메뉴 건너뛰기




Volumn 7, Issue 4, 2012, Pages

Inhibitors of phosphatidylinositol 3′-kinases promote mitotic cell death in HeLa cells

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; AUTOPHAGY PROTEIN 5; CASPASE 3; MYOSIN LIGHT CHAIN; NOCODAZOLE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; WORTMANNIN; 3-METHYLADENINE; ADENINE; ANDROSTANE DERIVATIVE; DRUG DERIVATIVE;

EID: 84860159791     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035665     Document Type: Article
Times cited : (66)

References (38)
  • 2
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: variations on a theme
    • Yuan TL, Cantley LC, (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 3
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, et al. (2004) Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428: 332-337.
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1    de Stanchina, E.2    Fridman, J.S.3    Malina, A.4    Ray, S.5
  • 4
    • 42049089732 scopus 로고    scopus 로고
    • Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death
    • Elis W, Triantafellow E, Wolters NM, Sian KR, Caponigro G, et al. (2008) Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Mol Cancer Res 6: 614-623.
    • (2008) Mol Cancer Res , vol.6 , pp. 614-623
    • Elis, W.1    Triantafellow, E.2    Wolters, N.M.3    Sian, K.R.4    Caponigro, G.5
  • 5
    • 34247880280 scopus 로고    scopus 로고
    • Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells
    • Kim SH, Juhnn YS, Song YS, (2007) Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells. Ann N Y Acad Sci 1095: 82-89.
    • (2007) Ann N Y Acad Sci , vol.1095 , pp. 82-89
    • Kim, S.H.1    Juhnn, Y.S.2    Song, Y.S.3
  • 6
    • 79952660192 scopus 로고    scopus 로고
    • New phosphatidylinositol 3-kinase inhibitors for cancer
    • Bowles DW, Jimeno A, (2011) New phosphatidylinositol 3-kinase inhibitors for cancer. Expert Opin Investig Drugs 20: 507-518.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 507-518
    • Bowles, D.W.1    Jimeno, A.2
  • 8
    • 33744996707 scopus 로고    scopus 로고
    • Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint
    • Brito DA, Rieder CL, (2006) Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Curr Biol 16: 1194-1200.
    • (2006) Curr Biol , vol.16 , pp. 1194-1200
    • Brito, D.A.1    Rieder, C.L.2
  • 9
    • 0038247837 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest
    • Deacon K, Mistry P, Chernoff J, Blank JL, Patel R, (2003) p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell 14: 2071-2087.
    • (2003) Mol Biol Cell , vol.14 , pp. 2071-2087
    • Deacon, K.1    Mistry, P.2    Chernoff, J.3    Blank, J.L.4    Patel, R.5
  • 10
    • 33947236886 scopus 로고    scopus 로고
    • Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway
    • Mhaidat NM, Zhang XD, Jiang CC, Hersey P, (2007) Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway. Clin Cancer Res 13: 1308-1314.
    • (2007) Clin Cancer Res , vol.13 , pp. 1308-1314
    • Mhaidat, N.M.1    Zhang, X.D.2    Jiang, C.C.3    Hersey, P.4
  • 11
    • 0035843123 scopus 로고    scopus 로고
    • Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53
    • Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, et al. (2001) Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 20: 147-155.
    • (2001) Oncogene , vol.20 , pp. 147-155
    • Bacus, S.S.1    Gudkov, A.V.2    Lowe, M.3    Lyass, L.4    Yung, Y.5
  • 12
    • 34247232176 scopus 로고    scopus 로고
    • Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis
    • Allan LA, Clarke PR, (2007) Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Mol Cell 26: 301-310.
    • (2007) Mol Cell , vol.26 , pp. 301-310
    • Allan, L.A.1    Clarke, P.R.2
  • 13
    • 0037434841 scopus 로고    scopus 로고
    • Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis
    • Basu A, Haldar S, (2003) Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. FEBS Lett 538: 41-47.
    • (2003) FEBS Lett , vol.538 , pp. 41-47
    • Basu, A.1    Haldar, S.2
  • 14
    • 0028904536 scopus 로고
    • Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer
    • Baguley BC, Marshall ES, Whittaker JR, Dotchin MC, Nixon J, et al. (1995) Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer. Eur J Cancer 31A: 230-237.
    • (1995) Eur J Cancer , vol.31 A , pp. 230-237
    • Baguley, B.C.1    Marshall, E.S.2    Whittaker, J.R.3    Dotchin, M.C.4    Nixon, J.5
  • 15
    • 0037211320 scopus 로고    scopus 로고
    • An association of Bcl-2 phosphorylation and Bax localization with their functions after hyperthermia and paclitaxel treatment
    • Salah-Eldin AE, Inoue S, Tsukamoto S, Aoi H, Tsuda M, (2003) An association of Bcl-2 phosphorylation and Bax localization with their functions after hyperthermia and paclitaxel treatment. Int J Cancer 103: 53-60.
    • (2003) Int J Cancer , vol.103 , pp. 53-60
    • Salah-Eldin, A.E.1    Inoue, S.2    Tsukamoto, S.3    Aoi, H.4    Tsuda, M.5
  • 16
    • 79955468660 scopus 로고    scopus 로고
    • Dual blockade of phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer
    • Xu R, Nakano K, Iwasaki H, Kumagai M, Wakabayashi R, et al. (2011) Dual blockade of phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer. Cancer Lett 306: 151-160.
    • (2011) Cancer Lett , vol.306 , pp. 151-160
    • Xu, R.1    Nakano, K.2    Iwasaki, H.3    Kumagai, M.4    Wakabayashi, R.5
  • 17
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ, Emr SD, (2000) Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 19
