIDOL; LACTATE DEHYDROGENASE; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1A LIGHT CHAIN 3; MICROTUBULE ASSOCIATED PROTEIN 1B LIGHT CHAIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME ACTIVITY; IN VITRO STUDY; NERVE CELL; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIPSYCHOTIC AGENTS; AUTOPHAGY; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CLOZAPINE; FLUORESCENT ANTIBODY TECHNIQUE; HALOPERIDOL; NEURONS; PHAGOSOMES; RATS;

EID: 84862786208     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.02.035     Document Type: Article

References (49)

1. Abekawa T., Ito K., Nakagawa S., Nakato Y., Koyama T. Effects of aripiprazole and haloperidol on progression to schizophrenia-like behavioural abnormalities and apoptosis in rodents. Schizophr Res 2011, 125:77-87.
2. Agostinho F.R., Jornada L.K., Schröder N., Roesler R., Dal-Pizzol F., Quevedo J. Effects of chronic haloperidol and/or clozapine on oxidative stress parameters in rat brain. Neurochem Res 2007, 32:1343-1350.
3. Aitchison K.J., Jann M.W., Zhao J.H., Sakai T., Zaher H., Wolff K., Collier D.A., Kerwin R.W., Gonzalez F.J. Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice. J Psychopharmacol 2000, 14:353-359.
4. Barakauskas V.E., Beasley C.L., Barr A.M., Ypsilanti A.R., Li H.Y., Thornton A.E., Wong H., Rosokilja G., Mann J.J., Mancevski B., Jakovski Z., Davceva N., Ilievski B., Dwork A.J., Falkai P., Honer W.G. A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia. Neuropsychopharmacology 2010, 35:1226-1238.
5. Barnes M.R., Huxley-Jones J., Maycox P.R., Lennon M., Thornber A., Kelly F., Bates S., Taylor A., Reid J., Jones N., Schroeder J., Scorer C.A., Davies C., Hagan J.J., Kew J.N., Angelinetta C., Akbar T., Hirsch S., Mortimer A.M., Barnes T.R., de Belleroche J. Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia. J Neurosci Res 2011, 89:1218-1227.
6. Benítez-King G., Ortíz-López L., Jiménez-Rubio G., Ramírez-Rodríguez G. Haloperidol causes cytoskeletal collapse in N1E-115 cells through tau hyperphosphorylation induced by oxidative stress: implications for neurodevelopment. Eur J Pharmacol 2010, 644:24-31.
7. Boland B., Nixon R.A. Neuronal macroautophagy: from development to degeneration. Mol Aspects Med 2006, 27:503-519.
8. Chu C.T. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol 2006, 65:423-432.
9. Crow T.J. Positive and negative schizophrenic symptoms and the role of dopamine. Br J Psychiatry 1980, 137:383-386.
10. Csernansky J.G., Martin M.V., Czeisler B., Meltzer M.A., Ali Z., Dong H. Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury. Pharmacol Biochem Behav 2006, 83:208-213.
11. Dwyer D.S., Lu X.H., Bradley R.J. Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism. Brain Res 2003, 971:31-39.
12. Flores R., Hirota Y., Armstrong B., Sawa A., Tomoda T. DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway. Neurosci Res 2011, 71:71-77.
13. Galili R., Mosberg, Gil-Ad I., Weizman A., Melamed E., Offen D. Haloperidol-induced neurotoxicity-possible implications for tardive dyskinesia. J Neural Transm 2000, 107:479-490.
14. Gardoni F., Frasca A., Zianni E., Riva M.A., Di Luca M., Fumagalli F. Repeated treatment with haloperidol, but not olanzapine, alters synaptic NMDA receptor composition in rat striatum. Eur Neuropsychopharmacol 2008, 18:531-534.
15. Gelders Y.G. Pharmacology, pharmacokinetics and clinical development of haloperidol decanoate. Int Clin Psychopharmacol 1986, 1(Suppl 1):1-11.
16. Hara T., Nakamura K., Matsui M., Yamamoto A., Nakahara Y., Suzuki-Migishima R., Yokoyama M., Mishima K., Saito I., Okano H., Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441:885-889.
17. Isidoro C., Biagioni F., Giorgi F.S., Fulceri F., Paparelli A., Fornai F. The role of autophagy on the survival of dopamine neurons. Curr Top Med Chem 2009, 9:869-879.
18. Katayama H., Yamamoto A., Mizushima N., Yoshimori T., Miyawaki A. GFP-like proteins stably accumulate in lysosomes. Cell Struct Funct 2008, 33:1-12.
19. Keilhoff G., Grecksch G., Bernstein H.G., Roskoden T., Becker A. Risperidone and haloperidol promote survival of stem cells in the rat hippocampus. Eur Arch Psychiatry Clin Neurosci 2010, 260:151-162.
20. Keshavan M.S., Amirsadri A. Early intervention in schizophrenia: current and future perspectives. Curr Psychiatry Rep 2007, 9:325-328.
