Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis

Molecular Pharmacology

Volumn 73, Issue 4, 2008, Pages 1052-1063

  King, Matthew A ^a   Hands, Sarah ^c   Hafiz, Farida ^a   Mizushima, Noboru ^b   Tolkovsky, Aviva M ^a   Wyttenbach, Andreas ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; POLYGLUTAMINE; RAPAMYCIN;

ANIMAL CELL; ARTICLE; ATG5 GENE; AUTOPHAGY; CELL INCLUSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; EMBRYO; EMBRYO CELL; GENE; GENETICS; KNOCKOUT GENE; MODULATION; MOUSE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROBABILITY; PROTEIN AGGREGATION; PROTEIN SYNTHESIS; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTI-BACTERIAL AGENTS; AUTOPHAGY; CELLS, CULTURED; CYCLOHEXIMIDE; FIBROBLASTS; GENE DELETION; GREEN FLUORESCENT PROTEINS; HUMANS; INCLUSION BODIES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SIROLIMUS; SODIUM DODECYL SULFATE; SOLUBILITY; UBIQUITIN; VIMENTIN;

EID: 41149159767     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.043398     Document Type: Article

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