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ, (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 20
    • 0005677775 scopus 로고
    • 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen PO, Gordon PB, (1982) 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 79: 1889-1892.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 22
    • 35148868751 scopus 로고    scopus 로고
    • 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition
    • Ito S, Koshikawa N, Mochizuki S, Takenaga K, (2007) 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition. Int J Oncol 31: 261-268.
    • (2007) Int J Oncol , vol.31 , pp. 261-268
    • Ito, S.1    Koshikawa, N.2    Mochizuki, S.3    Takenaga, K.4
  • 23
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5
  • 24
    • 0029068871 scopus 로고
    • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
    • Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, et al. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43.
    • (1995) Nature , vol.376 , pp. 37-43
    • Nicholson, D.W.1    Ali, A.2    Thornberry, N.A.3    Vaillancourt, J.P.4    Ding, C.K.5
  • 25
    • 0036473430 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells
    • Cimini D, Fioravanti D, Salmon ED, Degrassi F, (2002) Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells. J Cell Sci 115: 507-515.
    • (2002) J Cell Sci , vol.115 , pp. 507-515
    • Cimini, D.1    Fioravanti, D.2    Salmon, E.D.3    Degrassi, F.4
  • 26
    • 70349452101 scopus 로고    scopus 로고
    • Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly
    • Huang HC, Shi J, Orth JD, Mitchison TJ, (2009) Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell 16: 347-358.
    • (2009) Cancer Cell , vol.16 , pp. 347-358
    • Huang, H.C.1    Shi, J.2    Orth, J.D.3    Mitchison, T.J.4
  • 27
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    • Gascoigne KE, Taylor SS, (2008) Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 14: 111-122.
    • (2008) Cancer Cell , vol.14 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 28
    • 56249107716 scopus 로고    scopus 로고
    • Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
    • Orth JD, Tang Y, Shi J, Loy CT, Amendt C, et al. (2008) Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther 7: 3480-3489.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3480-3489
    • Orth, J.D.1    Tang, Y.2    Shi, J.3    Loy, C.T.4    Amendt, C.5
  • 30
    • 31544451511 scopus 로고    scopus 로고
    • RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells
    • Reagan-Shaw S, Ahmad N, (2006) RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells. Cancer Res 66: 1062-1069.
    • (2006) Cancer Res , vol.66 , pp. 1062-1069
    • Reagan-Shaw, S.1    Ahmad, N.2
  • 31
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan MA, Wilson L, (2004) Microtubules as a target for anticancer drugs. Nat Rev Cancer 4: 253-265.
    • (2004) Nat Rev Cancer , vol.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 32
    • 0037175401 scopus 로고    scopus 로고
    • hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells
    • DeLuca JG, Moree B, Hickey JM, Kilmartin JV, Salmon ED, (2002) hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. J Cell Biol 159: 549-555.
    • (2002) J Cell Biol , vol.159 , pp. 549-555
    • DeLuca, J.G.1    Moree, B.2    Hickey, J.M.3    Kilmartin, J.V.4    Salmon, E.D.5
  • 33
    • 0034520085 scopus 로고    scopus 로고
    • Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function
    • Cogswell JP, Brown CE, Bisi JE, Neill SD, (2000) Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function. Cell Growth Differ 11: 615-623.
    • (2000) Cell Growth Differ , vol.11 , pp. 615-623
    • Cogswell, J.P.1    Brown, C.E.2    Bisi, J.E.3    Neill, S.D.4
  • 34
    • 33846931644 scopus 로고    scopus 로고
    • The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1
    • Lenart P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, et al. (2007) The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol 17: 304-315.
    • (2007) Curr Biol , vol.17 , pp. 304-315
    • Lenart, P.1    Petronczki, M.2    Steegmaier, M.3    Di Fiore, B.4    Lipp, J.J.5
  • 35
    • 3042537050 scopus 로고    scopus 로고
    • Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy
    • Castedo M, Perfettini JL, Roumier T, Valent A, Raslova H, et al. (2004) Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene 23: 4362-4370.
    • (2004) Oncogene , vol.23 , pp. 4362-4370
    • Castedo, M.1    Perfettini, J.L.2    Roumier, T.3    Valent, A.4    Raslova, H.5
  • 37
    • 34447529458 scopus 로고    scopus 로고
    • BUB1 mediation of caspase-independent mitotic death determines cell fate
    • Niikura Y, Dixit A, Scott R, Perkins G, Kitagawa K, (2007) BUB1 mediation of caspase-independent mitotic death determines cell fate. J Cell Biol 178: 283-296.
    • (2007) J Cell Biol , vol.178 , pp. 283-296
    • Niikura, Y.1    Dixit, A.2    Scott, R.3    Perkins, G.4    Kitagawa, K.5
  • 38
    • 54349097938 scopus 로고    scopus 로고
    • Multiple origins of spontaneously arising micronuclei in HeLa cells: direct evidence from long-term live cell imaging
    • Rao X, Zhang Y, Yi Q, Hou H, Xu B, et al. (2008) Multiple origins of spontaneously arising micronuclei in HeLa cells: direct evidence from long-term live cell imaging. Mutat Res 646: 41-49.
    • (2008) Mutat Res , vol.646 , pp. 41-49
    • Rao, X.1    Zhang, Y.2    Yi, Q.3    Hou, H.4    Xu, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.