21. Keshavan M.S., Anderson S., Pettegrew J.W. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex?. The Feinberg hypothesis revisited. J Psychiatr Res 1994, 28:239-265.
22. Kim S.M., Yoon S.Y., Choi J.E., Park J.S., Choi J.M., Nguyen T., Kim D.H. Activation of eukaryotic initiation factor-2alpha-kinases in okadaic acid-treated neurons. Neuroscience 2010, 169:1831-1839.
23. Kim T., Park J.K., Kim H.J., Chung J.H., Kim J.W. Association of histone deacetylase genes with schizophrenia in Korean population. Psychiatry Res 2010, 178:266-269.
24. Koike M., Shibata M., Tadakoshi M., Gotoh K., Komatsu M., Waguri S., Kawahara N., Kuida K., Nagata S., Kominami E., Tanaka K., Uchiyama Y. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 2008, 172:454-469.
25. Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
26. Lieberman J.A., Johns C.A., Kane J.M., Rai K., Pisciotta A.V., Saltz B.L., Howard A. Clozapine-induced agranulocytosis: non-cross-reactivity with other psychotropic drugs. J Clin Psychiatry 1988, 49:271-277.
27. Lieberman J.A., Kane J.M., Johns C.A. Clozapine: guidelines for clinical management. J Clin Psychiatry 1989, 50:329-338.
28. Lim Y.W., Yoon S.Y., Choi J.E., Kim S.M., Lee H.S., Choe H., Lee S.C., Kim D.H. Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model. Biochem Biophys Res Commun 2010, 395:207-212.
29. Ling D., Salvaterra P.M. A central role for autophagy in Alzheimer-type neurodegeneration. Autophagy 2009, 5:738-740.
30. Magliaro B.C., Saldanha C.J. Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res 2009, 1283:14-24.
31. Meltzer H.Y. The mechanism of action of novel antipsychotic drugs. Schizophr Bull 1991, 17:263-287.
32. Mitchell I.J., Cooper A.C., Griffiths M.R., Cooper A.J. Acute administration of haloperidol induces apoptosis of neurones in the striatum and substantia nigra in the rat. Neuroscience 2002, 109:89-99.
33. Mizushima N., Yamamoto A., Matsui M., Yoshimori T., Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004, 15:1101-1111.
34. Niemegeers C.J., Laduron P.M. Pharmacology and biochemistry of haloperidol. Proc R Soc Med 1976, 69(Suppl 1):3-8.
35. Nixon R.A. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 2007, 120:4081-4091.
36. Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 2005, 64:113-122.
37. Perkins D.O. Neuroprotection: a new strategy in the treatment of schizophrenia. Early detection and intervention. CNS Spectr 2007, 12:10-13.
38. Qing H., Xu H., Wei Z., Gibson K., Li X.M. The ability of atypical antipsychotic drugs vs. haloperidol to protect PC12 cells against MPP+-induced apoptosis. Eur J Neurosci 2003, 17:1563-1570.
39. Reinke A., Martins M.R., Lima M.S., Moreira J.C., Dal-Pizzol F., Quevedo J. Haloperidol and clozapine, but not olanzapine, induces oxidative stress in rat brain. Neurosci Lett 2004, 372:157-160.
40. Rubinsztein D.C., Cuervo A.M., Ravikumar B., Sarkar S., Korolchuk V., Kaushik S., Klionsky D.J. In search of an "autophagomometer". Autophagy 2009, 5:585-589.
41. Sadasivan S., Zhang Z., Larner S.F., Liu M.C., Zheng W., Kobeissy F.H., Hayes R.L., Wang K.K. Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype. BMC Neurosci 2010, 11:21.
42. Spassieva S.D., Mullen T.D., Townsend D.M., Obeid L.M. Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J 2009, 424:273-283.
43. Wang H., Ma J., Tan Y., Wang Z., Sheng C., Chen S., Ding J. Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cells. J Alzheimers Dis 2010, 21:597-610.
44. Wang Y., Singh R., Xiang Y., Czaja M.J. Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress. Hepatology 2010, 52:266-277.
45. Yang T.T., Wang S.J. Aripiprazole and its human metabolite OPC14857 reduce, through a presynaptic mechanism, glutamate release in rat prefrontal cortex: possible relevance to neuroprotective interventions in schizophrenia. Synapse 2008, 62:804-818.
46. Yoon S.Y., Choi J.E., Kweon H.S., Choe H., Kim S.W., Hwang O., Lee H., Lee J.Y., Kim D.H. Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease. J Neurosci Res 2008, 86:3230-3239.
47. Yoshimoto K., Jikumaru Y., Kamiya Y., Kusano M., Consonni C., Panstruga R., Ohsumi Y., Shirasu K. Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Plant Cell 2009, 21:2914-2927.
48. Yulug B., Bakar M., Ozan E. The neuroprotective effect of olanzapine. J Neuropsychiatry Clin Neurosci 2008, 20:107-108.
49. Zhuravliova E., Barbakadze T., Natsvlishvili N., Mikeladze D.G. Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity. Neurochem Int 2007, 50:976-982.